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A Pilot Trial Testing the Feasibility of Using Molecular-Guided Therapy in Patients with Recurrent Neuroblastoma

Journal of Cancer Therapy 2012年第5期3卷 602-612页

作者： Giselle L. Saulnier Sholler William Ferguson Genevieve Bergendahl Erika Currier Shannon R. Lenox Jeffrey Bond marni slavik William Roberts Deanna Mitchell Don Eslin Jacqueline Kraveka Joel Kaplan Nehal Parikh Suman Malempati Gina Hanna Emily Eugster David Cherba Jeremy Miller Craig Webb Cardinal Glennon Children’s Hospital Saint Louis University School of Medicine St. Louis University St. Louis USA Center for Cancer Genomics and Computational Biology Pediatric Oncology Translational Research Program at the Van Andel Research Institute in Grand Rapids Grand Rapids USA Center for Children’s Cancer and Blood Disorders Arnold Palmer Hospital for Children MD Anderson Cancer Center Orlando Orlando USA Department of Pediatric Oncology Helen DeVos Children’s Hospital Michigan State University Grand Rapids USA Department of Pediatric Oncology Oregon Health Science University Portland USA Division of Hematology/Oncology 2J Connecticut Children’s Medical Center Hartford USA Pediatric Hematology/Oncology Medical University of South Carolina Charleston USA Pediatric Oncology Levine Children’s Hospital Charlotte USA Rady Children’s Hospital San Diego University of California San Diego School of Medicine at the University of California San Diego San Diego USA Vermont Cancer Center Department of Medicine University of Vermont Burlington USA

Background: Neuroblastoma is the most common extracranial solid tumor in children, and treatment options for recurrent neuroblastoma are limited. Using molecular profiling to target the molecular vulnerabilities of neuroblastoma with existing therapeutic agents may result in a rational, data-driven approach with potential to improve clinical outcomes. Methods: The primary objective of this pilot study was to evaluate the feasibility of supporting real-time treatment decisions through predictive modeling of genome-wide mRNA gene expression data from neuroblastoma tumor biopsies. Feasibility was defined as completion of tumor biopsy, histopathological evaluation, RNA extraction and quality control, gene expression profiling within a CLIA-certified laboratory, bioinformatic analysis, generation of a drug predicttion report, molecular tumor board review yielding a formulated treatment plan, and independent medical monitor review within a 2-week period. Results: Five patients with multiply relapsed or refractory neuroblastoma were enrolled between April and June 2010. All biopsies passed histopathology and RNA quality control. Generation of gene expression data and its analysis (3-7 days), reports which linked this data into medically actionable drug candidates (1-5 days), molecular tumor board (1-3 days) and independent medical monitor review (1 day) were all completed in real-time. The average time was 10.5 days for all patients. Conclusion: This study shows that it is feasible to create therapeutic treatment plans based on genomic profiling in less than 12 days. This warrants further testing in a Phase I study to determine safety of predicted treatments and evaluate whether the information obtained in these analyses would result in patient benefit.

关键词： Neuroblastoma Molecular Guided Therapy Predictive Therapies Molecular Profiling Genomic Profiling Pediatric Cancer

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A Pilot Trial Testing the Feasibility of Using Molecular-Guided Therapy in Patients with Recurrent Neuroblastoma

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Journal of Cancer Therapy（癌症治疗） 2012年第5期

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Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer

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Journal of Pharmaceutical Analysis 2022年第2期12卷 221-231页

作者： RamaRao Malla Rakshmitha marni Anindita Chakraborty Mohammad Amjad Kamal Cancer Biology Lab Department of Biochemistry and BioinformaticsInstitute of ScienceGandhi Institute of Technology and ManagementVisakhapatnam530045India Radiation Biology UGC-DAE-CSRKolkata CentreKolkata700098India King Fahd Medical Research Center King Abdulaziz UniversityJeddah21589Saudi Arabia Enzymoics HebershamNovel Global Community Educational FoundationNew South Wales2770Australia

Breast cancer is one of the leading causes of cancer-related deaths in women *** is a cancer that originates from the mammary ducts and involves mutations in multiple ***,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic ***,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast *** disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and *** present review highlights multidrug resistance mechanisms and their signaling pathways in breast *** review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.

关键词： Breast cancer Diallyl disulfide Diallyl trisulfide Drug resistance Metastasis

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Adherence to medication behavior among tuberculosis patients and their affecting factors:a cross-sectional study at Public Health Center of Wonogiri District, Indonesia

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Frontiers of Nursing 2020年第3期7卷 279-285页

作者： Nita Yunianti Ratnasari Putri Halimu Husna marni marni Susana Nurtanti Tantut Susanto Department of Nursing Giri Husada Nursing AcademyWonogiriJawa TengahIndonesia Department of Community Familyand Gerontic Health NursingFaculty of NursingUniversity of JemberJemberIndonesia

Objective:This study aimed to identify the influence of predisposing,enabling,and reinforcing factors and the adherence to medication behavior among tuberculosis patients in Selogiri Wonogiri Public Health ***:This study employed a descriptive cross-sectional research design.A questionnaire was used to collect primary *** data were obtained from patient treatment cards(Form TB 01).This research was carried out at Selogiri Health Center from November to December *** participants were patients,both new and old patients,who had completed their treatment in the last 2 months or more,recorded from January 2016 to December 2017.A total sampling technique was used in this *** regression analysis was used to analyze the influence of predisposing,enabling,and reinforcing factors and the adherence to medication among tuberculosis ***:The results of logistic regression analysis indicated that there were four independent variables that have a significant relationship with treatment variables,namely education(odds ratio(OR)=0.025;95%confidence interval(CI)=0.001-0.039);knowledge(OR=3.37;95%CI=0.19-57.71);type of drug(OR=0.448;95%CI=0.012-16.07),and means of transportation(OR=25.77;95%CI=1.33-500.47).Conclusions:Education,knowledge,type of drug,and means of transportation influence medication compliance among tuberculosis ***,supporting patients during medication program of tuberculosis is needed to improve their adherence medication during multidrug therapy.

关键词： tuberculosis adherence to medication predisposing enabling reinforcing

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Improving antibiotic prescribing in the emergency department for uncomplicated community-acquired pneumonia

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World Journal of Emergency Medicine 2020年第4期11卷 199-205页

作者： Rebekah Shaw Erica Popovsky Alyssa Abo marni Jacobs Nicole Herrera James Chamberlain AndreaHahn Division of Pediatrics Children’s National Health SystemWashingtonDCUSA Division of Emergency Medicine Children’s National Health SystemWashingtonDCUSA Department of Pediatrics George Washington University School of Medicine and Health SciencesWashingtonDCUSA Division of Biostatistics and Epidemiology Children’s National Health SystemWashingtonDCUSA Division of Infectious Diseases Children’s National Health SystemWashingtonDCUSA

BACKGROUND:The Pediatric Infectious Disease Society(PIDS)and Infectious Disease Society of America(IDSA)published an evidence-based guideline for the treatment of uncomplicated communityacquired pneumonia(CAP)in children,recommending aminopenicillins as the first-line *** guideline compliance with 10%–50%of patients admitted to the hospital receiving narrow-spectrum antibiotics has been reported.A new clinical practice guideline(CPG)was implemented in our emergency department(ED)for uncomplicated *** aim of this study was to examine baseline knowledge and ED provider prescribing patterns pre-and post-CPG ***:Prior to CPG-implementation,an anonymous case-based survey was distributed to evaluate knowledge of the current PIDS/IDSA guideline.A retrospective chart review of patients treated in the ED for CAP from January 2015 to February 2017 was performed to assess prescribing patterns for intravenous(IV)antibiotics in the ED at Children’s National Health System pre-and post-CPG ***:ED providers were aware of the PIDS/IDSA guideline recommendations,with 86.4%of survey responders selecting ampicillin as the initial antibiotic of ***,only 41.2%of patients admitted to the hospital with uncomplicated CAP pre-CPG received ampicillin(P<0.01).There was no statistically signifi cant increase in ampicillin prescribing post-CPG(P=0.40).CONCLUSIONS:Providers in the ED are aware of the PIDS/IDSA guideline regarding the first-line therapy for uncomplicated CAP;however,this knowledge does not translate into clinical *** of a CPG in isolation did not significantly change prescribing patterns for uncomplicated CAP.

关键词： Antibiotics Community-acquired pneumonia Emergency department Pediatrics

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Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal

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World Journal of Gastroenterology 2009年第28期15卷 3560-3564页

作者： marni Colvin Aris Delis Erika Bracamonte Hugo Villar Luis R Leon Jr Department of Surgical Oncology University Medical Center Tucson AZ 85724 United States Department of Pathology University Medical Center Tucson AZ 85724 United States Department of Vascular Surgery Tucson Medical Center Tucson AZ 85712 Department of Vascular Surgery University Medical Center Tucson AZ 85724 United States

Primary neoplasms arising in the anal canal are relatively *** particular, adenomas and adenocarcinomas are distinctly rare entities in this *** describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal *** is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous *** revealed a blood-covered pedunculated mass with a long stalk protruding from the *** lesion was amputated at the *** evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous *** was further evaluated under anesthesia and complete excision of distal anal tissue was *** report is the f irst describing the possible malignant degeneration of a villous adenoma in the anal canal.

关键词： Anal adenocarcinoma Anal canal Villousadenoma

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Electromyographic and Mechanomyographic Responses During Isokinetic Leg Extensions in Children Versus Adolescents

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Journal of Science in Sport and Exercise 2023年第3期5卷 226-235页

作者： Zachary M.Gillen marni E.Shoemaker Joel T.Cramer Department of Kinesiology Mississippi State University236 McCarthy GymnasiumStarkvilleMS 39762USA School of Health and Consumer Sciences South Dakota State UniversityBrookingsSDUSA College of Health Professions and Sciences University of Central FloridaOrlandoFLUSA

Purpose The purpose of this study was to examine peak torque(PT),mean power(MP),electromyographic(EMG)amplitude,mechanomyographic(MMG)amplitude,and neuromuscular efficiency from EMG and MMG amplitude(NME_(EMG)and NME_(MMG),respectively)across the velocity spectrum in children versus *** Seventeen children(n=8 males,n=9 females)and 22 adolescents(n=11 males,n=11 females)*** completed maximal concentric isokinetic leg extensions at 60,120,180,240 and 300°/***,MP,EMG amplitude,and MMG amplitude were quantified during all muscle ***_(EMG)and NME_(MMG)were quantified by expressing PT relative to EMG and MMG amplitude,respectively,for each muscle *** PT,MP,NME_(EMG),and NME_(MMG)were greater for the adolescents than the children collapsed across sex and veloc-ity(P≤0.021).There were no significant differences for EMG amplitude(P≥0.051),while MMG amplitude increased significantly from 60 to 240°/s(P<0.001)then decreased significantly from 240 to 300°/s(P<0.001)for all *** Overall,regardless of velocity,the expression of PT relative to EMG and MMG amplitude(NME_(EMG)and NME_(MMG),respectively),in conjunction with measurements of torque and power production,may provide practitioners a unique method of examining growth and development-related augmentations in neuromuscular function during dynamic movements.

关键词： Electromyography Mechanomyography Neuromuscular efficiency Growth and development

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Blood meal analysis of tabanid fly after it biting the rare Sumatran rhinoceros

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 95-99页

作者： Jeffrine Japning Rovie-Ryan Zainal Zahari Zainuddin Wahap marni Abdul Hamid Ahmad Laurentius N.Ambu Junaidi Payne Ex-Situ Conservation Division Department of Wildlife and National Parks(DWNP)Peninsular MalaysiaMinistry of Natural Resources and Environment Malaysia(NRE) Department of Zoology Faculty of Resource Science and TechnologyUniversiti Malaysia Sarawak(UNIMAS) Borneo Rhino Alliance(BORA) Locked Bag 207388999 Kota KinabaluSabahMalaysia Institute for Tropical Biology and Conservation(ITBC) Universiti Malaysia Sabah(UMS) Sabah Wildlife Department

Objective:To demonstrate a noninvasive large mammalian genetic sampling method using blood meal obtained from a tabanid ***:Blood meal was recovered from the abdomen of an engorged tabanid fly(Haematopota sp.)which was captured immediately after biting a Sumatran rhino in *** blood was applied on to a Whatman FTAblood *** laboratory work was conducted to extract,amplify and sequence the DNA from the *** was done by sampling the hair follicles and blood samples from the rhinoceros and subjecting it to the same laboratory ***:BLAST search and constructed phylogenetic trees confirmed the blood meal samples were indeed from the ***:This method could be used in the field application to noninvasively collect genetic *** of tabanids and other haematophagous arthropods(*** and ticks)and other blood-sucking parasites(*** and worms)could also provide information on vector-borne diseases.

关键词： Noninvasive DNA sampling Blood meal Tabanid fly Sumatran rhino

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Effects of Eccentric Pre-loading on Concentric Vertical Jump Performance in Young Female Athletes

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Journal of Science in Sport and Exercise 2021年第1期3卷 98-106页

作者： Zachary M.Gillen marni E.Shoemaker Nicholas A.Bohannon Sydney M.Gibson Joel T.Cramer Department of Kinesiology Mississippi State University236 McCarthy GymnasiumStarkvilleMS 39762USA College of Health Sciences The University of Texas at El PasoEl PasoTX 79968USA College of Medicine University of Nebraska Medical CenterOmahaNE 68198USA Department of Nutrition&Health Sciences University of Nebraska-LincolnLincolnNE 68583USA

Purpose This study examined changes in vertical jump performance with progressively greater eccentric pre-loading in relation to growth and development in young female *** Twenty young female athletes ranging from 9 to 17 years old performed the following vertical jumps in random order:static jumps(SJs),counter-movement jumps(CMJs),and drop jumps(DJs)from drop heights of 20,30,and 40 cm(DJ20,DJ30,and DJ40,respectively).Measurements included peak force(PF),peak rate of force development(RFD),peak power(PP),eccentric impulse(ECC),and concentric impulse(CON).Measurements of growth included age,maturity offset,height,body mass,fat-free mass,and thigh muscle cross-sectional area(CSA).Results PF increased from the SJ-DJ20(P<0.009),then plateaued from DJ20-DJ40(P=1.000).RFD remained the same from SJ-CMJ(P=1.000),increased from CMJ-DJ20(P<0.001),and plateaued from DJ20-DJ40(P=0.874).PP increased from the SJ-CMJ(P<0.001),then plateaued from the CMJ-DJ40(P≥0.486).CON remained the same across all verti-cal jumps(P=1.000),while ECC increased from the SJ-DJ40(P≤0.038).Jump height(JH)increased from the SJ-CMJ(P<0.001),decreased from CMJ-DJ20(P<0.001),and plateaued from DJ20-DJ40(P=1.000).The change in PP from the SJ-CMJ(ΔCMJ-SJ)was related to all measurements of growth except CSA(r=0.558-0.815).Conclusion Young females produced greater power during the CMJ than SJ,but equivalent power from the CMJ-DJ40,despite increases in ***,ΔCMJ-SJ was not related to CSA,which suggests other underlying mechanisms affect stretch-shortening cycle utilization in young female athletes.

关键词： Stretch-shortening cycle Youth Ground reaction force Kinetics

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Leg Extension Strength, Explosive Strength, Muscle Activation, and Growth as Predictors of Vertical Jump Performance in Youth Athletes

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Journal of Science in Sport and Exercise 2020年第4期2卷 336-348页

作者： Zachary M.Gillen marni E.Shoemaker Brianna D.McKay Nicholas A.Bohannon Sydney M.Gibson Joel T.Cramer Department of Nutrition and Health Sciences University of Nebraska-Lincoln211 Ruth Leverton HallLincolnNE 68583USA

Purpose The purpose of this study was to examine the relationships among leg extension strength,explosive strength,muscle activation,and measurements of growth to predictions of vertical jump performance in youth *** Height,body mass,skinfolds,and quadriceps femoris muscle cross-sectional area were measured in 39 sports active children(20 females,19 males,age=12.52±0.62 years old).Peak torque(PT),rate of torque development(RTD),rate of velocity development(RVD),and rate of electromyographic amplitude rise(RER)were measured during isometric and isokinetic leg ***,RTD,and RVD were expressed in absolute terms and normalized to body *** jump height(JH)and peak power(PP)were assessed during static(SJ),counter-movement(CMJ),and drop(DJ)*** JH exhibited greater correlations with PT normalized to body mass(r=0.387-0.758)than absolute PT(r=0.338-0.417),whereas PP exhibited greater correlations with absolute PT(r=0.368-0.837).Only negligible to moderate relation-ships existed between JH and PP across all jumps(r=0.053-0.605).Over 50%of the variability in PP was predicted in 24 of 30 regression models with absolute muscle strength,muscle activation,and measurements of growth,while only 6 of 30 models predicted more than 50%of the variability in *** Overall,absolute static and dynamic muscle strength,muscle activation,and growth better explained PP meas-ured during vertical jumps than estimated JH.

关键词： Children Adolescent Torque Jump height Power

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