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World Journal of Gastroenterology 2006年第23期12卷 3625-3627页

作者： Eric M Yoshida mark riley Laura T Arbour Department of Medicine University of British ColumbiaVancouverBCCanada Department of Pediatrics University of British Columbia Vancouver BC Canada Department of Medical Genetics the University of British Columbia. Vancouver BC Canada

Primary biliary cirrhosis (PBC) is a well-known but uncommon chronic liver disease that is presumed to be of autoimmune etiology. Recently, investigations in British Columbia (BC), a province of Canada situated along the Pacific North-West of North America, have suggested that PBC is not a rare disease amongst BC's Aboriginal (i.e. First Nations) communities. Geographically, BC is adjacent to South East Alaska, an American state that has also reported an increased prevalence of PBC amongst its Aboriginal communities. In this article, the medical evidence supporting a hypothesis of increased risk of PBC amongst BC's First Nations communities is reviewed. Evidence suggesting that autoimmune hepatitis is also more likely amongst BC's First Nations communities is also presented.

关键词： Primary biliary cirrhosis Aboriginal FirstNations British Columbia

A novel technique using hydrophilic polymers to promote axonal fusion

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Neural Regeneration Research 2016年第4期11卷 525-528页

作者： Ravinder Bamba D.Colton riley Nathaniel D.Kelm mark D.Does Richard D.Dortch Wesley P.Thayer Department of Plastic Surgery Vanderbilt University Medical Center Nashville TN USA Department of Surgery Georgetown University Washington DC USA Georgetown University School of Medicine Washington DC USA Vanderbilt University Institute of Imaging Science Nashville TN USA Department of Radiology and Radiological Sciences Vanderbilt University Nashville TN USA

The management of traumatic peripheral nerve injury remains a considerable concern for *** minimal innovations in surgical technique and a limited number of specialists trained to treat peripheral nerve injury,outcomes of surgical intervention have been *** inability to manipulate the pathophysiology of nerve injury（i.e.,Wallerian degeneration） has left scientists and clinicians depending on the slow and lengthy process of axonal regeneration（-1 mm/day）.When axons are severed,the endings undergo calcium-mediated plasmalemmal sealing,which limits the ability of the axon to be primarily *** glycol（PEG） in combination with a bioengineered process overcomes the inability to fuse *** mechanism for PEG axonal fusion is not clearly understood,but multiple studies have shown that a providing a calcium-free environment is essential to the process known as PEG *** proposed mechanism is PEG-induced lipid bilayer fusion by removing the hydration barrier surrounding the axolemma and reducing the activation energy required for membrane fusion to *** review highlights PEG fusion,its past and current studies,and future directions in PEG fusion.

关键词： peripheral nerve injury polyethylene glycol axonal fusion nerve transection traumatic neuropathy

Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage

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Neural Regeneration Research 2017年第1期12卷 72-74页

作者： mark R.Kelley Jill C.Fehrenbacher Pediatric Oncology Research Departments of Biochemistry&Molecular Biology and Pharmacology&Toxicology HB Wells Center for Pediatric ResearchBasic Science ResearchIndianaUniversity Simon Cancer CenterIndianapolisINUSA Department of Pharmacology and Toxicology Stark Neuroscience Research Institute Department of AnesthesiologyIndiana University School of MedicineIndianapolisINUSA

Background on chemotherapy-induced peripheral neuropathy（CIPN）Incidence,prevalence,and consequences：Up to 90%of cancer patients experience CIPN at some point during or after anticancer treatment（Seretny et al.,201... 详细信息

关键词： neuropathy chemotherapy consequences anticancer identifying oxidative prevalence DNA incidence repair

苏格兰猛禽监测计划:目标、前四年取得的成果以及未来发展计划

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AMBIO－人类环境杂志 2008年第6期37卷 442-446页

作者： Chris V. Wernham Brian Etheridge mark Holling Gordon Riddle Helen T. riley Patrick K.Stirling-Aird David Stroud Des B.A.Thompson Jeremy D.Wilson 静莹英国鸟类信托协会苏格兰鸟类学家俱乐部南斯爵斯克莱德猛禽研究小组苏格兰自然遗产保护协会苏格兰猛禽研究小组英国联合自然保护委员会苏格兰猛禽监测计划英国皇家保护鸟类学会研究部

苏格兰猛禽监测计划(SRMS)于2002年制定,包含7个合作机构。其动因是:1)英国政府所出版的《猛禽工作组报告》中提出了加强猛禽监测的建议;2)对应用资料的需求(比如选点所需的资料)越来越多;3)对某些物种现状的关注。苏格兰猛禽监测计划有... 详细信息

苏格兰猛禽监测计划(SRMS)于2002年制定,包含7个合作机构。其动因是:1)英国政府所出版的《猛禽工作组报告》中提出了加强猛禽监测的建议;2)对应用资料的需求(比如选点所需的资料)越来越多;3)对某些物种现状的关注。苏格兰猛禽监测计划有3个主要目标:1)促进各方之间的合作;2)通过分析猛禽数量、活动范围、存活率,繁育生产力的趋势并了解其变化原因,提供有关苏格兰猛禽种群的稳定而丰富的信息;3)在资料的收集、整理、审核、分析以及信息的报告方面保持高标准和统一标准。文中主要收集了19种猛禽的资料:14种昼行猛禽,4种鸮以及1种鸦科鸟类——渡鸦。本文将介绍监测计划的发展、面临的挑战、前4年所取得的成果、所收集资料的性质和价值以及未来的计划。

关键词：苏格兰猛禽监测收集资料统一标准英国政府活动范围工作组

Innovative Education and Training in high power laser plasmas(PowerLaPs) for plasma physics, high power laser-matter interactions and high energy density physics-theory and experiments

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High Power Laser Science and Engineering 2019年第2期7卷 22-26页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos Dimitri Batani Emmanouil P.Benis Marco Borghesi Eugene Clark Donna Cook Emmanuel D'Humieres Vasilios Dimitriou Brendan Dromey Michael Ehret Ioannis Fitilis Anastasios Grigoriadis Satya Kar Evaggelos Kaselouris Ondrej Klimo Michel Koenig Kyriaki Kosma George Koundourakis Milan Kucharik Aveen Lavery Jiri Limpouch Yannis Orphanos Nektarios A.Papadogiannis Stelios Petrakis Dave riley Maria Serena Rivetta Laura Tejada Pascual Joao Jorge Santos Alexandros Skoulakis Ioannis Tazes Vladimir Tikhonchuk Jocelain Trela Calliope Tsitou Luca Volpe Steven White mark Yeung Michael Tatarakis York Plasma Institute University of York Technological Educational Institute of Crete School of Applied SciencesCentre for Plasma Physics and Lasers-CPPL Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications) Department of Physics University of Ioannina Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University Belfast Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague LULI-CNRS Ecole Polytechnique CEA:UniversitéParis-Saclay UPMC Univ Paris 06:Sorbonne Universités CLPU Laser-Plasma Chair University of Salamanca Centro de Láseres Pulsados(CLPU) Edificio M5.Parque Cientfico.C/Adaja

The Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is *** PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme where teaching takes place in five separate institutes with a range of different aims and styles of *** ’in class’ time is limited to four weeks a year,and the programme spans two *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laserplasma interaction physics and inertial confinement fusion(ICF).Lectures are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Technological Educational Institute(TEI)of Crete,and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical-University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just completed its first *** far three Learning Teaching Training(LTT)activities have been held,at the Queen’s University Belfast,the University of Bordeaux and the Centre for Plasma Physics and Lasers(CPPL)of TEI *** last of these was a two-week long Intensive Programme(IP),while the activities at the other two universities were each five days in *** far work has concentrated upon training in both theoretical and experimental work in plasma physics,high power laser-matter interactions and high energy density *** nature of the programme will be described in detail and some metrics relating to the activities carried out to date will be presented.

关键词： higher education inertial confinement fusion laser-plasma interactions post-graduate education

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

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Genes & Diseases 2023年第1期10卷 267-283页

作者： Lakshmi Prabhu Matthew Martin Lan Chen Ozlem Demir Jiamin Jin Xiumei Huang Aishat Motolani Mengyao Sun Guanglong Jiang Harikrishna Nakshatri Melissa L.Fishel Steven Sun Ahmad Safa Rommie E.Amaro mark R.Kelley Yunlong Liu Zhong-Yin Zhang Tao Lu Department of Pharmacology and Toxicology Indiana University School of MedicineIndianapolisIN 46202USA Chemical Genomics Core Facility Indiana University School of MedicineIndiana University School of MedicineIndianapolisIN 46202USA Department of Biochemistry and Molecular Biology Indiana University School of MedicineIndiana University School of MedicineIndianapolisIN46202USA Department of Chemistry and Biochemistry University of CaliforniaSan DiegoCA 92093USA Department of Radiation Oncology Indiana University School of MedicineIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Medicine Indiana University School of MedicineIndianapolisIN 46202USA Department of Pediatrics Herman B Wells Center for Pediatric ResearchIndianapolisiN 46202USA Indiana University Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN46202USA

market drugs,suchas Foodand Drug Administration(FDA)or European Medicines Agency(EMA)-approved drugs for specific indications provide opportunities for repurposing for newer *** potentially saves resources invested in clinical trials that verify drug safety and tolerance in humans prior to alternative indication *** arginine methyltransferase 5(PRMT5)overexpression has been linked to promoting the tumor phenotype in several cancers,including pancreatic ductal adenocarcinoma(PDAC),colorectal cancer(CRC),and breast cancer(BC),making PRMT5 an important target for cancer ***,we showed that PRMT5-mediated methylation of the nuclear factor(NF)-kB,partially contributes to its constitutive activation observed in *** this study,we utilized an AlphaLiSA-based high-throughput screening method adapted in our lab,and identified one FDA-approved drug,Candesartan cilexetil(Can,used in hypertension treatment)and one EMA-approved drug,Cloperastine hydrochloride(Clo,used in cough treatment)that had significant PRMT5-inhibitory activity,and their anti-tumor properties were validated using cancer phenotypic assays in ***,PRMT5 selective inhibition of methyltransferase activity was confirmed by reduction of both NF-kB methylation and its subsequent activation upon drug *** in silico prediction,we identified critical residues on PRMT5 targeted by these drugs that may interfere with its enzymatic ***,Clo and Can treatment have exhibited marked reduction in tumor growth in ***,we provide basis for pursuing repurposing Clo and Can as anti-PRMT5 cancer *** study offers potential safe and fast repurposing of previously unknown PRMT5 inhibitors into clinical practice.

关键词： Cancer Research NF-kB Pharmacology PRMT5 PRMT5 inhibitors