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Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRnA expression of CDK4/CDKn2A

Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier martin-Broto Jeronimo mart.nez-Garcia David SMoura Andres Redondo Antonio gutierrez Antonio Lopez-Pousa Javier mart.nez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKn2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKn2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKn2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRnA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRnA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKn2A,and deserves further investigation in the sarcoma context.

关键词： CDKn2A sarcoma CDK4

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Description of the Factors Associated with Trigger Finger in Patients Treated at Petroleos Mexicanos “Pemex”

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Journal of Biosciences and Medicines 2023年第7期11卷 151-159页

作者： Fernando Barbosa-Villarreal Cuahutémoc Márquez-Espriella Rodrigo Dávila-Díaz Marco A. Cuervo-Vergara Blanca Y. Arambula-Sánchez Alberto I. Cahuana-Quispe Victor A. Esquivel-Chávez Carlos E. García-Córdova Ana P. Campollo-López Mauricio gutierrez-Alvarez Jesus R. García-Corral Alfredo Chama-naranjo Daniel de Luna-Gallardo Ricardo A. Pulido-López Isaac F. Recio-España Esteban I. Campos-Serna Carlos I. navarro-Delgadillo José C. mart.nez-López Victor H. Avalos-Gómez Alejandro Cruz-Zarate Department of Plastic and Reconstructive Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Background: The trigger finger, also known as stenosing tenosynovitis of the flexor tendon, is a common cause of hand disability;This can result in significant limitations in certain daily living activities. It is possible to treat this condition with conservative or surgical methods. Methods: This is a retrospective, observational, cross-sectional and descriptive study. The source population consisted of all patients with a diagnosis of trigger finger who had been treated in the department of plastic and reconstructive surgery of our institution between 2020 and 2023. The primary objective of this study is to determine the prevalence and characterize the clinical and surgical characteristics of the population affected by trigger finger in our hospital. Results: The total population was 237 patients, of which 165 were women (70%) and 72 men (30%). The most affected hand was the right hand, with a total of 158 patients (67%). In the right hand, the middle finger was the most affected (45%). Of the 237 patients, 80 of them had obesity (34%), 86 had type 2 diabetes mellitus (36%), 95 had systemic arterial hypertension (40%). Open technique was performed in 190 (80%) patients, while percutaneous technique was performed in 47 (20%) of them. Conclusion: The female sex was twice as frequent, and the middle finger and thumb were the most affected. Most of the patients received surgical treatment with open approach and percutaneous approach in 20% of them.

关键词： Trigger Finger Tendinopathy

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Pathogenesis of glomerular haematuria

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World Journal of nephrology 2015年第2期4卷 185-195页

作者： Claudia Yuste Eduardo gutierrez Angel Manuel Sevillano Alfonso Rubio-navarro Juan Manuel Amaro-Villalobos Alberto Ortiz Jesus Egido Manuel Praga Juan Antonio Moreno Department of nephrology Gregorio Mara?on Hospital Department of nephrology Renal Vascular and Diabetes Research LabⅡS-Fundación Jiménez Díaz Autonoma University (UAM) Renal Vascular and Diabetes Research LabⅡS-Fundación Jiménez DíazAutonoma University (UAM)

Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidneydisease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells （RBCs） with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological fndings.

关键词： Haematuria Pathogenesis Glomerular filtration barrier Dysmorphic red blood cells Chronic kidney disease Microscopic haematuria

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Limited long-distance dispersal success in a Western European fairy shrimp evidenced by nuclear and mitochondrial lineage structuring

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Current Zoology 2020年第3期66卷 227-237页

作者： Paula C.RODRIGUEZ-FLORES Ernesto RECUERO Yolanda JIMEnez-RUIZ Mario GARCIA-PARIS Museo nacional de Ciencias naturales(MnCn-CSIC) Jose Gutierrez Abascal2Madrid 28006Spain Centre d'Estudis Avanqats de Blanes(CEAB-CSIC) C.d'Acces Cala Sant Francesc 14Blanes 17300Spain

Anostraca are known by their ability for long-distance dispersal,but the existence in several species of deep,geographically structured mtDnA lineages suggests their populations are subjected to allopatric differentiation,isolation,and prevalence of local scale *** stagnalis is one of the most widespread species of Anostraca and previous studies revealed an unclear geographical pattern of mtDnA genetic ***,we analyze populations from the Iberian and Italian Peninsulas,Central Europe,and Scandinavia,with the aim to characterize the patterns of genetic diversity in a spatio-temporal framework using mtDnA and nuclear markers to test gene flow among close *** these aims we built a time-calibrated phylogeny and carried out Bayesian phylogeographic analyses using a continuous diffusion *** results indicated that *** presents a deeply structured genetic diversity,including 7 ancient lineages,some of them even predating the *** Iberian Peninsula harbors high diversity of lineages,with strong isolation and recent absence of gene flow between *** at local scale seems to be the prevailing dispersal mode of ***,which exhibits a pattern of isolation-bydistance in the Iberian *** remark the vulnerability of most of these lineages,given the limited known geographic distribution of some of them,and the high risk of losing important evolutionary potential for the species.

关键词： allopatric fragmentation Anostraca Crustacea nuclear markers Pleistocene phylogeography

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Empathy Gender in Dental Students in Latin America: An Exploratory and Cross-Sectional Study

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Health 2015年第11期7卷 1527-1535页

作者： Víctor Patricio Díaz-narváez Ana María Erazo Coronado Jorge Luis Bilbao Farith González Mariela Padilla Madeline Howard María Guadalupe Silva Mirian Bullen Fredy gutierrez Teresa Varela de Villalba Mercedes Salcedo Rioja Joyce Huberman Doris Carrasco Robert Utsman School of Dentistry Universidad San Sebastián Santiago Chile Associate Investigator Universidad Autónoma de Chile Santiago Chile Universidad Metropolitana Barranquilla Colombia School of Medicine Universidad Libre Seccional Barranquilla y Fundación Universitaria San Martín Sede Puerto Colombia Barranquilla Colombia School of Dentistry Universidad de Cartagena Campus de la Salud Barrio Zaragocilla Cartagena Colombia School of Health Sciences Universidad Latinoamericana de Ciencia y Tecnología San José Costa Rica School of Dentistry Universidad de Costa Rica San Pedro de Montes de Oca San José Costa Rica Institute for Scientific Research Universidad Central del Este San Pedro de Macorís Dominican Republic School of Dentistry Universidad de Panamá Panama City Panama Facultad de Estomatología Roberto Beltrán Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Católica de Córdoba Córdoba Argentina Department of Pediatric Dentistry School of Dentistry Universidad Nacional Mayor de San Marcos Lima Peru School of Dentistry Faculty of Clinical Medicine Universidad del Desarrollo Santiago Chile School of Dentistry Universidad de Concepción Concepción Chile Investigation of the School of Health Sciences Universidad Latinoamericana de Ciencia y Tecnología San José Costa Rica

Background: It is well-founded that empathy is an attribute that increases the likelihood of good communication between health professionals and patients, and it is usual that there is the conviction that empathy levels are higher in women than in men. Aims: A study comparing levels of empathy gender of students in 18 schools of dentistry from six Latin American countries was conducted. Method: An exploratory cross-sectional study of which empathy levels were measured by the Jefferson Scale of Empathy for dental students (S version) and these levels were compared between genders by t-student test, after verification of normal distribution and homoscedasticity. Results: Variability was found in the results of the comparisons. In some cases, empathy levels were higher in women, others in men and in most of them there were no differences between genders. Conclusions: The observed results do not support the belief that women are more empathetic than men. However, more studies must be performed in more powers and countries to verify that the results described constitute a scientific fact and not just a feature of dental students specifically in the countries studied.

关键词： Empathy Gender Dental Students

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling n.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.n. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama n.n. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.n. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan n. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai n.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.n. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUOn TAGGInG

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