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可复性平足症的分型与治疗

足踝外科电子杂志 2014年第1期 1-9页

作者： mark s myerson 李淑媛 Institute for Foot and Ankle Reconstruction Mercy Medical Center 首都医科大学附属北京同仁医院足踝外科矫形中心

可复性平足症涵盖的畸形范围非常之广,理解这一点对于后续的诊疗非常重要。术前仔细的临床查体与手术方案设计是保障手术成功的关键因素,而结合患者具体病情制定个性化手术方案是避免术后效果不佳的一个要点。本文旨在对可复性获得性平... 详细信息

可复性平足症涵盖的畸形范围非常之广,理解这一点对于后续的诊疗非常重要。术前仔细的临床查体与手术方案设计是保障手术成功的关键因素,而结合患者具体病情制定个性化手术方案是避免术后效果不佳的一个要点。本文旨在对可复性获得性平足症的分型、临床检查及手术治疗方法进行综述,重点介绍肌力平衡和跟骨截骨两种处理措施。在此,作者还将介绍一种新的、既往文献中没有报道过的胫后肌腱(posterior tibial tendon, PPT)重建术式及其适应证。

关键词：胫后肌腱平足症跟骨内移截骨弹簧韧带可复性内翻畸形足外翻趾长屈肌分型

《足与踝关节重建外科:并发症的防治》(第2版)

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足踝外科电子杂志 2014年第1期 74-74页

作者： mark s.myerson 徐林

出版时间2013-11-01出版单位人民卫生出版社定价170.00元Reconstructive Foot and Ankle surgery是足踝外科重建领域内享誉全球的领军人物marks.myerson教授30余年足踝外科行医经验的总结。中文译本《足与踝关节重建外科:并发症的防治》... 详细信息

出版时间2013-11-01出版单位人民卫生出版社定价170.00元Reconstructive Foot and Ankle surgery是足踝外科重建领域内享誉全球的领军人物marks.myerson教授30余年足踝外科行医经验的总结。中文译本《足与踝关节重建外科:并发症的防治》(第2版)由人民卫生出版社出版。该书主要针对临床中常见的问题提供了宝贵的诊疗经验,同时辅以大量失败、棘手病例的分析,让读者从中汲取教训,这些在多年临床实践中摸索出来的技能和技巧,将对于我们更好地治疗疾病提供极大的帮助。

关键词：足踝外科踝关节并发症并发病疾病

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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OCTNs:Will the real IBD5 gene please stand up?

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World Journal of Gastroenterology 2006年第23期12卷 3678-3681页

作者： mark s silverberg Mount sinai Hospital IBD Centre Departments of Medicine and SurgeryUniversity of Toronto441-600 University AvenueTorontoON M5G 1X5Canada

Crohn's disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with a substantial heritable component. The IBD5 region on chromosome 5q31 is one of only two loci widely confirmed to be associated with Crohn's disease in multiple independent cohorts. Although many populations have demonstrated association with IBD5, there remains uncertainty as to the causal variant within the region. A recent report identified polymorphisms in sLC22A4 (OCTN1) and sLC22A5 (OCTN2) as being responsible for the IBD5 association, however, these findings have not been replicated. This review discusses the data evaluating the IBD5 locus and the OCTN genes and their relationship to inflammatory bowel disease. several other genes, including IRF1 and P4HA2 may be equally as likely to contain the IBD5 causal variant as the OCTN genes.

关键词： IBD5 Inflammatory bowel disease

Introduction to Management science A Modeling and Case studies Approach with spreadsheets Frederick s. Hillier, mark s. Hillier 2nd ed.

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Calibration of coupled hydro-mechanical properties of grain-based model for simulating fracture process and associated pore pressure evolution in excavation damage zone around deep tunnels

丛书名： McGraw-Hill/Irwin series Operations and decision sciences

2003年

作者： Frederick s. Hillier mark s. Hillier

Includes index.

ISBN: (数字)0072493682

ISBN: (纸本)0072493682

Includes index.

关键词： Management science.

来源：畅想之星图书光盘版（南... 评论

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 60-83页

作者： Kiarash Farahmand mark s.Diederichs Department of Geological sciences and Geological Engineering Queen’s UniversityKingstonOntarioK7L 3N6Canada Golder Associates VancouverBritish ColumbiaCanada

The objective of this paper is to develop a methodology for calibration of a discrete element grain-based model(GBM)to replicate the hydro-mechanical properties of a brittle rock measured in the laboratory,and to apply the calibrated model to simulating the formation of excavation damage zone(EDZ)around underground ***,a new cohesive crack model is implemented into the universal distinct element code(UDEC)to control the fracturing behaviour of materials under various loading ***,a methodology for calibration of the components of the UDEC-Voronoi model is *** role of connectivity of induced microcracks on increasing the permeability of laboratory-scale samples is *** calibrated samples are used to investigate the influence of pore fluid pressure on weakening the drained strength of the laboratory-scale *** validity of the Terzaghi’s effective stress law for the drained peak strength of low-porosity rock is tested by performing a series of biaxial compression test ***,the evolution of damage and pore pressure around two unsupported circular tunnels in crystalline granitic rock is studied.

关键词： Coupled hydro-mechanical properties Excavation damage zone(EDZ) Grain-based model(GBM)calibration stress-fracturing of rock Cohesive crack model stress-dependent permeability

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Environmental noise alters gastric myoelectrical activity:Effect of age

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World Journal of Gastroenterology 2007年第3期13卷 403-407页

作者： James s Castle mark R Warner mark A Korsten Medical Program and Audiology service James J Peters VA Medical Center Bronx NY and Mount Sinai School of Medicine New York United States

AIM: To evaluate the effect of age and acoustic stress on gastric myoelectrical activity (GMA) and autonomic nervous system function. METHODs: Twenty-one male subjects (age range 22-71 years, mean 44 years) were recruited and exposed, in random order, to three auditory stimuli (Hospital noise, conversation babble and traffic noise) after a 20-min baseline. All periods lasted 20 min and were interspersed with a 10 min of recovery. GMA was obtained using a synectics Microdigitrapper. Autonomic nerve function was assessed by monitoring blood pressure and heart rate using an automatic recording device. REsULTs: Dominant power tended to decrease with increase of age (P sed during exposure to hospital noise (12.0%, P se (13.9%, P sation babble (7.1%). The subjects in the younger group (s) showed a consistent reduction in the percentage of 3 CPM activity during hospital noise (22.9%, P se (19.0%, P sation babble (15.5%). These observations were accompanied by a significant increase in bradygastria: hospital noise (P se (P st, the subjects over 50 years of age did not exhibit a significant decrease in 3 CPM activity. Regardless of age, noise did not alter blood pressure or heart rate. CONCLUsION: GMA changes with age. Loud noise can alter GMA, especially in younger individuals. Our data indicate that even short-term exposure to noise may alter the contractility of the stomach.

关键词： Noise, Acoustic stress, Gastric myoelectrical activity Electrogastmgram Autonomic nervous system

An assessment of interspecific competition between two introduced parasitoids of Diaphorina citri (Hemiptera: Liviidae)on caged citrus plants

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Insect science 2019年第1期26卷 119-127页

作者： Meghan A.Vankosky mark s.Hoddle Department of Entomology University of CalifomiaRiversideCalifomiaUSA Center for Invasive species Research University of CaliforniaRiversideCaliforniaUSA

Two parasitoids attacking nymphs of Asian citrus psyllid,Diaphorina citri Kuwayama (Hemiptera:Liviidae),Tamarixia radiata (Waterston)(Hymenoptera:Eulophi- dae)and Diaphoreneyrtus aligarhensis (shafee,Alam &Agarwal)(Hymenoptera:Encyrtidae)are being released in California,UsA in a classical biological control program. To evaluate the effect of multiple parasitoid species on *** mortality,we conducted mesocosm experiments under controlled conditions using a complete block design with 6 treatments (*** nymphs exposed to:no parasitoids;*** or *** alone;*** or *** released first (by 48 h);and both species released simultaneously).Parasitism of *** nymphs by *** exceeded 60%and was unchanged when *** were *** by *** was greatest when T. radiata was absent (-28%)and was reduced in all treatments with *** present (sitoid-related mortality *** was consistent across parasitoid *** results suggest that competition between *** and *** is asymmetric and favors *** may be difficult for *** to contribute significantly to *** biological control where *** is ***, results reported here suggest that competition between *** and *** is not likely to reduce parasitism by *** or reduce parasitoid-induced mortality of ***.

关键词： Asian citrus psyllid classical biological control competition Diaphorencyrtus aligarhensis Tamarixia radiata

Assessment of strain bursting in deep tunnelling by using the finite-discrete element method

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第1期11卷 12-37页

作者： Ioannis Vazaios mark s.Diederichs Nicholas Vlachopoulos Department of Ceological saences and Ceological Engineering Queen's UniversityKingstonCanada

Rockbursting in deep tunnelling is a complex phenomenon posing significant challenges both at the design and construction stages of an underground excavation within hard rock masses and under high in situ stresses. While local experience, field monitoring, and informed data-rich analysis are some of the tools commonly used to manage the hazards and the associated risks, advanced numerical techniques based on discontinuum modelling have also shown potential in assisting in the assessment of rockbursting. In this study, the hybrid finite-discrete element method(FDEM) is employed to investigate the failure and fracturing processes, and the mechanisms of energy storage and rapid release resulting in bursting, as well as to assess its utility as part of the design process of underground *** the calibration of the numerical model to simulate a deep excavation in a hard, massive rock mass, discrete fracture network(DFN) geometries are integrated into the model in order to examine the impact of rock structure on rockbursting under high in situ stresses. The obtained analysis results not only highlight the importance of explicitly simulating pre-existing joints within the model, as they affect the mobilised failure mechanisms and the intensity of strain bursting phenomena, but also show how the employed joint network geometry, the field stress conditions, and their interaction influence the extent and depth of the excavation induced damage. Furthermore, a rigorous analysis of the mass and velocity of the ejected rock blocks and comparison of the obtained data with well-established semi-empirical approaches demonstrate the potential of the method to provide realistic estimates of the kinetic energy released during bursting for determining the energy support demand.

关键词： Rockburst Finite-discrete element method(FDEM) Deep tunnelling Hard rock excavations Brittle fracturing Discrete fracture network(DFN)

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