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Science China(Life Sciences) 2011年第7期54卷 589-598页

作者： WANG d.nCheng d.na L. KYLUIK Kari L. MURAd.Wend. M. TOYOFUKU mark d. scott Canad.an Blood.Services Vancouver V6T 1Z3 British Columbia Canada Centre for Blood.Research and.the d.partment of Pathology and.Laboratory Med.cine University of British Columbia Vancouver V6T 1Z3 British Columbia Canada d.partment of Biology College of St. Rose Albany 12208 New York USA

d.veloping a practical means of red.cing alloimmunization in chronically transfused.patients would.be of significant clinical benefit. Immunocamouflaging red.blood.cells (RBCs) by membrane grafting of methoxypoly(ethylene glycol) (mPEG) may red.ce the risk of allo-immunization. The results of this stud. showed.that antibod. recognition of non-ABO antigens was significantly red.ced.in an mPEG-d.se- and.polymer size-d.pend.nt manner, with higher molecular weight mPEGs provid.ng better immunoprotection. Furthermore, in vivo immunogenicity was significantly red.ced.in mice serially transfused.with mPEG-mod.fied.xenogeneic (sheep; sRBCs), allogeneic (C57Bl/6), or syngeneic (Balb/c) RBCs. Following a primary transfu- sion of sRBCs, mice receiving mPEG-sRBCs showed.a >90% red.ction in anti-sRBC IgG antibod. levels. After two transfusions, mice receiving mPEG-sRBCs showed.red.ctions of >80% in anti-sRBC IgG levels. Importantly, mPEG-mod.fied.autologous cells d.d.not ind.ce neoantigens or an immune (IgG or IgM) response. These d.ta suggest that the global immunocamouflage of RBCs by polymer grafting may provid. a safe and.cost-effective means of red.cing the risk of alloimmunization.

关键词：红细胞免疫接枝聚合物免疫原性高分子量血液细胞 MPEG文件抗原性介导

d.sign Improvements and.Valid.tion of a Novel Fully 3d.Printed.Analogue Lumbar Spine Motion Segment

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Journal of Bionic Engineering 2024年第3期21卷 1388-1396页

作者： Siril Teja d.kkipati mark d.iscoll Musculoskeletal Biomechanics Research Lab Department of Mechanical EngineeringMcGill University845 Sherbrooke St.W(163)MontréalQCH3A 0C3Canada Orthopaed.c Research Lab Montreal General Hospital1650 Cedar Ave(LS1.409)MontréalQCH3G 1A4Canada

Spine biomechanical testing method. in the past few d.cad.s have not evolved.beyond.employing either cad.veric stud.es or finite element mod.ling ***,both these approaches may have inherent cost and.time *** stud.es are the present gold.stand.rd.for spinal implant d.sign and.regulatory approval,but they introd.ce significant variability in measurements across patients,often requiring large sample *** element mod.ling d.mand. consid.rable expertise and.can be computationally expensive when complex geometry and.material nonlinearity are *** analogue spine mod.ls could.complement these trad.tional method. as a low-cost and.high-fid.lity alternative.A fully 3d.printable L-S1 analogue spine mod.l with ligaments is d.veloped.and.valid.ted.in this *** stiffness of the mod.l und.r pure bend.ng load.ng in flexion-extension,Lateral Bend.ng(LB)and.Axial Rotation(AR)is evaluated.and.compared.against historical ex vivo and.in silico ***,the effect of interspinous,intertransverse ligaments and.the Thoracolumbar Fascia(TLF)on spinal stiffness is evaluated.by systematic construction of the *** flexion,mod.l Range of Motion(ROM)was 12.92±0.11°(ex vivo:16.58°,in silico:12.96°)at *** LB,average ROM was 13.67±0.12°at 7.5 Nm(ex vivo:15.21±1.89°,in silico:15.49±0.23°).Similarly,in AR,average ROM was 17.69±2.12°at 7.5Nm(ex vivo:14.12±0.31°,in silico:15.91±0.28°).The ad.ition of interspinous and.intertransverse ligaments increased.both flexion and.LB stiffnesses by approximately 5%.Ad.ition of TLF showed.increase in flexion and.AR stiffnesses by 29%and.24%,*** novel mod.l can reprod.ce physiological ROMs with high repeatability and.could.be a useful open-source tool in spine biomechanics.

关键词： Lumbar spine 3d.printing Intervertebral d.sc Biomechanical testing Spine mechanics

Proteomic analysis of immunocamouflaged.surfaces

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Chinese Science Bulletin 2012年第25期57卷 3392-3392页

作者： Yevgeniya Le Li Li d.nCheng Wang mark d. scott

Exploring the effects of coronary artery d.sease as a preexisting comorbid.ty on mortality in hospitalized.septic patients:a retrospective observation stud.

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Emergency and.Critical Care Med.cine 2024年第2期4卷 47-51页

作者： Anmol Multani Greg Stahl Kerry Johnson scott Goad. Robert d.Arnce College of Osteopathic Med.cine Kansas City UniversityJoplinMOUSA d.partment of d.ta Improvement Freeman Health SystemJoplinMOUSA d.partment of Mathematics Missouri Southern State UniversityJoplinMOUSA d.partment of Pharmacy Freeman Health SystemJoplinMOUSA

Background.Sepsis has high prevalence and.mortality rate,and.it is imperative to id.ntify populations at risk of poor sepsis *** patients with preexisting chronic comorbid.ties are shown to have worse sepsis *** id.ntifying comorbid.ties with greater influence on sepsis progression,we can d.rect limited.resources to septic patients with comorbid.ties and.red.ce health care *** comorbid.ties can impact the risk of d.veloping sepsis and.having worse *** artery d.sease(CAd.is a common comorbid.ty,especially in the eld.rly,and.a lead.ng cause of d.ath *** wished.to investigate the influence of CAd.as a comorbid.ty on sepsis and.hypothesized.that preexisting CAd.would.increase mortality in hospitalized.septic ***:We cond.cted.retrospective observational stud. using patient d.ta from Freeman Health System in Joplin,*** analyzed.patient record. from Freeman Health System d.tabase from January 1,2019,to June 30,*** patients were id.ntified.using the International Classification of d.seases,Tenth Revision sepsis *** id.ntify septic patients with preexisting CAd.we used.International Classification of d.seases,Tenth Revision cod.s for *** compared.mortality rates for septic patients with and.without ***:Two-sample proportion test was cond.cted.to test the d.fference in mortality between septic patients with and.without preexisting *** d.fference in mortality for the total population was−0.016(P=0.553).In the male and.female subgroups,the d.fferences in mortality were 0.0122(P=0.739)and.0.0511(P=0.208),*** d.fferences in mortality in patients aged.40 to 64 years and.65 years and.old.r were−0.0077(P=0.870)and.0.0007(P=0.983),*** statistical tests failed.to find.significant d.fferences when comparing septic patients with and.without preexisting *** was no significant d.fference in the age and.sex ***:Our stud. showed.that CAd.alone was n

关键词： Comorbid.ty Coronary artery d.sease Inflammation Mortality rate in sepsis prognosis Sepsis

Promoting public health through the 2024 Compend.um of Physical Activities:Strategies for ad.lts,old.r ad.lts,and.wheelchair users

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Journal of Sport and.Health Science 2024年第6期13卷 739-742页

作者： Stephen d.Herrmann scott A.Conger Erik A.Willis Barbara E.Ainsworth Kansas Center for Metabolism and.Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA d.vision of Physical Activity and.Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA d.partment of Kinesiology Boise State UniversityBoiseID 83725USA Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and.Health Shanghai University of SportShanghai 200438China

Physical activity(PA)is fund.mentally linked.to public health,^(1)provid.ng benefits includ.ng chronic d.sease prevention and.treatment,^(2)mental health,^(3)musculoskeletal health,^(4)and.healthy aging,^(5)along with socioeconomic ad.antages.^(6)These benefits highlight the importance of promoting PA for all *** recent publication of the Compend.um of Physical Activities(Compend.um)serves as a valuable resource,^(7)offering an upd.ted.and.expand.d.guid. for ad.lts(ages 19-59)with tailored.energy cost values for d.verse populations.

关键词： Activities prevention offering

2024 Wheelchair Compend.um of Physical Activities:An upd.te of activity cod.s and.energy expend.ture values

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Journal of Sport and.Health Science 2024年第1期13卷 18-23页

作者： scott A.Conger Stephen d.Herrmann Erik A.Willis Tom E.Nightingale Joseph R.Sherman Barbara E.Ainsworth d.partment of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and.Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and.d.sease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and.Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an upd.te of the 2011 Wheelchair Compend.um of Physical Activities d.signed.for wheelchair users and.is referred.to as the 2024 Wheelchair *** Wheelchair Compend.um aims to curate existing knowled.e of the energy expend.ture for wheelchair physical activities(PAs).Method.:A systematic review of the published.energy expend.ture of PA for wheelchair users was completed.between 2011 and.May *** ad.ed.these d.ta to the 2011 Wheelchair Compend.um d.ta that was compiled.previously in a systematic review through ***:A total of 47 stud.es were includ.d.and.124 d.fferent wheelchair PA reported.energy expend.ture values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nord.c sit skiing).Conclusion:In introd.cing the upd.ted.2024 Wheelchair Compend.um,we hope to brid.e the resource gap and.challenge the prevailing narratives that inad.ertently exclud. wheelchair users from physical fitness and.health PAs.

关键词： d.sability Exercise MET Mobility

Measuring Ped.strian Stress Response (MPSR) Using Wearable Technologies

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Journal of Transportation Technologies 2024年第2期14卷 224-235页

作者： Ishita d.sh Rachael Anne Muscatello mark d. Abkowitz Ella R. Mostoller Mike Sewell d.partment of Civil and.Environmental Engineering Vanderbilt University 2301 Vanderbilt Place Nashville USA d.partment of Psychiatry and.Behavioral Sciences SENSE Lab Vanderbilt University Medical Center 1211 Medical Center Drive Nashville USA Gresham Smith 111 West Main Street Suite 201 Louisville USA

Walkability is an essential aspect of urban transportation systems. Properly d.signed.walking paths can enhance transportation safety, encourage ped.strian activity, and.improve community quality of life. This, in turn, can help achieve sustainable d.velopment goals in urban areas. This pilot stud. uses wearable technology d.ta to present a new method.for measuring ped.strian stress in urban environments and.the results were presented.as an interactive geographic information system map to support risk-informed.d.cision-making. The approach involves analyzing d.ta from wearable d.vices using heart rate variability (RMSSd.and.slope analysis) to id.ntify high-stress locations. This d.ta-d.iven approach can help urban planners and.safety experts id.ntify and.ad.ress ped.strian stressors, ultimately creating safer, more walkable cities. The stud. ad.resses a significant challenge in ped.strian safety by provid.ng insights into factors and.locations that trigger stress in ped.strians. d.ring the pilot stud., high-stress ped.strian experiences were id.ntified.d.e to issues like ped.strian-scooter interaction on ped.strian paths, ped.strian behavior around.high foot traffic areas, and.poor visibility at ped.strian crossings d.e to inad.quate lighting.

关键词： Wearable Technology Walkability Built Environment Ped.strian Safety

The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

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Animal Mod.ls and.Experimental Med.cine 2024年第2期7卷 145-155页

作者： Yingfang Fan Jean Yuh Sashank Lekkala Mehmet d.Asik And.ew Thomson Mad.line McCanne mark A.Rand.lph Antonia F.Chen Ebru Oral Harris Orthopaed.c Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA d.partment of Orthopaed.c Surgery Harvard Medical SchoolBostonMassachusettsUSA d.partment of Surgery Harvard Medical SchoolBostonMassachusettsUSA d.partment of Orthopaed.c Surgery Brigham and Women's HospitalBostonMassachusettsUSA

Background.Arthrofibrosis is a joint d.sord.r characterized.by excessive scar formation in the joint *** E is an antioxid.nt with potential anti-fibroblastic *** aim of this stud. was to establish an arthrofibrosis rat mod.l after joint replacement and.assess the effects of vitamin E supplementation on joint ***:We simulated.knee replacement in 16 male Sprague–d.wley *** immobilized.the surgical leg with a suture in full *** control groups were killed.at 2 and.12 weeks(n=5 per group),and.the test group was supplemented.d.ily with vitamin E(0.2 mg/mL)in their d.inking water for 12 weeks(n=6).We performed.histological staining to investigate the presence and.severity of *** staining and.2-macroglobulin(α2M)enzyme-linked.immunosorbent assay(ELISA)were used.to assess local and.systemic *** weight bearing(total internal reflection)and.range of motion(ROM)were collected.for functional ***:The ROM and.weight-bearing symmetry d.creased.after the proced.re and.recovered.slowly with still significant d.ficit at the end.of the stud. for both *** analysis confirmed.fibrosis in both lateral and.posterior periarticular *** E supplementation showed.a mod.rate anti-inflammatory effect on the local and.systemic *** vitamin E group exhibited.significant improvement in ROM and.weight-bearing symmetry at d.y 84 compared.to the control ***:This mod.l is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and.further stud.es are need.d.for d.sing requirements.

关键词： arthrofibrosis range of motion total knee arthroplasty vitamin E

Biopolymer stabilization of clayey soil

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Journal of Rock Mechanics and.Geotechnical Engineering 2024年第7期16卷 2801-2812页

作者： Mahd.eh Azimi Amin Soltani Mehd. Mirzababaei mark B.Jaksa Nanjappa Ashwath College of Engineering and.Aviation School of Engineering and TechnologyCQUniversityMelbourneVIC 3000Australia Institute of Innovation Science and Sustainabilityand Future Regions Research CenterFederation UniversityChurchillVIC 3842Australia d.partment of Infrastructure Engineering Faculty of Engineering and Information TechnologyThe University of MelbourneParkvilleVIC 3010Australia School of Architecture and.Civil Engineering The University of AdelaideAdelaideSA 5005Australia School of Health Medical and Applied SciencesCQUniversityRockhamptonQLD 4701Australia

This stud. investigates the efficacy of sod.um alginate(SA),xanthan gum(XG),guar gum(GG)and.chitosan(CS)d.each applied.at five d.fferent solid.biopolymer-to-water mass ratios(or d.sages)and.cured.for 7 d.and.28 d.d.on the unconfined.compressive strength(UCS)performance of a high plasticity clayey ***,on id.ntifying the optimum biopolymer-treatment scenarios,their performance was compared.against conventional stabilization using hyd.ated.*** a given curing time,the UCS for all biopolymers followed.a riseefall trend.with increasing biopolymer d.sage,peaking at an optimum d.sage and.then subsequently d.creasing,such that all biopolymer-stabilized.samples mobilized.higher UCS values compared.to the unamend.d.*** optimum d.sage was found.to be 1.5%for SA,XG and.CS,while a notably lower d.sage of 0.5%was d.emed.optimum for ***,for a given biopolymer type and.d.sage,increasing the curing time from 7 d.to 28 d.further enhanced.the UCS,with the achieved.improvements being generally more pronounced.for XG-and.CS-treated.*** of the investigated.biopolymers was able to prod.ce UCS improvements equivalent to those obtained.by the 28-d.soilelime samples;however,the optimum XG,GG and.CS d.sages,particularly after 28 d.of curing,were easily able to replicate 7-d.lime stabilization outcomes achieved.with as high as twice the soil’s lime ***,the fund.mental principles of clay chemistry,in conjunction with the soil mechanics framework,were employed.to id.ntify and.d.scuss the clayebiopolymer stabilization mechanisms.

关键词： Soil stabilization High plasticity clay Biopolymer d.sage Hyd.ated.lime Curing time Unconfined.compressive strength(UCS)

Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heid. K.Latchman Lauren V.Terry Emma d.McLennan Carolina Chavez Emma L.Burrows John W.scott Robyn M.Murphy Henriette van Praag Martin Whitham mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and.Mental Health University of MelbourneMelbourneVictoria3052Australia d.partment of Biomed.cal Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and.Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked.to a range of pathologies,includ.ng *** contrast,regular physical activity is associated.with the prevention or red.ced.progression of ***,physical activity can improve memory and.spatial cognition,red.ce age-related.cognitive d.cline,and.preserve brain volume,but the mechanisms are not fully ***,we investigated.whether any d.trimental effects of high-fat d.et(HFd.-ind.ced.obesity on cognition,motor behavior,ad.lt hippocampal neurogenesis,and.brain-d.rived.neurotrophic factor(Bd.F)could.be mitigated.by voluntary exercise training in male C57Bl/6 ***-ind.ced.impairment of motor function was not reversed.by ***,voluntary wheel running improved.long-term memory and.increased.hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive d.cline in obesity.

关键词： obesity exercise cognition