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Aberrant expression of CD56 by circulating Sézary syndrome malignant T lymphocytes

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World Journal of Immunology 2013年第3期3卷 68-71页

作者： Nicolas Thonnart Caroline Ram-Wolff martine bagot Armand Bensussan Anne Marie-Cardine INSERM U976 Saint Louis Hospital 75010 Paris France University Paris Diderot Sorbonne Paris Cité 75013 Paris France AP-HP Department of Dermatology Saint Louis Hospital 75010 Paris France

Sézary syndrome(SS) is an aggressive variant of cutaneous T cell lymphoma characterized by the presence of malignant T cells in the skin, peripheral blood and lymph nodes. The tumoral population typically displays a CD3+ CD4+ CD45RO+ memory T cell phenotype. We report a case of SS with an aberrant CD56+ immunophenotype. This patient presented with a generalized erythroderma and palpable small axillary lymph ***(stage IVA) was diagnosed on histological criteria and by the detection of a major T cell clone in skin and blood, an elevated CD4/CD8 T cell ratio and Sézary cells count > 1000/mm3. Beside the Sézary cell marker KIR3DL2, immunostainings revealed that two third of the malignant cells expressed CD56 but no other natural killer(NK) cell marker such as CD16, CD160 or NKp46. This atypical expression was not linked to an activation-dependent process and remained stable during the time course of the disease. No loss of the panT-cell markers CD2, CD3 or CD4 was detected while a complete down-modulation of CD26 was observed. Despite several lines of treatment, no durable amelioration was observed and patient died after 10 mo of follow-up. Because this CD4+ CD56+ SS case is the only one reported so far, the functional significance of CD56 expression remained difficult to assess in terms of aggressiveness and prognosis.

关键词： Cutaneous T cell lymphomas Sézary syndrome CD56

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

An ensemble deep learning based IDS for IoT using Lambda architecture

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Cybersecurity 2023年第3期6卷 1-17页

作者： Rubayyi Alghamdi martine Bellaiche Computer and Software Engineering Department école PolytechniqueMontrealCanada

The Internet of Things(IoT)has revolutionized our world today by providing greater levels of accessibility,connectivity and ease to our everyday *** enables massive amounts of data to be traversed across multiple heterogeneous devices that are all *** phenomenon makes IoT networks vulnerable to various network attacks and *** an Intrusion Detection System(IDS)for IoT networks is challenging as they enable a massive amount of data to be aggregated,which is difficult to handle and analyze in real time mainly because of the heterogeneous nature of IoT *** inefficient,traditional IDS approach accentuates the need to develop advanced IDS techniques by employing Machine or Deep *** paper presents a deep ensemble-based IDS using Lambda architecture by following a multi-pronged classification *** classification uses Long Short Term Memory(LSTM)to differentiate between malicious and benign traffic,while the multi-class classifier uses an ensemble of LSTM,Convolutional Neural Network and Artificial Neural Network classifiers to detect the type of *** model training is performed in the batch layer,while real-time evaluation is carried out through model inferences in the speed layer of the Lambda *** proposed approach gives high accuracy of over 99.93%and saves useful processing time due to the multi-pronged classification strategy and using the lambda architecture.

关键词： IoT IDS Lambda architecture Cyber-attacks Deep learning Ensemble learning

Mechanisms of species divergence through visual adaptation and sexual selection:Perspectives from a cichlid model system

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Current Zoology 2010年第3期56卷 285-299页

作者： martine E.MAAN Ole SEEHAUSEN Institute of Ecology & Evolution University of Bern Eawag Centre of Ecology Evolution and Biogeochemistry(CEEB)

The theory of ecological speciation suggests that assortative mating evolves most easily when mating preferences aredirectly linked to ecological traits that are subject to divergent selection. Sensory adaptation can play a major role in this process,because selective mating is often mediated by sexual signals: bright colours, complex song, pheromone blends and so on. Whendivergent sensory adaptation affects the perception of such signals, mating patterns may change as an immediate ***, mating preferences can diverge as a result of indirect effects: assortative mating may be promoted by selectionagainst intermediate phenotypes that are maladapted to their (sensory) environment. For Lake Victoria cichlids, the visual environmentconstitutes an important selective force that is heterogeneous across geographical and water depth gradients. We investigatethe direct and indirect effects of this heterogeneity on the evolution of female preferences for alternative male nuptial colours(red and blue) in the genus Pundamilia. Here, we review the current evidence for divergent sensory drive in this system, extractgeneral principles, and discuss future perspectives [Current Zoology 56 (3): 285-299, 2010].

关键词： Cichlid Sexual selection Species divergence Visual adaptation

New generation of breast cancer clinical trials implementing molecular profiling

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Cancer Biology & Medicine 2016年第2期13卷 226-235页

作者： Dimitrios Zardavas martine Piccart-Gebhart Breast International Group(BIG) Brussels 100Belgium Medicine Department Institue Jules BordetUniversite Libre de BruxellesBrussels 100Belgium

The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients' enrolment in oncology trials shifts towards the implementation of molecular profiling as prescreening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i)longitudinal cohort studies that implement(or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.

关键词： Clinical trial molecular profiling breast cancer study design

Finite Volume Multilevel Approximation of the Shallow Water Equations

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Chinese Annals of Mathematics,Series B 2013年第1期34卷 1-28页

作者： Arthur BOUSQUET martine MARION Roger TEMAM The Institute for Scientific Computing and Applied Mathematics Indiana University Département Mathématique Informatique Université de LyonEcole Centrale de Lyon

The authors consider a simple transport equation in one-dimensional space and the linearized shallow water equations in two-dimensional space, and describe and implement a multilevel finite-volume discretization in the context of the utilization of the incremental unknowns. The numerical stability of the method is proved in both cases.

关键词： Finite-volume methods Multilevel methods Shallow water equations Stability analysis

Numerical accuracy and convergence with EMC3-EIRENE

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Plasma Science and Technology 2020年第5期22卷 5-15页

作者： Kristel GHOOS Heinke FRERICHS Wouter DEKEYSER Giovanni SAMAEY martine BAELMANS KU Leuven Department of Mechanical EngineeringB-3001LeuvenBelgium University of Wisconsin Madison Department of Engineering PhysicsWI 53706United States of America KU Leuven Department of Computer ScienceB-3001LeuvenBelgium

The iterative Monte Carlo(MC)code EMC3-EIRENE is frequently used for plasma edge simulations in 3 D *** far,a quantitative evaluation of the numerical quality of the code results remains an open *** this paper,we demonstrate a framework for the practical assessment of accuracy and convergence with ***,we provide a first accuracy analysis with EMC3-EIRENE for a DIII-D divertor edge plasma ***,we introduce post-processing averaging to efficiently reduce the variance of the statistical ***,we estimate the deterministic error contributions based on their theoretical reduction rates by comparing solutions with a different grid resolution,time step,or number of MC particles per ***,using parameterized expressions for the error and the computational time,suitable numerical parameters are determined to achieve faster and/or more accurate *** found that simulations can be more than twice as fast without losing accuracy by making use of post-processing averaging and choosing optimal *** addition,we conclude that the discretization error is the dominant error contribution for the case selected in this paper,which demonstrates the importance of constructing an adequate mesh.

关键词： convergence Monte Carlo numerics plasma edge EMC3-EIRENE

Expression and modulation of neuroligin and neurexin in the olfactory organ of the cotton leaf worm Spodoptera fittoralis

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Insect Science 2017年第2期24卷 210-221页

作者： Nicolas Durand Thomas Chertemps Francoise Bozzolan martine Maibeche Sorbonne Universites UPMC - Univ Paris 06 Institut d'Ecologie et des Sciences de 'Environnement de Paris INRA CNRS IRD UPECD6partement d'Ecologie Sensorielle F-75252 Paris France

Carboxylesterases are enzymes widely distributed within living organisms. In insects, they have been mainly involved in dietary metabolism and detoxification function. Interestingly, several members of this family called carboxylesterase-like ad- hesion molecules （CLAMs） have lost their catalytic properties and are mainly involved in neuro/developmental functions. CLAMs include gliotactins, neurotactins, glutactins, and neuroligins. The latter have for binding partner the neurexin. In insects, the function of these proteins has been mainly studied in Drosophila central nervous system or neuro- muscular junction. Some studies suggested a role of neuroligins and neurexin in sensory processing but CLAM expression within sensory systems has not been investigated. Here, we reported the identification of 5 putative CLAMs expressed in the olfactory system of the model pest insect Spodoptera littoralis. One neuroligin, Slnlg4-yll and its putative binding partner neurexin Slnrxl were the most expressed in the antennae and were surprisingly associated with olfactory sensilla. In addition, both transcripts were upregulated in male antennae after mating, known to modulate the sensitivity of the peripheral olfactory system in S. littoralis, suggesting that these molecules could be involved in sensory plasticity.

关键词： carboxylesterase-like adhesion molecules insect neurexin neuroligins olfaction

Synthesis of a novel uridine analogue and its use in attempts to form new cyclonucleosides using ring-closing metathesis

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Science China Chemistry 2010年第9期53卷 1932-1936页

作者： MONDON martine LEN Christophe UMR 6514 Université de Poitiers CNRS Synthèse et Réactivité des Substances Naturelles EA4297 Université de Technologie de Compiègne UTC-Ecole Supérieure de Chimie Organique et Minérale ESCOM

One novel nucleoside analogue having a hex-5-enyl group and an allyl group in the 5'-C and 3-N position was synthesized regioand diastereoselectively from D-glucose in twelve *** order to reach a particular conformation of nucleosides the nucleoside formation of restricted cyclonucleoside analogues was studied via Ring-Closing Metathesis.

关键词： nucleoside restrictedconformation metathesis