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4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei kato Daisuke Nishizaki Hirotaka Miyashita Suzanna Lee mary k.nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi ko Jason k.Sicklick Razelle kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

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Turning teawaste particles into magnetic bio-sorbents particles for arsenic removal from wastewater:Isotherm and kinetic studies

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Particuology 2024年第4期87卷 179-193页

作者： mary McGeogh Hamza Annath Chirangano Mangwandi School of Chemistry and Chemical Engineering Queen's University BelfastDavid Kier BuildingBT95AGUnited Kingdorm Department of Chermnistry Lancaster UniversityBailrigsLancasterLA14YBUnited Kingdom

The primary objective of this research was to assess the potential of magnetic bleached biochar(MBBC)as a cost-effective adsorbent for arsenic *** achieve this,locally collected tea wastes underwent meticulous cleaning,bleaching,and modifications via thermal and chemical *** non-magnetic and magnetic biochar adsorbents were thoroughly characterized using Fourier transform-infrared spectroscopy(FT-IR)and thermo-gravimetric analysis(TGA).Subsequently,the adsorptive performance of MBBC in removing arsenic from wastewater samples was investigated,considering various crucial parameters such as adsorbent-adsorbate contact time,concentration of As,temperature,adsorbent dosage,and the regeneration-ability of the *** experimental data for the adsorption process were best represented by the Langmuir isotherm,indicating its suitability for the MBBC ***,the MBBC demonstrated a maximum Langmuir adsorption capacity of approximately 714 mg/g at room temperature,highlighting its efficiency as an arsenic ***,the Lagergren's Pseudo-second order kinetic model proved to be the most suitable for describing the adsorption kinetics,confirming the chemisorption nature of the *** results also indicated that the adsorption process is endothermic and feasible,suggesting its viability for practical *** all findings into account,the comprehensive analysis strongly supports the potential use of MBBC as a highly promising and cost-effective adsorbent for efficiently removing arsenic from aqueous *** research contributes valuable insights to the field of wastewater treatment and offers a sustainable and environmentally friendly solution for tackling arsenic contamination in water sources.

关键词： Arsenics Wastewater Adsorption Magnetic bio-char Teawaste

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A toast to a zebrafish germ cell induction cocktail

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Science China(Life Sciences) 2024年第6期67卷 1314-1315页

作者： mary C.Mullins Department of Cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGCs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

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Geothermo-mechanical alterations due to heat energy extraction in enhanced geothermal systems: Overview and prospective directions

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Deep Underground Science and Engineering 2024年第3期3卷 256-268页

作者： mary C.Ngoma Oladoyin kolawole Olufemi Olorode John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkUSA Department of Petroleum Engineering Louisiana State UniversityBaton RougeUSA

Geothermal energy from deep underground (or geological) formations,with or without its combination with carbon capture and storage (CCS),can be a key technology to mitigate anthropogenic greenhouse gas emissions and meet the 2050 net‐zero carbon emission *** resources in low‐permeability and medium‐and high‐temperature reservoirs in sedimentary sequence require hydraulic stimulation for enhanced geothermal systems (EGS).However,fluid migration for geothermal energy in EGS or with potential CO_(2) storage in a CO_(2)‐EGS are both dependent on the in situ flow pathway network created by induced fluid *** thermo‐mechanical interactions can be complex and induce varying alterations in the mechanical response when the working fluid is water (in EGS) or supercritical CO_(2)(in CO_(2)‐EGS),which could impact the geothermal energy recovery from geological ***,there is a need for a deeper understanding of the heat extraction process in EGS and CO_(2)‐*** study presents a systematic review of the effects of changes in mechanical properties and behavior of deep underground rocks on the induced flow pathway and heat recovery in EGS reservoirs with or without CO_(2) storage in CO_(2) ‐***,we proposed waterless‐stimulated EGS as an alternative approach to improve heat energy extraction in ***,based on the results of our literature review and proposed ideas,we recommend promising areas of investigation that may provide more insights into understanding geothermo‐mechanics to further stimulate new research studies and accelerate the development of geothermal energy as a viable clean energy technology.

关键词： CO_(2)-EGS enhanced geothermal systems geomechanics geothermal energy underground thermal energy

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Directives and references in selected coronavirus-motivated internet memes

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Language and Semiotic Studies 2024年第2期10卷 245-266页

作者： Ayo Osisanwo Toluwalope mary Falade Department of English University of IbadanIbadanNigeria Institute of English Studies Leuphana UniversitätLüneburgGermany Department of English and General Studies Ladoke Akintola UniversityOgbomosoNigeria

The use of directives in communicating the nature of the pandemic and reference to social experiences were promoted using images on social media *** images or memes are used to create awareness and reinforce the criteria for safety during the *** studies on internet memes have concentrated on humor generation,speaker-hearer shared knowledge,neologism,and multimodality among others,with insufficient attention paid to the use of directives and references in such coronavirus-motivated *** paper,therefore,examines how directives and references are employed in conveying expected social responsibilities through coronavirus-motivated internet memes in Nigeria and other socio-cultural *** data,one hundred coronavirus-motivated memes were purposively selected from Facebook,and eight representative memes were subjected to pragmatic analysis using aspects of Jacob Mey’s(***:An introduction,2nd ***:Blackwell Publishing)pragmatic acts theory to unearth insights from *** paper observes that the various spheres of life that are relatable to an online audience help to express what the pandemic is about and enhance the meaning of the pandemic with the context of the use of the memes,giving clearer perspectives on the *** and references are useful tools for conveying social responsibilities to online audience.

关键词： directives references coronavirus internet memes social responsibilities

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Assessment of nano-to-micro-scale geomechanical properties and their time-dependent behavior: Current status and progressive perspectives

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第1期3卷 1-15页

作者： mary C.Ngoma Oladoyin kolawole John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA

Rocks can deform at varying scales(nano-,micro-and macro-scale)under different temperatures,pressures,stresses,and time ***-core scale(nano-to micro-scale)changes in rock properties can influence local(fine-scale)and bulk scale(macro-scale)rock ***,there is a lack of comprehensive knowledge on how rock deformation at sub-core scale(i.e.,nano-to micro-scale)is assessed and its potential to accurately predicte and estimate the macro-scale mechanical behavior of *** study presents a comprehensive and forward-leaning review of the assessment of nano-scale and micro-scale rock mechanical parameters,their timedependent behavior,and potential applications in rock ***,we highlighted the key findings based on experimental and numerical methods for evaluating rock mechanical parameters,and presented the limitations of these ***,we discussed the reliability of sub-core scale mechanical assessments in predicting macromechanical(larger-scale)properties and the behavior of rocks in ***,we offer recommendations to advance investigations focused on rock mechanical assessments at these smaller scales and provide a more accurate characterization at the sub-core scale.

关键词： Rock mechanics Rock deformation Nanomechanics Rock creep Rock engineering

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan mary C.Stephenson Sharifah Badriyah Alhadad kelvin W.Z.Loh Tuck Wah Soong Jason k.W.Lee Ivan C.C.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance Centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and Technological Enterprise(CREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity Cognition Heat stress Hyperthermia Motor function

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Citrobacter Causing Septic Arthritis: A Case Report

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Infectious Diseases & Immunity 2024年第3期4卷 146-148页

作者： kimberly k.Levine mary Dahl Abubakar Tauseef Joseph Thirumalareddy Department of Internal Medicine Creighton University School of MedicineOmaha 68124NEUSA

The genus Citrobacter commonly found in water and soil as well as the intestinal and urinary tracts of animals and *** Citrobacter infections are infrequently diagnosed in environmental contexts,the rising incidence of nosocomial manifestations underscores the importance of considering this organism in the differential diagnosis of hospital-acquired *** present a case of patient with septic arthritis of the shoulder who had been originally admitted for the management of acute-on-chronic congestive heart failure exacerbation and severe *** hospital day 1,joint aspiration cultures and Gram stain confirmed the presence of Citrobacter koseri,a pathogen not commonly associated with septic arthritis,and ceftriaxone was administered to target *** hospital day 7,antibiotic was transitioned to levofloxacin,every other day for 4 *** patient was discharged to an acute rehabilitation facility after a 14-day hospital *** case stresses the importance of maintaining a broad differential diagnosis for any patients who present with fever and joint inflammation or swelling,especially in a postoperative setting.

关键词： Citrobacter koseri Bacteremia Septic arthritis

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Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

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Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.k.k.Vikla k.koichumanova Songbo He k.Seshan Joint International Research Laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands CoRe Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction *** this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 *** them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst *** the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst *** proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect

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Monkeypox: A Viral Zoonotic Disease of Rising Global Concern

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Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran Ani Betsy Joseph mary Thomas Vishnupriya k.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of Periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and Research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

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