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Lateral migration with telescoping of a trochanteric fixation nail in the treatment of an intertrochanteric hip fracture

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Chinese Medical Journal 2014年第4期127卷 680-684页

作者： Liu Wanjun Michael J.Weaver mark s.vrahas Zhou Dongsheng Department of Orthopaedics Shandong Provincial HospitalShandong University Jinan Shandong 250021 China Department of Orthopaedics Beijing Jishuitan Hospital Beijing 100035 China Partners Orthopaedics Massachusetts General Hospital Harvard School of Medicine Boston MA 02114 USA

Background The trochanteric fixation nail （TFN） can be used to treat stable and unstable fractures of intertrochanteric hip *** study the common lateral migration that occurs with telescoping of intertrochanteric hip fractures treated with TFN and identify the predictors and relationships to clinical *** Patient demographic information,fracture type （Arbeitsgemeinschaft f＆#252;r Osteosynthesefragen （AO）/Orthopaedic Trauma Association （OTA） classification）,radiographic data,and clinical data were *** migration with telescoping was *** analyses were performed to determine which variables predicted lateral migration with *** outcome scores were recorded using the Modified Harris Hip score （MHHs）,Hip Outcome score-Activity of Daily Living （HOs-ADL）,and Visual Analog scale for *** Two hundred and twenty-three patients （67 males,156 females） fitted the radiographic and follow-up （average 24.6 months） *** average age was 77.2 *** average lateral migration with telescoping was 4.8 ***-one patients （9.4%） had excessive lateral migration with telescoping （≥10 mm）.The quality of calcar reduction （P=0.01） and unstable fracture patterns （P=0.006） were significant predictive factors of lateral migration with *** mean outcome scores （MHHs and HOs-ADL） were 80.1 points and 78.7 points,*** subjects had no significant relationship to lateral migration with telescoping （P 〉0.05）.Of all the patients who developed lateral migration with telescoping,only one required removal of the blade for hip pain and all patients went on to uneventful union at an average time of 4.5 *** Lateral migration with telescoping is a common mechanical complication of intertrochanteric hip fracture treated with the TFN *** was predicted by the quality of calcar reduction and fracture ***,this did not affect stable fixation and fracture healing,so rarely l

关键词： trochanteric fixation nail intertrochanteric hip fracture fracture fixation helical blade complications

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Use of Teriparatide to improve fracture healing: What is the evidence?

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World Journal of Orthopedics 2015年第6期6卷 457-461页

作者： satish Babu Nemandra A sandiford mark vrahas Core surgical Trainee St. George’s Hospital Lower Limb and Tumor Reconstruction Fellow University of British Columbia Orthopaedic Trauma service Massachusetts General Hospital

Teriparatide is a recombinant form of the biologicallyactive component of Parathyroid hormone. It has been shown to increase bone mass and prevent fractures in osteoporotic bone. It is licensed by the Food and Drug Administration for the treatment of Osteoporosis. Over the last decade, a growing body of evidence has accumulated suggesting a role for Teriparatide in the management of fractures. studies in both normal and delayed healing models have shown improvement in callus volume and mineralisation, bone mineral content, rate of successful union and strength at fracture sites. However most of these results have been derived from animal studies. The majority of this research on humans has comprised low level evidence, with few randomised controlled trials, many case reports and case series. Nevertheless, the results from these studies seem to support research from animal models. This has led to a growing number of clinicians using Teriparatide "off license" to treat fractures and non-unions in their patients. This review presents a critical appraisal of the current evidence supporting the use of Teriparatide for fracture healing, delayed unions and non unions and in the setting of osteoporotic fractures, the studies producing this evidence and their transferability to human beings.

关键词： Teriparatide Fractures Healing Bone Osteoporosis

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Calibration of coupled hydro-mechanical properties of grain-based model for simulating fracture process and associated pore pressure evolution in excavation damage zone around deep tunnels

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 60-83页

作者： Kiarash Farahmand mark s.Diederichs Department of Geological sciences and Geological Engineering Queen’s UniversityKingstonOntarioK7L 3N6Canada Golder Associates VancouverBritish ColumbiaCanada

The objective of this paper is to develop a methodology for calibration of a discrete element grain-based model(GBM)to replicate the hydro-mechanical properties of a brittle rock measured in the laboratory,and to apply the calibrated model to simulating the formation of excavation damage zone(EDZ)around underground ***,a new cohesive crack model is implemented into the universal distinct element code(UDEC)to control the fracturing behaviour of materials under various loading ***,a methodology for calibration of the components of the UDEC-Voronoi model is *** role of connectivity of induced microcracks on increasing the permeability of laboratory-scale samples is *** calibrated samples are used to investigate the influence of pore fluid pressure on weakening the drained strength of the laboratory-scale *** validity of the Terzaghi’s effective stress law for the drained peak strength of low-porosity rock is tested by performing a series of biaxial compression test ***,the evolution of damage and pore pressure around two unsupported circular tunnels in crystalline granitic rock is studied.

关键词： Coupled hydro-mechanical properties Excavation damage zone(EDZ) Grain-based model(GBM)calibration stress-fracturing of rock Cohesive crack model stress-dependent permeability

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An assessment of interspecific competition between two introduced parasitoids of Diaphorina citri (Hemiptera: Liviidae)on caged citrus plants

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Insect science 2019年第1期26卷 119-127页

作者： Meghan A.Vankosky mark s.Hoddle Department of Entomology University of CalifomiaRiversideCalifomiaUSA Center for Invasive species Research University of CaliforniaRiversideCaliforniaUSA

Two parasitoids attacking nymphs of Asian citrus psyllid,Diaphorina citri Kuwayama (Hemiptera:Liviidae),Tamarixia radiata (Waterston)(Hymenoptera:Eulophi- dae)and Diaphoreneyrtus aligarhensis (shafee,Alam &Agarwal)(Hymenoptera:Encyrtidae)are being released in California,UsA in a classical biological control program. To evaluate the effect of multiple parasitoid species on *** mortality,we conducted mesocosm experiments under controlled conditions using a complete block design with 6 treatments (*** nymphs exposed to:no parasitoids;*** or *** alone;*** or *** released first (by 48 h);and both species released simultaneously).Parasitism of *** nymphs by *** exceeded 60%and was unchanged when *** were *** by *** was greatest when T. radiata was absent (-28%)and was reduced in all treatments with *** present (sitoid-related mortality *** was consistent across parasitoid *** results suggest that competition between *** and *** is asymmetric and favors *** may be difficult for *** to contribute significantly to *** biological control where *** is ***, results reported here suggest that competition between *** and *** is not likely to reduce parasitism by *** or reduce parasitoid-induced mortality of ***.

关键词： Asian citrus psyllid classical biological control competition Diaphorencyrtus aligarhensis Tamarixia radiata

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Assessment of strain bursting in deep tunnelling by using the finite-discrete element method

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第1期11卷 12-37页

作者： Ioannis Vazaios mark s.Diederichs Nicholas Vlachopoulos Department of Ceological saences and Ceological Engineering Queen's UniversityKingstonCanada

Rockbursting in deep tunnelling is a complex phenomenon posing significant challenges both at the design and construction stages of an underground excavation within hard rock masses and under high in situ stresses. While local experience, field monitoring, and informed data-rich analysis are some of the tools commonly used to manage the hazards and the associated risks, advanced numerical techniques based on discontinuum modelling have also shown potential in assisting in the assessment of rockbursting. In this study, the hybrid finite-discrete element method(FDEM) is employed to investigate the failure and fracturing processes, and the mechanisms of energy storage and rapid release resulting in bursting, as well as to assess its utility as part of the design process of underground *** the calibration of the numerical model to simulate a deep excavation in a hard, massive rock mass, discrete fracture network(DFN) geometries are integrated into the model in order to examine the impact of rock structure on rockbursting under high in situ stresses. The obtained analysis results not only highlight the importance of explicitly simulating pre-existing joints within the model, as they affect the mobilised failure mechanisms and the intensity of strain bursting phenomena, but also show how the employed joint network geometry, the field stress conditions, and their interaction influence the extent and depth of the excavation induced damage. Furthermore, a rigorous analysis of the mass and velocity of the ejected rock blocks and comparison of the obtained data with well-established semi-empirical approaches demonstrate the potential of the method to provide realistic estimates of the kinetic energy released during bursting for determining the energy support demand.

关键词： Rockburst Finite-discrete element method(FDEM) Deep tunnelling Hard rock excavations Brittle fracturing Discrete fracture network(DFN)

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salicaceae detoxification abilities in Florida tiger swallowtail butterflies （Papilio glaucus maynardi Gauthier）＂ Novel ability or Pleistocene holdover？

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Insect science 2012年第3期19卷 337-345页

作者： Matthew s. Lehnert J. mark scriber McGuire Center for Lepidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville Florida Department of Entomology Soils and Plant Sciences Clemson University Clemson South Carolina Department of Entomology Michigan State University East Lansing Michigan USA

Florida populations of the eastern tiger swallowtail butterfly, Papilio glaucus L., have unique morphological features and ecological adaptations that have contributed to their subspecies status （P. g. rnaynardi Gauthier）. We describe geographically unique abilities for detoxification of Carolina willow, salix caroliniana Michx. （salicaceae）, for several Florida populations of P. g. maynardi. Of all the approximately 570 worldwide species of the Papilionidae, such salicaceae detoxification abilities exist only in the allopatric North American western and northernmost species （P. rutulus Lucas, R eurymedon Lucas and P. canadensis Rothschild ＆ Jordan）. Females of P. glaucus collected from populations in southeastern UsA were examined for oviposition preference in 5-choice assays, and displayed a low preference for salicaceae （〈5%）, but larvae from Florida populations exhibited a high survival （〉 60%） on these plants. Detoxification abilities have previously shown to be autosomally inherited, and can be transferred via natural or hand-paired interspecific hybrid introgression. However, these Florida populations are at least 700-1 500 km from the nearest hybrids or the hybrid species, 17. appalachiensis Pavulaan ＆ Wright, which possess these detoxification abilities. In any case, the Z （ = X）-linked oviposition preferences for salicaceae are lacking in these Florida populations, illustrating genetic independence ofoviposition preference determination and larval survival/performance abilities. The origins of detoxification abilities are unlikely to be due to recent climate-driven introgression, and may represent ancestral trait carry-overs from interglacial refugium populations of the Pleistocene epoch.

关键词： eastern tiger swallowtail genetic introgression interglacial island refugia,Papilio glaucus maynardi Papilionidae host plants salicaceae detoxification

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Productivity and technical efficiency of Robusta coffee farms at varying elevation categories in sultan Kudarat, Philippines: implications on sustainability

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Journal of Mountain science 2024年第11期21卷 3615-3629页

作者： mark James s.sAGUIMPA Larry N.DIGAL Agri-Aqua Value Chain Laboratory University of the Philippines MindanaoDavao City 8000Philippines school of Management University of the Philippines MindanaoDavao City 8000Philippines

Elevation can affect agricultural outputs,affecting farms’productivity and *** article identified the significant production inputs influencing productivity and factors influencing technical efficiency(TE)and determined the average TE scores of Robusta coffee farms at varying elevations in sultan Kudarat,***-sectional data from the Mahintana Foundation,*** random stratified sampling and power analysis from september 9,2021,to January 13,2022,were used to analyze 604 farms from areas ranging from 0.33 to 1284.18 above mean sea level(amsl),classified as low,medium,and high ***-Data-Kit-based(ODK)mobile data collection systems were utilized to precisely determine the farms’coordinates and *** stochastic frontier analysis,results showed that increasing the total fertilizer amount and total trees by 1%significantly increased yield by 0.20%and 0.79%,***,increasing the total land area by 1%,including areas unutilized for coffee farming,decreases total yield by 0.11%.Regarding TE,results showed that TE decreases by approximately 0.58%at high ***,increasing net income from coffee farming alone by 1%significantly increases TE by 0.00008%.With an average TE of 0.60,0.77,and 0.63 in low,medium,and high elevations,farms may be incentivized to improve farming practices to increase their TE *** improvement recommendations include promoting coffee-agroforestry systems and ecolabelling at medium elevations,such as shade-grown coffee,to promote sustainable production in Robusta coffee farms by assigning a premium to consumers demanding environmental conservation.

关键词： Cobb-Douglas production function Elevation Philippines Robusta coffee farms stochastic frontier analysis Technical efficiency

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The whole day matters: Understanding 24-hour movement guideline adherence and relationships with health indicators across the lifespan

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Journal of sport and Health science 2020年第6期9卷 493-510页

作者： scott Rollo Olga Antsygina mark s.Tremblay Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaONK1H 8L1Canada Department of Pediatrics Faculty of MedicineUniversity of OttawaOttawaONK1H 8M5Canada Department of Health sciences Carleton UniversityOttawaONK1S 5B6Canada

Background:New research suggests that the composition(mix)of movement behaviors within a 24-h period may have important implications for health across the *** with this integrated movement behavior paradigm,a number of countries across the world have developed and released 24-h movement guidelines for specific age *** purpose of this systematic review was to examine the associations between the 24-h time-use composition of movement behaviors,or adherence to 24-h movement guidelines,and multiple health indicators across the ***:Five online databases(PsycINFO,PubMed,sPORTDiscus,Web of science,and Ovid MEDLINE)were searched for relevant peer-reviewed studies published between January 2015 and January 2020 that met the a priori inclusion criteria,with no study design *** methodological quality of research evidence for each individual study and for each health indicator was assessed by using a modified version of the Downs and Black ***:A total of 51 studies from 20 different countries met the inclusion criteria.A total of 31 studies examined adherence(meeting *** meeting)to 24-h movement guidelines,and 20 studies used compositional analyses to explore the 24-h time-use composition of movement *** indicated that meeting the 24-h movement guidelines were(1)not associated with adiposity among toddlers,(2)favorably associated with health-related quality of life,social-cognitive development,and behavioral and emotional problems among preschoolers,(3)favorably associated with global cognition,health-related quality of life,and healthy dietary patterns in children,and(4)favorably associated with adiposity,fitness,and cardiometabolic,mental,social,and emotional health among children and *** associations were also found between the composition of 24-h movement behaviors and indicators of(1)adiposity and bone and skeletal health among preschoolers,(2)health-related quality of life among child

关键词： Compositional analysis Movement behaviors Physical activity sedentary behavior sleep

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Phosphinic Acid/Nal Mediated Reductive Cyclization Approach for Accessing the L-1-Deoxynojirimycin Using a Two-Component Three-Centered (2C3C) Ugi Type Reaction

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Chinese Journal of Chemistry 2021年第6期39卷 1503-1510页

作者： Chandra s Azad Pratibha shukla mark A Olson Anudeep K Narula Institute for Molecular Design and synthesis School of Pharmaceutical Science&TechnologyHealth Science PlatformTianjin University92 Weijin RoadNankai DistrictTianjin 300072China "Hygeia" Centre of Excellence in Pharmaceutical SciencesGuru Gobind Singh Indraprostho UniversitySector 16-CDwarkaNew Delhi 110078India Department of Chemistry Northwestern University2145 Sheridan RoodEvanstonIL 60208USA

A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron *** new and quite mild catalytic system,comprised of phenylphosphinic ... 详细信息

关键词： Azasugars Multicomponent reactions Nitrilium ion Isocyanide Reductive cyclization

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