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Rangeland hillslope lengths:A case study at the Walnut Gulch Experimental Watershed,southeastern Arizona

International Soil and Water conservation Research 2022年第4期10卷 597-609页

作者： Li Li Mark A.Nearing Philip Heilman mary H.Nichols D.P.Guertin c.J.Williams School of Natural Resources and the Environment University of ArizonaTucsonAZ85705USA USDA-Agricultural Research Service Southwest Watershed Research CenterTucsonAZ85719USA

Rangeland hillslopes provide much of the sediment supplied to channel systems and their lengths exert a fundamental constraint on hillslope diffusive ***,information regarding lengths of rangeland hillslopes,and how best to estimate them,is *** this study,three groups of watersheds(10 in total)were selected from the Walnut Gulch Experimental Watershed according to their geology,soil and vegetation *** 1 watersheds were at lower elevations dominated by shrubs,Group 3 were at high elevations dominated by grass,and Group 2 were mixed shrub and *** hillslope lengths were calculated from 1 m-resolution DEMs using three methods:a flow routing algorithm,slope-area relationships,and inverted relationship with drainage *** that characterize the current watersheds,including Hack's exponent and coefficient,watershed shape coefficient,channel concavity and steepness,and surface roughness,were quantified and related to hillslope *** shows:(1)estimated hillslope lengths were different for the three methods and between the three groups of watersheds;(2)hillslope lengths that measured from the flow routing algorithm for the ten selected watersheds primarily ranged from 30 to 100 m,with a median value of 63.0 m,which was 20%e50%greater than those derived from slope-area plots or drainage densities;(3)hillslope lengths estimated from the flow routing method were greater in Group 3 watersheds than in Group 2 and then in Group 1 *** attributed these differences in hillslope lengths to the historic epeirogenic pulses,watershed and drainage network morphology,and differences in vegetation characteristics;(4)measured hillslope lengths from the flow routing algorithm were best correlated with hillslope relief,then surface roughness,channel steepness and *** results would benefit the applications of hydrological and erosion models in rangelands.

关键词： Rangeland hillslope Slope length Drainage density Slope-area relationship Hillslope hydrology

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cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

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conserving Agricultural Heritage Systems through Tourism: Exploration of Two Mountainous communities in china

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Journal of Mountain Science 2013年第6期10卷 962-975页

作者： SUN Ye-hong mary jane DELA cRUZ MIN Qing-wen LIU Mou-cheng ZHANG Ling-yun Institute of Tourism Beijing Union University Land and Water Division Natural Resources and Environment Management Department Food and Agriculture Organization Institute of Geographic Sciences and Natural Resources research Chinese Academy of Sciences

community plays an important role in the preservation of agricultural heritage system(AHS).Recently, many AHS have been valorized as interesting resources for rural tourism. The expectations are that tourism development(TD) can be supportive for the conservation of AHS while creating benefits for local communities. In this study,two mountainous pilot villages(Longxian and Xiaohuang) in a global conservation project for traditional agricutural systems – Globally Important Agricultural Heritage Systems(GIAHS) were selected to identify the relationship between AHS conservation and TD. The study undertook in-depth interviews,and questionnaires of village residents and informal discussions with local villagers. A t-test and a linear regression model were implemented to explore the comparative dimensions of the two communities with different geographical location, economic situation,and stage of TD. The research found some similarities and differences in the two mountainous communities during AHS conservation and TD. Firstly, AHS are preservaed well in both villages unconsiously, while the residents in Xiaohuang value more highly the heritage elements than the respondents in Longxian,and the villagers in Xiaohuang are more worried about their heritage system; Secondly, both villages expect lots of benefits from TD and they clearly perceive more positive than negative impact from tourism and thus approve TD, while the hugedifferent perception on transportation and accessibility in the two villages reflects the bottleneck of TD in Xiaohuang village. At the same time, the respondents from Xiaohuang perceive more positive and fewer negative impact from tourism than the respondents from Longxian. Thirdly, the respondents in the two villages all show positive attitudes towards participation in tourism mostly motivated by the high income expectation. The main factors to determine the community perception in two villages were also analyzed based on the data process. A location-ba

关键词：旅游业发展节约型农业遗产系统社区勘探山区中国线性回归模型

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活动期糖尿病夏科神经性骨关节病诊疗指南——《国际糖尿病足工作组:糖尿病相关的足病预防与管理指南(2023)》的一部分

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感染、炎症、修复 2024年第1期25卷 52-71页

作者： Dane K.Wukich Nicolaas c.Schaper catherine Gooday Arun Bal Robert Bem Avneesh chhabra mary Hastings crystal Holmes Nina L.Petrova Maria Gala Santini Araujo Eric Senneville Katherine M.Raspovic on behalf of the International Working Group on the Diabetic Foot 赵宏谋徐俊(译) 张明珠(审校) Department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA Division of Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtthe Netherlands Elsie Bertram Diabetes centre Norfolk&Norwich University Hospitals NHS Foundation TrustNorfolkUK Secretary International Association of Diabetic Foot SurgeonsMumbaiIndia Diabetes centre Institute for Clinical and Experimental MedicinePrague Department of Radiology UT Southwestern Medical CenterDallasTexasUSA Program in Physical Therapy Washington University School of MedicineSt.LouisMissouriUSA The Division of Metabolism Endocrinology and DiabetesThe University of Michigan Medical SchoolAnn ArborMichiganUSA Department of Diabetes Diabetic Foot ClinicKing’s College Hospital NHS Foundation TrustLondonUK Italian Hospital of Buenos Aires Buenos AiresArgentina Department of Infectious Diseases Gustave Dron HospitalTourcoingFrance 不详西安交通大学医学院附属红会医院陕西西安710054 天津医科大学朱宪彝纪念医院天津300314 首都医科大学附属同仁医院北京100730

国际糖尿病足工作组(IWGDF)自1999年以来发布了糖尿病足病预防和治疗的循证指南。这是IWGDF发布的第一部关于糖尿病患者活动期夏科神经性骨关节病诊断和治疗的指南。我们遵循GRADE方法,以人群-评估-比较-结局(PAcO)和人群-干预-比较-结... 详细信息

国际糖尿病足工作组(IWGDF)自1999年以来发布了糖尿病足病预防和治疗的循证指南。这是IWGDF发布的第一部关于糖尿病患者活动期夏科神经性骨关节病诊断和治疗的指南。我们遵循GRADE方法,以人群-评估-比较-结局(PAcO)和人群-干预-比较-结局(PIcO)的格式设计临床问题,系统检索医学文献,并提出有依据的推荐。这些推荐是基于我们系统综述的证据,如无证据则参考专家意见,并考虑到与干预相关的受益和危害、患者偏好、可行性和适用性以及成本的权衡。我们在本章节介绍了2023年糖尿病患者活动期夏科神经性骨关节病的诊断和治疗指南,并提出了未来的关键研究方向。

关键词：糖尿病夏科神经性骨关节病,活动期诊断治疗国际糖尿病足工作组指南

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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

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Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang jane LLiesveld Laura Mcalvi Brea cLipe Lianping Xing Michael WBecker Edward MSchwarz Shu-chi A.Yeh center for Musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Wilmot cancer center University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HScs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

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Orthogonal quantification of soluble inducible T-cell costimulator(IcOS)in healthy and diseased human serum

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Journal of Pharmaceutical Analysis 2022年第2期12卷 317-323页

作者： Kevin McKinski Dean McNulty Francesca Zappacosta mary Birchler Matt Szapacs christopher Evans Bioanalysis Immunogenicity&BiomarkersGlaxoSmithKlineCollegevillePA19426USA

Inducible T-cell costimulator(IcOS),a homodimeric protein expressed on the surface of activated T-cells,is being investigated as a potential therapeutic target to treat various *** studies have reported aberrant increases in the soluble form of IcOS(sIcOS)in human serum in disease-state patients,primarily using commercial ELISA ***,results from our in-house immunoassay did not show these aberrant increases,leading us to speculate that commercial sIcOS ELISAs may be prone to *** directly tested that hypothesis and found that one widely used commercial kit yields falsepositives and is prone to human anti-mouse antibody *** then analyzed a panel of healthy,cancer,chronic hepatitis c virus,systemic lupus erythematosus,and diffuse cutaneous systemic sclerosis human serum using our in-house immunoassay and reported the measured sIcOS concentrations in these *** even well characterized immunoassay methods are prone to non-specific interference,we also developed a novel sIcOS Lc-MS/MS method to confirm the *** these orthogonal approaches,we show that sIcOS is a low abundance soluble protein that cannot be measured above approximately 20 pg/mL in human serum.

关键词： IcOS Immunoassay Lc-MS/MS Biomarker HAMA

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The evolution of the atmosphere in the Archaean and early Proterozoic

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chinese Science Bulletin 2011年第1期56卷 4-13页

作者： NISBET Euan FOWLER c mary R Deptartment of Earth Sciences Royal HollowayUniversity of London

Key steps in atmospheric evolution occurred in the *** Hadean atmosphere was created by the inorganic processes of volatile accretion from space and degassing from the interior,and then modified by chemical and photochemical *** air was probably initially anoxic,though there may have been a supply of oxidation power as a consequence of hydrodynamic escape to space of hydrogen from *** subduction may have removed cO2 and the Hadean planet may have been *** the Archaean,as anoxygenic and then oxygenic photosynthesis evolved,biological activity remade the *** evidence implies there were liquid oceans despite the faint young *** oceans may have been sustained by the greenhouse warming effect of biologically-made *** in the late Archaean would have released free O2 into the *** would have created oxic surface waters,challenging the methane *** the Great Oxidation Event around 2.3 to 2.4 billion years ago,the atmosphere itself became oxic,perhaps triggering a glacial crisis by cutting methane-caused greenhouse *** the early Proterozoic,all the key biochemical processes that maintain the modern atmosphere were probably present in the microbial community.

关键词：晚太古代大气演化早元古代二氧化碳温室效应光化学过程微生物群落调制解调器

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Breeding system and pollination ecology of a potentially invasive alien clematis vitalba *** Ireland

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Journal of Plant Ecology 2018年第1期11卷 56-63页

作者： conor M.Redmond jane c.Stout Faculty of Science University of South BohemiaCeske BudejoviceBranisovska 176037005 Ceske BudejoviceCzech Republic Biology centre Institute of EntomologyThe Czech Academy of SciencesBranisovska 3137005 Ceske BudejoviceCzech Republic School of Natural Sciences and Trinity centre for Biodiversity Research Trinity College DublinDublin 2Ireland

Aims Invasive alien plants can greatly affect native communities and eco-system processes but only a small fraction of alien plant species become *** to establishment and invasion include reproductive *** vitalba *** been a popular hor-ticultural species for the past century and is widely distributed and can be highly *** Ireland,it is considered naturalized and potentially *** this,little is known about its reproduc-tive *** We carried out manipulative field experiments in Ireland and com-pared fruit and seed set from a number of pollination treatments,namely cross-pollination,geitonogamy,autogamy and natural *** also recorded floral visitation to *** through a series of timed *** Findings We found that *** is capable of uniparental reproduction via geitonogamy and autonomous selfing,albeit at a reduced rate com-pared with outcrossing *** vitalba was visited by at least 10 native pollinator taxa,with hoverflies dominating *** fruit set nor seed set in our study population was pollen *** the lack of reproductive constraint,*** may easily spread in suitable *** is of concern in Ireland,given its prevalence in some of the country’s most floristically diverse regions.

关键词： clematis vitalba plant invasion invasive traits mutualism

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UvWhi2 Is Required for Stress Response and Pathogenicity in Ustilaginoidea virens

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Rice science 2022年第1期29卷 47-54,I0018-I0023页

作者： MENG Shuai QIU Jiehua XIONG Meng LIU Zhiquan jane Sadhna JAGERNATH LIN Fucheng SHI Huanbin KOU Yanjun State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China Key Laboratory of Horticultural Plant Biology Ministry of Education/College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Managing Biotic and chemical Threats to the Quality and Safety of Agro-Products Institute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory for Managing Biotic and chemical Threats to the Quality and Safety of Agro-Products Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Some stress response-related genes have been identified in Ustilaginoidea virens,but it is not clear whether and how defects of stress responses affect the pathogenesis processes of *** this study,we identified a general stress response factor UvWHI2 as a homolog of Saccharomyces cerevisiae Whi2 in *** relative expression level of Uv Whi2 was significantly up-regulated during infection,suggesting that UvWHI2 may be involved in ***,knockout of Uv Whi2 showed decreased mycelial growth,increased conidiation in the potato sucrose medium and a defect in *** addition,the RNA-Seq and phenotypic analysis showed that UvWHI2 was involved in response to oxidative,hyperosmotic,cell wall stress and nutrient *** studies revealed that the defects of stress responses of the?Uvwhi2 mutant affected the formation of secondary spores on the nutrient limited surface and the rice surface,resulting in a significant reduction of pathogenicity of *** results suggest that UvWHI2 is necessary for fungal growth,stress responses and the formation of secondary spores in *** addition,the defects of stress responses can affect the formation of secondary spores on the rice surface,and then compromise the pathogenicity of ***.

关键词： Whi2 rice false smut Ustilaginoidea virens pathogenesis secondary spore

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A Registry-Based Observational Study on the Maternal and Fetal Outcomes of cOVID-19 Patients in Hong Kong

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母胎医学杂志(英文) 2024年第3期6卷 156-163页

作者： Leung Hillary HY Ma Teresa WL Yu Florrie NY Kong Meliza cW Lo Tsz Kin So Pauline PL Leung Wing-cheong Shu Wendy cheung Ka Wang Moungmaithong Sakita Wang chi chiu Poon Liona c. Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Hong Kong China Department of Obstetrics and Gynaecology Queen Elizabeth Hospital Hong Kong China Department of Obstetrics and Gynaecology United Christian Hospital Hong Kong China Department of Obstetrics and Gynaecology Princess Margaret Hospital Hong Kong China Department of Obstetrics and Gynaecology Tuen Mun Hospital Hong Kong China Department of Obstetrics and Gynaecology Kwong Wah Hospital Hong Kong China Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern Hospital Hong Kong China Department of Obstetrics and Gynaecology Queen Mary Hospital Hong Kong China

Objective: To report the clinical maternal and fetal outcomes of pregnant women with coronavirus disease 2019 (cOVID-19), along with any associated pregnancy complications, in Hong Kong, china, and to assess the impact of cOVID-19 vaccination on these ***: This prospective registry-based observational study included pregnant women who were recruited through convenient sampling and had a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection with a cycle threshold (ct) value result available on admission to eight local hospitals in Hong Kong, china. Data on clinical symptoms, laboratory results, medical treatments, delivery timing and mode, and pregnancy complications were extracted from the Hospital Authority’s electronic medical record system. Maternal, fetal, and pregnancy outcomes were compared between unvaccinated pregnant women with cOVID-19 and those who had received at least one dose of cOVID-19 vaccine before diagnosis. Nonparametric continuous variables and categorical variables were analyzed using the Mann-WhitneyU test and the Pearson’s chi-squared test respectively. AP value less than 0.05 was considered statistically ***: A total of 164 pregnant women were included, of whom 78 (47.56%) were nulliparous. cOVID-19 was diagnosed before 28 weeks’ gestation in 30 (18.29%), while 134 (81.71 %) were diagnosed at or after 28 weeks’ gestation. Sixty-two (37.80%) women received at least one dose of cOVID-19 vaccine. There were no significant differences between vaccinated and unvaccinated groups in the time interval between cOVID-19 diagnosis and delivery, the ct value, and the gestational age at infection onset or delivery (P > 0.05). The majority of women were symptomatic at diagnosis regardless of vaccination status (55 (88.71%) in vaccinated groupvs. 78 (76.47%) in unvaccinated group (P = 0.052). Symptoms did not significantly differ between groups except for cough (62.90%vs. 47.06%,P = 0.049). The overall

关键词： cOVID-19 Maternal outcomes: Fetal outcomes Pregnancy complications Severe cOVID-19

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