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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey Sinforiano Posadas María E.Quiros-ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Development and screening of(Ca-P-Si-F)-PEO coatings for biodegradability control of Mg-Zn-Ca alloys

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Journal of Magnesium and Alloys 2022年第8期10卷 2220-2237页

作者： Lara moreno marta Mohedano Raul Arrabal Endzhe Matykina Departamento de Ingeniería Química y de Materiales Facultad de Ciencias QuímicasUniversidad Complutense de Madrid28040 MadridSpain

PEO coatings were developed on MgZnxCayalloys for biomedical applications using different treatment times and a novel transparent electrolyte containing Ca,P,Si and *** characteristics and chemical composition of studied materials were evaluated using scanning electron microscopy,X-ray diffraction and optical *** investigations were performed for uncoated and coated materials using potentiodynamic polarization,electrochemical impedance spectroscopy and hydrogen evolution measurements in three media(0.9wt.%NaCl,α-MEM and inorganic part ofα-MEM).Findings revealed that Zn-rich intermetallics favour the formation of large voids in the ***,P,F and Si are successfully incorporated into the *** consist of crystalline phases(Mg O,Mg F_(2)and Ca,Si-rich compounds)and amorphous *** and organic components ofα-MEM solution accelerate corrosion of the bare substrates but have no significant influence on the corrosion resistance of coated ***,inorganicα-MEM can be considered as an appropriate medium for fast screening of PEO *** relatively small amount of F content in the barrier layer facilitates early failure of the coatings,which show undercoating ***-rich intermetallic particles in the undercoating crevice induce a more aggressive corrosive environment and enhanced micro-galvanic couple effect with the Mg *** leads to faster degradation of the coated alloys compared to the bare substrates.

关键词： Magnesium Biomaterials Plasma electrolytic oxidation Corrosion

As-cast and extruded Mg-Zn-Ca systems for biodegradable implants:Characterization and corrosion behavior

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Journal of Magnesium and Alloys 2023年第3期11卷 1102-1120页

作者： Lara moreno Endzhe Matykina Kiryl A.Yasakau Carsten Blawert Raul Arrabal marta Mohedano Departamento de Ingeniería Química y de Materiales Facultad de Ciencias QuímicasUniversidad Complutense de Madrid28040 MadridSpain Department of Materials and Ceramic Engineering CICECO-Aveiro institute of materialsUniversity of Aveiro3810-193 AveiroPortugal Institute of Surface Science Helmholtz-Zentrum HereonMax-Planck Strasse 1Geesthacht 21502Germany

The aim of the present study is to evaluate the effect of alloy processing and composition as well as the pH control and testing medium on the in vitro corrosion performance of Mg-Zn-Ca systems for biodegradable *** grain size and secondary phases were analyzed by optical microscopy,scanning electron microscopy,transmission electron microscopy,and X-ray *** kelvin probe force microscopy(SKPFM)was used to analyze the Volta potential values of the second *** corrosion performance of the three alloys was evaluated by electrochemical and hydrogen evolution methods inα-MEM with and without organic species(*** and inorganicα-MEM).Two strategies were followed to evaluate the influence of the pH on the corrosion behavior:daily solution replacement and CO_(2)flow based pH *** all the materials,the organic medium accelerates the corrosion *** pH maintained by CO_(2)flow through the medium results in considerably higher corrosion rates for all *** impact of pH is lesser on the as-cast alloys due to the barrier effect of the secondary phases,particularly pronounced in the Mg1Zn1Ca alloy which showed the lowest corrosion *** wrought Mg0.5Zn0.2Ca alloy that lacks the refined secondary phase network and exhibits high number of twins undergoes accelerated uniform corrosion under constant pH conditions.

关键词： MgZnCa Magnesium Biomaterials Characterization Corrosion

Pure and mixed plantations of Persian walnut (Juglans regia L.) for high quality timber production in Chile, South America

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Journal of Plant Ecology 2020年第1期13卷 12-19页

作者： Verónica Loewe-Muñoz Mónica Balzarini marta ortega González Chilean Forest Institute(INFOR) Metropolitan OfficeSucre 2397ÑuñoaSantiagoChile CONICET Biometry Unit College of AgricultureUniversidad Nacional de CórdobaCiudad UniversitariaCC509CP 5000CórdobaArgentina Chilean Forest Institute(INFOR) Biobío OfficeCamino a Coronel Km 7.5San Pedro de la PazConcepciónChile

Aims Persian walnut(Juglans regia L.),an interesting forest species for the veneering industry,requires adequate management to produce valuable high-quality *** species associations and management level can improve stand productivity,the novelty of this work was to assess Persian walnut performance in different planting mixtures and in pure plantations conditioned to management *** Growth,straightness and survival measurements were taken annually for 7 years after planting pure and mixed plantations under two contrasting management *** were recorded at Age 7 in all *** each management intensity,besides the monoculture,three mixtures were tested:a mixture of only main forest species,main forest species plus one arboreal companion species,Black alder(Alnus glutinosa L.)and main species plus the shrub Russian olive(Elaeagnus angustifolia L.)as nurse species.A test of interaction between plantation type and management scenario was conducted using repeated growth *** Findings The interaction was significant,indicating the presence of different mechanisms underlying plantation effects under high and low management *** with pure plantations,Persian walnut associated with the nurse shrub exhibited 78%higher height and 53%higher diameter growth in plantations under low *** benefits(lower presence of walnut blight than in the monoculture)and better straightness were also found in the association including the shrub when the management intensity was not *** beneficial effects in the presence of Russian olive were not present under high management intensity(irrigation,fertilization,tutoring and frequent pruning).Site-specific designs for Persian walnut plantations would depend on the foreseen management intensity.

关键词： noble wood monoculture forest associations companion species Russian olive

NHC-catalysed[3+2]-asymmetric annulation between pyrazolin-4,5-diones and enals:synthesis of novel spirocyclic pyrazolone γ-butyrolactones and computational study of mechanism and stereoselectivity

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Organic Chemistry Frontiers 2022年第2期9卷 420-427页

作者： marta Gil-Ordonez Alicia Maestro Pablo ortega Pablo G.Jambrina Jose M.Andres GIR-SintACat-Instituto Universitario CINQUIMA y Departamento de Química Orgánica Facultad de CienciasUniversidad de ValladolidPaseo Belén 747011 ValladolidSpain Departamento de Química Física University of Salamanca37008 SalamancaSpain

Chiral pyrazolones with a spirocyclic centre at the C4-position are widely found in a large family of medically relevant *** recent years,organocatalysis,particularly that performed with quiral N-heterocyclic carbenes(NHCs),has allowed the enantioselective synthesis of these spirocyclic compounds despite its inherent *** this work,we describe the fully diastereo-and highly enantioselective synthesis of novel spirocyclic pyrazolone γ-butyrolactones via NHC-catalysed[3+2]annulation reaction of enals and 1H-pyrazol-4,*** understand the catalytic mechanism and origin of stereoselectivity,electronic structure calculations were carried *** considering various pathways,we concluded that the stereoselectivity-determining step is the formation of the lactone that proceeds after addition of the NHC derived homoenolate to the electrophilic carbonyl group of pyrazolin-4,*** calculations predict that the free energy barrier is lower for the(RS)product,which is also the main product experimentally obtained.

关键词： synthesis spiro mechanism

Hyperthermic intraperitoneal chemotherapy:Rationale and technique

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 68-75页

作者： Santiago González-moreno Luis A González-Bayón Gloria ortega-Pérez Peritoneal Surface Oncology Program Department of Surgical OncologyCentro Oncológico MD Anderson International Espaa28033 MadridSpain

The combination of complete cytoreductive surgery and perioperative intraperitoneal chemotherapy provides the only chance for long-term survival for selected patients diagnosed with a variety of peritoneal neoplasms,either primary or secondary to digestive or gynecologic *** intraperitoneal chemotherapy (HIPEC) delivered in the operating room once the cytoreductive surgical procedure is fi nalized,constitutes the most common form of administration of perioperative intraperitoneal *** may be complemented in some instances with early postoperative intraperitoneal chemotherapy (EPIC).HIPEC combines the pharmacokinetic advantage inherent to the intracavitary delivery of certain cytotoxic drugs,which results in regional dose intensification,with the direct cytotoxic effect of *** exhibits a selective cell-killing effect in malignant cells by itself,potentiates the cytotoxic effect of certain chemotherapy agents and enhances the tissue penetration of the administered *** chemotherapeutic agents employed in HIPEC need to have a cell cycle nonspecific mechanism of action and should ideally show a heat-synergistic cytotoxic *** of HIPEC requires an apparatus that heats and circulates the chemotherapeutic solution so that a stable temperature is maintained in the peritoneal cavity during the *** open abdomen (Coliseum) or closed abdomen technique may be used,with no signif icant differences in eff icacy proven to *** ic technical training and a solid knowledge of regional chemotherapy management are *** about safety of the procedure for operating room personnel are expected but are manageable if universal precautions and standard chemotherapy handling procedures are *** HIPEC drug regimens and dosages are currently in use.A tendency for concurrent intravenous chemotherapy administration (bidirectional chemotherapy,so-called "HIPEC plus") has been observed in rece

关键词： Hyperthermia Intracavitary chemotherapy Peritoneal neoplasms Peritoneal carcinomatosis Cytoreductive surgery

Effect of inductively coupled plasma surface treatment on silica gel and mesoporous MCM-41 particles

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Plasma Science and Technology 2018年第6期20卷 104-113页

作者： J A JUAREZ-moreno U CHACON-ARGAEZ J BARRON-ZAMBRANO C CARRERA-FIGUEIRAS P QUINTANA-OWEN W TALAVERA-PECH Y PEREZ-PADILLA A AVILA-ortega facultad de ingeniería química-uady periférico norte kilómetro 33.5col.chuburna de hidalgo inn C.P. 97203 Mérida Yucatan México centro de investigación y de estudios avanzados del ipn-unidad mérida km.6 antigua carretera a progreso apdo. Postal 73 Cordemex 97310 Méfida Yucatán México

Silica gel and MCM-41 synthesized mesoporous materials were treated with either oxygen（O_2）,hexamethyldisiloxane（HMDSO） and organic vapors like ethanol（Et OH）,and acrylonitrile（AN）inductive *** radiofrequency power for the modification was fixed to 120 W and30 min,assuring a high degree of organic ionization energy in the *** surface properties were studied by infrared spectroscopy（FTIR）,scanning electron microscopy,x-ray photoelectron spectroscopy and dynamic light scattering technique was used for characterizing size *** the silica and MCM-41 particles were modified by AN and HMDSO plasma gases,the surface morphology of the particles was changed,presenting another color,size or *** contrast,the treatments of oxygen and Et OH did not affect the surface morphology of both particles,but increased the oxygen content at the surface bigger than the AN and HMDSO plasma *** this study,we investigated the influence of different plasma treatments on changes in morphology and the chemical composition of the modified particles which render them a possible new adsorbent for utilization in sorptive extraction techniques for polar compounds.

关键词： silica MCM-41 nanoparticles plasma treatment

International NeuroAIDS: prospects of HIV-1 associated neurological com-plications

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Cell Research 2005年第Z1期15卷 962-969页

作者： J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL marta ortega-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO Institute of Human Virology University of Maryland Biotechnology Institute 725 W Lombard Street Baltimore MD 21201 USA Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil Clinical Research Unit in Human Retrovirology University of CampinasSao Paulo 01246 Brazil. Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil

Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain.

关键词： NeuroAIDS HIV-1 neurotropism AIDS dementia complex.