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Polarisation optics for biomedical and clinical applications:a review

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Light(Science & Applications) 2021年第11期10卷 2028-2047页

作者： Chao He Honghui He jintao Chang Binguo Chen Hui Ma martin j.booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Guangdong Engineering Center of Polarisation Imaging and Sensing Technology Tsinghua Shenzhen International Graduate SchoolTsinghua University518055 ShenzhenChina Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua University518055 ShenzhenChina Department of Physics Tsinghua University100084 BeijingChina Department of Biomedical Engineering Tsinghua University100084 BeijingChina

Many polarisation techniques have been harnessed for decades in biological and clinical research,each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by *** advanced vector measurement/sensing techniques,physical interpretation methods,and approaches to analyse biomedically relevant information have been developed and *** this review,we focus mainly on summarising methodologies and applications related to tissue polarimetry,with an emphasis on the adoption of the Stokes-Mueller *** recent breakthroughs,development trends,and potential multimodal uses in conjunction with other techniques are also *** primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research.

关键词： clinical optics breakthrough

Zwitterion-doped liquid crystal speckle reducers for immersive displays and vectorial imaging

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Light(Science & Applications) 2023年第11期12卷 2363-2377页

作者： Yihan jin Nathan P.Spiller Chao He Grahame Faulkner martin j.booth Steve j.Elston Stephen M.Morris Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK

Lasers possess many attractive features(e.g.,high brightness,narrow linewidth,well-defined polarization)that make them the ideal illumination source for many different scientific and technological endeavors relating to imaging and the display of high-resolution ***,their high-level of coherence can result in the formation of noise,referred to as speckle,that can corrupt and degrade ***,we demonstrate a new electro-optic technology for combatting laser speckle using a chiral nematic liquid crystal(LC)dispersed with zwitterionic *** are presented that demonstrate when driven at the optimum electric field conditions,the speckle noise can be reduced by>90%resulting in speckle contrast(C)values of C=0.07,which is approaching that required to be imperceptible to the human *** LC technology is then showcased in an array of different display and imaging applications,including a demonstration of speckle reduction in modern vectorial laser-based imaging.

关键词： polarization speckle crystal

Revealing complex optical phenomena through vectorial metrics

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Advanced Photonics 2022年第2期4卷 59-67页

作者： Chao He jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq jingyu Wang jacopo Antonello Yang Dong ji Qi jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma martin j.booth University of Oxford Department of Engineering ScienceOxfordUnited Kingdom Tsinghua University Department of PhysicsBeijingChina Tsinghua University Tsinghua Shenzhen International Graduate SchoolGuangdong Engineering Center of Polarization Imaging and Sensing TechnologyShenzhenChina The Chinese University of Hong Kong Department of StatisticsHong KongChina University Bordeaux CNRSLOMAUMR 5798TalenceFrance Mirpur University of Science and Technology Department of PhysicsMirpurPakistan Research Center for Intelligent Sensing Zhejiang LabHangzhouChina Imperial College London Hamlyn Centre for Robotic SurgeryLondonUnited Kingdom Shenzhen Second People’s Hospital Respiratory DepartmentShenzhenChina

Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical *** polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial *** forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal *** simpler vectorial metrics are derived from subsets of the MM *** metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these *** harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous *** provides new insight for the broader usage of such asymmetric inferred vectorial information.

关键词： polarization imaging vectorial metrics Mueller matrix

Adaptive optical microscopy: the ongoing quest for a perfect image

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Light(Science & Applications) 2014年第1期3卷 243-249页

作者： martin j booth Department of Engineering Science University of OxfordOxford OX13PJUK Centre for Neural Circuits and Behaviour University of OxfordOxford OX13SRUnited Kingdom School in Advanced Optical Technologies Friedrich-Alexander Universita¨t Erlangen-Nu¨rnberg91052 ErlangenGermany

Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of *** is proving particularly promising for applications that require images from deep within biological tissue *** review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.

关键词： aberrations adaptive optics microscopy

Four-dimensional light shaping: manipulating ultrafast spatiotemporal foci in space and time

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Light(Science & Applications) 2017年第1期6卷 293-299页

作者： Bangshan Sun Patrick S Salter Clemens Roider Alexander jesacher johannes Strauss johannes Heberle Michael Schmidt martin j booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Institute of Photonic Technologies Friedrich-Alexander-University Erlangen-NurembergKonrad-Zuse-Strasse 3/5Erlangen 91052Germany Division of Biomedical Physics Innsbruck Medical UniversityMullerstrasse 44Innsbruck 6020Austria Graduate School in Advanced Optical Technologies(SAOT) Friedrich-Alexander University Erlangen-NurembergPaul-Gordan-Strasse 6Erlangen 91052Germany Centre for Neural Circuits and Behaviour University of OxfordMansfield RoadOxford OX13SRUK

The spectral dispersion of ultrashort pulses allows the simultaneous focusing of light in both space and time,which creates socalled spatiotemporal *** space–time coupling may be combined with the existing holographic techniques to give a further dimension of control when generating focal light *** the present study,it is shown that a phase-only hologram placed in the pupil plane of an objective and illuminated by a spatially chirped ultrashort pulse can be used to generate threedimensional arrays of spatio-temporally focused *** exploiting the pulse front tilt generated at focus when applying simultaneous spatial and temporal focusing(SSTF),it is possible to overlap neighboring foci in time to create a smooth intensity *** resulting light field displays a high level of axial confinement,with experimental demonstrations given through two-photon microscopy and the non-linear laser fabrication of glass.

关键词： laser material processing light shaping spatiotemporal focusing ultrafast lasers

Universal adaptive optics for microscopy through embedded neural network control

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Light(Science & Applications) 2023年第12期12卷 2597-2609页

作者： Qi Hu martin Hailstone jingyu Wang Matthew Wincott Danail Stoychev Huriye Atilgan Dalia Gala Tai Chaiamarit Richard M.Parton jacopo Antonello Adam M.Packer Ilan Davis martin j.booth Department of Engineering Science University of OxfordOxfordUK Department of Biochemistry University of OxfordOxfordUK Department of Physiology Anatomyand GeneticsUniversity of OxfordOxfordUK

The resolution and contrast of microscope imaging is often affected by aberrations introduced by imperfect optical systems and inhomogeneous refractive structures in *** optics(AO)compensates these aberrations and restores diffraction limited performance.A wide range of AO solutions have been introduced,often tailored to a specific microscope type or *** now,a universal AO solution-one that can be readily transferred between microscope modalities-has not been *** propose versatile and fast aberration correction using a physics-based machine learning assisted wavefront-sensorless AO control(MLAO)*** previous ML methods,we used a specially constructed neural network(NN)architecture,designed using physical understanding of the general microscope image formation,that was embedded in the control loop of different microscope *** approach means that not only is the resulting NN orders of magnitude simpler than previous NN methods,but the concept is translatable across microscope *** demonstrated the method on a two-photon,a three-photon and a widefield three-dimensional(3D)structured illumination *** showed that the method outperformed commonly-used modal-based sensorless AO *** also showed that our ML-based method was robust in a range of challenging imaging conditions,such as 3D sample structures,specimen motion,low signal to noise ratio and activity-induced fluorescence ***,as the bespoke architecture encapsulated physical understanding of the imaging process,the internal NN configuration was no-longer a"black box",but provided physical insights on internal workings,which could influence future designs.

关键词： optics illumination correction

Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber

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Light(Science & Applications) 2018年第1期7卷 1-6页

作者： Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren martin Plöschner Zahid Padamsey martin j.booth TomášČižmár Nigel j.Emptage Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK School of Engineering Physics and MathematicsCollege of ArtScience&EngineeringUniversity of DundeeNethergateDundee DD14HN ScotlandUK. Institute of Scientific Instruments of the CAS Královopolská14761264 BrnoCzech Republic

Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–*** in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–*** report a compact and highly optimized approach for minimally invasive in vivo brain imaging *** volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core ***,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+*** results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo.

关键词： multimode fiber resolution

A Tutorial Review of the Solar Power Curve: Regressions, Model Chains, and Their Hybridization and Probabilistic Extensions

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Advances in Atmospheric Sciences 2024年第6期41卷 1023-1067页

作者： Dazhi YANG Xiang’ao XIA martin jános MAYER School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Key Laboratory for Middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3Budapest H-1111Hungary

Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly *** numerous trending topics,energy meteorology has been attracting the most attention *** essential skill of solar energy meteorologists is solar power curve modeling,which seeks to map irradiance and auxiliary weather variables to solar power,by statistical and/or physical *** this regard,this tutorial review aims to deliver a complete overview of those fundamental scientific and engineering principles pertaining to the solar power *** power curves can be modeled in two primary ways,one of regression and the other of model *** classes of modeling approaches,alongside their hybridization and probabilistic extensions,which allow accuracy improvement and uncertainty quantification,are scrutinized and contrasted thoroughly in this review.

关键词： review energy meteorology solar power curve model chain solar power prediction

Shrinking multiplexed orbital angular momentum to the nanoscale

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Light(Science & Applications) 2021年第11期10卷 2026-2027页

作者： Chao He Yijie Shen Andrew Forbes martin j.booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Department of Engineering Science University of OxfordParks RoadOxfordOX13PJUK

Orbital angular momentum interactions at the nanoscale have remained elusive because the phase structure becomes *** researchers have shown how to overcome this with tightly focused beams,demonstrating a recordhigh si... 详细信息

关键词： momentum nanoscale overcome