Addition of Metanx in pregabalin partial responders for painful diabetic neuropathy
Addition of Metanx in pregabalin partial responders for painful diabetic neuropathy作者机构：Saint Louis University School of Medicine Saint Louis USA University of Texas School of Public Health Dallas USA
出 版 物：《Journal of Diabetes Mellitus》 (糖尿病（英文）)
年 卷 期：2013年第3卷第3期
页 面：134-138页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：L-Methylfolate Methylcobalamin Metanx Diabetic Neuropathy
摘 要：Objective: To study the effect of addition of Metanx?on burning parasthesias in patients with symptomatic diabetic neuropathy who had obtained only partial symptom resolution with pregabalin. Research design and methods: This was an open-label pilot study. There were 16 patients (7 males, 9 females) in the study group and 8 patients (3 males, 5 females) in the control group. A patient numeric rating scale (0 - 10) of neuropathy associated pain was obtained at baseline and at 20 weeks. The control group continued on a fixed dosage of pregabalin (Lyrica) without additional medication, while the study group was supplemented with Metanx?(L-methylfolate, methylcobalamin, and pyridoxal 5- phosphate), in addition to being continued on a fixed dosage of pregabalin. Results: After 20 weeks, patients in the study group experienced greater pain relief compared to the control group, (87.5% vs. 25% respectively, p = 0.005). The average pain score reduction after 20 weeks in the study group was 3 compared to0.25 inthe control group (p 0.001). Conclusion: Our study suggested that addition of Metanx?may be used for the relief of pain in patients that have obtained only partial resolution of symptomatology from pregabalin.
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