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E11是骨陷窝细胞特异抗原和机械应力感应分子

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E11是骨陷窝细胞特异抗原和机械应力感应分子

Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes

中华医学会第三次全国骨质疏松和骨矿盐疾病学术会议

作者：张克勤叶林 Shiva Kotha mark dallas 陆永波 Stephen E.Harris 冯建全 Lynda.F.Bonewald 美国密苏里大学

成骨细胞合成骨基质和促进钙化,最终自身被骨基质包埋,细胞形态也从立方形转变成树枝状,此时称骨陷窝细胞(Osteocyte,简称ocy)。骨陷窝细胞在形态及功能方面均不同于其前体细胞——成骨细胞,因此我们推测骨陷窝细胞必然存在不同于成骨...

成骨细胞合成骨基质和促进钙化,最终自身被骨基质包埋,细胞形态也从立方形转变成树枝状,此时称骨陷窝细胞(Osteocyte,简称ocy)。骨陷窝细胞在形态及功能方面均不同于其前体细胞——成骨细胞,因此我们推测骨陷窝细胞必然存在不同于成骨细胞的特异蛋白。1996年WettenvaId等报告E11是大鼠骨陷窝细胞的特异蛋白,这种蛋白也特异地存在于肺泡Ⅰ

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Bone Research 2019年第1期7卷 41-53页

作者： Delphine B.Maurel Tsutomu Matsumoto Julian A.Vallejo mark L.Johnson Sarah L.dallas Yukiko Kitase Marco Brotto Michael J.Wacker Marie A.Harris Stephen E.Harris Lynda F.Bonewald Department of Oral and Craniofacial Sciences University of Missouri-Kansas City School of DentistryKansas CityMOUSA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisINUSA Bone.Muscle Collaborative Sciences College of Nursing and Health InnovationUniversity of Texas at ArlingtonArlingtonUSA Department of Biomedical Sciences University of Missouri-Kansas City School of MedicineKansas CityMOUSA University of Texas Health Science Center San AntonioTXUSA Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisINUSA Pharmaceutical Sciences Department Universite de BordeauxBio-TisINSERM Unité1026 BioTis146 Rue Léo Saignat33076 BordeauxFrance

Transgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology,function and *** numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts,few target osteocytes specifically,particularly mature *** goal was to create a spatial and temporal conditional Cre model using tamoxifen to induce Cre activity in mature osteocytes using a Bac construct containing the 5’and 3’regions of the Sost gene(Sost ERT2 Cre).Four founder lines were crossed with the Ai9 Cre reporter *** founder line showed high and specific activity in mature *** and organs were imaged and fluorescent signal *** no activity was observed in 2 day old pups,by 2 months of age some osteocytes were positive as osteocyte Cre activity became spontaneous or‘leaky’with *** percentage of positive osteocytes increased following tamoxifen injection,especially in males,with 43%to 95%positive cells compared to 19%to 32%in *** signal was observed in any bone surface cell,bone marrow,nor in muscle with or without tamoxifen *** spontaneous signal was observed in any other ***,with tamoxifen injection,a few positive cells were observed in kidney,eye,lung,heart and *** other organs,28 in total,were negative with tamoxifen ***,with age,a muscle phenotype was apparent in the Sost-ERT2 Cre ***,although this mouse model may be useful for targeting gene deletion or expression to mature osteocytes,the muscle phenotype may restrict the use of this model to specific applications and should be considered when interpreting data.

关键词： cell knowledge model

Cooperative visibility maintenance in SE（3） for multi-robot-networks with limited field-of-view sensors

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Control Theory and Technology 2017年第4期15卷 246-257页

作者： Hasan A. Poonawala mark W. Spong Institute for Computational Engineering & Sciences University of Texas Austin U.S.A. Erik Jonsson School of Engineering & Computer Science University of Texas at Dallas Richardson U.S.A.

Coordination of motion between multiple robots requires the robots to sense their relative poses. Common sensors depend on maintaining a line-of-sight between the sensor and the object being sensed. When the robots move relative to one another, they must coordinate their motions to ensure that these lines-of-sight are preserved. We propose a control method to preserve desired lines-of-sight in a multi-robot system where each robot has configuration space SE（3）. A key feature of the control method is its ability to reject persistent bounded disturbances, enabling its use alongside additional control tasks. We demonstrate the effectiveness of the edge-preserving control in simulations involving additional input velocities that tend to break the edges.

关键词： Multi-robot coordination decentralized control graph theoretic control

Multitarget stool DNA tests increases colorectal cancer screening among previously noncompliant Medicare patients

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World Journal of Gastroenterology 2017年第3期23卷 464-471页

作者： mark Prince Lynn Lester Rupal Chiniwala Barry Berger USMD Health System ArlingtonTX 76017United States USMD Health System Fort WorthTX 76104United States USMD Health System Irving TexasTX 75039United States Exact Sciences Corporation MadisonWI 53729United States

AIM To determine the uptake of noninvasive multitarget stool DNA (mt-s DNA) in a cohort of colorectal cancer(CRC) screening non-compliant average-risk Medicare *** This cross sectional primary care office-based study examined mt-s DNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, dallas, TX) from October, 2014-September, 2015. Investigators performed a Health Insurance Portability and Accountability Act compliant retrospective review of electronic health records to identify mt-s DNA use in patients who were either > 10 years since last colonoscopy and/or > 1 year since last fecal occult blood test. Test positive patients were advised to get diagnostic colonoscopy and thereafter patients were characterized by the most clinically significant lesion documented on histopathology of biopsies or excisional tissue. Descriptive statistics were employed. Key outcome measures included mt-s DNA compliance and diagnostic colonoscopy compliance on positive *** Over 12 mo, 77 providers ordered 393 mt-sD NA studies with 347 completed (88.3% compliance). Patient mean age was 69.8 (50-85) and patients were 64% female. Mt-sD NA was negative in 85.3%(296/347) and positive in 14.7%(51/347). Follow-up colonoscopy was performed in 49 positive patients (96.1% colonoscopy compliance) with two patients lost to follow up. Index findings included: colon cancer(4/49, 8.2%), advanced adenomas (21/49, 42.9%), non-advanced adenomas(15/49, 30.6%), and negative results (9/49, 18.4%). The positive predictive value for advanced colorectal lesions was 51.0% and for any colorectal neoplasia was 81.6%. The mean age of patients with colorectal cancer was 70.3 and all CRC's were localized Stage Ⅰ(2) and Stage Ⅱ (2), three were located in the proximal colon and one was located in the distal *** Mt-s DNA provided medi

关键词： Multitarget stool DNA Advanced adenoma Screening compliance Colonoscopy Colorectal cancer screening Preventive

Evidence of neurodegeneration in autism spectrum disorder

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Translational Neurodegeneration 2013年第1期2卷 113-118页

作者： Janet K Kern David A Geier Lisa K Sykes mark R Geier Institute of Chronic Illnesses IncorporationSilver SpringMDUSA University of Texas Southwestern Medical Center at dallas DallasTXUSA CoMeD IncorporationSilver SpringMDUSA

Autism spectrum disorder(ASD)is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and *** of neurological function in ASD,as observed in affected children who have regressed,can be explained as *** there is research evidence of neurodegeneration or progressive encephalopathy in ASD,the issue of neurodegeneration in ASD is still under *** of neurodegeneration in the brain in ASD includes:(1)neuronal cell loss,(2)activated microglia and astrocytes,(3)proinflammatory cytokines,(4)oxidative stress,and(5)elevated 8-oxo-guanosine *** evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities,and that research into treatments to address the issue of neurodegeneration in ASD are warranted.

关键词： Autism spectrum disorder(ASD) Autism Neurodegeneration Regression Neuronal cell loss Microglia Oxidative stress Cytokines

Highlights of the 2015 San Antonio Breast Cancer Symposium

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Genes & Diseases 2016年第2期3卷 110-113页

作者： mark Keaton Debu Tripathy Joyce O’Shaughnessy Shou-Ching Tang Georgia Regents University Cancer Center 1411 Laney Walker Blvd.AugustaGA 30912USA The University of Texas MD Anderson Cancer Center 1515 HolcombeUnit 1354HoustonTX 77030USA Baylor University Medical Center Texas OncologyUS Oncology3410 Worth St Suite 400DallasTX 75246USA Tianjin Medical University Cancer Institute and Hospital TianjinChina

This manuscript provides a comprehensive review and highlights of the 2015 San Antonio Breast Cancer Symposium by the leading breast cancer specialists and investigators in the field.

关键词： San Antonio Breast Cancer highlights Breast cancer prognosis Diagnosis and treatment Biomarkers Immunotherapy and targeted therapies

Chemical-sensitive graphene modulator with a memory effect for internet-of-things applications

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Microsystems & Nanoengineering 2016年第1期2卷 230-238页

作者： Haiyu Huang Li Tao Fei Liu Li Ji Ye Hu mark Ming-Cheng Cheng Pai-Yen Chen Deji Akinwande Department of Electrical and Computer Engineering University of Texas at AustinAustinTX 78712USA Maxim Integrated Inc. DallasTX 75240USA School of Medicine Stanford UniversityStanfordCA 94305USA Houston Methodist Hospital Research Institute HoustonTX 77030USA Department of Electrical and Computer Engineering Wayne State UniversityDetroitMI 48202USA

Modern internet of things(IoTs)and ubiquitous sensor networks could potentially take advantage of chemically sensitive nanomaterials and ***,their heterogeneous integration with other electronic modules on a networked sensor node,such as silicon-based modulators and memories,is inherently challenging because of compatibility and integration *** we report a novel paradigm for sensing modulators:a graphene field-effect transistor device that directly modulates a radio frequency(RF)electrical carrier signal when exposed to chemical agents,with a memory effect in its electrochemical *** demonstrated the concept and implementation of this graphene-based sensing modulator through a frequency-modulation(FM)experiment conducted in a modulation cycle consisting of alternating phases of air exposure and ethanol or water *** addition,we observed an analog memory effect in terms of the charge neutrality point of the graphene,Vcnp,which strongly influences the FM results,and developed a calibration method using electrochemical gate-voltage pulse *** graphenebased multifunctional device shows great potential for use in a simple,low-cost,and ultracompact nanomaterial-based nodal architecture to enable continuous,real-time event-based monitoring in pervasive healthcare IoTs,ubiquitous security systems,and other chemical/molecular/gas monitoring applications.

关键词： chemical sensing microsystems CVD graphene graphene field-effect sensors internet of nano-things microsensor networks RF and analog microdevices

Addition of Metanx in pregabalin partial responders for painful diabetic neuropathy

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Journal of Diabetes Mellitus 2013年第3期3卷 134-138页

作者： Allen mark Jacobs Dunlei Cheng Saint Louis University School of Medicine Saint Louis USA University of Texas School of Public Health Dallas USA

Objective: To study the effect of addition of Metanx?on burning parasthesias in patients with symptomatic diabetic neuropathy who had obtained only partial symptom resolution with pregabalin. Research design and methods: This was an open-label pilot study. There were 16 patients (7 males, 9 females) in the study group and 8 patients (3 males, 5 females) in the control group. A patient numeric rating scale (0 - 10) of neuropathy associated pain was obtained at baseline and at 20 weeks. The control group continued on a fixed dosage of pregabalin (Lyrica) without additional medication, while the study group was supplemented with Metanx?(L-methylfolate, methylcobalamin, and pyridoxal 5- phosphate), in addition to being continued on a fixed dosage of pregabalin. Results: After 20 weeks, patients in the study group experienced greater pain relief compared to the control group, (87.5% vs. 25% respectively, p = 0.005). The average pain score reduction after 20 weeks in the study group was 3 compared to0.25 inthe control group (p < 0.001). Conclusion: Our study suggested that addition of Metanx?may be used for the relief of pain in patients that have obtained only partial resolution of symptomatology from pregabalin.

关键词： L-Methylfolate Methylcobalamin Metanx Diabetic Neuropathy

The Potential Impact of Incentives on Managed Lane Travel

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Journal of Transportation Technologies 2018年第4期8卷 255-272页

作者： Namoo A. Han mark W. Burris Freese and Nichols Dallas TX USA Texas A&M University College Station TX USA

The use of managed lanes to control and maximize freeway throughput is increasing. One way of encouraging more managed lane use is through the implementation of incentives. In the dallas-Fort Worth area, a managed lane is being added to the I-30 (Tom Landry freeway) and incentives to maximize the use of this lane were planned. Since the managed lanes were not yet open and the incentives were hypothetical, a stated preference survey was used to gauge the potential impact of the incentives on traveler behavior. The stated preference questions were designed using Db-efficient and random adaptive designs. The incentives were chosen by looking at other programs around the country and through discussion with transportation experts. Once ready, the survey was administered online to travelers in the area and a total of 898 usable responses were gathered. From the responses, a mixed-logit model was developed to describe and predict traveler behavior. From the model, elasticities were calculated to predict the impact of the incentives on mode choice. The model found that incentives with discounts and free trips (a transit fare discount, express bus service to downtown, a free trip for every X number of paid trips, and a discount offered to select businesses) were more effective at encouraging managed lane use. The other incentives (gift card worth $5 for every X number of trips and $5 in credit for every X number of trips taken by transit) had less of an impact.

关键词： Managed Lanes Incentives Stated Preference Survey