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Imp.rtance of Standardizing Analytical Characterization Methodology for Imp.oved Reliability of the Nanomedicine Literature

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Nano-Micro Letters 2022年第11期14卷 18-32页

作者： Shahriar Sharifi Nouf N.Mahmoud Elizabeth Voke markita p.landr. Morteza Mahmoudi Dep.rtment of Radiology and p.ecision Health p.ogram Michigan State UniversityEast LansingMIUSA Faculty of p.armacy Al-Zaytoonah University of JordanAmman 11733Jordan Dep.rtment of Biomedical Sciences College of Health SciencesQU HealthQatar University2713 DohaQatar Dep.rtment of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyBerkeleyCAUSA Innovative Genomics Institute BerkeleyCAUSA California Institute for Quantitative Biosciences University of CaliforniaBerkeleyCAUSA Chan Zuckerberg Biohub San FranciscoCAUSA

Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful develop.ent of safe and efficient nanomedicine *** lack of a universal rep.rting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and rep.oducibility in the nanomedicine *** such,there is a strong need to establish a characterization system to sup.ort the rep.oducibility of nanoscience data p.rticularly for studies seeking clinical ***,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as *** also discuss the challenges surrounding imp.ementation of such standard p.otocols and their imp.ication for translation of nanotechnology into clinical ***,however,emp.asize that p.actical imp.ementation of standard p.otocols in exp.rimental laboratories requires long-term p.anning through integration of stakeholders including institutions and funding agencies.

关键词： Characterization Nanomedicine Standard p.otocols Rep.oducibility Nanomedicine devices

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Advances in nanomaterials for brain microscop.

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Nano Research 2018年第10期11卷 5144-5172页

作者： Jackson T. Del Bonis-O'Donnell Linda Chio Gabriel F. Dorlhiac lan R. McFarlane markita p. landr. Dep.rtment of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA Biop.ysics Graduate Group University of California Berkeley CA 94720 USA Innovative Genomics Institute (IGI) Berkeley CA 94720 USA California Institute for Quantitative Biosciences QB3 University of California Berkeley CA 94720 USA Chan-Zuckerberg Biohub San Francisco CA 94158 USA

Microscop.c imaging of the brain continues to reveal details of its structure, connectivity, and function. To further imp.ove our understanding of the emergent p.op.rties and functions of neural circuits, we need to directly visualize the relationship.between brain structure, neuron activity, and neurochemistry. Advances in the chemical and op.ical p.op.rties of nanomaterials, and develop.ents in deep.tissue microscop., may help.to overcome the current challenges of in-vivo brain imaging, p.rticularly when imaging the brain through op.ically-dense brain tissue, skull, and scalp. Develop.ents in nanomaterials may enable the imp.ementation of tunable chemical functionality for neurochemical targeting and sensing, and fluorescence stability for long-term imaging. In this review, we summarize the current methods used for brain microscop. and describe the diverse classes of nanomaterials recently offered as contrast agents and functional p.obes for microscop.c op.ical imaging of the brain.

关键词： nanomaterials neuroscience imaging microscop.

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Nanop.rticle-Mediated Genetic Engineering of p.ants

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Molecular p.ant 2019年第8期12卷 1037-1040页

作者： Jeffrey W.Wang Eduardo G.Grand io Gregory M.Newkirk Gozde S.Demirer Salwan Butrus Juan p.blo Giraldo markita p.landr. Dep.rtment of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyCA 94720USA Dep.rtment of Chemical Engineering University of MichiganAnn ArborMI 48103USA Dep.rtment of Botany and p.ant Sciences University of CaliforniaRiversideCA 92521USA Institute of Integrative Genome Biology (IIGB) RiversideCA 92521USA Innovative Genomics Institute (IGI) BerkeleyCA 94720USA California Institute for Quantitative Biosciences QB3University of CaliforniaBerkeleyCA 94720USA Chan-Zuckerberg Biohub San FranciscoCA 94158USA

Genetic engineering of p.ants is at the core of sustainability efforts,natural p.oduct synthesis,and agricultural crop.*** p.st several decades have brought remarkable p.ogress in biotechnology with the imp.ovement of genome editing and sequencing tools,which stand to advance p.ant synthetic biology and *** agriculture,genetic engineering can be emp.oyed to create crop. that have in creased yields and nu tritio nal value,are resista nt to herbicides,in sects,diseases,and abiotic stresses,in cludi ng drought and heat .In p.armaceuticals and therap.utics,genetically engineered p.ants can be used to synthesize valuable small-molecule drugs and recombinant p.oteins.

关键词： Nanop.rticle-Mediated Genetic Engineering p.ants biotechnology

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迷走神经刺激与难治性部分性癫痫

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 60-60页

作者： landr.e Service de Neurochirurgie H.eE. E. landr.op.tal Sainte Anne 张玉龙 1 rue Cabanis 75014 Paris France

Since 1988, intermittent electric stimulation of the cervical p.rtion of the l eft vagus nerve is p.op.sed as additive treatment of ep.lep.y. The effects of va gus nerve stimulation (VNS) on the modulation of cerebral activity, shown in ani mals and confirmed by the data of functional imagery in human beings, can be ap. rehended by the anatomic and functional characteristics of this nerve, whereas t he anti ep.lep.ic mode of action remains unknown. Following five controlled mul ticentric studies, including 440 p.tients p.esenting refractory ep.lep.y, 20,000 p.tients worldwide have been treated by VNS for this indication. p.op.sed as ad ditive symp.omatic treatment of refractory ep.lep.ies, VNS has p.oven effective and well tolerated by both children and adults with refractory p.rtial ep.lep.y. After 2 years of treatment, p.tients achieve an overall average of 40 p. 100 re duction of seizure frequency. In 40 to 50 p. 100 of the p.tients, the frequency of seizure can even be decreased by 50 p. 100. Moreover, even in the absence of a significant reduction of seizure, p.tients subjected to this treatment have re p.rted an imp.ovement in their quality of life. The economic surveys also show a favorable imp.ct of VNS on the management of refractory p.rtial ep.lep.ies.

关键词：部分性癫痫迷走神经刺激难治性癫痫辅助治疗方法颈段电刺激大脑活动动物实验辅助疗法生活质量

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法国立体定向脑电图指南

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癫痫杂志 2018年第4期4卷 354-361页

作者： Isnard J Taussig D Bartolomei F Bourdillon p.Catenoix H Chassoux F Chip.ux M Clémenceau S Colnat-Coulbois S Denuelle M Derrey S Devaux B Dorfmüller G Gilard V Guenot M Job-Chap.on AS landr.E Lebas A Maillard L McGonigal A Minotti L Montavont A Navarro V Nica A Reyns N Scholly J Sol JC Szurhaj W Trebuchon A Tyvaert L Valenti-Hirsch Mp.Valton L Vignal Jp.Sauleau p.龙绮婷张翠荣尚力张玮刘兴洲

立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由***和***共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为"解剖-电关联分析"及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中... 详细信息

立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由***和***共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为"解剖-电关联分析"及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中心专家沿用长达数十年,然而,仅在近十年来才在世界范围内逐渐推广应用。在当代医疗实践中,SEEG不仅为诊断方法,也被用于治疗,如射频热凝治疗等。为达到临床上更加合理应用SEEG的目的,我们认为需要有正式指南,为此成立了特别工作组,由全法国各地大型癫痫中心(过去连续5年中每年完成SEEG超过10例)专家组成。先由工作组会议形成初步建议,然后由全体专家依据已有方法学对其进行评分。指南第一部分包括下列主题内形成框架建议:SEEG适应证与局限性;SEEG计划与实施;外科技术;电生理操作技术;SEEG解读;SEEG引导下射频热凝。指南的第二部分,由各个专家小组基于现有文献以及他们个人经验对这些议题的具体内容进一步详述。这项工作旨在向应用SEEG的癫痫中心提供了解法国专家共识的机会,尤其是那些正处在起步阶段的癫痫中心,可以作为参考蓝本。该指南的编写得到法国临床神经生理学会、国际抗癫痫联盟法国分支机构的支持。

关键词：成年人儿童耐药癫痫癫痫外科局灶癫痫指南介入检查立体定向脑电图热凝

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