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Recurrent Clostridium difficile infections:The importance of the intestinal microbiota

World Journal of Gastroenterology 2014年第23期20卷 7416-7423页

作者： Marie Céline Zanella Terrier martine louis simonet Philippe Bichard Jean louis Frossard Service of General Internal Medicine Geneva University Hospital1211 GenevaSwitzerland Service of Gastroenterology and Hepatology Geneva University Hospital1211 GenevaSwitzerland

Clostridium difficile infections(CDI)are a leading cause of antibiotic-associated and nosocomial *** effective antibiotic treatments,recurrent infections are *** the recent emergence of hypervirulent isolates of ***,CDI is a growing epidemic with higher rates of recurrence,increasing severity and *** microbiota transplantation(FMT)is an alternative treatment for recurrent CDI.A better understanding of intestinal microbiota and its role in CDI has opened the door to this promising therapeutic *** is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent *** the first reported use of FMT for recurrent CDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic *** article focuses on current guidelines for CDI treatment,the role of intestinal microbiota in CDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability.

关键词： Clostridium difficile infection Clostridium difficile recurrence Fecal microbiota transplantation Stool transplantation Microbiota

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RTM与三维增强材料:固体燃料发动机的技术突破

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航空制造技术 2008年第15期51卷 69-70页

作者： martine Dauchier Jean-louis Limousin Jean-Claude Tricot 戴棣 Snecma Propulsion Solid公司

为降低成本和提高二维增强酚醛材料的力学性能,开发了一种新的工艺方法。该方法采用三维高强碳增强体和RTM酚醛树脂,具有减少加工步骤的特点,并使安全和环保方面的条件得以改善。

关键词： RTM 加工步骤力学性能增强体增强材料降低成本预制体纤维取向防热航空制造技术

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Natural killer reprogramming in cutaneous T-cell lymphomas: Facts and hypotheses

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World Journal of Immunology 2013年第1期3卷 1-6页

作者： Christian Schmitt Anne Marie-Cardine martine Bagot Armand Bensussan INSERM U976 F-75010 Paris France Dermatology and Oncology Laboratory of Immunology Univ Paris Diderot Sorbonne Paris Cité UMRS 976 F-75475 Paris France AP-HP Hopital Saint-Louis F-75475 ParisFrance

To better understand the pathogenesis of Sézary cells, distinguish them from reactive skin-infltrating T-cells and improve disease treatment, efforts have been made to identify molecular targets deregulated by the malignant process. From immunophenotypic analysis and subtractive differential expression experiments to pan-genomic studies, many approaches have been used to identify markers of the disease. During the last decade several natural killer （NK） cell markers have been found aberrantly expressed at the surface of Sézary cells. In particular, KIR3DL2/CD158k, expressed by less than 2% of healthy individuals CD4＋ T-cells, is an excellent marker to identify and follow the tumor burden in the blood of Sézary syndrome patients. It may also represent a valuable target for specifc im-munotherapy. Other products of the NK cluster on chromosome 19q13 have been detected on Sézary cells, raising the hypothesis of an NK reprogramming process associated with the malignant transformation that may induce survival functions.

关键词： Sézary syndrome Mycosis fungoides Natural killer receptors KIR3DL2 Cutaneous T-cell lymphomas

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Aberrant expression of CD56 by circulating Sézary syndrome malignant T lymphocytes

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World Journal of Immunology 2013年第3期3卷 68-71页

作者： Nicolas Thonnart Caroline Ram-Wolff martine Bagot Armand Bensussan Anne Marie-Cardine INSERM U976 Saint Louis Hospital 75010 Paris France University Paris Diderot Sorbonne Paris Cité 75013 Paris France AP-HP Department of Dermatology Saint Louis Hospital 75010 Paris France

Sézary syndrome(SS) is an aggressive variant of cutaneous T cell lymphoma characterized by the presence of malignant T cells in the skin, peripheral blood and lymph nodes. The tumoral population typically displays a CD3+ CD4+ CD45RO+ memory T cell phenotype. We report a case of SS with an aberrant CD56+ immunophenotype. This patient presented with a generalized erythroderma and palpable small axillary lymph ***(stage IVA) was diagnosed on histological criteria and by the detection of a major T cell clone in skin and blood, an elevated CD4/CD8 T cell ratio and Sézary cells count > 1000/mm3. Beside the Sézary cell marker KIR3DL2, immunostainings revealed that two third of the malignant cells expressed CD56 but no other natural killer(NK) cell marker such as CD16, CD160 or NKp46. This atypical expression was not linked to an activation-dependent process and remained stable during the time course of the disease. No loss of the panT-cell markers CD2, CD3 or CD4 was detected while a complete down-modulation of CD26 was observed. Despite several lines of treatment, no durable amelioration was observed and patient died after 10 mo of follow-up. Because this CD4+ CD56+ SS case is the only one reported so far, the functional significance of CD56 expression remained difficult to assess in terms of aggressiveness and prognosis.

关键词： Cutaneous T cell lymphomas Sézary syndrome CD56

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