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eye and Vision 2019年第1期6卷 291-297页

作者： Ke Liu Li Ma Timothy Y.Y.Lai marten e.brelen Pancy O.S.Tam Clement C.Tham Chi Pui Pang Li Jia Chen Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina

Background:Neovascular age-related macular degeneration(AMD)and polypoidal choroidal vasculopathy(PCV)are sight-threatening maculopathies with both environmental and genetic risk *** have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and ***:In this study,we investigated the haplotype-tagging single nucleotide polymorphisms(SNPs)in the complement component 5(C5)gene in 708 unrelated Chinese individuals:200 neovascular AMD patients,233 PCV patients and 275 *** tagging SNPs in C5 were *** single SNP association analysis,haplotype-based association analysis and gene-gene interaction analysis between C5 and other AMD-associated genes were ***:The results revealed none of the six tagging SNPs of the C5 gene had a significant association with neovascular AMD or PCV(P>0.05).We also found insignificant haplotype-based association,and no significant SNPSNP interaction between C5 and other genes(including C2-CFB-RDBP-SKIV2L,SeRPING1,CeTP,ABCG1,PGF,ANGPT2,CFH and HTRA1)for neovascular AMD and ***:This study showed no statistical significance in the genetic association of C5 with neovascular AMD or PCV in a Hong Kong Chinese *** studies in large samples from different populations are warranted to elucidate the role of C5 in the genetic susceptibility of AMD and PCV.

关键词： Age-related macular degeneration Polypoidal choroidal vasculopathy Complete component 5 C5 Genetic association Single-nucleotide polymorphism

Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis:a 12-year review

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International Journal of Ophthalmology(english edition) 2020年第12期13卷 1933-1940页

作者： Chun Yue Mak Mary Ho Lawrence Pui-leung Iu Helena Pui-yee Sin Li Jia Chen Grace Lui marten erik brelen Alvin Lerrmann Young Department of Ophthalmology and Visual Sciences Prince of Wales HospitalNew TerritoriesHong KongChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongNew TerritoriesHong KongChina Division of Infectious Diseases Department of Medicine and Therapeuticsthe Chinese University of Hong KongNew TerritoriesHong KongChina

AIM:To identify the clinical features and treatment outcomes of endogenous Klebsiella pneumoniae endophthalmitis and investigate prognostic factors of poor visual ***:The clinical records of all patients diagnosed with endogenous Klebsiella endophthalmitis between January 2007 to December 2018 in Prince of Wales Hospital,Hong Kong,China were retrospectively *** ophthalmological examination findings were recorded in the case note,including visual acuity testing,slit-lamp examination,indirect ophthalmoscopy and B-scan ultrasonography if media opacity precluded fundus ***:A total of 18 eyes in 14 patients were *** involvement was noted in 4 patients(28.6%).Hepatobiliary sepsis was the source in 9 patients(64.3%).Culture of intraocular fluid was positive in 5 out of 18 eyes(27.8%).Mortality was noted in 2 patients(14.3%).Mean final visual acuity was 20/*** out of 16 eyes had total loss of sight(37.5%)and 3 eyes required evisceration(18.8%).Multivariate linear regression revealed poor presenting visual acuity(P=0.031)and lack of fundus view due to vitritis(P=0.02)as prognostic factors of poor visual ***:Visual outcome of endogenous Klebsiella endophthalmitis is *** presenting visual acuity and lack of fundus view predict poor visual *** index of suspicion for endophthalmitis is important in Klebsiella sepsis patients with complaints of ocular *** screening is recommended in noncommunicable patients with Klebsiella sepsis.

关键词： Klebsiella pneumoniae endogenous endophthalmitis screening liver abscess sepsis

Mapping nanoscale topographic features in thick tissues with speckle diffraction tomography

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Light(Science & Applications) 2023年第9期12卷 1877-1885页

作者： Sungsam Kang Renjie Zhou marten brelen Heather K.Mak Yuechuan Lin Peter T.C.So Zahid Yaqoob Laser Biomedical Research Center G.R.Harrison Spectroscopy LaboratoryMassachusetts Institute of TechnologyCambridgeMA 02139USA Department of Biomedical engineering The Chinese University of Hong KongHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina Department of Mechanical engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Biological engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Biomedical engineering Boston UniversityBostonMA 02215USA

Resolving three-dimensional morphological features in thick specimens remains a significant challenge for label-free *** report a new speckle diffraction tomography(SDT)approach that can image thick biological specimens with~500 nm lateral resolution and~1μm axial resolution in a reflection *** SDT,multiple-scattering background is rejected through spatiotemporal gating provided by dynamic speckle-field interferometry,while depth-resolved refractive index maps are reconstructed by developing a comprehensive inverse-scattering model that also considers specimen-induced *** from the high-resolution and full-field quantitative imaging capabilities of SDT,we successfully imaged red blood cells and quantified their membrane fluctuations behind a turbid medium with a thickness of 2.8 scattering mean-free *** importantly,we performed volumetric imaging of cornea inside an ex vivo rat eye and quantified its optical properties,including the mapping of nanoscale topographic features of Dua’s and Descemet’s membranes that had not been previously visualized.

关键词： speckle inverse interferometry

evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging

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Bioactive Materials 2022年第9期7卷 382-391页

作者： Jonathan espiritu Mostafa Berangi Christina Yiannakou eduarda Silva Roberto Francischello Andre Kuehne Thoralf Niendorf Soren Konneker Regine Willumeit-Romer Jan-marten Seitz Syntellix AG HannoverGermany MRI.TOOLS GmbH BerlinGermany Charit´e-Universitatsmedizin Berlin Corporate Member of Freie Universitat Berlin and Humboldt Universitat zu BerlinBerlinGermany Berlin Ultrahigh Field Facility(B.U.F.F.) Max-Delbrueck Center for Molecular Medicine in the Helmholtz AssociationBerlinGermany Hannover Medical School HannoverGermany Institute of Clinical Physiology National Research CouncilPisaItaly Chemistry and Industrial Chemistry Department Universita di PisaVia Moruzzi 13PisaItaly Fondazione Toscana Gabriele Monasterio Via Moruzzi 1PisaItaly Institute for Materials Research Helmholtz Zentrum HereonGeesthachtGermany

Magnesium(Mg)implants have shown to cause image artefacts or distortions in magnetic resonance imaging(MRI).Yet,there is a lack of information on how the degradation of Mg-based implants influences the image quality of MRI *** this study,Mg-based implants are analysed in vitro,ex vivo,and in the clinical setting for various magnetic field strengths with the aim to quantify metallic artefact *** vitro corroded Mg-based screws and a titanium(Ti)equivalent were imaged according to the ASTM ***-based and Ti pins were also implanted into rat femurs for different time points and scanned to provide insights on the influence of soft and hard tissue on metallic ***,MRI data of patients with scaphoid fractures treated with Ce-approved Mg-based compression screws(MAGNeZIX®)were analysed at various time points *** artefact production of the Mg-based material decreased as implant material degraded in all *** worst-case imaging scenario was determined to be when the imaging plane was selected to be perpendicular to the implant ***,the Mg-based implant outperformed the Ti equivalent in all experiments by producing lower metallic artefact(pestigation demonstrates that Mg-based implants generate significantly lower metallic distortion in MRI when compared to *** positive findings suggest and support further research into the application of Mg-based implants including post-operative care facilitated by MRI monitoring of degradation kinetics and bone/tissue healing processes.

关键词： Magnetic resonance imaging Magnesium Biodegradable implants Medical imaging Translational medicine

氯乙烯高转化率聚合—本体、悬浮和乳液聚合过程

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聚氯乙烯 1982年第3期 14-14页

作者： A.e.Hamielec ,L.marten ,刘训富锦西化工研究院

氯乙烯高转化率聚合的特点除压力降以外还有聚合物颗粒中单体浓度降低,聚合物链节缠结现象增加和自由体积减小。这些现象迫使游离基终止速率降低,因而游离基的居集数目迅速增加。

关键词：高转化率氯乙烯乙烯基氯氯代烃自由体积

急性肺栓塞:多排CT心脏径线测量预测肺心病和患者短期存活率

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放射学实践 2007年第1期22卷 95-95页

作者： engelke C Rummeny e marten K 杨岷（译）夏黎明（校）不详华中科技大学同济医学院附属同济医院

目的：探讨多排CT胸部检查测量心脏形态学参数对评价可疑和突发急性肺栓塞（Pe）患者预后的价值。方法：对连续2335例行MSCT检查的患者进行肺栓塞（Pe）的筛查。以肺动脉和心腔的强化程度和可诊断性作为评价扫描质量的指标。对所有MSCT... 详细信息

目的：探讨多排CT胸部检查测量心脏形态学参数对评价可疑和突发急性肺栓塞（Pe）患者预后的价值。方法：对连续2335例行MSCT检查的患者进行肺栓塞（Pe）的筛查。以肺动脉和心腔的强化程度和可诊断性作为评价扫描质量的指标。对所有MSCT检查发现的Pe患者，测量舒张期左心室和右心室短轴（RVD，LVD）及室间隔偏移（ISD），并结合其超声心动图检查结果。其临床诊断依据包括心肺及其它相关并发症，全身抗凝治疗（ACT）及30天后的疗效。采用单变量和多变量Lo—gistic回归方法分析可能性比率（OR）、受试者工作特征曲线（receive operating characteristic curve，ROC），对Pe所致急性肺心病和短期预后的各个预测因子的阴性和阳性预测值（NPV，PPV）进行计算。结果：本组共发现90例急性肺栓塞患者，其中36例为临床疑诊病例，54例为突发性。26例患者有心肺合并症。4例患者接受全身性溶栓治疗，

关键词：急性肺栓塞心脏形态学阳性预测值急性肺心病径线测量多排CT 存活率受试者工作特征曲线

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老年患者除皱术安全性探讨

中国美容整形外科杂志 2011年第11期22卷 I0011-I0018页

作者： esteban marten Claude-Jean Langevin Sumesh Kaswan James e. Zins 魏峰（译）高景恒（译）张晨（译）美国俄亥俄州克利夫兰市克利夫兰医院整形外科；佛罗里达州奥兰多市奥兰多M．D．Anderson癌症中心；罗切斯特大学整形外科中心《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的本研究旨在评价老年患者施行面部提升手术的安全性。并特别探讨年龄递增是否是老年患者除皱术并发症发生率增加的独立危险凶素（即是否随年龄的增长，老年患者除皱术后并发症的发生概率有所增加）。方法笔者对同一医师3年内... 详细信息

背景与目的本研究旨在评价老年患者施行面部提升手术的安全性。并特别探讨年龄递增是否是老年患者除皱术并发症发生率增加的独立危险凶素（即是否随年龄的增长，老年患者除皱术后并发症的发生概率有所增加）。方法笔者对同一医师3年内施行除皱术的216例患者的临床资料进行回顾性分析。将患者分为2组，即〈65岁组（148例）和≥65岁组（68例）。应用统计学分析对手术合并症、手术细节和并发症情况进行分析。结果年龄较大（≥65岁）组患者平均年龄70．0岁，年龄较小（〈65岁）组患者平均年龄57．6岁。年龄较大组与年龄较小组相比，其美国麻醉医师学会病情分级得分较高，且首次面部提升术者更多（41．2％：17．6％，P〈0．001）。年龄较大组与年龄较小组相比，其并发症发生率差异无统计学意义（主要并发症2．9％：2．0，P=0．65；次要并发症5．9％：6．1％．P=0．99）。两组患者均无死亡。结论笔者通过对认真筛选的老年患者的分析认为，面部提升手术并发症的发生率与年龄较小的患者组相比，其差异无统计学意义。笔者认为，单独的年龄递增不是面部提升于术术后并发症发生概率增加的独立危险因素。而超过65岁的老年患者，保证其面部提升手术安全性的年龄限制是否存在（或具体为多少）仍需进一步研究确定。

关键词：手术安全性老年患者除皱术并发症发生率面部提升术手术并发症统计学分析平均年龄

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优质水貂皮初加工时应注意的问题

畜牧与饲料科学 2009年第5期30卷 137-138页

作者：高雅琴王宏博常玉兰席斌牛春娥杜天庆农业部动物毛皮及制品质量监督检验测试中心(兰州) 甘肃兰州730050 中国农业科学院兰州畜牧与兽药研究所甘肃兰州730050

主要从影响貂皮质量的初加工工序,如剥皮时间、屠宰方法、剥皮方法、洗皮、晾晒、储存及包装等方面,详细论述了各环节需掌握的关键技术,并提出了获取优质貂皮应对初加工过程中的人为因素加强控制的建议。

关键词：水貂皮初加工技术控制