检索结果-南通市图书馆

主动脉-肱动脉弹性比值:一种独立于血压的血管老化指标

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2016年第12期24卷 1102-1102页

作者：刘莉叶鹏 Fortier C Sidibé A Desjardins MP marquis k De Serres SA Mac-Way F Agharazii M

主动脉硬化是一种心血管病危险因素,取决于平均动脉压（mean arterial pressure,MAP）。主动脉硬化对心血管预后的影响可能是通过动脉弹性强度的减弱或增强介导。研究人员假设MAP对动脉弹性变化的影响十分微弱,并探讨MAP与主动脉弹性、... 详细信息

主动脉硬化是一种心血管病危险因素,取决于平均动脉压（mean arterial pressure,MAP）。主动脉硬化对心血管预后的影响可能是通过动脉弹性强度的减弱或增强介导。研究人员假设MAP对动脉弹性变化的影响十分微弱,并探讨MAP与主动脉弹性、肱动脉弹性、动脉弹性梯度的相关性。在一项透析人群的横断面研究（A组,n=304）和一个估算的肾小球滤过率〉45mL/（min·1.73m^2）的高血压或接受肾移植患者（B组，n=114）群体中，通过测定颈股动脉脉搏波传导速度（carotid-femoral pulse wave velocities, cfPWV）和颈桡动脉脉搏波传导速度（carotid-radial pulse wave velocities, crPWV）分别评估主动脉和肱动脉弹性。

关键词：动脉弹性主动脉硬化血管老化肾小球滤过率脉搏波传导速度透析人群桡动脉脉搏横断面研究平均动脉压心血管疾病

在线全文

学校读者我要写书评

暂无评论

规划具有影响力的继续教育课程:挑战与机遇

中国继续医学教育 2012年第1期4卷 50-50页

作者： Damon k.marquis 国际继续卫生职业教育联盟

美国的医务工作者主要通过参加继续教育活动提高临床实践水平,改善患者疗效,因此对经过认证的高质量继续教育项目的需求不断增加。继续医学教育认证主要包括对医师教育、护士教育、助理医师教育、药师教育等的认证。虽然各专业的认证标... 详细信息

美国的医务工作者主要通过参加继续教育活动提高临床实践水平,改善患者疗效,因此对经过认证的高质量继续教育项目的需求不断增加。继续医学教育认证主要包括对医师教育、护士教育、助理医师教育、药师教育等的认证。虽然各专业的认证标准不同,但其核心内容都包括标准、政策、规则、规章、系统性的实践评估和认证资格的确定。美国继续医学教育项目的开展需要达到相应评审机构如美国继续医学教育认证委员会(ACCME)的评估标准。虽然有人认为ACCME制定的认证标准极为繁复,但这些标准有助于提高继续医学教育提供者的能力,从而实现更高质量的继续医学教育。

关键词：继续教育患者提供者继续工程教育诊疗结果继续医学教育

血液透析患者活性维生素D和动脉硬化进程加速的关系:一项纵向观察研究

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2015年第3期23卷 298-298页

作者： Fortier C Mac-Way F De Serres SA marquis k Douville P Desmeules S Lariviere R Agharazii M 练桂丽叶鹏

研究者假设高剂量的活性维生物D[阿法骨化醇（alphacalcidol,α-calcidol）]治疗慢性肾脏病患者的继发性甲状旁腺功能亢进,会加速血管钙化和动脉硬化进程。方法：85例慢性血液透析患者,其中70例患者服用α-calcidol〈2μg/周,15例患者... 详细信息

研究者假设高剂量的活性维生物D[阿法骨化醇（alphacalcidol,α-calcidol）]治疗慢性肾脏病患者的继发性甲状旁腺功能亢进,会加速血管钙化和动脉硬化进程。方法：85例慢性血液透析患者,其中70例患者服用α-calcidol〈2μg/周,15例患者服用≥2μg/周（药理学剂量）。检测患者血清甲状旁腺激素、25-羟维生素D、成纤维生长因子23和α-klotho。

关键词：血液透析患者活性维生素D 动脉硬化继发性甲状旁腺功能亢进血清甲状旁腺激素 25-羟维生素D 成纤维生长因子慢性肾脏病

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

透析患者中心动脉超压升高的决定因素:透析形式和动静脉瘘的作用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华高血压杂志 2020年第11期28卷 1098-1098页

作者： Paré M Goupil R Fortier C Mac-Way F Madore F marquis k Hametner B Wassertheurer S Schultz MG Sharman JE Agharazii M 袁源(译) 叶鹏(审校) 不详

动脉储备波分析(reservoir-wave analysis,RWA)是一种新型动脉血流动力学模型,将动脉波分解为储备压和超压。超压积分(excess pressure integral,反映心室搏动中除完成正常射血外的不必要做功,即反映血管功能障碍)与临床不良结局风险相... 详细信息

动脉储备波分析(reservoir-wave analysis,RWA)是一种新型动脉血流动力学模型,将动脉波分解为储备压和超压。超压积分(excess pressure integral,反映心室搏动中除完成正常射血外的不必要做功,即反映血管功能障碍)与临床不良结局风险相关。本研究目的是在大型血液透析和腹膜透析患者队列中,探究超压积分的决定因素,探究透析治疗和动静脉瘘的存在是否与超压积分升高有关。

关键词：动静脉瘘血管功能障碍腹膜透析患者动脉血流动力学透析治疗不良结局血液透析超压

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Development of Data Sheets for Statistical Evaluation of Fatigue Data

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2011年第5期18卷 70-78页

作者： Gary marquis Timo Bjrk Lappeenranta University of Technology

Instructions were developed for statistical analysis of the laboratory fatigue data step-by-step. Practical cases for solving several questions raised in the treatment of test data,which involved estimation of necessary sample size,verification of the statistical equivalence of the collated sets of data,and determination of characteristic curves in different cases,were given by using the methods and formulae in the document IIW-XIII-2138-06 （best practice guide on the statistical analysis of fatigue data） as a demonstration of various statistical methods of developing a sound procedure for creating reliable calculation rules for the fatigue analysis.

关键词： fatigue verification statistical equivalence

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified