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Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases

International Journal of Ophthalmology(English edition) 2019年第5期12卷 779-783页

作者： Michael Kinori Narasimhan Jagannathan Anne M Langguth marjorie a sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid The Goldschleger Eye Institute Sheba Medical CenterTel Ha ShomerAffiliated to the Sackler Faculty of MedicineTel Aviv University Department of Pediatric Anesthesiology Ann & Robert H.Lurie Children's Hospital of Chicago Division of Ophthalmology Ann & Robert H.Lurie Children's Hospital of Chicago Department of Ophthalmology Northwestern University Feinberg School of Medicine Department of Surgical Services Ann & Robert H.Lurie Children's Hospital of Chicago

AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions.

关键词： posterior capsular opacification YAG capsulotomy general anesthesia pediatric cataract

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Shock index and its variants as predictors of mortality in severe traumatic brain injury

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World Journal of Critical Care Medicine 2024年第1期13卷 40-48页

作者： Randhall B Carteri Mateus Padilha Silvaine sasso de Quadros Eder Kroeff Cardoso Mateus Grellert Department of Nutrition Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Analysis and Systems Development Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Nutrition Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Department of Physiotherapy Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Institute of Informatics Federal University of Rio Grande do Sul(UFRGS)Porto Alegre 91501-970Rio Grande do SulBrazil

BACKGROUND The increase in severe traumatic brain injury(sTBI)incidence is a worldwide phenomenon,resulting in a heavy disease burden in the public health systems,specifically in emerging *** shock index(SI)is a physiological parameter that indicates cardiovascular status and has been used as a tool to assess the presence and severity of shock,which is increased in *** the high mortality of sTBI,scrutinizing the predictive potential of SI and its variants is *** To describe the predictive potential of SI and its variants in *** This study included 71 patients(61 men and 10 women)divided into two groups:Survival(S;n=49)and Non-survival(NS;n=22).The responses of blood pressure and heart rate(HR)were collected at admission and 48 h after *** SI,reverse SI(rSI),rSI multiplied by the Glasgow Coma Score(rSIG),and Age multiplied SI(AgeSI)were *** comparisons included Shapiro-Wilk tests,and independent samples *** predictive analysis,logistic regression,receiver operator curves(ROC)curves,and area under the curve(AUC)measurements were *** No significant differences between groups were identified for SI,rSI,or *** AgeSI was significantly higher in NS patients at 48 h following admission(S:26.32±14.2,and NS:37.27±17.8;P=0.016).Both the logistic regression and the AUC following ROC curve analysis showed that only AgeSI at 48 h was capable of predicting sTBI *** Although an altered balance between HR and blood pressure can provide insights into the adequacy of oxygen delivery to tissues and the overall cardiac function,only the AgeSI was a viable outcome-predictive tool in sTBI,warranting future research in different cohorts.

关键词： Head trauma Critical patient Neuro-cardio axis Predictive tool Clinical practice

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Vitamin B12-induced spermatogenesis recovery in cimetidine-treated rats： effect on the spermatogonia number and sperm concentration

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Asian Journal of Andrology 2017年第5期19卷 567-572页

作者： Flavia L Beltrame Estela sasso-Cerri Department of Morphology and Genetics Federal University of Sao Paulo (UNIFESP/EPM) Sao Paulo Brazil Department of Morphology Laboratory f Histology and Embryology Dental School - Sao Paulo State University (UNESP/FOAr) Araraquara Sao Paulo Brazil

The H2-receptor antagonist cimetidine is an antiulcer drug also used for the treatment of cancer due to its antiangiogenic effect. However, this drug has caused structural changes in the seminiferous tubules. Vitamin B12 has been used as a therapeutic agent for the treatment of male infertility. The supplementation of rats with vitamin B12 during cimetidine treatment has recovered the damaged seminiferous tubules, but how this vitamin restores the seminiferous epithelium has not been clarified. In this study, we evaluated whether vitamin B12 improves the number of spermatogonia, spermatocytes, and sperm concentration in cimetidine-treated rats. Adult male rats were treated for 50 days as follows： cimetidine group received 100 mg kg^-1 b.w. of cimetidine, cimetidine-B12 group received cimetidine and 3 μg of vitamin B12-hydroxocobalamin, B12 group received only 3 μg of vitamin, and control group received saline. Sperm concentration was calculated and historesin-embedded testes sections were used for the quantitative analyses of spermatogonia （A; In/B） and spermatocytes. TUNEL method and PCNA immunofluorescence were performed. Cimetidine caused a significant reduction in sperm concentration. TUNEL-positive spermatogonia and spermatocytes were correlated to a significant reduction in the number of these cells. In cimetidine-B12 group, sperm concentration was higher than cimetidine group and a significant increase in the number of spermatogonia （stages Ⅱ-Ⅵ） was correlated to a high incidence of PCNA-immunolabeled spermatogonia and spermatocytes. The results show that the supplementation of rats with vitamin B12 during cimetidine treatment increases sperm concentration and exerts a potential effect in the recovery of spermatogonia and spermatocytes.

关键词： cimetidine fertility spermatogenesis testis vitamin B12

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Depression and chronic heart failure in the elderly： an intriguing relationship

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Journal of Geriatric Cardiology 2018年第6期15卷 451-459页

作者： Ilaria Liguori Gennaro Russo Francesco Curcio Giuseppe sasso David Della-Morte Gaetano Gargiulo Flora Pirozzi Francesco Cacciatore Domenico Bonaduce Pasquale Abete Gianluca Testa Department of Translational Medical Sciences University of Naples 'Federico Ⅱ' Naples Italy Department of Systems Medicine University of Rome Tor Vergata Rome ltaly IRCCS San Raffaele Pisana Rome Italy Division of Internal Medicine A OU San Giovanni di Dio e Ruggi di Aragona Salerno Italy Azienda Ospedaliera dei Colli Monaldi Hospital Heart Transplantation Unit Naples Italy Department of Medicine and Health Sciences University of Molise Campobasso Italy

Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outcomes and vice versa, especially in the elderly. The negative synergism between chronic heart failure and depression in the elderly may be approached only taking into account the multifaceted pathophysiological characteristics underlying both these conditions, such as behavioural factors, neurohormonal activation, inflammatory mediators, hypercoagulability and vascular damage. Nevertheless, the pathophysiological link between these two conditions is not well established yet. Despite the high prevalence of depression in chronic heart failure elderly patients and its negative prognostic value, it is often unrecognized especially because of shared symptoms. So the screening of mood disorders, using reliable questionnaires, is recommended in elderly patients with chronic heart failure, even if cannot substitute a diagnostic interview by mental health professionals. In this setting, treatment of depression requires a multidisciplinary approach including： psychotherapy, antidepressants, exercise training and electroconvulsive therapy. Pharmacological therapy with selective serotonin reuptake inhibitors, despite conflicting results, improves quality of life but does not guarantee better outcomes. Exercise training is effective in improving quality of life and prognosis but at the same time cardiac rehabilitation services are vastly underutilized.

关键词： Chronic heart failure Depression The elderly

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Predictors of early and late hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2023年第8期29卷 1243-1260页

作者： Riccardo Nevola Rachele Ruocco Livio Criscuolo Angela Villani Maria Alfano Domenico Beccia Simona Imbriani Ernesto Claar Domenico Cozzolino Ferdinando Carlo sasso Aldo Marrone Luigi Elio Adinolfi Luca Rinaldi Department of Advanced Medical and Surgical Sciences University of Campania“Luigi Vanvitelli”Naples 80138Italy Internal Medicine and Hepatology Unit Ospedale Evangelico BetaniaNaples 80147Italy

Hepatocellular carcinoma(HCC)is the most frequent liver neoplasm,and its incidence rates are constantly *** the availability of potentially curative treatments(liver transplantation,surgical resection,thermal ablation),long-term outcomes are affected by a high recurrence rate(up to 70%of cases 5 years after treatment).HCC recurrence within 2 years of treatment is defined as“early”and is generally caused by the occult intrahepatic spread of the primary neoplasm and related to the tumor burden.A recurrence that occurs after 2 years of treatment is defined as“late”and is related to de novo HCC,independent of the primary *** HCC recurrence has a significantly poorer prognosis and outcome than late *** pathogenesis corresponds to different predictors of the risk of early or late *** adequate knowledge of predictive factors and recurrence risk stratification guides the therapeutic strategy and post-treatment *** at high risk of HCC recurrence should be referred to treatments with the lowest recurrence rate and when standardized to combined or adjuvant therapy *** review aimed to expose the recurrence predictors and examine the differences between predictors of early and late recurrence.

关键词： Hepatocellular carcinoma Early recurrence Late recurrence Predictors Liver transplant Liver resection Thermal ablation

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Shade and sapling size influence restoration of Araucaria angustifolia

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Journal of Forestry Research 2021年第5期32卷 1833-1841页

作者： Simone Aparecida Zolet sasso JoséAbramo Marchese Amanda Pacheco Cardoso Moura Bruna Valéria Gil Anelise Tessari Perboni Joel Donazzolo Fabrícia Lorrane Rodrigues Oliveira Bruno Francisco Sant’Anna-Santos Angela Rohr Moeses Andrigo Danner Agronomy Department Universidade Tecnológica Federal do Paraná(UTFPR)Campus Pato BrancoVia do Conhecimentokm 01Pato BrancoParaná85503-390Brazil UTFPR Campus Dois VizinhosEstrada para Boa Esperançakm 04Dois VizinhosParaná85660-000Brazil Biological Sciences Department Universidade Federal do Paraná(UFPR)Avenida Coronel Francisco H.dos Santos100CuritibaParaná81531-980Brazil

Toward improving reforestation of Brazilian pine(Araucaria angustifolia),two contrasting sapling sizes in either full sun or in the shade of a mixed plantation and the effect of opening the canopy were evaluated for survival,growth,gas exchange,photosynthetic pigments,and leaf anatomy 18 months after being *** 23 months after planting,a partial opening was made in the canopy in the mixed plantation,then the saplings were evaluated again after 2 months for the same morphophysiological *** 18 months,saplings planted in the full sun had higher survival,growth,pigments,and photosynthesis compared to the shaded *** saplings had higher survival and growth compared to the small *** leaves were thinner and little differentiation of palisade parenchyma and *** opening of the canopy,photo synthetically active radiation was 10 times higher,and the saplings quickly grew in height due to increased ***,although the species can tolerate shade,growth in the shade is *** recommend that for reforestation purposes of Brazilian pine,large saplings should be selected and planted in the open for better development.

关键词： Brazilian pine Luminosity Gas exchanges Photosynthetic pigments Leaf anatomy

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采用GC/MS方法检测苹果汁和苹果酒中的天然棒曲霉素

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食品安全导刊 2015年第4期 30-31页

作者： Pat sasso 安捷伦科技有限公司

随着苹果生长期的延长以及苹果和苹果浓缩汁出口能力的提高,它们摄入污染产品的可能性也随之增加。棒曲霉素是一种真菌霉素,在苹果腐烂过程中产生.本文描述了一种采用安捷伦超高惰性色谱柱检测棒曲霉素的方法,该方法无需样品衍生化。该... 详细信息

随着苹果生长期的延长以及苹果和苹果浓缩汁出口能力的提高,它们摄入污染产品的可能性也随之增加。棒曲霉素是一种真菌霉素,在苹果腐烂过程中产生.本文描述了一种采用安捷伦超高惰性色谱柱检测棒曲霉素的方法,该方法无需样品衍生化。该色谱分析方法可以分离5-羟甲级糠醛（HMF）,它是一种由苹果产品中的糖在过度加热时生成的产物。

关键词：棒曲霉素 GC/MS 苹果酒苹果浓缩汁菌霉素出口能力二乙烯苯固相萃取果汁生产污染产品

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Covalent functionalization of decellularized tissues accelerates endothelialization

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Bioactive Materials 2021年第11期6卷 3851-3864页

作者： Eleonora Dal sasso Annj Zamuner Andrea Filippi Filippo Romanato Tiziana Palmosi Luca Vedovelli Dario Gregori Jose Luís Gòmez Ribelles Teresa Russo Antonio Gloria Laura Iop Gino Gerosa Monica Dettin Department of Cardiac Thoracic and Vascular Sciences and Venetian Institute of Molecular MedicinePaduaItaly Department of Industrial Engineering University of PaduaPaduaItaly LIFELAB Program Consorzio per la Ricerca SanitariaCORISVeneto RegionItaly Department of Physics and Astronomy“G.Galilei” University of PaduaPaduaItaly Fondazione Bruno Kessler TrentoItaly Institute of Pediatric Research Citt`a della Speranza PaduaItaly Center for Biomaterials and Tissue Engineering CBITUniversitat Polit`ecnica de Val`enciaVal`enciaSpain Biomedical Research Networking Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValenciaSpain Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyNaplesItaly

In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological *** drawbacks might be prevented by specific biomaterial functionalization to induce selective endothelial cell(EC)*** bovine pericardia and porcine aortas were selectively functionalized with a REDV tetrapeptide at 10^(-5)M and 10^(-6)M working *** scaffold-bound peptide was quantified and REDV potential EC adhesion enhancement was evaluated in vitro by static seeding of human umbilical vein *** viable cells and MTS production were statistically higher in functionalized tissues than in *** histoarchitecture,geometrical features,and mechanical properties were unaffected by peptide *** selective immobilization of REDV was effective in accelerating ECs adhesion while promoting proliferation in functionalized decellularized tissues intended for blood-contacting applications.

关键词： Decellularized pericardium Decellularized aorta Covalent functionalization Endothelialization REDV Mechanical analysis

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Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction

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Journal of Geriatric Cardiology 2015年第4期12卷 346-352页

作者： Flora Pirozzi AntoneUa Paglia Laura sasso Pasquale Abete Angelo Carlomagno Carlo G Tocchetti Domenico Bonaduce Mario Petretta Department of Translational Medical Sciences Section of Internal Medicine Federico Ⅱ University Naples ltaly

Objective Doppler derived mitral peak early diastolic filling velocity to deceleration time ratio （E/DT） has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/DT over clinical, conven- tional eehocardiographic and mitral-Doppler variables in patients hospitalized for decompensated heart failure （HF）. Methods We analyzed 95 HF patients （mean age 64.8 ± 12.2 years） hospitalized at our institution from January 2010 to March 2012. The primary end-point was cardiac death or hospitalization, whichever occurred first. Cox regression analysis was performed to identify significant predictors of outcomes. Results During follow-up （median 37.7 months） 13 patients died and 44 were hospitalized for a cardiac event. At univariable analysis, New York Heart Association （NYHA） functional class, furosemide dosage, lateral tricuspidal annular plane systolic excursion, deceleration lime and E/DT were predictive of outcome. At multivariable analysis, E/DT was the only predictor of prognosis （hazard ratio = 1.02, P = 0.018）, giving incremental prognostic information to clinical and other echocardio-graphic measures （global chi-square from 15.4 to 25.2; P = 0.032）. Conclusions FJDT gives independent and incremental prognostic information in HF patients.

关键词： Echocardiographic evaluation Left venlricular function Risk stratification

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Impact of chronic liver disease on SARS-CoV-2 infection outcomes:Roles of stage,etiology and vaccination

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World Journal of Gastroenterology 2023年第5期29卷 800-814页

作者： Riccardo Nevola Livio Criscuolo Domenico Beccia Augusto Delle Femine Rachele Ruocco Simona Imbriani Maria Alfano Angela Villani Antonio Russo Pasquale Perillo Raffaele Marfella Luigi Elio Adinolfi Ferdinando Carlo sasso Aldo Marrone Luca Rinaldi Department of Advanced Medical and Surgical Sciences University of Campania“Luigi Vanvitelli”Naples 80138Italy Internal Medicine and Hepatology Unit Ospedale Evangelico BetaniaNaples 80147Italy Department of Mental Health and Public Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy

Since the first identification in December of 2019 and the fast spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,it has represented a dramatic global public health *** affecting mainly the respiratory system,SARS-CoV-2 disease,defined as coronavirus disease 2019(COVID-19),may have a systemic involvement leading to multiple organ *** evidence about the SARS-CoV-2 tropism for the liver and the increasing of hepatic cytolysis enzymes during infection support the presence of a pathophysiological relationship between liver and *** the other side,patients with chronic liver disease have been demonstrated to have a poor prognosis with *** particular,patients with liver cirrhosis appear extremely vulnerable to ***,the etiology of liver disease and the vaccination status could affect the COVID-19 *** review analyzes the impact of the disease stage and the related causes on morbidity and mortality,clinical outcomes during SARS-CoV-2 infection,as well as the efficacy of vaccination in patients with chronic liver disease.

关键词： SARS-CoV-2 infection COVID-19 Chronic liver disease Cirrhosis Nonalcoholic fatty liver disease Liver injury

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