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Weather influenced nestling growth of an insectivorous but not a granivorous grassland passerine in Argentina

Avian Research 2024年第2期15卷 156-162页

作者： Martín Alejandro Colombo Adrian Jauregui Luciano N.segura Laboratorio de Ecología de Aves.Institute“Dr.Raúl A.Ringuelet”(ILPLA)-UNLP/CONICET Boulevard 1201437La PlataB1900Buenos AiresArgentina

Nestling growth of birds can be affected by weather *** general,it is expected that higher temper-atures favor growth by improving food availability and nestling metabolism,while rain hinders it by reducing foraging ***,most of these patterns have been described in insectivorous cavity-nesting birds in temperate *** tested these predictions in two neotropical grassland ground-nesting birds with contrasting nestling diets and therefore potentially different responses to *** measured nestlings of the Hellmayr’s Pipit(Anthus hellmayri,an insectivorous passerine)and the Grassland Yellow-Finch(Sicalis luteola,which feeds its nestlings exclusively with seeds)during three breeding seasons(2017-2020)in central-eastern *** took measurements of tarsus and body mass,modeled growth curves using nonlinear mixed-effects models,and evaluated the effects of minimum daily temperature and precipitation during the growth period and the 30 days prior to *** pipits(60 nestlings from 21 nests),minimum temperatures during the growth period were positively associated with tarsus and body mass ***,there was a positive association between precipitation during the pre-hatching period and tarsus ***,none of the weather variables analyzed had significant effects on nestling growth of finches(131 nestlings from 35 nests).Dietary contrast between species may explain the different *** activity and abundance can be affected by weather variations within the span of a breeding season,whereas seeds may depend on conditions from previous years,making the effects harder to *** with reduced asymptotic size can have reduced chances of ***,pipit populations could be impacted if they experience cold and dry conditions during their breeding season,which is of major relevance in the current context of climate change.

关键词： Finches Grassland birds Neotropical birds Pipits Precipitation Temperature

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Are Trkb receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

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Neural Regeneration Research 2024年第1期19卷 29-34页

作者： marta Zagrebelsky Martin Korte Division of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz Centre for Infection Research AG NINDBraunschweigGermany

brain-derived neurotrophic factor signaling via its receptor tro pomyosin receptor kinase b regulates several crucial physiological *** has been shown to act in the brain,promoting neuronal survival,growth,and plasticity as well as in the rest of the body where it is involved in regulating for instance aspects of the *** to its crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels and alterations in the brain-derived neurotrophic factor/tropomyosin receptor kinase b signaling have been found to be associated with a wide spectrum of neurological *** r,because of its poor bioavailability and pharmacological properties,brain-derived neurotrophic factor itself has a very low therapeutic ***,the concomitant binding of exogenous brain-derived neurotrophic factor to the p75 neurotrophin receptor has the potential to elicit several unwanted and deleterious side *** re,developing tools and approaches to specifically promote tropomyosin receptor kinase b signaling has become an important goal of translational *** the newly developed tools are different categories of tropomyosin receptor kinase b receptor agonist *** this review,we give a comprehensive description of the diffe rent tro pomyosin receptor kinase b receptor agonist drugs developed so far and of the res ults of their application in animal models of several neurological ***,we discuss the main benefits of tropomyosin receptor kinase b receptor agonists,concentrating especially on the new tropomyosin receptor kinase b agonist *** benefits observed both in vitro and in vivo upon application of tropomyosin receptor kinase b receptor agonist drugs seem to predominantly depend on their general neuroprotective activity and their ability to promote neuronal ***,tro pomyosin receptor kinase b agonist antibodies have been shown to specifically bind the tropomyosin recepto

关键词： Alzheimer's disease brain-derived neurotrophic factor depression Parkinson's disease tropomyosin receptor kinase b receptor

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brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-borràs marta b.lanyà-segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase b receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated Trkb/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorb

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biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HbMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAb)by blending human bone-ECM(b)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HbMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(bMP-2)with the HbMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay bone 3D bioprinting

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The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula bONA Juliana STERLI Marcelo Saúl de la FUENTE Eduardo OLIVERO marta S.FERNÁNDEZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the Leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the La Meseta and Submeseta formations(Antarctica)and the Waihao and burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene La Meseta Formation Submeseta Formation Leticia Formation

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Vanadium mineralization at Los Chihuidos sediment-hosted Cu-V deposit,Neuquén basin,Argentina:An approach to vanadium ore forming processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： Ana L.Rainoldi Daniel beaufort marta b.Franchini Adolfo Giusiano Sabine Petit Patricia Patrier M.Josefina Pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

Vanadium mineralization at Los Chihuidos deposit of the Neuquén basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the V ore with minor amounts of *** the implementation of the redox interface,abundant V-montmorillonite and V-hematite precipitated at the more oxidizing conditions and Cu-V-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with V-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including V-bearing montmorillonite,Cu-V-corrensite-type,V-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor V-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of V and/or Cu bearing clay minerals observed through the mineralized redox front at Los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of V-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals V-chlorite Redox front bleaching Hydrocarbons

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Use of endoscopic ultrasound-guided gallbladder drainage as a rescue approach in cases of unsuccessful biliary drainage

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World Journal of Gastroenterology 2024年第1期30卷 70-78页

作者： Alessandro Fugazza Kareem Khalaf Katarzyna M Pawlak Marco Spadaccini Matteo Colombo marta Andreozzi Marco Giacchetto Silvia Carrara Chiara Ferrari Cecilia binda benedetto Mangiavillano Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSRozzano 20089MilanoItaly Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8ONCanada Department of Anesthesia Humanitas Research Hospital-IRCCSRozzano 20089MilanoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsRomagna 47121Italy Gastrointestinal Endoscopy Unit Humanitas Mater DominiCastellanza 21100Italy Gastroenterology and Digestive Endoscopy Unit Fondazione IRCCS Policlinico San MatteoPavia 27100Italy

This narrative review provides an overview of the utilization of endoscopic ultrasound-guided gallbladder drainage(EUS-GbD)as a salvage approach in cases of unsuccessful conventional ***-GbD is a minimally invasive and effective technique for drainage in patients with acute cholecystitis with high risk of *** procedure has demonstrated impressive technical and clinical success rates with low rates of adverse events,making it a safe and effective option for appropriate ***,EUS-GbD can also serve as a rescue option for patients who have failed endoscopic retrograde cholangiopancreatography or EUS biliary drainage for relief of jaundice in malignant biliary ***,patient selection is critical for the success of EUS-GbD,and proper patient selection and risk assessment are important to ensure the safety and efficacy of the *** the field continues to evolve and mature,ongoing research will further refine our understanding of the benefits and limitations of EUS-GbD,ultimately leading to improved outcomes for patients.

关键词： Endoscopic ultrasound-guided gallbladder drainage Gallbladder drainage Acute cholecystitis Malignant obstruction Interventional endoscopic ultrasound Lumen-apposing metal stents

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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian bracco marta Gallarate Marco badinella Martini Corrado Magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

bACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis b virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class b 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodulebarcelona Clinic Liver Cancer(bCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,bCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia marta burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail David C bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

bACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

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Influence of agriculture and aquaculture activities on the response of autotrophic picoplankton in Laguna Macapule, Gulf of California (Mexico)

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Ecological Processes 2017年第1期6卷 41-51页

作者： Aída Martínez-López Cristian Hakspiel-segura Diana Cecilia Escobedo-Urías bárbara González-Acosta Centro Interdisciplinario de Ciencias Marinas-IPN(CICIMAR) Av.IPN s/nCol.Playa Palo de Santa RitaLa PazB.C.S.23096Mexico Centro de Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR–Unidad Sinaloa)Bulevar Juan de Dios Bátiz Paredes 250Col.San JoachinGuasaveSinaloa 81101Mexico

Introduction:The lagoon is a component of coastal zones,whose populations of autotrophic picoplankton(APP)remain largely *** lagoons display high-nutrient productivity and additionally may also be subjected to anthropogenic *** study selected Laguna Macapule,located on the eastern shore in the mid-region of the Gulf of California,due to the fact that a drainage network servicing the surrounding agricultural region(>230,000 hectares under cultivation)directs irrigation runoff,shrimp farm effluents,and urban wastewater containing large quantities of nutrients to be discharged into this *** propose to identify the APP’s response to various types of environmental and anthropogenic influence in this highly impacted coastal ***:Two sites(separated by 2.7 km)were monitored from December 2007 to December ***,located at the entrance to Laguna Macapule(oceanic influence)and the other a discharge canal(eutrophic conditions)inside the lagoon at El Tortugó***:APP was the numerically dominant phytoplankton fraction(15×106 to 620×106 cells L−1)with coccoidal cyanobacteria as the dominant fraction throughout the *** levels were reached in spring-early autumn and they were the second largest contributor to *** of APP cells corresponds to the lagoon’s eutrophic *** numbers and a higher average of APP were recorded at the El Tortugón channel during the warm season(months with SST higher than 24°C).The general positive relationship of the APP’s annual cycle at both sites as well as a negative relationship with heterotrophic nanoflagellates(HNF)abundance,supports the idea that natural forcing,in particular sea surface temperature(SST)is the predominant influences on APP’s seasonal ***:Distinguishable significant differences in APP abundances and nutrients were recognizable between the two *** interplay of these variables contributed to lower densities of APP in winter and high de

关键词： Aquaculture Autotrophic picoplankton Eutrophic conditions Heterotrophic ciliates Heterotrophic nanoflagellates Urea

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