Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer

作     者：RamaRao Malla Rakshmitha Marni Anindita Chakraborty Mohammad Amjad Kamal RamaRao Malla;Rakshmitha Marni;Anindita Chakraborty;Mohammad Amjad Kamal

作者机构：Cancer Biology LabDepartment of Biochemistry and BioinformaticsInstitute of ScienceGandhi Institute of Technology and ManagementVisakhapatnam530045India Radiation BiologyUGC-DAE-CSRKolkata CentreKolkata700098India King Fahd Medical Research CenterKing Abdulaziz UniversityJeddah21589Saudi Arabia EnzymoicsHebershamNovel Global Community Educational FoundationNew South Wales2770Australia 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第2期

页      面：221-231页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100214[医学-肿瘤学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by UGC-DAE-CSR Kolkata(Grant No.:KC/CRS/19/RB-04/1047) 

主　　题：Breast cancer Diallyl disulfide Diallyl trisulfide Drug resistance Metastasis 

摘      要：Breast cancer is one of the leading causes of cancer-related deaths in women *** is a cancer that originates from the mammary ducts and involves mutations in multiple ***,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic ***,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast *** disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and *** present review highlights multidrug resistance mechanisms and their signaling pathways in breast *** review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.