Phosphinic Acid/Nal Mediated Reductive Cyclization Approach for Accessing the L-1-Deoxynojirimycin Using a Two-Component Three-Centered (2C3C) Ugi Type Reaction

作     者：Chandra S Azad Pratibha Shukla Mark A Olson Anudeep K Narula Chandra S Azad;Pratibha Shukla;Mark A Olson;Anudeep K Narula

作者机构：Institute for Molecular Design and SynthesisSchool of Pharmaceutical Science&TechnologyHealth Science PlatformTianjin University92 Weijin RoadNankai DistrictTianjin 300072China "Hygeia"Centre of Excellence in Pharmaceutical SciencesGuru Gobind Singh Indraprostho UniversitySector 16-CDwarkaNew Delhi 110078India Department of ChemistryNorthwestern University2145 Sheridan RoodEvanstonIL 60208USA 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第6期

页      面：1503-1510页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：GGS IP Universality Tianjin University, TJU 

主　　题：Azasugars Multicomponent reactions Nitrilium ion Isocyanide Reductive cyclization 

摘      要：A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron *** new and quite mild catalytic system,comprised of phenylphosphinic acid/Nal,was used to synthesize both the L-allo-DNJ and L-altro-DNJ in high yield.