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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk laura Nadal marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through l-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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UGT76B1 controls the growth-immunity trade-off during systemic acquired resistance

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Molecular Plant 2021年第4期14卷 544-546页

作者： marta Pastorczyk-Szlenkier Pawei Bednarek Institute of Bioorganic Chemistry Polish Academy of SciencesNoskowskiego 12/1461-704 PoznanPoland

Higher plants evolved multiple innate immune systems to combat pathogens present in their living ***,activation of the complex immune responses allocates nutrient resources into biosynthesis of various defense molecules,and this in turn often represses growth and development of the entire *** the years,the significance of the effective coregulation of growth and immunity has been demonstrated with dwarf phenotypes of autoimmune mutant lines of model plants displaying constitutive defense responses(van Wersch et al.,2016).This tightly regulated balance,termed the growthimmunity trade-off,is an important objective in plant breeding,which ultimately aims at plant cultivars that are both highly resistant and efficient in terms of growth and yield(Ning et al.,2017).

关键词： breeding cultivar dwarf

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lower serum expression of miR-181c-5p is associated with increased plasma levels of amyloid-beta 1-40 and cerebral vulnerability in normal aging

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Translational Neurodegeneration 2019年第1期8卷 423-432页

作者： marta Manzano-Crespo Mercedes Atienza Jose l.Cantero laboratory of Functional Neuroscience Pablo de Olavide UniversityCtra.de Utrera Km 141013 SevilleSpain CIBERNED Network Center for Biomedical Research in Neurodegenerative Diseases28031MadridSpain

Background:Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β(Aβ)deposition and chronic cerebral hypoperfusion,both factors largely associated with the development of ***,reduced 2-[18F]fluoro-2-deoxy-D-glucose(FDG)-PET brain metabolism and volume loss of regions of the medial temporal lobe have been generally recognized as hallmarks of *** on this evidence,we have here investigated potential associations between serum levels of miR-181c-5p and these AD signatures in asymptomatic elderly ***:Ninety-five normal elderly subjects underwent clinical,cognitive,structural MRI,and FDG-PET *** expression levels of miR-181c-5p and plasma Aβ concentrations were further analyzed in this *** analyses were performed to assess associations between serum miR-181c-5p levels and cognitive functioning,plasma Aβ,structural and metabolic brain ***:Decreased serum expression of miR-181c-5p was associated with increased plasma levels of Aβ1–40,deficits in cortical glucose metabolism,and volume reduction of the entorhinal *** significant associations were found between lower miR-181c-5p levels and cognitive deficits or cortical ***:These findings suggest that deregulation of serum miR-181c-5p may indicate cerebral vulnerability in late life.

关键词： Aging Alzheimer’s disease Blood biomarkers microRNAs Amyloid-beta FDG-PET Entorhinal cortex

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Production of Camphene by Isomerization Reaction on Sulfated ZrO_2

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Chinese Journal of Chemical Engineering 2000年第1期8卷 64-67页

作者： Nora Alejandra Comelli Omar Masini Alfredo lzaro Carrascull Esther Natalia Ponzi marta Isabel Ponzi INTEQUI(CONICET-UNSl) Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaCINDECA(CONICET-UNLP)Calle 47 N°2571900 La PlataArgentina

The kinetics of camphene production in liquid phase from α-pinene was experimentally determined in an isothermal batch reactor. To this end, a sulfated ZrO2 catalyst was used and the reaction studied in the temperature range of 370-403 K. By analyzing the experimental data, second reaction order for α-pinene was found. A kinetic model is presented which includes term for the catalyst load used. The specific rate constant at 393K was 2.19×10^-3 mol·l^-1·min^-1, the activation energy being 93kJ·mo1·^-1. Both values are within the range of literature results.

关键词：生产工艺莰烯异构化反应硫酸盐催化剂 ZrO2 反应动力学 α-蒎烯

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Changes in hydrological regime in High Arctic non-glaciated catchment in 1979-2020 using a multimodel approach

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Advances in Climate Change Research 2022年第4期13卷 517-530页

作者： Marzena OSUCH Tomasz WAWRZYNIAK marta MAJERSKA Institute of Geophysics Polish Academy of SciencesWarsaw 01-452Poland

Assessing hydrological consequences of climate change at the catchment scale is recently among key problems in *** study focuses on the estimation of changes in the hydrological regime in the Fuglebekken catchment in SW Spitsbergen(Svalbard).For this purpose,50 rainfll-runoff models were calibrated using available hydrometeorological *** models were validated based on archival flow and SWE observations,and proxy data from time-lapse *** models(FlEX-IS,GSM-SOCONT,PRMS,HBV,Nordic HBV,and GR4J)with the best performance were applied to reconstruct the past hydrological conditions and analyse the trends in flow regime in the period *** significant changes at 0.05 level in the flow regime indicators were detected,including the number of days with the active flow during the calendar year(10.8 d per decade),during the mid-May-November period(9.8 d per decade),the date of the first day with the flow(-4.7 d per decade),and the last day with the flow during mid-May-November(8.4 d per decade).A statistically significant increase in runoff was estimated for two periods from mid-May to the end of June and the second part of August till *** changes in the first period result from increases in air temperature and earlier snowmelt-driven *** estimated runoff increase in the second period corresponds to large increases in *** increase in air temperature,earlier disappearance of snow,and decrease in precipitation in July and the first part of August result in runoff *** presented results show that the Fuglebekken‘catchment's hydrological regime has already *** magnitude of the changes is larger compared to catchments located in lower latitudes.

关键词： Hydrological regime Climate change Svalbard High Aretic catchment hydrology Multimodel approach

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N-acetyl-l-leucine: a promising treatment option for traumatic brain injury

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Neural Regeneration Research 2022年第9期17卷 1957-1958页

作者： Chinmoy Sarkar marta M.lipinski Shock Trauma and Anesthesiology Research(STAR)CenterDepartment of AnesthesiologyUniversity of Maryland School of MedicineBaltimoreMDUSA Department of Anatomy and Neurobiology University of Maryland School of MedicineBaltimoreMDUSA

Traumatic brain injury(TBI)is a mechanical injury to the brain,which can be sustained due to falls,accidents,contact sports or in combat *** is a serious health problem-affecting people of all ages *** per the recent epidemiological study,more than 55 million people suffer from TBI annually(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019),and its prevalence has increased by almost 8.4%between 1990 and 2016(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019).Depending on severity,TBI can lead to premature death and disability.

关键词： sustained Traumatic injury

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The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community in stored barley in a laboratory experiment

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Insect Science 2014年第1期21卷 65-73页

作者： Jan Hubert marta Nesvorna Jan Kopecky Crop Research Institute Praha 6 Czech Repubfic

The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community composition was studied in nonsterile barley grain. The experiments included following treatments： control barley without mites; barley containing l0 or 50 mites without preincubation on E poae （Tpl0 and TpS0）; barley containing 10 or 50 mites after preincubation on E poae （FTp 10 and FTp50）. The number of mites, suc cessful transfer of E poae, and changes in the fungal communities were examined after 21 d of experiment. Increase of deoxynivalenol （DON） content in the barley was chosen as a criterion of successful Epoae transfer. The preincubation of T. putrescentiae on Epoae increased DON level approximately to 800 and 300μg/kg of grain for FTpl0 and FTpS0, respectively. T. putrescentiae population growth in FTpl0 was lower than in Tpl0, while no difference was found between FTp50 and Tp50. Fungal communities were compared by amplification, cloning and sequencing of ITS fragments, and operational taxonomic units （OTU） analysis. The OTU analysis did not support the transfer ofF. poae via mites. From the analyzed clones, only 13 cloned sequences clustered with E poae in an OTU defined at distance level 0.07. The related clones originated from FTpl0, Tpl 0, Tp50 and control treatments, but not from FTp50. However, the presence of E poae in FTp50 was confirmed by PCR amplification with specific primers. The observation may be explained by different effect of mite population density, that is, in the high density, （FTp50 treatment） the fungus was overgrazed, while the lower population density （FTp 10） supported E poae transfer.

关键词： barley deoxinivalenol (DON) Fusariumpoae mites mycotoxin storage

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Repeated penile girth enhancement with biodegradable scaffolds： microscopic ultrastructural analysis and surgical benefits

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Asian Journal of Andrology 2018年第5期20卷 488-492页

作者： Miroslav l Djordjevic Uros Bumbasirevic Borko Stojanovic Tamara Kravic Stevovic Tamara Martinovic marta Bizic Vladimir Kojovic School of Medicine University of Belgrade Belgrade 11000 Serbia University Children's Hospital Belgrade 11000 Serbia Institute for Urology Clinical Center ofSerbia Belgrade 11000 Serbia

Autologous tissue engineering using biodegradable scaffolds as a carrier is a well-known procedure for penile girth enhancement. We evaluated a group of previously treated patients with the aim to analyze histomorphometric changes after tissue remodeling and to estimate the benefits of repeated procedure. Between February 2012 and December 2016, a group of 21 patients, aged 22-37 （mean 28.0） years, underwent a repeated penile girth enhancement procedure with biodegradable scaffolds. Procedure included insertion of two poly-lactic-co-glycolic acid scaffolds seeded with laboratory-prepared fibroblasts from scrotal tissue specimens. During this procedure, biopsy specimens of tissue formed after the first surgery were taken for microscopic analysis. The mean follow-up was 38 months. Connective tissue with an abundance of connective tissue fibers, small blood vessels, and inflammatory cells were observed in all analyzed surgically removed tissue. Ultrastructural analysis of these tissue samples discovered the presence of large quantities of collagen fibrils running parallel to each other, forming bundles, with a few widely spread fibroblasts. In total, the mean values of flaccid and erect gain in girth after the second surgery were 1.1 ± 0.4 （range： 0.6- 1.7） cm and 1.0±0.3 （range： 0.6-1.5） cm, respectively. Microscopic evaluation of newly formed tissue, induced by autologous tissue engineering using biodegradable scaffolds, showed the presence of vascularized loose connective tissue with an abundance of collagen fibers, fibroblasts, and inflammatory cells, indicating active neovascularization and fibrinogenesis. The benefit of the repeated enhancement procedure was statistically significant.

关键词： biodegradable scaffolds microscopy penile enhancement tissue engineering

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A comprehensive study of the proteins involved in salinity stress response in roots and shoots of the Fl478 genotype of rice(Oryza sativa l. ssp. indica)

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The Crop Journal 2021年第5期9卷 1154-1168页

作者： Camilo lopez-Cristoffanini Mireia Bundo Xavier Serrat Blanca San Segundo marta lopez-Carbonell Salvador Nogues Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsSeccio de Fisiologia VegetalUniversitat de Barcelona08028 BarcelonaSpain Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBEdifici CRAGCampus de la UAB08193 BellaterraBarcelonaSpain Consejo Superior de Investigaciones Científicas(CSIC) BarcelonaSpain

Rice,a major staple,is the most salt-sensitive *** salinity triggers several adaptive responses in rice to cope with osmotic and ionic stress at the physiological,cellular,and molecular levels.A major QTl for salinity tolerance,named Saltol,is present on chromosome 1 of Indian landraces such as Pokkali and Nona *** early proteomic and physiological responses to salinity in roots and shoots of Fl478,an inbred rice line harboring the Saltol QTl,were *** were cultured in hydroponic cultures with 100 mmol l^(-1) Na Cl and evaluated at 6,24,and 48 *** the physiological level,root length significantly increased at 48 h,whereas shoot length was *** Na^(+)/K^(+) ratio was maintained at lower levels in shoots than in roots,suggesting that roots play a protective *** than 2000 proteins were detected in both *** showed a faster and more coordinated proteomic response than shoots,evident after only 6 h of *** responses showed clear correspondence with those of proteins involved in transcription and *** of mitochondrial activity and amino acid metabolism in roots,and activation of stress-responsive proteins such as dehydrins and PlAT in shoots,may play a key role during the response of the plant to salinity *** and physiological responses showed that roots respond in a more highly adaptive manner than shoots to salinity stress,suggesting that this tissue is critical to the tolerance observed in cultivars harboring Saltol.

关键词： Fl478 Shotgun proteomics Rice Salinity Root Saltol

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Multiple factors correlating with wing malformations in the population of Parnassius apollo (lepidoptera: Papilionidae) restituted from a low number of individuals: A mini review

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Insect Science 2019年第3期26卷 380-387页

作者： Karolina Pierzynowska marta Skowron Volponi Grzegorz Wegrzyn Department of Molecular Biology University of Gdansk Gdansk Poland

The Apollo butterfly, Parnassius apollo (linnaeus), was common in Europe over 100 years ago, but currently it is considered as near threatened. Different conservation programs have promoted the persistence of this species;however, it is still endangered. An example of such programs was the action devoted to reestablish the Apollo butterfly population in Pieniny National Park (Poland) from only 20-30 individuals which had survived till the last decade of the 20th century. This reintroduction has been successful;however, unexpected developmental problems appeared. Butterflies with deformed or reduced wings became frequent in the population living in the natural habitat, and particularly among those reared under seminatural conditions (in the same environment, but fenced by a net). Until recently, reasons for these malformations remained unknown. However, reports published during last months indicated that there are genetic, biochemical, and microbiological factors contributing to this phenomenon. In the malformed individuals, lesions in the wingless gene and dysfunctions of laccase 1 and 2 were found to be significantly more frequent than in normal insects. A large fraction of butterflies with deformed or reduced wings was devoid of the prokaryotic symbiont Wolbachia, which was present in most normal individuals. Moreover, Yersinia pseudotuberculosis (Pfeiffer) Smith and Thai, and Serratia sp., bacteria pathogenic to insects, were detected in the biological material from both normal and malformed butterflies from this population. These findings are summarized and discussed in this review, in the light of conservation of insects and restitution of their populations from a low number of individuals.

关键词： Apollo butterfly laccases malformed wings population reconstitution wingless gene Wolbachia

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