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Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia:a systematic review and meta‑analysis

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World Journal of Pediatrics 2022年第9期18卷 589-597页

作者： Ilari Kuitunen Panu Kiviranta Ulla Sankilampi marjo Renko Institute of Clinical Medicine Department of PediatricsUniversity of Eastern FinlandKuopioFinland Department of Pediatrics Mikkeli Central HospitalPorrassalmenkatu 35-3750100 MikkeliFinland Department of Pediatrics Kuopio University HospitalKuopioFinland

Background Neonatal hyperbilirubinemia is observed in most newborns,and 5–15%of neonates require *** is efective but often prolongs hospitalization and has both short-term and potential long-term *** aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid(UDCA)combined with phototherapy in neonatal *** A literature search was conducted on September 1,2021;590 studies were screened,and 17 full texts were assessed by two *** included randomized controlled trials with or without placebo *** outcomes were changes in total bilirubin levels at 24 hours and phototherapy *** calculated mean diferences with 95%confdence intervals(CI).Results Six studies with 880 neonates were *** these studies,only two used a placebo-controlled double-blinded *** overall risk of bias was high in one and moderate in four of the included *** mean decrease in the total bilirubin level during the frst 24 hours was 2.06 mg/dL(95%CI 0.82–3.30;six studies)greater in the UDCA treatment *** phototherapy duration was 19.7 hours(95%CI 10.4–29.1;fve studies)shorter in the UDCA treatment *** We found low-quality evidence that UDCA as an adjuvant to phototherapy seems to decrease total bilirubin faster and shorten phototherapy duration compared to standard *** studies are needed to confrm the efcacy,acute and long-term outcomes,and safety before implementing UDCA as an adjuvant to phototherapy in neonatal hyperbilirubinemia.

关键词： Jaundice Phototherapy Unconjugated hyperbilirubinemia Ursodeoxycholic acid

Impact of male condition on his spermatophore and consequences for female reproductive performance in the Glanville fritillary butterfly

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Insect Science 2018年第2期25卷 284-296页

作者： Anne Duplouy Luisa Woestmann Juan Gallego Zamorano marjo Saastamoinen Metapopulation Research Centre Department of Biosciences University of Helsinki Helsinki Finland Czech University of Life Science Faculty of Environmental Sciences Department of Ecology Prague Czech Repubfi

In butterflies, male reproductive success is highly related to the quality and the size of the spermatophore transferred to the female. The spermatophore is a capsule produced by the male during copulation, which in many species contains sperm in addition to a nuptial gift, and which is digested by the female after copulation. The nuptial gift may contribute to egg production and offspring quality, and in some cases also to female body maintenance. The production of the spermatophore, however, represents a cost for the male and, in polyandrous species, ejaculates are sometimes allocated adaptively across matings. Nonetheless, although the ecological factors affecting the reproductive success of female butterflies have been the topic of numerous studies, little information exists on the factors affecting males＇ contribution to reproduction, and the indirect impacts on female fecundity and fitness. We used the Glanville fritillary butterfly, Melitaea cinxia （Linnaeus, 1758）（Nymphalidae）, in order to assess variation in male allocation to matings. In this species, smaller males produce smaller spermatophores, but variation in spermatophore size is not correlated with female reproductive success. We show that spermatophore size increases with male age at first mating, decreases with mating frequency and adult food-deprivation, and is not influenced by developmental food-limitation. The length of copulation period does not influence the spermatophore size nor influences the polyandrous mating behavior in this species. Male contribution to his spermatophore size is clearly influenced by his condition and adult-resource at the time of mating. Despite this variation, spermatophore size does not seem to have a direct impact on female reproductive output or mating behavior.

关键词： ejaculate fecundity food-restriction Melitaea cinxia

Non-systemic fungal endophytes in Festuca rubra plants infected by Epichloë festucae in subarctic habitats

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Fungal Diversity 2013年第3期60卷 25-32页

作者： Iñigo Zabalgogeazcoa Pedro E.Gundel marjo he.ande. Kari Saikkonen Instituto de Recursos Naturales y Agrobiología(IRNASA-CSIC) Apartado 257SalamancaSpain MTT Agrifood Research Finland Plant Production Research31600 JokioinenFinland IFEVA-CONICET–Faculty of Agronomy Buenos Aires University(UBA)Av.San Martín 4453(C1417DSE)Buenos AiresArgentina Section of Ecology Department of BiologyUniversity of Turku20014 TurkuFinland

Epichloëfestucae is an endophytic fungus that infects systemically the aerial tissues of the host grass Festuca *** fungus is transmitted vertically from the mother plant to ***,the presence of *** could affect the infection of a plant by other fungal *** could occur if *** metabolites produced in planta interfere negatively with other fungal infections;or alternatively,if the modulation of plant defenses by the endophyte favour further fungal *** have analyzed the presence of culturable non-systemic endophytes in plants of *** infected(E+)and not infected(E−)by *** in two subarctic habitats,meadows and riverbanks in Northern *** observed non-systemic endophyte infection frequencies were similar among E+and E−plants from riverbanks,and E+plants from *** contrast to these,the infection frequency was significantly lower in E−plants from *** result suggests that the presence of *** is not a main factor determining the presence of non-systemic endophytes in ***,plant genetic characteristics related to compatibility with *** and other endophytes in the more stable meadow populations might play a role in these fungus–fungus–plant *** a result of the survey,18 different taxa of non-systemic endophytes were identified in plants of *** were ascomycetes except for one *** endophytic taxa could not be ascribed to a genus,but sequence data indicated that they were conspecific with other unidentified endophytes that have been isolated in cold biomes at different locations.

关键词： Grass Fungi Diversity Finland

Biochar as adsorbent in purification of clear-cut forest runoff water:adsorption rate and adsorption capacity

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Biochar 2020年第2期2卷 227-237页

作者： Taija Saarela Elham Kakaei Lafdani Ari Laurén Jukka Pumpanen marjo Palviainen Department of Environmental and Biological Sciences University of Eastern FinlandYliopistonranta 1 EFI-70210 KuopioFinland School of Forest Sciences University of Eastern FinlandYliopistokatu 7FI-80101 JoensuuFinland Department of Forest Sciences University of HelsinkiLatokartanonkaari 7FI-00014 HelsinkiFinland

Forest management practices in boreal peatlands increase nutrient export and suspended solids to watercourses calling for development of new water protection *** potential solution could be adsorption-based purification of runoff water using *** aim of this study was to determine the adsorption rate and capacity for Norway spruce and silver birch biochars to design a biochar-filled reactor for a ditch *** a 10-day laboratory experiment,biochar was stirred with runoff water from a clear-cut peatland forest,and changes in water pH,total nitrogen,nitrate nitrogen,ammonium nitrogen,phosphorus,and total organic carbon concentrations were *** on the concentration changes,adsorption was quantified and adsorption model containing the adsorption rate and capacity was fitted to the *** results indicate that biochar effectively adsorbs both inorganic and organic nitrogen from runoff *** biochar had higher adsorption capacity of nitrogen than spruce *** study demonstrates that the adsorption of nitrogen compounds onto biochar surfaces increases with increasing initial ***,aquatic ecosystems exposed to high nutrient loads from fertile peatlands would particularly benefit from biochar-based water purification.

关键词： Adsorption Ammonium Biochar Nitrate Nutrients Total nitrogen Water quality

Symbiotic interactions as drivers of trade-offs in plants: effects of fungal endophytes on tall fescue

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Fungal Diversity 2013年第3期60卷 5-14页

作者： Pedro E.Gundel Lucas A.Garibaldi marjo he.ande. Kari Saikkonen Department of Plant Production MTT Agrifood Research Finland31600 JokioinenFinland IFEVA-CONICET-Faculty of Agronomy Buenos Aires University(UBA)Buenos AiresArgentina Sede Andina Universidad Nacional de Río Negro(UNRN)and Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Mitre 6308400 San Carlos de BarilocheRío NegroArgentina Section of Ecology Department of BiologyUniversity of TurkuTurkuFinland

Studying the controls on biomass allocation trade-offs in plants are important since they affect harvestable product yields and are critical to understanding symbiotic *** fungal endophytes associate with cool-season grasses,growing systemically within the plant inter-cellular spaces and are transmitted through *** explore the endophytes influence on the relationship between the plant reproductive and vegetative aboveground biomass(reproductive effort:RE)and on the trade-off between two components of the reproductive biomass,number and weight of panicles(RPN),using tall fescue as a model *** endophyte-colonized,manipulatively endophyte-free,and naturally endophyte-free plants from Northern European wild-populations together with the cultivar Kentucky-31 were grown under different environmental conditions(nutrients x water).The endophyte had an effect on the RPN(E+:6.19,ME-:4.68 and E-:4.40)which indicates how reproductive biomass is partitioned into number and mass of panicles,but not on RE(≈0.06).As expected,wild plants showed higher reproductive effort(≈0.06)compared to the cultivar KY-31(0.05),irrespective of endophyte ***-colonized plants had lighter panicles than endophyte-free plants,a pattern that was clear among low-yielding ***,the tradeoff between RPN and RE was higher for endophytecolonized *** was again evident among plants with low RE indicating that colonized plants split the yield into either greater number of panicles and/or lighter *** effect of vertically transmitted endophytes has earlier been studied as ratios(***);however,our study shows that this approach may hide size-dependent endophyte effects on these *** study reveals that Neotyphodium endophyte affects trade-offs in tall fescue plants in a complex manner,and is influenced by a number of biological and abiotic factors.

关键词： Allometry Biomass partitioning Neotyphodium Festuca Symbiosis Plant-endophyte interaction

Response of soil bacterial community to biochar application in a boreal pine forest

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Journal of Forestry Research 2023年第3期34卷 749-759页

作者： Yan Ge Xiao-li Li marjo Palviainen Xuan Zhou Jussi heinonsalo Frank Berninger Jukka Pumpanen Kajar Köster Hui Sun Collaborative Innovation Center of Sustainable Forestry in Southern China College of ForestryNanjing Forestry UniversityNanjing 210037China Department of Forest Sciences University of HelsinkiLatokartanonkaari 7P.O.Box 2700014 HelsinkiFinland Department of Environmental and Biological Sciences University of Eastern FinlandYliopistonranta 1 EP.O.Box 162770211 KuopioFinland

Boreal forests commonly suff er from nitrogen defi ciency due to low rate of nitrogen *** may promote soil organic matter decomposition and accelerate nitrogen *** this study,Illumina NovaSeq sequencing combined with functional annotation of prokaryotic taxa(FAPROTAX)analysis was used to investigate the eff ect of biochar pyrolysis temperatures,the amount of applied biochar,and the period since the biochar application(2-and 3-year)on soil bacterial *** results show that biochar pyrolysis temperatures(500℃ and 650℃)and the amount of applied biochar(0.5 kg m^(−2)and 1.0 kg m^(−2))did not change soil ***,the interaction of biochar pyrolysis temperature and the amount had signifi cant eff ects on bacterial species richness and evenness(Phe application of biochar produced at 500℃ had a lower abundance of Actinobacteria and Verrucomicrobia,while that produced at 650℃ had a higher abundance of Conexibacter and *** biochar produced at 650℃ was applied,applying 0.5 kg m^(−2)had a higher abundance of Cyanobacteria,Conexibacter,and Phenylobacterium than that of 1.0 kg m^(−2)(Phe abundance of the aromatic compound degradation group increased with the extension of application time and increase of pyrolysis *** time since application played an important role in the formation of soil bacterial communities and their functional ***-term studies are necessary to understand the consequence of biochar on bacterial communities in boreal forests.

关键词： Biochar application Bacterial communities Community function Boreal pine forests

Neotyphodium fungal endophyte in tall fescue (Schedonorus phoenix): a comparison of three Northern European wild populations and the cultivar Kentucky-31

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Fungal Diversity 2013年第3期60卷 15-24页

作者： Pedro E.Gundel marjo he.ande. Cecilia Casas Cyd E.Hamilton Stanley H.Faeth Kari Saikkonen MTT Agrifood Research Finland Plant Production Research31600 JokioinenFinland IFEVA-CONICET–Faculty of Agronomy Buenos Aires University(UBA)Buenos AiresArgentina Department of Biology Section of EcologyUniversity of Turku20014 TurkuFinland Soil Science Division Faculty of AgronomyBuenos Aires University(UBA)Buenos AiresArgentina Department of Biology University of North CarolinaGreensboroNC 27402-6170USA

Pooideae grasses may be colonized by systemic fungal *** fitness of endophyte depends entirely on resources and seed transmission from the host plant,while colonized plants may gain increased survival,growth,and reproduction relative to their uncolonized *** research of endophyte-grass interactions have been carried out on few cultivars of tall fescue(Schedonorus phoenix)and their symbiont Neotyphodium *** of studies using wild populations of tall fescue across the species natural distribution range,however,limits the understanding of the ecological and evolutionary role of the symbiosis in *** performed a common garden experiment in Southern Finland with three wild,tall fescue populations from northern Europe and the forage cultivar Kentucky-31(KY-31).For each population,we used naturally endophyte-colonized,naturally endophytecolonized but endophyte removed(decolonized),and naturally uncolonized plants to separate effects due to the host genotype from the *** evaluated growth variables and survival in four environmental treatments of varying water and *** of water and nutrients increased plant biomass and reproductive effort in all *** effect was higher for KY-31 plants which produced on average 55%more seeds than wild plants,indicating better adaptation to high resource ***,the higher incidence of Claviceps *** the low winter survival indicated KY-31 tall fescue is mal-adapted to Northern European *** colonized plants had greater plant biomass(≈12%),reproductive effort(≈22%)and seed mass(≈29%)than naturally uncolonized and decolonized ***,endophyte colonization did not affect plant survival,and the effects of endophyte colonization on tiller number,panicle/tiller ratio and Claviceps *** depended on the population *** the wild populations,endophyte removal only reduced the number of tillers(≈29%lower),while the differen

关键词： Plant-microbial symbiosis Grass Symbiosis Vertically transmitted symbiont Claviceps

Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis

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Journal of Geriatric Cardiology 2018年第4期15卷 261-267页

作者： marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere Erasmus Medical Center Department of Cardiology Thorax Center Rotterdam the Netherlands Erasmus Medical Center Section of Geriatrics Department of Internal Medicine Rotterdam the Netherlands Erasmus Medical Center Department of Child and Adolescent Psychiatry/Psychology Sophia Children 's Hospital Rotterdam the Netherlands The Netherlands Research Institute of Child Development and Education University of Amsterdam the Netherlands

Background Transcatheter aortic valve implantation （TAVI） has become the standard treatment for patients with severe symptomatic aortic stenosis （AS） considered at very high risk for surgical aortic valve replacement. The purpose of this sub-study was to evaluate long-term （〉 4 years） health-related quality of life （QoL） in octogenarians who underwent TAVI. Methods A single center observational registry in twenty patients who underwent frame analysis assessment ≥ 4 years after TAVI. health-related QoL was evaluated, using the Short Form-36 （SF-36）, the EuroQoL-5D （EQ-5D） and the visual analogue score （EQ-VAS） questionnaires. Results The mean SF-36 subscale scores at follow-up were physical functioning 40.8 ± 26.3, role physical functioning 67.7 ± 34.9, vitality 54.6 ± 21.6, general health 52.1 ± 20.4, social functioning 63.8 ± 37.7, role emotional functioning 70.2 ± 36.0, mental health 73.2 ± 23.3 and bodily pain 80.9 ± 22.9. The mean EQ-VAS score 〉 4 years after TAVI was 64.7 ± 15.1. With respect to functional class, 80% of the patients were in NYHA class I/II at follow-up compared to 15% prior to TAVI. Conclusions This sub-study reports a significant improvement in functional class （NYHA） in a selected group of very elderly patients 〉 4 years after TAVI. Furthermore, all patients showed a satisfactory QoL despite their age and multiple comorbidities. In addition, our study reveals a lower QoL when compared with the general age matched Dutch population.

关键词： Octogenarians Quality of life Transcatheter aortic valve implantation

Prehabilitation prior to intestinal resection in Crohn’s disease patients:An opinion review

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World Journal of Gastroenterology 2022年第22期28卷 2403-2416页

作者： Michiel T J Bak Marit F E Ruiterkamp Oddeke van Ruler marjo J E Campmans-Kuijpers Bart C Bongers Nico L U van Meeteren C Janneke van der Woude Laurents P S Stassen Annemarie C de Vries Department of Gastroenterology and hepatology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery IJsselland HospitalCapelle aan den IJssel 2906 ZCNetherlands Department of Surgery Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Gastroenterology and hepatology University Medical Center Groningen and University of GroningenGroningen 9713 GZNetherlands Department of Nutrition and Movement Sciences School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6200 MDNetherlands Department of Epidemiology Care and Public Health Research InstituteMaastricht UniversityMaastricht 6200 MDNetherlands Department of Anaesthesiology Erasmus MC University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

Patients with Crohn’s disease(CD)are at a considerable risk for intestinal *** 25%of patients with CD will undergo an intestinal resection within 10 years of *** complications after CD surgery have been reported in 20%-47%of the *** general and CD-related risk factors are associated with postoperative complications,and comprise non-modifiable(e.g.,age)and potentially modifiable risk factors(e.g.,malnutrition).Prehabilitation focuses on the preoperative period with strategies designed to optimize modifiable risk factors concerning the physical and mental condition of the individual *** aim of prehabilitation is to enhance postoperative recovery and return to or even improve preoperative functional *** improvement of nutritional status,physical fitness,cessation of smoking,psychological support,and critical revision of preoperative use of CD medication are important *** of the effect on postoperative outcome in CD patients are scarce,and guidelines lack recommendations on tailored *** this opinion review,we review the current evidence on the impact of screening and management of nutritional status,physical fitness,CD medication and laboratory values on the postoperative course following an intestinal resection in CD *** addition,we aim to provide guidance for individualized multimodal prehabilitation in clinical practice concerning these modifiable factors.

关键词： Crohn’s disease Prehabilitation strategies Nutrition Physical fitness Medication Laboratory values