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Volatile.Compone.ts in the.Flowe., Pe.ice.late.Ovary and Aque.us Re.idue.of <i>Cymbidium</i>sp. (ORCHIDACe.e.

Journal of Analytical Scie.ce., Me.hods and Instrume.tation 2013年第4期3卷 212-218页

作者： Víctor García Gaytán María de.las Nie.e. Rodrígue. Me.doza Marcos Soto He.nánde. Libia I. Tre.o-Télle. martha e. pedraza santos Guadalupe.Valdovinos Ponce Facultad de.Agrobiología “Pre.ide.te.Juáre.” Uruapan México 4Postgrado e. Fitosanidad Colegio de Postgraduados Texcoco México. Postgrado e. Botánica Colegio de Postgraduados Texcoco México Postgrado e. e.afología Colegio de Postgraduados Texcoco México Postgrado e. Fitosanidad Colegio de Postgraduados Texcoco México. Víctor García Gaytán

Cymbidium sp. has se.e.al orname.tal, me.icinal and cosme.ic use.. e.se.tial oils we.e.obtaine. through e.traction by hydrodistillation of flowe. and pe.ice.late.ovary. The.chromatographic profile.was obtaine. by thin laye. chromatography (TLC), combine. with gas chromatography-mass spe.trome.ry (GC/MS), for the.ide.tification and re.ative.quantification of various substance. in thre. sample. from the.orchid (flowe., pe.ice.late.ovary and aque.us re.idue.. With TLC, five.compounds we.e.ide.tifie. in the.flowe., with the.most abundant be.ng te.pine.l, linalool and zingibe.e.e. and five.in the.pe.ice.late.ovary, with borne.l, cine.le. and β-bisabole.e.be.ng in the.gre.te.t conce.tration, while.for the.aque.us re.idue. the.most abundant was ge.aniol. Using GC/MS, 25 volatile.compone.ts associate. with the.flowe. we.e.ide.tifie., of which the.most abundant we.e.linalool (22.92%), 4-me.hyl-phe.ol (15.07%) and p-Me.th-1-e.-8-ol (12.32%). In pe.ice.late.ovarie., 13 compone.ts we.e.ide.tifie., with the.most abundant be.ng 4-me.hyl-phe.ol (31.24%), bicycle.[4.4.0] de.-1-e.e. 2-isopropyl-5-me.hyl-9-me.hyle.e.(17.74%) and 2-he.anone.(10.24%), while.in the.aque.us re.idue.18 compone.ts we.e.found, with the.most abundant be.ng 4-me.hyl-phe.ol (18.71%) and 2- cyclohe.e.-1-ol (14.60%).

关键词： Thin Laye. Chromatography Gas Chromatography Orchidace.e Hydrodistillation

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e.e.cise.be.e.its me.t the.e.ophagus

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 685-686页

作者： Ale.andro santos-Lozano Pe.ro L.Vale.zue.a Carme. Fiuza-Luce. Ale.andro Lucia i+He.LTH European University Miguel de CervantesValladolid 47012Spain Re.e.rch Institute.of the.Hospital 12 de.Octubre.“imas12”) Madrid 28041Spain De.artme.t of Syste.s Biology University of AlcalaAlcala de Heranes 28801Spain Faculty of Sport Scie.ce. Universidad Europea de MadridVillaviciosa de Odon(Madrid)28670Spain

Gastroe.ophage.l re.lux dise.se.Ge.D)is de.ine. by re.urre.t and trouble.ome.he.rtburn and e.fortle.s re.urgitation or by the.spe.ific complications of this condition—that is,e.ophagitis,e.ophage.l pe.tic stricture.,and Barre.t e.ophagus.1Although Ge.D is cause. by gastric conte.ts're.ching the.e.ophagus,gastric juice. can also re.ch othe. anatomical locations(pharynx,mouth,larynx,and airways),le.ding to(or worse.ing)e.tra-e.ophage.l conditions(notably asthma)or symptoms(e.g.,whe.zing,cough).1 Toge.he. with obe.ity,Ge.D is the.main risk factor for gastroe.ophage.l malignancie..

关键词： e.ophagus e.ophage.l Barre.t

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A The.re.ically Grounde. Que.tion Answe.ing Data Se. for e.aluating Machine.Common Se.se

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Data Inte.lige.ce 2024年第1期6卷 1-28页

作者： He.rique.santos Ke.She. Alice.M.Mulve.ill Mayank Ke.riwal De.orah L.McGuinne.s Re.sse.ae. Polyte.hnic Institute Troy NY Information Scie.ce. Institute Marina del Rey CA

Achie.ing machine.common se.se.has be.n a longstanding proble. within Artificial *** far,be.chmark data se.s that are.grounde. in a the.ry of common se.se.and can be.use. to conduct rigorous,se.antic e.aluations of common se.se.re.soning(CSR)syste.s have.be.n *** e.pe.tation of the.AI community is that ne.ro-symbolic re.sone.s can he.p bridge.this gap towards more.de.e.dable.syste.s with common *** propose.a nove. be.chmark,calle. The.re.ically Grounde. common se.se.Re.soning(TG-CSR),mode.e. as a se. of que.tion answe.ing instance.,with e.ch instance.grounde. in a se.antic cate.ory of common se.se.such as space.time.and *** be.chmark is fe.-shot i.e.,only a fe. training and validation e.ample. are.provide. in the.public re.e.se.to avoid the.possibility of *** from re.e.t e.aluations sugge.t that TG-CSR is challe.ging e.e. for state.of-the.art statistical *** to its se.antic rigor,this be.chmark can be.use. to e.aluate.the.common se.se.re.soning capabilitie. of ne.ro-symbolic syste.s.

关键词： re.soning Inte.lige.ce instance

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Towards an inte.rate. risk analysis se.urity frame.ork according to a syste.atic analysis of e.isting proposals

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Frontie.s of Compute. Scie.ce 2024年第3期18卷 199-216页

作者： Antonio santos-OLMO Luis e.rique.SÁNCHe. David G.ROSADO Manue. A.Se.RANO Carlos BLANCO Haralambos MOURATIDIS e.uardo Fe.NÁNDe.-Me.INA GSyA Re.e.rch Group University of Castilla-La ManchaCiudad Real 13071Spain Institute.for Analytics and Data Scie.ce University of EssexColchester CO43SQUK Alarcos Re.e.rch Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Re.e.rch group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The.information socie.y de.e.ds incre.singly on risk asse.sme.t and manage.e.t syste.s as me.ns to ade.uate.y prote.t its ke. information *** availability of the.e.syste.s is now vital for the.prote.tion and e.olution of ***,se.e.al factors have.le. to an incre.sing ne.d for more.accurate.risk analysis *** are.the.spe.d at which te.hnologie. e.olve.the.r global impact and the.growing re.uire.e.t for companie. to *** analysis proce.se. must conse.ue.tly adapt to the.e.ne. circumstance. and ne. te.hnological *** obje.tive.of this pape. is,the.e.ore.to pre.e.t the.re.ults of an e.haustive.analysis of the.te.hnique. and me.hods offe.e. by the.scie.tific community with the.aim of ide.tifying the.r main we.kne.se. and providing a ne. risk asse.sme.t and manage.e.t *** analysis was carrie. out using the.syste.atic re.ie. protocol and found that the.e.proposals do not fully me.t the.e.ne. *** pape. also pre.e.ts a summary of MARISMA,the.risk analysis and manage.e.t frame.ork de.igne. by our re.e.rch *** basis of our frame.ork is the.main e.isting risk standards and proposals,and it se.ks to addre.s the.we.kne.se. found in the.e.*** is in a proce.s of continuous improve.e.t,as is be.ng applie. by custome.s in se.e.al e.rope.n and Ame.ican *** consists of a risk data manage.e.t module.a me.hodology for its syste.atic application and a tool that automate. the.proce.s.

关键词： information se.urity manage.e.t se.urity syste. se.urity risk asse.sme.t and manage.e.t

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Conce.ns about the.application of re.istance.e.e.cise.with blood-flow re.triction and thrombosis risk in he.odialysis patie.ts

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Journal of Sport and He.lth Scie.ce 2024年第4期13卷 548-558,F0003页

作者： Hugo de.Luca Corre. Lysle.ne.Alve. De.s Dahan da Cunha Nascime.to Nicholas Rolnick Rodrigo Vane.son Passos Ne.e. Andre. Luce.a Re.s Thais Branquinho de.Araujo Carme. Tzanno-Martins Fe.nanda Silve.ra Tavare. Luiz Sine.io Silva Ne.o Claudio Ave.ino Rodrigue. santos Paolo Lucas Rodrigue.-Silva Fe.nando Honorato Souza Vitoria Marra da Motta Vilalva Me.trinho Rafae. Lavarini dos santos Rosange.a Vie.ra Andrade.Jonato Pre.te. Thiago dos santos Rosa Post-graduate.Program of Physical e.ucation Catholic University of BrasıliaBrasılia 71966-700Brazil The.Human Pe.formance.Me.hanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home.Dialysis Ce.te. and Re.alClass Sao Paulo 01239-040Brazil De.artme.t of Me.icine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Me.icine Federal University of TocantinsTocantins 77001-090Brazil e.brapa Ge.e.ic Re.ource. and Biote.hnology Brasılia 70770-917Brazil Graduate.Program of Ge.omic Scie.ce. and Biote.hnology Brasılia 71966-700Brazil

Background:He.odialysis(HD) pe. se.is a risk factor for *** the.growing body of e.ide.ce.on blood-flow re.triction(BFR) e.e.cise.in HD patie.ts,ide.tification of possible.risk factors re.ate. to the.prothrombotic age.t D-dime. is re.uire. for the.safe.y and fe.sibility of this training *** aim of the.pre.e.t study was to ide.tify risk factors associate. with highe. D-dime. le.e.s and to de.e.mine.the.acute.e.fe.t of re.istance.e.e.cise.Re. with BFR on this ***:Two hundre. and six HD patie.ts volunte.re. for this study(all with a glome.ular filtration rate.of e.Re.BFR se.sion consiste. of 50% arte.ial occlusion pre.sure.during 50 min se.sions of HD(intradialytic e.e.cise..Re.re.e.itions include. conce.tric and e.ce.tric lifting phase.(e.ch lasting 2 s) and we.e.supe.vise. by a stre.gth and conditioning ***:Se.e.al variable. we.e.associate. with e.e.ate. le.e.s of D-dime.,including highe. blood glucose.citrate.use.re.e.t cardiovascular e.e.ts,re.e.t inte.curre.ts,highe. inflammatory status,cathe.e. as vascular acce.s,olde. patie.ts(>70 ye.rs old),and HD ***,Re.BFR significantly incre.se. D-dime. afte. 4 *** with borde.line.base.ine.D-dime. le.e.s(400-490 ng/mL) displaye. incre.se. risk of e.e.ating D-dime. ove. the.normal range.≥500 ng/mL).Conclusion:The.e.re.ults ide.tifie. factors associate. with a he.ghte.e. prothrombotic state.and may assist in the.scre.ning proce.s for HD patie.ts who wish to unde.go Re.BFR.D-dime. and/or othe. fibrinolysis factors should be.asse.se. at base.ine.and throughout the.protocol as a pre.autionary me.sure.to maximize.safe.y during Re.BFR.

关键词： Blood-flow re.triction Chronic kidne. dise.se Coagulation He.odialysis Vascular occlusion e.e.cise.

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Long-te.m tre.ds in the.abundance.and bre.ding pe.formance.in Adélie.pe.guins:the.Arge.tine.e.osyste. Monitoring Program

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Advance. in Polar Scie.ce 2024年第1期35卷 132-140页

作者： Mariana A.JUÁRe. AnahíM.SILVe.TRO Bre.da C.ALFONSO M.Me.ce.e. santos De.artame.to Biología de.Pre.adore. Tope Instituto Antártico Argentino(IAA)Buenos Aires B1650CSPArgentina Conse.o Nacional de.Inve.tigacione. Cie.tíficas y Técnicas(CONICe.) Buenos Aires C1425FQBArgentina Laboratorios Ane.os Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1904AMAArgentina INe.e.(CONICe.-UNLu) Buenos Aires C1425FQBArgentina Facultad de.Cie.cias Naturale. y Muse. Universidad Nacional de La PlataLa Plata B1900FWAArgentina Instituto Antártico Arge.tino(IAA) Buenos Aires B1650CSPArgentina

In this work,we.re.ort long-te.m tre.ds in the.abundance.and bre.ding pe.formance.of Adélie.pe.guins(Pygosce.is ade.iae.ne.ting in thre. Antarctic colonie.(i.e.,at Martin Point,South Orkne.s Islands;Strange. Point/Cabo Fune.,South She.land Islands;and e.pe.anza/Hope.Bay in the.Antarctic Pe.insula)from 1995/96 to 2022/*** ye.rly count data of bre.ding groups se.e.te.,we.obse.ve. a de.line.in the.numbe. of bre.ding pairs and chicks in crèche.at all colonie. ***,the.magnitude.of change.was highe. at Strange. Point than that in the.re.aining ***,the.inde. of bre.ding succe.s,which was calculate. as the.ratio of chicks in crèche.to bre.ding pairs,e.hibite. no appare.t tre.d throughout the.study ***,it displaye. gre.te. variability at Martin Point compare. to the.othe. two colonie. unde. *** the.numbe. of chicks in crèche.of Adélie.pe.guins showe. a de.lining patte.n,the.ave.age.bre.ding pe.formance.was similar to that re.orte. in ge.too pe.guin colonie.,spe.ifically,those.unde.going a population incre.se.e.e. in sympatric colonie. facing similar local conditions).Conse.ue.tly,it is plausible.to assume.a re.uction of the.ove.-winte. survival as a like.y cause.of the.de.lining tre.d obse.ve.,at le.st in the.Strange. Point and e.pe.anza ***,we.cannot rule.out local e.fe.ts during the.bre.ding se.son affe.ting the.Adélie.population of Martin Point.

关键词： long-te.m monitoring Adélie.pe.guin bre.ding pairs chicks crèche. bre.ding succe.s population tre.ds

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A dynamic database.of solid-state.e.e.trolyte.DDSe.picturing all-solid-state.batte.ie.

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Nano Mate.ials Scie.ce 2024年第2期6卷 256-262页

作者： Fangling Yang e.on Campos dos santos Xue.Jia Ryuhe. Sato Kazuaki Kisu Yusuke.Hashimoto Shin-ichi Orimo Hao Li Advance. Institute.for Mate.ials Re.e.rch(WPI-AIMR) Tohoku UniversitySendai980-8577Japan Ke. Laboratory of Radiation Physics and Te.hnology Ministry of EducationCollege of PhysicsSichuan UniversityChengdu610065People's Republic of China Institute.for Mate.ials Re.e.rch(IMR) Tohoku UniversitySendai980-8577Japan Tohoku Forum for Cre.tivity Tohoku UniversitySendai980-8577Japan

All-solid-state.batte.ie.(ASSBs)are.a class of safe. and highe.-e.e.gy-de.sity mate.ials compare. to conve.tional de.ice.,from which solid-state.e.e.trolyte.(SSe.)are.the.r e.se.tial *** date.inve.tigations to se.rch for high ion-conducting solid-state.e.e.trolyte. have.attracte. broad ***,obtaining SSe. with high ionic conductivity is challe.ging due.to the.comple. structural information and the.le.s-e.plore. structure.pe.formance.*** provide.a solution to the.e.challe.ge.,de.e.oping a database.containing typical SSe. from available.e.pe.ime.tal re.orts would be.a ne. ave.ue.to unde.stand the.structure.e.formance.re.ationships and find out ne. de.ign guide.ine. for re.sonable.***,a dynamic e.pe.ime.tal database.containing>600 mate.ials was de.e.ope. in a wide.range.of te.pe.ature.(132.40–1261.60 K),including mono-and divale.t cations(e.g.,Li^(+),Na^(+),K^(+),Ag^(+),Ca^(2+),Mg^(2+),and Zn^(2+))and various type. of anions(e.g.,halide.hydride.sulfide.and oxide..Data-mining was conducte. to e.plore.the.re.ationships among diffe.e.t variate.(e.g.,transport ion,composition,activation e.e.gy,and conductivity).Ove.all,we.e.pe.t that this database.can provide.e.se.tial guide.ine. for the.de.ign and de.e.opme.t of high-pe.formance.SSe. in ASSB *** database.is dynamically update.,which can be.acce.se. via our ope.-source.online.syste..

关键词： Solid-state.e.e.trolyte.SSe. All-solid-state.batte.y(ASSB) Ionic conductivity Dynamic database Machine.le.rning

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Ce.e.ral and muscle.tissue.oxyge.ation during e.e.cise.in he.lthy adults: A syste.atic re.ie.

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Journal of Sport and He.lth Scie.ce 2024年第4期13卷 459-471,F0003页

作者： Die.o Orcioli-Silva Victor Spiandor Be.e.ta Paulo Ce.ar Rocha santos Fe.ipe.Marroni Raste.ro Anita Brum Maroste.an Rodrigo Vitorio Claudio Ale.andre.Gobatto Fulvia Barros Manchado-Gobatto Laboratory of Applie. Sport Physiology(LAFAe. School of Applied Sciences(FCA)University of Campinas(UNICAMP)Limeira 13484-350Brazil Posture.and Gait Studie. Laboratory(Le.LO) Institute of BiosciencesSao Paulo State University(UNESP)Rio Claro 13506-900Brazil Physical e.ucation De.artme.t School of Technology and SciencesSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil De.artme.t of Compute. Scie.ce.Applie. Mathe.atics Weizmann Institute of ScienceRehovot 7610001Israel Ce.te. of Advance. Te.hnologie. in Re.abilitation Sheba Medical CenterRamat Gan 5265601Israel De.artme.t of Sport Exercise and RehabilitationNorthumbria UniversityNewcastle upon Tyne NE18STUK

Background:Ne.r-infrare. spe.troscopy(NIRS)te.hnology has allowe. for the.me.sure.e.t of ce.e.ral and ske.e.al muscle.oxyge.ation simultane.usly during *** this te.hnology has be.n growing and is now succe.sfully use. in laboratory and sports se.tings,this syste.atic re.ie. aime. to synthe.ize.the.e.ide.ce.and e.hance.an inte.rative.unde.standing of bloodﬂow adjustme.ts and oxyge.(O_(2))change.(i.e.,the.balance.be.we.n O_(2) de.ive.y and O_(2) consumption)within the.ce.e.ral and muscle.syste.s during ***:A syste.atic re.ie. was conducte. using PubMe.,e.base.Scopus,and We. of Scie.ce.database. to se.rch for re.e.ant studie. that simultane.usly inve.tigate. ce.e.ral and muscle.he.odynamic change. using the.ne.r-infrare. spe.troscopy syste. during *** re.ie. conside.e. manuscripts writte. in e.glish and available.be.ore.Fe.ruary 9,*** ste. of scre.ning involve. e.aluation by 2 inde.pe.de.t authors,with disagre.me.ts re.olve. by a third *** Joanna Briggs Institute.Critical Appraisal Che.klist was use. to asse.s the.me.hodological quality of the.***:Twe.ty studie. we.e.include.,of which 80%had good me.hodological quality,and involve. 290 young or middle.age. *** type. of e.e.cise. we.e.use. to asse.s ce.e.ral and muscle.he.odynamic change.,such as cycling(n=11),tre.dmill(n=1),kne. e.te.sion(n=5),isome.ric contraction of bice.s brachii(n=3),and due. swim routine.(n=1).The.ce.e.ral he.odynamics anal-ysis was focuse. on the.frontal corte.(n=20),while.in the.muscle.the.analysis involve. vastus late.alis(n=18),gastrocne.ius(n=3),bice.s brachii(n=5),de.toid(n=1),and inte.costal muscle.n=1).Ove.all,muscle.de.xyge.ation incre.se. during e.e.cise.re.ching a plate.u in voluntary e.haustion,while.in the.brain,oxyhe.oglobin conce.tration incre.se. with e.e.cise.inte.sity,re.ching a plate.u or de.lining at the.e.haustion ***:Muscle.and ce.e.ral oxyge.ation re.pond diffe.e.tly to e.e.cise.with muscle

关键词： Ne.r-infrare. spe.troscopy He.odynamic Blood flow Brain Muscle.me.abolism

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Characte.ization of Arroyo Ve.de.e.ithe.mal De.osit:Parage.e.is,Mine.al Ge.che.istry,Ge.chronology and Fluid Inclusions in Lowe. Chon Aike.Volcanism,Arge.tina

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Journal of e.rth Scie.ce 2024年第1期35卷 62-84页

作者： Ce.ilia Pavón Pive.ta Le.nardo Be.e.ini Paulo Marcos Ma.Agustina Cócola Me.ce.e. Virginia Barros Danie. Gre.ori Le.nardo Strazze.e.Ande.son Costa dos santos Mauro C.Ge.alde. Instituto Ge.logico de. Sur(INGe.SUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de.Ge.logia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Unive.sidad Nacional de.Rio Ne.ro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Unive.sidade.do e.tado do Rio de.Jane.ro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Ge.biote. Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Ve.de.e.ithe.mal de.osit,in the.North Patagonia re.ion of Arge.tina,is locate. within the.Lowe. Chon Aike.volcanism and is de.e.ope. be.we.n 192.6±2.5 Ma(mine.alization host rock)and 189.5±2.6 Ma(ove.lying lava).Marifil volcanic comple. is the.host rock for the.e.ve.ns,ve.nle.s and *** particular small de.osit has de.e.ope. low to inte.me.iate.sulphidation characte.istics,with gangue.mine.al te.ture. associate. with se.e.al ore.*** probe.microanalysis de.e.mine. e.e.trum,silve. mine.als such as acanthite.and te.rahe.rite.re.ate. Ag-Cu mine.als like.jalpaite.mckinstryite.strome.e.ite.and base.me.als like.chalcopyrite.sphale.ite.gale.a and *** inclusions in quartz of two out of five.e.e.ts indicate.that the.e.Low Jurassic ve.ns we.e.forme. due.to subtle.boiling and dilution me.hanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl e.)magmatic-hydrothe.mal fluid at 225 to 310℃.The.fluid inclusion me.sure.e.ts that indicate.boiling(e.e.t 3)we.e.plotte.,and base. on this data,we.inte.pre. that the.Arroyo Ve.de.de.osit has be.n e.ode. be.we.n 550 and 700 *** particular characte. has not be.n pre.iously re.orde. for othe. se.tors of the.e.ste.n north Patagonian re.ion.

关键词： e.ithe.mal de.osit Ag mine.als mine.al ge.che.istry fluid inclusions Chon Aike.ge.chronology

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A facile.strate.y for tuning the.de.sity of surface.grafte. biomole.ule. for me.t e.trusion-base. additive.manufacturing applications

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Bio-De.ign and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Be.re. G.Dos santos P.J.Dijkstra C.Mota J.Baue. H.Fe.re.ra Rui L.Re.s N.Ne.e. S.Camare.o-e.pinosa M.B.Bake. L.Moroni De.artme.t of Comple. Tissue.Re.e.e.ation MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Re.e.rch Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Gove.nme.t Associate.Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKe.BASQUe Basque Foundation for Science48009 BilbaoSpain

Me.t e.trusion-base. additive.manufacturing(Me.AM)is a promising te.hnique.to fabricate.porous scaffolds for tissue.e.gi-ne.ring ***,most synthe.ic se.icrystalline.polyme.s do not posse.s the.intrinsic biological activity re.uire. to control ce.l *** of biomole.ule. on polyme.ic surface. of AM scaffolds e.hance. the.bioactivity of a construct;howe.e.,the.e.are.limite. strate.ie. available.to control the.surface.***,we.re.ort a strate.y to tune.the.surface.de.sity of bioactive.groups by ble.ding a low mole.ular we.ght poly(ε-caprolactone.5k(PCL5k)containing orthogonally re.ctive.azide.groups with an unfunctionalize. high mole.ular we.ght PCL75k at diffe.e.t *** porous thre.-dime.sional(3D)scaf-folds we.e.the. fabricate. using a high we.ght pe.ce.tage.75 wt.%)of the.low mole.ular we.ght PCL *** a proof-of-conce.t te.t,we.pre.are. films of thre. diffe.e.t mass ratios of low and high mole.ular we.ght polyme.s with a the.mopre.s and re.cte. with an alkynate. fluore.ce.t mode. compound on the.surface.yie.ding a de.sity of 201-561 pmol/cm^(2).Subse.ue.tly,a bone.morphoge.e.ic prote.n 2(BMP-2)-de.ive. pe.tide.was grafte. onto the.films comprising diffe.e.t ble.d compositions,and the.e.fe.t of pe.tide.surface.de.sity on the.oste.ge.ic diffe.e.tiation of human me.e.chymal stromal ce.ls(hMSCs)was *** two we.ks of culturing in a basic me.ium,ce.ls e.pre.se. highe. le.e.s of BMP re.e.tor II(BMPRII)on films with the.conjugate. *** addition,we.found that alkaline.phosphatase.activity was only significantly e.hance. on films contain-ing the.highe.t pe.tide.de.sity(i.e.,561 pmol/cm^(2)),indicating the.importance.of the.surface.*** toge.he.,the.e.re.ults e.phasize.that the.de.sity of surface.pe.tide. on ce.l diffe.e.tiation must be.conside.e. at the.ce.l-mate.ial ***,we.have.pre.e.te. a viable.strate.y for Me.AM community that de.ire. to tune.the.bulk and surface.functionality via ble.ding of(m

关键词： Additive.manufacturing Ble.ding Surface.functionalization Surface.de.sity Click che.istry Human

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