Impact of chronic liver disease on SARS-CoV-2 infection outcomes:Roles of stage,etiology and vaccination

作     者：Riccardo Nevola Livio Criscuolo Domenico Beccia Augusto Delle Femine Rachele Ruocco Simona Imbriani Maria Alfano Angela Villani Antonio Russo Pasquale Perillo Raffaele Marfella Luigi Elio Adinolfi Ferdinando Carlo Sasso Aldo Marrone Luca Rinaldi 

作者机构：Department of Advanced Medical and Surgical SciencesUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Internal Medicine and Hepatology UnitOspedale Evangelico BetaniaNaples 80147Italy Department of Mental Health and Public MedicineUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第5期

页      面：800-814页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：SARS-CoV-2 infection COVID-19 Chronic liver disease Cirrhosis Nonalcoholic fatty liver disease Liver injury 

摘      要：Since the first identification in December of 2019 and the fast spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,it has represented a dramatic global public health *** affecting mainly the respiratory system,SARS-CoV-2 disease,defined as coronavirus disease 2019(COVID-19),may have a systemic involvement leading to multiple organ *** evidence about the SARS-CoV-2 tropism for the liver and the increasing of hepatic cytolysis enzymes during infection support the presence of a pathophysiological relationship between liver and *** the other side,patients with chronic liver disease have been demonstrated to have a poor prognosis with *** particular,patients with liver cirrhosis appear extremely vulnerable to ***,the etiology of liver disease and the vaccination status could affect the COVID-19 *** review analyzes the impact of the disease stage and the related causes on morbidity and mortality,clinical outcomes during SARS-CoV-2 infection,as well as the efficacy of vaccination in patients with chronic liver disease.