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Rand.mised.stud. of bailout intracranial angioplasty following thrombectomy for acute large vessel occlusion(ANGEL-REBOOT):protocol of a multicentre rand.mised.controlled.trial

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Stroke & Vascular Neurology 2024年第2期9卷 181-188页

作者： Feng Gao Xu Tong Baixue Jia Ming Yang Yuesong Pan Zeguang Ren William scott Burgin Liping Liu Xingquan Zhao Yilong Wang Yongjun Wang Zhongrong Miao Interventional Neurorad.ology Department of NeurologyBeijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological d.seases Beijing Tiantan HospitalBeijingChina d.partment of Neurosurgery University of South FloridaTampaFloridaUSA d.partment of Neurology Morsani College of MedicineUniversity of South FloridaTampaFloridaUSA Comprehensive Stroke Center Tampa General HospitalTampaFloridaUSA d.partment of Neurology Beijing Tiantan HospitalBeijingChina

Rationale Unsuccessful thrombectomy of acute large vessel occlusions(LVOs)has been associated.with unfavourable *** rand.mised.controlled.trials(RCTs)have reported.a failure rate of 12%–41%for thrombectomy *** factors contribute to failed.thrombectomy,includ.ng technical d.fficulties in accessing the occlusion,unsuccessful thrombus retrieval,thrombotic reocclusion and.pre-existing intracranial atherosclerotic *** some stud.es have explored.balloon d.lation or permanent stenting as rescue intracranial angioplasty for failed.thrombectomy in ind.vid.al cases,there is currently no evid.nce from RCTs on this specific *** To evaluate the potential superiority of bailout angioplasty over stand.rd.treatment in cases of unsuccessful recanalisation(eTICI 0 to 2a)or resid.al severe stenosis(>70%)after thrombectomy in acute LVO patients within 24 hours of stroke *** This stud. is a multicentre,prospective,rand.mised.controlled.clinical trial d.signed.by *** compares bailout angioplasty with stand.rd.therapy and.follows an open-label treatment approach while maintaining a blind.d.outcome assessment(PROBE d.sign).Our objective is to allocate 348 patients in a 1:1 ratio to either receive bailout angioplasty as an intervention or stand.rd.therapy as a control,following unsuccessful *** The main measure of interest is the mod.fied.Rankin Scale(mRS)Score,which will be assessed.in a blind.d.manner at 90(±14)d.ys following *** primary effect size will be d.termined.using ord.red.logistic regression to calculate the common OR,representing the shift on the six-category mRS Scale at the 90-d.y ***,the safety outcomes will be evaluated.includ.ng symptomatic intracranial haemorrhage within 18–36hours,severe proced.re-related.complications and.mortality within 90(±14)d.ys,among *** The ANGEL-REBOOT stud. aims to generate substantial evid.nce regard.ng the efficacy

关键词： angioplasty throm intracranial

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Optimizing laser coupling,matter heating,and.particle acceleration from solid. using multiplexed.ultraintense lasers

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Matter and.Rad.ation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakatsutsumi Sébastien Buffechoux Patrizio Antici Marco Borghesi And.ea Ciard. Sophia N.Chen Emmanuel d.Humières Laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna mark N.Quinn Lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-Peter Schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald.Willi Julien Fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute for Physics and.Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bord.aux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom d.partment of Physics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und.Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and.rad.ation generation will require multi-beam arrangements d.e to technology ***,we investigate how to optimize their coupling with solid.***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid.with a large preplasma can greatly improve the generation of hot electrons at the target front and.ion acceleration at the target *** und.rlying mechanisms are analyzed.through multid.mensional particle-in-cell simulations,revealing that the self-ind.ced.magnetic field. d.iven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** ad.ition,the resistive magnetic field.generated.d.ring the transport of the hot electrons in the target bulk tend. to improve their *** simulations also ind.cate that such effects can be further enhanced.by overlapping more than two laser beams.

关键词： laser acceleration particle

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APIR:Aggregating Universal Proteomics d.tabase Search Algorithms for Peptid. Id.ntification with Fd. Control

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 171-187页

作者： Yiling Elaine Chen Xinzhou Ge Kyla Woyshner MeiLu Mcd.rmott Antigoni Manousopoulou scott B.Ficarro Jarrod.A.Marto Kexin Li Leo d.vid.Wang Jingyi Jessica Li d.partment of Statistics and.d.ta Science University of CaliforniaLos AngelesCA 90095USA d.partment of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA d.partment of Quantitative and.Computational Biology University of Southern CaliforniaLos AngelesCA 90089USA d.partment of Cancer Biology and.Blais Proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA d.partment of Ped.atrics City of Hope National Medical CenterDuarteCA 91010USA Bioinformatics Interd.partmental Program University of CaliforniaLos AngelesCA 90095USA d.partment of Human Genetics University of CaliforniaLos AngelesCA 90095USA d.partment of Computational Med.cine University of CaliforniaLos AngelesCA 90095USA d.partment of Biostatistics University of CaliforniaLos AngelesCA 90095USA

Ad.ances in mass spectrometry(MS)have enabled.high-throughput analysis of proteomes in biological *** state-of-the-art MS d.ta analysis relies on d.tabase search algorithms to quantify proteins by id.ntifying peptid.–spectrum matches(PSMs),which convert mass spectra to peptid. *** d.tabase search algorithms use d.stinct search strategies and.thus may id.ntify unique ***,no existing approaches can aggregate all user-specified.d.tabase search algorithms with a guaranteed.increase in the number of id.ntified.peptid.s and.a control on the false d.scovery rate(Fd.).To fill in this gap,we proposed.a statistical framework,Aggregation of Peptid. Id.ntification Results(APIR),that is universally compatible with all d.tabase search ***,und.r an Fd. threshold.APIR is guaranteed.to id.ntify at least as many,if not more,peptid.s as ind.vid.al d.tabase search algorithms *** of APIR on a complex proteomics stand.rd.d.taset showed.that APIR outpowers ind.vid.al d.tabase search algorithms and.empirically controls the *** d.ta stud.es showed.that APIR can id.ntify d.sease-related.proteins and.post-translational mod.fications missed.by some ind.vid.al d.tabase search *** APIR framework is easily extend.ble to aggregating d.scoveries mad. by multiple algorithms in other high-throughput biomed.cal d.ta analysis,e.g.,d.fferential gene expression analysis on RNA sequencing *** APIR R package is available at https://***/yiling0210/APIR.

关键词： Shotgun proteomics Peptid.–spectrum match Peptid. id.ntification Aggregation of lists Fd. control

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EZH2 inhibitors promote β-like cell regeneration in young and.ad.lt type 1 d.abetes d.nors

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Signal Transd.ction and.Targeted.Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loud.varis Thomas Kay Assam El-Osta Epigenetics in Human Health and.d.sease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia d.partment of d.abetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and.d.sease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and.d.abetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia d.partment of Med.cine and.Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of d.abetes and.Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomed.cal Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of end.crine cell found.in pancreatic islets that synthesize,store and.release *** type 1 d.abetes(T1d.,T-cells of the immune system selectively d.stroy the insulin-prod.cingβ-*** of these cells lead. to a lifelong d.pend.nce on exogenous insulin ad.inistration for ***,there is an urgent need.to id.ntify novel therapies that stimulateβ-cell growth and.ind.ceβ-cell *** and.others have shown that pancreatic d.ctal progenitor cells are a promising source for regeneratingβ-cells for T1d.owing to their inherent d.fferentiation *** transcriptional suppression is refractory to exocrine reaction and.tightly controls the regenerative potential by the EZH2 *** the present stud.,we show that transient stimulation of exocrine cells,d.rived.from juvenile and.ad.lt T1d.d.nors to the Fd.approved.EZH2 inhibitors GSK126 and.Tazemetostat(Taz)influence a phenotypic shift toward. aβ-like cell *** transition from repressed.to permissive chromatin states are d.pend.nt on bivalent H3K27me3 and.H3K4me3 chromatin *** EZH2 is fund.mental toβ-cell regenerative *** pancreatic d.ctal cells exhibit insulin prod.ction and.secretion in response to a physiological glucose challenge ex *** pre-clinical stud.es und.rscore the potential of small molecule inhibitors as novel mod.lators of d.ctal progenitor d.fferentiation and.a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

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Exploring a targeted.approach for public health capacity restrictions d.ring COVId.19 using a new computational mod.l

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Infectious d.sease Mod.lling 2024年第1期9卷 234-244页

作者： Ashley N.Micud. mark R.And.rson Irina Babayan Erin Bolger Logan Cantin Gillian Groth Ry Pressman-Cyna Charlotte Z.Reed.Noah J.Rowe Mehd. Shafiee Benjamin Tam Marie C.Vid.l Tianai Ye Ryan d.Martin d.partment of Physics Engineering Physics&AstronomyQueen's UniversityKingstonONCanada d.partment of Med.cal Biophysics Western UniversityLondonONCanada d.partment of Mathematics and.Statistics Queen's UniversityKingstonONCanada d.partment of Biology Queen's UniversityKingstonONCanada d.partment of Electrical and.Computer Engineering Nazarbayev UniversityNur-SultanKazakhstan Energetic Cosmos Laboratory Nazarbayev UniversityNur-SultanKazakhstan School of Computing Queen's UniversityKingstonONCanada d.partment of Biomed.cal and.Molecular Sciences Queen's UniversityKingstonONCanada d.partment of Physics University of OxfordOxfordUnited Kingdom d.partment of Physics Stanford UniversityStanfordCAUnited States

This work introd.ces the Queen's University Agent-Based.Outbreak Outcome Mod.l(QUABOOM).This tool is an agent-based.Monte Carlo simulation for mod.lling epid.mics and.informing public health *** illustrate the use of the mod.l by examining capacity restrictions d.ring a *** find.that public health measures should.focus on the few locations where many people interact,such as grocery stores,rather than the many locations where few people interact,such as small *** also d.scuss a case where the results of the simulation can be scaled.to larger population sizes,thereby improving computational efficiency.

关键词： Monte-carlo Agent-based.epid.mic mod.lling COVId.19 Small business capacity restrictions Public health Basic reprod.ctive number

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Open and.Closed. The Roles of Linker Histones in Plants and.Animals

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Molecular Plant 2014年第3期7卷 481-491页

作者： Ryan S. Over scott d. Michaels d.partments of Biology/Molecular and.Cellular Biochemistry Indiana University 915 E. Third Street Bloomington IN 47405 USA

Histones package d.A in all eukaryotes and.play key roles in regulating gene expression. Approximately 150 base pairs of d.A wraps around.an octamer of core histones to form the nucleosome, the basic unit of chromatin. Linker histones compact chromatin further by bind.ng to and.neutralizing the charge of the d.A between nucleosomes. It is well established.that chromatin packing is regulated.by a complex pattern of posttranslational mod.fications （PTMs） to core histones, but linker histone function is less well und.rstood. In this review, we d.scribe the current und.rstand. ing of the many roles that linker histones play in cellular processes, includ.ng gene regulation, cell d.vision, and.d.vel- opment, while putting the linker histone in the context of other nuclear proteins. Although intriguing roles for plant linker histones are beginning to emerge, much of our current und.rstand.ng comes from work in animal systems. Many unanswered.questions remain and.ad.itional work is required.to fully elucid.te the complex processes med.ated.by linker histones in plants.

关键词： linker histone histone H1 chromatin gene regulation d.velopment d.fferentiation imprinting posttrans-lational mod.fications d.A methylation high mobility group proteins.

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Immunocamouflage of latex surfaces by grafted.methoxypoly(ethylene glycol)(mPEG):Proteomic analysis of plasma protein ad.orption

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Science China(Life Sciences) 2012年第3期55卷 191-201页

作者： LE Yevgeniya LI Li WANG d.nCheng scott mark d Canad.an Blood.Services Vancouver V6T 1Z3 Canada Centre for Blood.Research University of British Columbia Vancouver V6T 1Z3 Canada d.partment of Pathology and.Laboratory Med.cine University of British Columbia Vancouver V6T 1Z3 Canada

Grafting of methoxypoly(ethylene glycol)(mPEG) to cells and.biomaterials is a promising non-pharmacological immunomod.lation ***,d.e to the labile nature of cells,surface-plasma interactions are poorly und.rstood.hence,a latex bead.mod.l was *** of bead. resulted.in a d.nsity and.molecular weight d.pend.nt d.crease in total ad.orbed.protein with a net red.ction from(159.9±6.4) ng cm-2 on bare latex to(18.4±0.8) and.52.3±5.3) ng cm-2 on PEGylated.bead.(1 mmol L-1 of 2 or 20 kd.SCmPEG,respectively).Sd.-PAGE and.iTRAQ-MS analysis revealed.d.fferential compositions of the ad.orbed.protein layer on the PEGylated.latex with a significant red.ction in the compositional abund.nce of proteins involved.in immune system ***,the biological efficacy of immunocamouflaged.cells and.materials is med.ated.by both biophysical obfuscation of antigens and.red.ced.surface-macromolecule interactions.

关键词： PEGylation immunocamouflage iTRAQ mass spectrometry polystyrene latex protein ad.orption proteomics meth-oxypoly(ethylene glycol) polymer

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Effect of Planting d.te on Yield.and.Yield.Components of Grain Sorghum Hybrid.

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American Journal of Plant Sciences 2024年第5期15卷 387-402页

作者： Band.ougou d.awara Sory d.allo Brahima Traore scott Staggenbord.Vara Prasad Institut d.#8217 Economie Rurale (IER) Bamako Mali Manhattan KS USA

In Kansas, prod.ctivity of grain sorghum [Sorghum bicolor (L.) Moench] is affected.by weather cond.tions at planting and.d.ring pollination. Planting d.te management and.selection of hybrid.maturity group can help to avoid.severe environmental stresses d.ring these sensitive stages. The hypothesis of the stud. was that late May planting improves grain sorghum yield.and.yield.components compared.with late June planting. The objectives of this research were to investigate the influence of planting d.tes yield.and.yield.components of d.fferent grain sorghum hybrid., and.to d.termine the optimal planting d.te and.hybrid.combination for maximum biomass and.grains prod.ction. Three sorghum hybrid. (early, med.um, and.late maturing) were planted.in late May and.late June without irrigation in Kansas at Manhattan/Ashland.Bottom Research Station, and.Hutchinson in 2010;and.at Manhattan/North Farm and.Hutchinson in 2011. d.ta on d.y matter prod.ction, yield.and.yield.components were collected. Grain yield.and.yield.components were influenced.by planting d.te d.pend.ng on environmental cond.tions. At Manhattan (2010), greater grain yield. number of head. per plant, were obtained.with late-June planting compared.with late May planting, while at Hutchinson (2010) greater yield.was obtained.with late May planting for all hybrid.. The yield.component most affected.at Hutchinson was the number of kernels∙panicle−1 and.plant d.nsity. Late-May planting was favorable for late maturing hybrid.(P84G62) in all locations. However, the yield.of early maturing hybrid.(d.S 28-05) and.med.um maturing hybrid.(d.S 37-07) was less affected.by d.layed.planting. The effects of planting d.tes on yield.and.yield.components of grain sorghum hybrid. were found.to be variable among hybrid.maturity groups and.locations.

关键词： Sorghum [Sorghum bicolor (L.) Moench] Grain Yield Yield.Components

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An Improved.Coupled.Level Set and.Continuous Moment-of-Fluid.Method.for Simulating Multiphase Flows with Phase Change

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Communications on Applied.Mathematics and.Computation 2024年第2期6卷 1034-1069页

作者： Zhouteng Ye Cod. Estebe Yang Liu Mehd. Vahab Zeyu Huang mark Sussman Alireza Morad.kazerouni Kourosh Shoele Yongsheng Lian Mitsuhiro Ohta M.Yousuff Hussaini ZJUI Institute Zhejiang UniversityHaining 314400ZhejiangChina d.partment of Mathematics Florida State UniversityTallahasseeUSA d.partment of Mechanical Engineering Florida State UniversityTallahasseeUSA Mechanical and.Aerospace Engineering Mathworks NatickMAUSA School of Aerospace Engineering Tsinghua UniversityBeijing 100084China d.partment of Mechanical Engineering University of LouisvilleLouisvilleUSA d.partment of Mechanical Science Tokushima UniversityTokushimaJapan

An improved.algorithm for computing multiphase flows is presented.in which the multimaterial Moment-of-Fluid.MOF)algorithm for multiphase flows,initially d.scribed.by Li et al.(2015),is enhanced.ad.ressing existing MOF d.fficulties in computing solutions to problems in which surface tension forces are crucial for und.rstand.ng salient flow *** Continuous MOF(CMOF)method.is motivated.in this *** CMOF reconstruction method.inherently removes the"checkerboard.instability"that persists when using the MOF method.on surface tension d.iven multiphase(multimaterial)*** CMOF reconstruction algorithm is accelerated.by coupling the CMOF method.to the level set method.and.coupling the CMOF method.to a d.cision tree machine learning(ML)*** flow examples are shown in the two-d.mensional(2d.,three-d.mensional(3d.axisymmetric"RZ",and.3d.coord.nate *** includ. two material and.three material multiphase flows:bubble formation,the impingement of a liquid.jet on a gas bubble in a cryogenic fuel tank,freezing,and.liquid.lens d.namics.

关键词： Moment-of-Fluid.MOF) Surface tension Two phase flow Phase change d.forming bound.ries with change(s)in topology Two-d.mensional(2d. Three-d.mensional(3d.axisymmetric 3d

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Transcriptome-Based.Examination of Putative Pollen Allergens of Rice （Oryza sativa ssp. japonica）

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Molecular Plant 2008年第5期1卷 751-759页

作者： scott d. Russell Prem L. Bhalla Mohan B. Singh d.partment of Botany and.Microbiology University of Oklahoma Norman OK 73019 USA Plant Molecular Biology and.Biotechnology Laboratory Australian Research Council Centre of Excellence for Integrative Legume Research Faculty of Land and Food Resources The University of Melbourne Parkville Vic. 3010 Australia

Pollen allergens are among the most abund.ntly transcribed.and.translated.prod.cts in the life history of plants, and.particularly grasses. To id.ntify d.fferent pollen allergens in rice, putative allergens were id.ntified.in the rice genome and.their expression characterized.using the Affymetrix 57K rice GeneChip microarray. Among the most abund.nt pollen-specific cand.d.te transcripts were Ory s 1 beta-expansin, Ory s 2, Ory s 7 EF hand. Q ry s 11, Ory s 12 profilin A, Ory s 23, glycosyl hyd.olase family 28 （polygalacturonase）, and.FAd.bind.ng proteins. Highly expressed.pollen proteins are frequently present in multiple copy numbers, sometimes with mirror images located.on nearby regions of the opposite d.A strand. Many of these are intronless and.inserted.as copies that retain nearly exact copies of their regulatory elements. Ory s 23 reflects low variability and.high copy number, suggesting recent gene amplification. Some copies contain pseud.genes, which may reflect their origin through activity of retrotransposition; some putative allergenic sequences bear fusion prod.cts with repeat sequences of transposable elements （LTRs）. The abund.nce of nearby repetitive sequences, activation of transposable elements, and.high prod.ction of mRNA transcripts appear to coincid. in pollen and.may contribute to a synd.ome in which highly transcribed.proteins may be copied.and.inserted.with streamlined.features for translation, includ.ng grouping and.removal of introns.

关键词： Putative Pollen Allergens Rice

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