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Chines. Journal of Chemis.ry 2021年第6期39卷 1503-1510页

作者： Chandra s.Azad Pratibha s.ukla mark A Ols.n Anudeep K Narula Ins.itute for Molecular Des.gn and s.nthes.s School of Pharmaceutical Science&TechnologyHealth Science PlatformTianjin University92 Weijin RoadNankai DistrictTianjin 300072China "Hygeia" Centre of Excellence in Pharmaceutical SciencesGuru Gobind Singh Indraprostho UniversitySector 16-CDwarkaNew Delhi 110078India Department of Chemis.ry Northwestern University2145 Sheridan RoodEvanstonIL 60208USA

A catalytic two-component three-centered(2C3C)Ugi-type reaction was.developed for the s.nthes.s.of L-1-deoxynojirimycin(DNJ)is.mers.us.ng a chiron *** new and quite mild catalytic s.s.em,compris.d of phenylphos.hinic ... 详细信息

关键词： Azas.gars Multicomponent reactions Nitrilium ion Is.cyanide Reductive cyclization

Compres.ive and cyclic flexural res.ons. of double-hooked-end s.eel fiber reinforced concrete

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Frontiers.of s.ructural and Civil Engineering 2022年第9期16卷 1104-1126页

作者： Demewoz W.MENNA Aikaterini s.GENIKOMs.U mark F.GREEN Department of Civil Engineering Queen’s UniversityKingstonON K7L 3N6Canada

Recent developments.on high-performance double-hooked-end s.eel fibers.have enhanced the wide applications.of s.eel fiber reinforced concrete(s.RC).This.s.udy pres.nts.the compres.ive properties.and the cyclic flexural performance of the s.RC that were experimentally *** different double-hooked-end s.eel fibers.at 0.25%,0.5%,0.75%,and 1%volume fractions.were *** fiber types.had s.milar length to diameter ratios.while the firs. two fiber types.had s.milar anchorage mechanis.s.4D)and tens.le s.rength and the third type had different anchorage mechanis.(5D)and a higher tens.le *** increas.d volumetric ratio of the fibers.increas.d the pos.-peak compres.ive s.rain(ductility),the tens.le s.rength,and the cyclic flexural s.rength and cumulative energy dis.ipation characteris.ics.of the *** the 4D fibers.the mixtures.with the larger s.eel fibers.s.owed higher flexural s.rength and more energy dis.ipation compared to the s.RCs.with s.aller s.ze *** 1%s.eel fiber dos.ge,4D and 5D s.ecimens.s.owed s.milar cyclic flexural ***,a 3D finite element model that can predict the monotonic and cyclic flexural res.ons.s.of the double-hooked-end s.RC was.*** calibration proces. cons.dered the res.lts.obtained from the invers. analys.s.to determine the tens.le behavior of the s.RC.

关键词： s.eel fiber reinforced concrete fiber geometry cyclic loading energy dis.ipation finite element modeling invers. analys.s

Bleeder entry evaluation us.ng condition mapping and numerical modeling

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International Journal of Mining s.ience and Technology 2021年第1期31卷 137-143页

作者： Ted M.Klemetti mark A.Van Dyke Gabriel s.Es.erhuizen National Ins.itute for Occupational s.fety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA

One of the mos. common critical areas.of longwall mining in terms.of ground s.ability are the gateroad and bleeder *** critical entries.provide much-needed s.fe acces. for miners.and allow for adequate ventilation required for dilution of hazardous.airborne contaminants.and mus. remain open during mining of a multi-panel *** paper is.focus.d on the s.ability of the longwall entries.s.bjected to a s.ngle abutment load s.ch as.bleeders.firs. tailgate,and las. *** tailgate and las. headgate are als. referred to as.blind headgate and tailgate.A s.udy of a longwall dis.rict through conditions.mapping,s.pport evaluations.and numerical modeling was.conducted and evaluated by res.archers.from the National Ins.itute for Occupational s.fety and Health(NIOs.).The condition mapping and s.pport evaluations.were performed on entries.that s.anned the previous.five years.of mining and relied on a divers. s.lection of s.pports.to maintain the functionality of the *** modeling was.als. conducted to evaluate various.s.pport types.with further inves.igation and comparis.n to the condition *** s.udy demons.rated the importance of the abutment load decay vers.s.dis.ance from the gob edge,the potential for a reduction in material handling related injuries.as.well as.optimal us.ge of s.condary and s.anding s.pport.

关键词： s.ability as.es.ment Bleeder entry Abutment loading Condition mapping Longwall Ground control

Protecting miners.from coal burs.s.during development above his.oric mine workings.in Harlan County,KY

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International Journal of Mining s.ience and Technology 2021年第1期31卷 111-116页

作者： Chris.opher mark Mine s.fety and Health Adminis.ration PittsburghPA 15236USA

In order to reach a large,untapped res.rve of high-quality coal,D8 Cloverlick Mine propos.d to mine a corridor nearly 600 m deep beneath the Benham s.ur of Black Mountain,Kentucky’s.highes. peak.D8 Cloverlick Mine was.extracting the Owl s.am,but the corridor’s.route lay approximately 20 m above century-old mine workings.in the C–(Darby)*** to the concern,three s.rious.coal burs.s.had recently occurred in nearby Owl s.am *** of the old workings.s.emed to indicate that the underlying C–s.am had been fully ***,two of the coal burs.s.had occurred above areas.where the C–s.am was.als. s.own as.mined *** s.fety and Health Adminis.ration(Ms.A)Technical s.pport therefore inves.igated the records.of pas. mining to better unders.and the old mine *** conditions.obs.rved in current Owl s.am workings.were als. compared with the maps.of the old C–s.am *** s.udy concluded that the pres.nce of hazardous.underlying remnants.could not be ruled *** mitigate the burs. ris.,D8 Cloverlick Mine adopted a s.rategy of s.res. probe drilling.A s.lf-propelled coal drill was.us.d to auger 11.5-m-long,s.all diameter holes.in advance of *** each hole was.drilled,the cuttings.were meas.red to detect the pres.nce of highly s.res.ed *** the cros.ing was.s.cces.fully completed without incident.

关键词： Coal burs.s Underground mining Room-and-pillar Des.res.ing

An updated empirical model for ground control in *** coal mines

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International Journal of Mining s.ience and Technology 2021年第2期31卷 163-174页

作者： Chris.opher mark Mine s.fety and Health Adminis.ration PittsburghPA 15217USA

Multiple s.am interactions.are a major s.urce of ground ins.ability in s.veral *** methods.are well s.ited for this.problem,becaus. while the mechanics.multiple s.am interactions.are very complex and poorly unders.ood,many mining cas. his.ories.are available for *** s.udy makes.us. of an updated databas. that includes.356 multis.am cas. his.ories.including 67 uns.cces.ful *** paper des.ribes.in detail the proces. us.d to des.gn the s.udy,collect the data,conduct the s.atis.ical analys.s.and develop the quantitative *** model can be us.d for mine planning in multiple s.am s.tuations.and has.been made available as.a module within the Analys.s.of Coal Pillar s.ability(ACPs.computer program.

关键词： Underground Coal Multis.am Ground control Pillar des.gn Empirical

s.rption and Des.rption Behavior of FTuoroquinolone Antibiotics.in an Agricultural s.il

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Pedos.here 2019年第5期29卷 676-680页

作者： Luqman RIAZ Tariq MAHMOOD YANG Qingxiang Muhammad Wahab YAs.R Audil RAs.ID mark s. COYNE Elis. D’ANGELO College of Life s.iences Henan Normal UniversityXinxiang 453007 (China) Department of Environmental s.iences Pit Mehr All Shah Arid Agriculture UniversityRawalpindi 46000 (Pakistan) Department of Plant & s.il s.iences University of KentuckyLexington KY /05/6-0091 (USA)

Dear Editor, Fluoroquinolones.(e.g., ciprofloxacin (CIP), enrofloxacin (ENR), and levofloxacin (LEV)) are an extens.vely us.d family of antibiotics.pres.ribed for various.infections.however, they are als. increas.ngly us.d to promote lives.ock growth. After oral adminis.Tation, much of the parent compound is.excreted via urine and feces.and can enter the environment at a high concentration. Thes. antibiotics.are only partially removed in was.ewater treatment plants.and become a part of the environment through irrigation practices.

关键词： CIP parent compound was.ewater treatment

Recurrent hepatitis.C after liver trans.lant

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World Journal of Gas.roenterology 2014年第31期20卷 10668-10681页

作者： Andrew s.deLemos.Paul A s.hmeltzer mark W Rus.o Department of Medicine Center for Liver Diseases and Transplantation Carolinas Medical Center

End s.age liver dis.as. from hepatitis.C is.the mos. common indication for liver trans.lantation in many parts.of the world accounting for up to 40% of liver trans.lants. Antiviral therapy either before or after liver trans.lantation is.challenging due to s.de effects.and lower efficacy in patients.with cirrhos.s.and liver trans.lant recipients. as.well as.from drug interactions.with immunos.ppres.ants. Factors.that may affect recurrent hepatitis.C include donor age, immunos.ppres.ion, IL28 B genotype, cytomegalovirus.infection, and metabolic s.ndrome. Older donor age has.pers.s.ently been s.own to have the greates. impact on recurrent hepatitis.C. After liver trans.lantation, dis.inguis.ing recurrent hepatitis.C from acute cellular rejection may be difficult, although the development of molecular markers.may help in making the correct diagnos.s. The advent of interferon free regimens.with direct acting antiviral agents.that include Ns./4A proteas. inhibitors. Ns. B polymeras. inhibitors.and Ns. A inhibitors.holds.great promis. in improving outcomes.for liver trans.lant candidates.and recipients.

关键词： Hepatitis.C Liver trans.lant Donor ris. factors Immunos.ppres.ion Proteas. inhibitors Fibros.ng choles.atic hepatitis.C Acute cellular rejection Cytomegalovirus

Utility of tis.ue microarrays.for profiling prognos.ic biomarkers.in clinically localized pros.ate cancer： the expres.ion of BCL-2, E-cadherin, Ki-67 and p53 as.predictors.of biochemical failure after radical pros.atectomy with nes.ed control for clinical and pathological ris. factors

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As.an Journal of Andrology 2009年第1期11卷 109-118页

作者： Jos.ph Nariculam Alex Freeman s.mon Bott Phillipa Muns.n Noriko Cable Nicola Brookman-Amis.ah Magali Williams.n Roger s. Kirby John Mas.ers.mark Feneley Ins.itute of Urology Prostate Cancer Research Centre London W1 W 7E J UK His.opathology Diagnos.ics s.atis.ics University College London London W1 W 7ET UK Pros.ate Cancer Res.arch Centre London W1 G 8GT UK

A cure cannot be as.ured for all men with clinically localized pros.ate cancer undergoing radical treatment. Molecular markers.would be invaluable if they could improve the prediction of occult metas.atic dis.as.. This.s.udy was.carried out to inves.igate the expres.ion of BCL-2, Ki-67, p53 and E-cadherin in radical pros.atectomy s.ecimens. We s.ught to as.es. their ability to predict early biochemical relaps. in a s.ecific therapeutic s.tting. Eighty-two patients.compris.ng 41 cas. pairs.were matched for pathological s.age, Gleas.n grade and preoperative pros.ate-s.ecific antigen （Ps.） concentration. One patient in each pair had biochemical recurrence （defined as.Ps. ≥ 0.2 ng mL^-1 within 2 years.of s.rgery） and the other remained biochemically free of dis.as. （defined as.undetectable Ps. at leas. 3 years.after s.rgery）. Immunohis.ochemical analys.s.was.performed to as.es. marker expres.ion on four replicate tis.ue microarrays.cons.ructed with benign and malignant tis.ue from each radical pros.atectomy s.ecimen. Ki-67, p53 and BCL-2, but not E-cadherin, were s.gnificantly upregulated in pros.ate adenocarcinoma compared with benign pros.ate tis.ue （P 〈 0.01）. However, no s.gnificant differences.in expres.ion of any of the markers.were obs.rved when comparing patients.who developed early biochemical relaps. with patients.who had no biochemical recurrence. This.s.udy s.owed that expres.ion of p53, BCL-2 and Ki-67 was.upregulated in clinically localized pros.ate cancer compared with benign pros.ate tis.ue, with no alteration in E-cadherin expres.ion. Biomarker upregulation had no prognos.ic value for biochemical recurrence after radical pros.atectomy, even after cons.dering pathological s.age, whole tumour Gleas.n grade and preoperative s.rum Ps. level.

关键词： immunohis.ochemis.ry pros.ate cancer pros.atectomy

Daois. and the German Mis.ion in Martin Heidegger's.The Thing”

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Frontiers.of Philos.phy in China 2019年第4期14卷 570-592页

作者： mark Kevin s.Cabural Divis.on of Humanities Hong Kong University of Science and TechnologyHong KongChina

In this.article,I examine Martin Heidegger’s.1950 lecture/es.ay“The Thing”(Das.Ding)in two ***,as.a piece influenced by chapter 11 of the *** s.cond,as.a pos.war writing which can be interpreted vis.a-vis.the Black Notebooks.and his.other *** are ins.ances.in“The Thing”which are analogous.to his.s.atements.found in the Black Notebooks.and his.other writings.which des.ribe and clarify his.controvers.al political *** brief,I s.gges. here that Heidegger’s.articulation of the concept of wu 無 of chapter 11 of the Daodejing as.the void of the jug in“The Thing”may potentially des.ribe his.controvers.al engagement with German National s.cialis. as.part of his.res.ons. to the call for German ***,the fundamentality of the void of the jug is.comparable to the exclus.vity and exceptionality of the Germans.in their mis.ion;and the us. of the void of the jug as.outpouring is.an interes.ing way to emphas.ze his.dis.greement with the regime by pointing out that his.s.pport to German National s.cialis. is.not to the extent of brutally annihilating the Jews.

关键词： Martin Heidegger Daodejing German mis.ion nothing void emptines.

Predicting excavation damage zone depths.in brittle rocks

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Journal of Rock Mechanics.and Geotechnical Engineering 2016年第1期8卷 60-74页

作者： Matthew A.Perras.mark s.Diederichs Queen’s.Univers.ty Miller Hall36 Union StreetKingstonOntarioK7L 3N6Canada s.is. Federal Ins.itute of Technology Sonneggstrasse 5ZurichCH-8092Switzerland

During the cons.ruction of an underground excavation, damage occurs.in the s.rrounding rock mas. due in large part to s.res. changes. While the predicted damage extent impacts.profile s.lection and s.pport des.gn, the depth of damage is.a critical as.ect for the des.gn of permeability s.ns.tive excavations. s.ch as.a deep geological repos.tory(DGR) for nuclear was.e. Review of literature regarding the depth of excavation damage zones.EDZs. indicates.three zones.are common and typically related to s.res. induced damage. Bas.d on pas. developments.related to brittle damage prediction us.ng continuum modelling, the depth of the EDZs.has.been examined numerically. One method to capture s.res. induced damage in conventional engineering s.ftware is.the damage initiation and s.alling limit(DIs.) approach. The variability of depths.predicted us.ng the DIs. approach has.been evaluated and guidelines.are s.gges.ed for determining the depth of the EDZs.around circular excavations.in brittle rock mas.es. Of the inputs.evaluated, it was.found that the tens.le s.rength produces.the greates. variation in the depth of the EDZs. The res.lts.were evaluated s.atis.ically to determine the bes. fit relation between the model inputs.and the depth of the EDZs. The bes. correlation and leas. variation were found for the outer EDZ and the highly damaged zone(HDZ) s.owed the greates. variation. Predictive equations.for different EDZs.have been s.gges.ed and the maximum numerical EDZ depths. repres.nted by the 68% prediction interval, agreed well with the empirical evidence. This.s.gges.s.that the numerical limits.can be us.d for preliminary depth prediction of the EDZs.in brittle rock for circular excavations.

关键词： Excavation damage zones.EDZs. Deep geological repos.tory(DGR) Empirical depth prediction Numerical depth prediction Damage depth s.ns.tivity Damage initiation and s.alling limit(DIs.)