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Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

World Journal of Gastroenterology 2018年第29期24卷 3293-3301页

作者： Svein Oskar Frigstad marte lie hoivik Jorgen Jahnsen Milada Cvancarova Tore Grimstad Ingrid Prytz Berset Gert Huppertz-Hauss Oistein Hovde Tomm Bernklev Bjorn Moum Lars-Petter Jelsness-Jorgensen Department of Medicine Vestre Viken Baeum HospitalGjettum 1346Norway Department of Gastroenterology Ostfold Hospital KalnesGralum 1714Norway Department of Health Sciences Ostfold University CollegeHalden 1757Norway Department of Gastroenterology Stavanger University HospitalStavanger 4068Norway Department of Research Otfold Hospital KalnesGralum 1714Norway Department of Gastroenterology Oslo University HospitalOslo 0424Norway Department of Gastroenterology Akershus University HospitalLorenskog 1478Norway Faculty of Health Sciences Oslo Metropolitan UniversityOslo 0130Norway Department of Medicine Alesund Hospital TrustAlesund 6026Norway Department of Gastroenterology Telemark Hospital TrustSkien 3710Norway Department of Medicine Innlandet Hospital TrustGjovik 2819Norway Department of Research and Development Vestfold Hospital TrustTonsberg 3103Norway

AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease(IBD).METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire(FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep *** In total, 405 patients were included in the analyses, of which 227(56%) had Crohn's disease(CD) and 178(44%) had ulcerative colitis(UC). Vitamin D deficiency(< 50 nmol/L) was present in half(203/405) of the patients. Chronic fatigue was reported by 116(29%) of all included patients with substantial fatigue reported by 194(48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD *** In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Fatigue Chronic fatigue Vitamin D deficiency

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Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 235-241页

作者： Magnus Hofrenning Wanderas Bjorn A Moum marte lie hoivik Oistein Hovde Department of Medicine Innlandet Hospital Trust Faculty of Medicine University of Oslo Department of Gastroen-terology Oslo University Hospital Institute of Clinical Medicine University of Oslo Department of Gastroenterology Innlandet Hospital Trust

Ulcerative colitis(UC)is characterized by chronic inflammation of the large bowel in genetically suscep-tible individuals exposed to environmental risk *** disease course can be difficult to predict,with symptoms ranging from mild to *** is no generally accepted definition of severe UC,and no single outcome is sufficient to classify a disease course as *** are several outcomes indicating a severe disease course,including progression of the disease’s extension,a high relapse rate,the development of acute severe colitis,colectomy,the occurrence of colorectal cancer and UC-related *** evaluating a patient’s prognosis,it is helpful to do so in relation to these *** these outcomes also makes it easier to isolate factors predictive of severe *** aims of this article are to evaluate different disease outcomes and to present predictive factors for these outcomes.

关键词： Ulcerative colitis Disease course Prognosis Severity Colectomy Relapse Acute severe colitis Cancer Mortality

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