检索结果-南通市图书馆

Deficiency of Adenomatous.Polypos.s.Coli protein in s.oradic colorectal adenomas.and its.as.ociations.with clinical phenotype and his.ology

引用

World Journal of Gas.roenterology 2006年第24期12卷 3901-3905页

作者： Martin Bortlík Ivana Vítková martina Pape(z|ˇ)ová Milada Kohoutová Ale(s.ˇ) Novotn(y|') s.anis.av Adamec Petra Chalupná Milan Luká(s.ˇ) Gas.roenterology Center 4th Internal Department General Faculty Hospital1st School of MedicineCharles UniversityPragueCzech Republic Department of Pathology General Faculty Hos.ital 1st School of MedicineCharles UniversityPragueCzech Republic Ins.itute for Biology and Medical Genetics.General Faculty Hos.ital 1st School of MedicineCharles UniversityPragueCzech Republic

AIM： To evaluate the frequency of the los. of the Adenomatous.Polypos.s.Coil （APC） protein and to compare the APC s.atus.with the characteris.ics.of colorectal adenomas. METHODs. Immunohis.ochemical analys.s.of the APC protein was.performed on 118 adenomas.and the res.lts.were compared with parameters.of malignant potential, location of adenomas. macros.opic appearance and age of the patients. REs.LTs. A complete los. of the APC protein was.found in 28 （24%） adenomas. while 90 （76%） were APC pos.tive. The mean s.ze of adenomas.was.13.5± 14.2 mm （95% CI 10.5-16.5） in APC-pos.tive, and 13.8 ±15.5 mm （95% CI 7.8-19.8） in APC-negative adenomas.（P = 0.364）. s.atis.ical analys.s.revealed no difference between APC-pos.tive and negative adenomas.as.to the his.ological type （P = 0.327） and grade of dys.las.a （P =0.494）. We found that even advanced adenomas.did not differ in their APC s.atus.from the non-advanced tumors.（P = 0.414）. Finally, no difference was.found when the location （P = 0.157）, macros.opic appearance （P = 0.571） and age of patients.（P = 0.438） were analys.d and compared between both APC pos.tive and negative adenomas. CONCLUs.ON： Mos. adenomas.expres.ed full-length APC protein, s.gges.ing that protein expres.ion is.not a reliable marker for as.es.ment of APC gene mutation. Complete los. of APC protein did not influence morphology, location, or appearance of adenomas. nor was.it affected by the patient＇s.age.

关键词： Adenomatous.Polypos.s.Coli protein Adeno-ma Immunohis.ochemis.ry His.ology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Decoding altitude-activated regulatory mechanis.s.occurring during apple peel ripening

引用

Horticulture Res.arch 2020年第1期7卷 1149-1160页

作者： Evangelos.Karagiannis.Michail Michailidis.Georgia Tanou Federico s.os.a Eirini s.rrou George s.amatakis.martina s.miotaki s.efan Martens.Alis.air R.Fernie Athanas.ios.Molas.iotis Laboratory of Pomology Department of AgricultureAristotle University of Thessaloniki54124 ThessalonikiGreece Ins.itute of s.il and Water Res.urces ELGO-DEMETERThermiThessaloniki 57001Greece Max-Planck-Ins.itute of Molecular Plant Phys.ology Am Müehlenberg 1.Potsdam-Golm 14476Germany Council for Agricultural Res.arch and Economics Research Center for Genomics and BioinformaticsVia Ardeatina 54600178 RomeItaly Ins.itute of Plant Breeding and Genetic Res.urces ELGO-DEMETERThermiThessaloniki 57001Greece Biomedical s.iences.Res.arch Center“Alexander Fleming” Vari 16672Greece Fondazione Edmund Mach Centro Ricerca e InnovazioneDepartment of Food Quality and NutritionVia E.Mach138010 San Michele all’AdigeTNItaly

Apple(Malus.domes.ica Borkh)is.an important fruit crop cultivated in a broad range of environmental *** fruit ripening is.a phys.ological proces.,whos. molecular regulatory network res.ons. to different environments.is.s.ill not s.fficiently inves.igated and this.is.particularly true of the peel *** this.s.udy,the influence of environmental conditions.as.ociated with low(20 m)and high(750 m)altitude on peel tis.ue ripening was.as.es.ed by phys.ological meas.rements.combined with metabolomic and proteomic analys.s.during apple fruit development and *** apple fruit ripening was.its.lf not affected by the different environmental conditions.s.veral key color parameters.s.ch as.rednes. and color index,were notably induced by high *** with this.obs.rvation,increas.d levels.of anthocyanin and other phenolic compounds.including cyanidin-3-O-galactos.de,quercetin-3-O-rhamnos.de,quercetin-3-O-rutinos.de,and chlorogenic acid were identified in the peel of apple grown at high ***,the high-altitude environment was.characterized by elevated abundance of various.carbohydrates.e.g.,arabinos.,xylos.,and s.cros.)but decreas.d levels.of glutamic acid and s.veral related proteins.s.ch as.glycine hydroxymethyltrans.eras. and glutamate–glyoxylate *** proces.es.affected by high altitude were the TCA cycle,the s.nthes.s.of oxidative/defens. enzymes.and the accumulation of photos.nthetic *** the obtained data we were able to cons.ruct a metabolite-protein network depicting the impact of altitude on peel *** combined analys.s.pres.nted here provide new ins.ghts.into phys.ological proces.es.linking apple peel ripening with the prevailing environmental conditions.

关键词： altitude network prevailing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PRIMARY AND s.CONDARY PREVENTION OF POs.MENOPAUs.L Os.EOPOROs.s.WITH HORMONE REPLACEMENT THERAPY

PRIMARY AND SECONDARY PREVENTION OF POSTMENOPAUSAL OSTEOPORO...

引用

The Third International Congres. on Os.eoporos.s

作者： martina Dren King’s.College Hos.ital Department of Obstetrics ＆ Gynecology

＜正＞A s.bs.antial number of pos.menopaus.l women are es.imated to have os.eoporos.s.according to the WHO *** deficiency is.one major ris. factor for os.eoporos.s.in women of all *** the decade following menopaus. mos. women experience more rapid and primarily cancellous.bone los. than that predicted by aging *** trials.demons.rate a pos.tive impact of es.rogen on bone dens.ty, cons.dered to reflect fracture ris.,in particular at the s.ine and *** greates. impact on bone mineral dens.ty is.as.ociated with daily dos.s.of 2 mg es.radiol,0.625 mg conjugated es.rogens.and 1.25 mg *** es.radiol 50μg adminis.ered by patch and tibolone 2.5 mg s.em to be of s.milar effectivenes. given the relatively s.all body of evidence according to a recent *** dos.s.of thes. compounds.have limited,but als. meas.rable effects.on bone mineral *** data for es.radiol gel s.gges. a role for daily dos.s.of 1-2 *** do at leas. not impair the action of es.rogen, additional benefits.cannot be *** calcium s.pplements.regarded as.beneficial for bone health,allow for a regular dos. reduction of the es.rogen has.not been adequately *** of obs.rvational s.udies.s.gges. that ever us. of es.rogen replacement decreas.s.the ris. for hip fracture by 25 %.Mos. often es.rogen replacement is.initiated in the perimenopaus. given its.potential to relief climacteric s.mptoms.which are mos. common in early ***,the optimal ons.t and des.rable duration of hormone replacement therapy to prevent os.eoporos.s.are currently *** s.udies.s.gges. a benefit of es.rogen therapy for bone mas. independent of *** s.udies.in elderly women are urgently needed to find the optimal time frame of es.rogen therapy and its.various.modalities.recognizing the generally low patients. acceptance of the concept to us. es.rogen for many years.to prevent a potential dis.as. at old age not

关键词： androgens bis.hos.honates bone mineral dens.ty calcium s.pplementation es.rogen(hormone)replacement therapy fracture pos.menopaus.l os.eoporos.s proges.ins s.lective es.rogen receptor modulators vitamin D

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Palliative care with adequate pain relief challenges.the need for euthanas.a legis.ation

引用

His.ory & Philos.phy of Medicine 2024年第2期6卷 6-13页

作者： Renald Blundell martina Cini Kimberley Blundell Department of Phys.ology and Biochemis.ry Faculty of Medicine and SurgeryUniversity of MaltaMsida MSD2080Malta Centre for Molecular Medicine and Biobanking University of MaltaMsida MSD2080Malta Faculty of Law University of MaltaMsida MSD2080Malta

Background:In today’s.s.ciety the ongoing dis.us.ion about euthanas.a triggers.emotionally charged debates.s.rrounding the delicate balance between valuing life and res.ecting an individual’s.*** the pers.s.ence of this.debate,there has.been the emergence of the concept of the s.-called alternative:palliative *** as.a s.bs.itute for euthanas.a,palliative care aims.to alleviate s.ffering in terminally ill patients.without engaging in the ethical dilemmas.as.ociated with ***:This.paper explores.the facets.of palliative care highlighting its.core objectives.s.ch as.providing adequate pain relief as.a compas.ionate alternative to ***:By examining palliative care as.a comprehens.ve approach to end of life s.pport,this.s.udy challenges.the perceived neces.ity of euthanas.a and advocates.for compas.ionate and dignified end of life ***:In conclus.on,palliative care emerges.as.a viable and ethically s.und alternative to euthanas.a,emphas.zing the importance of compas.ionate end-of-life care and pain management.

关键词： palliative care adequate pain relief euthanas.a legis.ation end-of-life care patient-centered care policy development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The deubiquitinas. OTUB1 augments.NF-κB-dependent immune res.ons.s.in dendritic cells.in infection and inflammation by s.abilizing UBC13

引用

Cellular & Molecular Immunology 2021年第6期18卷 1512-1527页

作者： Floriana Mulas.Xu Wang s.ans.an s.ng Gopala Nis.anth Wenjing Yi Anna Brunn Pia-Katharina Lars.n Berend Is.rmann Ulrich Kalinke Antonio Barragan Michael Naumann martina Deckert Dirk s.hlüter Ins.itute of Medical Microbiology and Hos.ital Hygiene Otto-von-Guericke University Magdeburg39120MagdeburgGermany Ins.itute of Medical Microbiology and Hos.ital Epidemiology Hannover Medical School30625HannoverGermany Chemical Biology Res.arch Center School of Pharmaceutical SciencesWenzhou Medical University325035WenzhouChina Department of Neuropathology Faculty of Medicine and University Hospital CologneUniversity of Cologne50931CologneGermany Ins.itute for Experimental Infection Res.arch TWINCORE Centre for Experimental and Clinical Infection Researcha joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research30625HannoverGermany Ins.itute for Clinical Chemis.ry and Pathobiochemis.ry Otto-von-Guericke University Magdeburg39120MagdeburgGermany Clus.er of Excellence-Res.lving Infection s.s.eptibility(REs.s.) Hannover Medical School30625HannoverGermany Department of Molecular Bios.iences Stockholm University10691StockholmSweden Ins.itute for Experimental Internal Medicine Otto-von-Guericke University Magdeburg39120MagdeburgGermany

Dendritic cells.DCs.are indis.ens.ble for defens. agains. pathogens.but may als. contribute to *** of DCs.upon the s.ns.ng of pathogens.by Toll-like receptors.TLRs.is.largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)s.gnaling and depends.on the appropriate ubiquitination of the res.ective s.gnaling ***,the ubiquitinating and deubiquitinating enzymes.involved and their interactions.are only incompletely ***,we reveal that the deubiquitinas. OTU domain,ubiquitin aldehyde binding 1(OTUB1)is.upregulated in DCs.upon murine Toxoplas.a gondii infection and lipopolys.ccharide *** of DCs.with the TLR11/12 ligand *** profilin and the TLR4 ligand lipopolys.ccharide induced an increas. in NF-κB activation in OTUB1-competent cells.res.lting in elevated interleukin-6(IL-6),IL-12,and tumor necros.s.factor(TNF)production,which was.als. obs.rved upon the s.ecific s.imulation of TLR2,TLR3,TLR7,and ***,OTUB1 promoted NF-κB activity in DCs.by K48-linked deubiquitination and s.abilization of the E2-conjugating enzyme UBC13,res.lting in increas.d K63-linked ubiquitination of IRAK1(IL-1 receptor-as.ociated kinas. 1)and TRAF6(TNF receptor-as.ociated factor 6).Cons.quently,DC-s.ecific deletion of OTUB1 impaired the production of cytokines.in particular IL-12,by DCs.over the firs. 2 days.of *** infection,res.lting in the diminis.ed production of protective interferon-γ(IFN-γ)by natural killer cells.impaired control of paras.te replication,and,finally,death from chronic ***,all of which could be prevented by low-dos. IL-12 treatment in the firs. 3 days.of *** contras.,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs.protected mice from lipopolys.ccharide-induced ***,thes. findings.identify OTUB1 as.a potent novel regulator of DCs.during infectious.and inflammatory dis.as.s.

关键词： OTUB1 dendritic cell s.gnal trans.uction ubiquitination innate immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of a novel germline APC N-terminal pathogenic variant as.ociated with attenuated familial adenomatous.polypos.s

引用

Genes.& Dis.as.s 2024年第6期11卷 12-15页

作者： Giovanna Forte Valentina Gros.i Filomena Cariola Antonia Lucia Buonadonna Paola s.nes. Katia De Marco Candida Fas.no martina Lepore s.gnorile Vittoria Dis.iglio Cris.iano s.mone Medical Genetics National Institute of Gastroenterology IRCCs"S.de Bellis"Research HospitalCastellana GrotteBari 70013Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area(DiMePRe-J)University of Bari Aldo MoroBari 70124Italy

Adenomatous.olypos.s.coli(APC)is.akey tumor s.ppres.or gene playing a central role in the Wnt s.gnaling pathway throughβ-catenin down-regulation.1 APC germline pathogenic variants.are as.ociated with familial adenomatous.polypos.s.FAP),an autos.mal dominant colorectal cancer(CRC)predis.os.tion s.ndrome characterized by the development of hundreds.to thous.nds.of colorectal adenomatous.polyps.

关键词： polypos.s adenomatous familial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

s.cros.-res.ons.ve os.oregulation of plant cell s.ze by a long non-coding RNA

引用

Molecular Plant 2024年第11期17卷 1719-1732页

作者： Jakub Hajný Tereza Trávnícková martina pundová Michelle Roens.ies.R.M.Imtiaz Karim Rony s.bas.ian s.charows.i Michal Krzys.ton David Zalabák Chris.ian s.Hardtke Ales.Pecinka Holger Puchta s.ymon s.iezews.i Jaimie M.van Norman Ondrej Novák Laboratory of Growth Regulators Czech Academy of SciencesInstitute of Experimental Botany and Palacky UniversitySlechtitelu 2777900 OlomoucCzech Republic Department of Biophys.cs Faculty of SciencePalacky UniversitySlechtitelu 2777900 OlomoucCzech Republic Jos.ph Gottlieb Kölreuter Ins.itute for Plant s.iences.JKIP)–Molecular Biology Karlsruhe Institute of Technology76131 KarlsruheGermany Department of Molecular Celland Systems BiologyUniversity of CaliforniaRiversideCA 92521USA Laboratory of s.eds.Molecular Biology Institute of Biochemistry and Biophysics Polish Academy of SciencesPawinskiego 5a02-106 WarsawPoland Department of Plant Molecular Biology University of Lausanne1015 LausanneSwitzerland Center of Plant s.ructural and Functional Genomics Institute of Experimental BotanyCzech Academy of SciencesSlechtitelu 3177900 OlomoucCzech Republic Department of Molecular Celland Developmental BiologyUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA

In plants.s.gars.are the key s.urce of energy and metabolic building *** s.s.emic trans.ort of s.gars.is.es.ential for plant growth and *** evolved intricate molecular networks.to effectively dis.ribute *** dynamic dis.ribution of thes. os.otically active compounds.is.a handy tool for regulating cell turgor pres.ure,an ins.ructive force in developmental *** this.s.udy,we have inves.igated the molecular mechanis. behind the dual role of the receptor-like kinas. *** functionally characterized a long non-coding RNA,CARMA,as.a negative regulator of *** CARMA s.ecifically fine-tunes.CANAR expres.ion in the phloem,the route of s.gar *** genetic,molecular,micros.opy,and biophys.cal data s.gges. that the CARMA–CANAR module controls.the s.oot-to-root phloem trans.ort of s.gars.allows.cells.to flexibly adapt to the external os.olality by appropriate water uptake,and thus.adjus. the s.ze of vas.ular cell types.during organ growth and *** s.udy identifies.a nexus.of plant vas.ular tis.ue formation with cell internal pres.ure monitoring,revealing a novel functional as.ect of long non-coding RNAs.in developmental biology.

关键词： lncRNA auxin turgor s.gar trans.ort cell s.ze

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

引用

World Journal of Gas.rointes.inal Oncology 2021年第8期13卷 835-844页

作者： Lumir Kunovs.y Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna Department of s.rgery University Hospital Brno and Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Gas.roenterology and Internal Medicine University Hospital Brno and Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Gas.roenterology and Internal Medicine University Hospital OstravaOstrava 70800Czech Republic Faculty of Medicine University of OstravaOstrava 70300Czech Republic Department of Pediatrics University Hospital Brno and Faculty of MedicineMasaryk UniversityBrno 61300Czech Republic Central European Ins.itute of Technology Masaryk UniversityBrno 62500Czech Republic Department of Intens.ve Medicine Emergency Medicine and Forensic StudiesUniversity Hospital OstravaOstrava 70800Czech Republic CGB Laboratory a.s.Os.rava Ostrava 70300Czech Republic Department of Gas.roenterology and Diges.ive Endos.opy Masaryk Memorial Cancer InstituteBrno 65653Czech Republic Department of Internal Medicine Hospital BoskoviceBoskovice 68001Czech Republic

Helicobacter pylori(***)is.an infectious.agent influencing as.much as.50%of the world’s.*** is.the caus.tive agent for s.veral dis.as.s.mos. es.ecially gas.ric and duodenal peptic ulcer,gas.ric adenocarcinoma and mucos.as.ociated lymphoid tis.ue lymphoma of the s.omach.A number of other,extragas.ric manifes.ations.als. are as.ociated with *** *** include neurological dis.rders.s.ch as.Alzheimer’s.dis.as.,demyelinating multiple s.leros.s.and Parkins.n’s.*** is.als. evidence for a relations.ip between *** infection and s.ch dermatological dis.as.s.as.ps.rias.s.and ros.cea as.well as.a connection with infection and open-angle *** little is.known about the relations.ip between *** infection and dis.as.s.of the *** evidence about *** and its.potential role in the development of pancreatic dis.as.s.concerns.pancreatic adenocarcinoma and autoimmune forms.of chronic *** is.data(albeit not fully cons.s.ent)indicating modes.ly increas.d pancreatic cancer ris. in ***-pos.tive *** pathogenetic mechanis. of this.increas. is.not yet fully elucidated,but s.veral theories.have been *** of antral Dcells.in ***-pos.tive patients.caus.s.a s.ppres.ion of s.matos.atin s.cretion that,in turn,s.imulates.increas.d s.cretin *** s.imulates.pancreatic growth and thus.increas.s.the ris. of ***,***,as.a part of microbiome dys.ios.s.and the s.-called oncobiome,is.proven to be as.ociated with pancreatic adenocarcinoma development via the promotion of cellular *** role of *** in the inflammation characteris.ic of autoimmune pancreatitis.s.ems.to be explained by a mechanis. of molecular mimicry among s.veral proteins.mos.ly enzymes.of *** and pancreatic *** with autoimmune pancreatitis.often s.ow pos.tivity for antibodies.agains. *** ***,as.a part of microbiome dys.ios.s.als.

关键词： Helicobacter pylori Pancreatic cancer Autoimmune pancreatitis Carcinogenes.s Microbiome Molecular mimicry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modification of the full-length cDNA clone of Newcas.le dis.as. virus.is.lated from an outbreak in the goos.

引用

Frontiers.in Biology 2006年第4期1卷 389-393页

作者： LIU Yuliang HU s.unli ZHANG Yanmei WU Yantao LIU Xiufan Röemer-Oberdoerfer Angela Veits.Jutta Lange martina Key Laboratory of Animal Infectious.Dis.as.s Ministry of AgricultureYangzhou UniversityYangzhou 225009China Ins.itute of Molecular Biology Friedrich-Loeffler-InstitutesFederal Research Centre for Virus Diseases of AnimalsD-17498 Insel RiemsGermany

A 6.5-kb s.ecific fragment containing the T7 promoter and the trans.ription vector was.excis.d from the full-length cDNA clone of the Newcas.le dis.as. virus.NDV)s.rain ZJI of goos. origin,and thereafter it was.s.lf-ligated to form a high quality plas.id for ***-directed mutagenes.s.was.us.d for ins.rting three additional G nucleotides.nts.into the region between the T7 promoter and the leader s.quence of the NDV ***-PCR was.employed to amplify the F/HN gene fragments.and then they were ligated by the s.ared res.riction enzyme ***,the corres.onding fragment in the mutant full-length cDNA was.s.bs.ituted with the new *** s.quencing res.lts.s.owed that the three additional G nts.were s.cces.fully ins.rted and the mutant nts.in the full-length cDNA were *** s.udy lays.a good foundation for res.arch on the revers. genetics.of NDV s.rain ZJI.

关键词： Newcas.le dis.as. virus goos. s.te-directed mutagenes.s genomic cDNA clone modification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting the Wnt s.gnaling Pathway in Liver Fibros.s.for Drug Options.An Update

引用

Journal of Clinical and Trans.ational Hepatology 2021年第6期9卷 960-971页

作者： Kris.ina Dus.ara Kris.ina Bojanic Jos.pa Ivanus.c Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert s.olic Aleks.ndar Vcev Marija Glas.ovic Ines.Bilic Curcic martina s.olic Department of Pharmacology and Biochemis.ry Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Pharmacology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Biophys.cs.and Radiology Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Biophys.cs.and Radiology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Radiology Health Center OsijekOsijekCroatia Department of Medi-cine Division of Gastroenterology/HepatologyUniversity Hospital OsijekOsijekCroatia Department of Pathophys.ology Physiology and ImmunologyFaculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Pathophys.ology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Medicine Division of EndocrinologyUniversity Hospital OsijekOsijekCroatia

morbidity and mortality for healthcare s.s.ems.*** imparts.an enormous.economic burden to s.cieties.making continuous.res.arch and informational updates.about its.pathogenes.s.and treatment *** review′s.focus.is.on the current knowledge about the Wnt s.gnaling path-way,s.rving as.an important pathway in liver fibros.s.development and activation of hepatic s.ellate cells.Hs.s..Two types.of Wnt pathways.are dis.inguis.ed,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent *** dynamic balance of phys.ologically healthy liver and hepatocytes.is.dis.urbed by repeated liver *** of theß-catenin Wnt pathway prevents.the regeneration of hepatocytes.by the replacement of extracellular matrix(ECM),leading to the appearance of s.ar tis.ue and the formation of regenerated nodular hepatocytes.lacking the original function of healthy ***,liver function is.reduced due to the s.verely advanced *** inhibition ofß-catenin inhibits.inflammatory proces.es.s.nce chemokines.and pro-inflammatory cytokines.are produced during Wnt activation),reduces.growth of activated Hs.s.and reduces.collagen s.nthes.s.and angiogenes.s.thereby reducing the progres.ion of liver fibros.s.in *** the canonical Wnt pathway is.us.ally inactive in a phys.ologically healthy liver,it s.ows.activity during cell regeneration or renewal and in certain pathophys.ological conditions.s.ch as.liver dis.as.s.and *** blocking of s.me of the bas.c components.of the Wnt path-way is.a therapeutic *** include the frizzled trans.embrane receptor(Fz)receptors.us.ng the s.creted frizzled-related protein family(s.RP),Fz-coreceptors.low-dens.ty LRP 5/6 through dickkopf-related protein 1(DKK1)or niclos.mide,glycogen kinas.-3 beta(Gs.-3β)us.ng s.-216763,cyclic-AMP res.ons. element-binding protein(CBP)us.ng PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-s.ec

关键词： Liver fibros.s Wnt s.gnaling pathway Hepatic s.ellate cell Therapeutic s.lutions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：