检索结果-南通市图书馆

维普期刊数据库

Development of Moderate Intensity Focused Ultrasound(MIFU)for Ocular Drug Delivery

在线全文

学校读者我要写书评

暂无评论

Biomedical Engineering Frontiers 2022年第1期3卷 240-247页

作者： Alejandra Gonzalez-Calle Runze Li Isaac Asante Juan Carlos Martinez-Camarillo stan Louie Qifa Zhou Mark S.Humayun USC Ginsburg Institute for Biomedical Therapeutics University of Southern CaliforniaLos Angeles CaliforniaUSA USC Roski Eye Institute Keck School of MedicineUniversity of Southern CaliforniaLos Angeles CaliforniaUSA Department of Biomedical Engineering University of Southern CaliforniaLos Angeles CaliforniaUSA USC School of Pharmacy University of Southern CaliforniaLos Angeles CaliforniaUSA

The purpose of this study is to develop a method for delivering antiinflammatory agents of high molecular weight(e.g.,Avastin)into the posterior segment that does not require injections into the eye(i.e.,intravitreal injections;IVT).Diseases affecting the posterior segment of the eye are currently treated with monthly to bimonthly intravitreal injections,which can predispose patients to severe albeit rare complications like endophthalmitis,retinal detachment,traumatic cataract,and/or increased *** this study,we show that one time moderate intensity focused ultrasound(MIFU)treatment can facilitate the penetration of large molecules across the scleral barrier,showing promising evidence that this is a viable method to deliver high molecular weight medications not *** validate the efficacy of the drug delivery system,IVT injections of vascular endothelial growth factor(VEGF)were used to create an animal model of *** creation of this model allowed us to test anti-VEGF medications and evaluate the efficacy of the *** vivo testing showed that animals treated with our MIFU device improved on the retinal tortuosity and clinical dilation compared to the control group while evaluating fluorescein angiogram(FA)Images.

关键词： viable Focus MIF

A PERFECT CITY BOLTHOLE Neat living in the former French Concession

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

城市漫步（上海版、英文） 2015年第2期 34-35页

作者： MARLANNA CERINL stan ARON 不详

Entrepreneur and long-term Shanghai resident Patrick Davin is a man who knows what he *** living in a high-rise for almost six years,eight months ago he decided it was time to have a'real lane house experience'and set out to look for the perfect *** two-story apartment-cum-loft was *** up a rugged industrial interior with contemporary furniture and wooden touch-es,the house weaves traditional Shanghai living together with the sleekness of a New York attic,making for the perfect bachelor pad.

关键词： perfect interior French

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电子技术完全手册

Hybrid energy module for remote environmental observations, experiments, and communications

作者： (美)stan Gibilisco

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Advances in Polar Science 2020年第3期31卷 156-166页

作者： Misha B.KRASSOVSKI Jeffery S.RIGGS Chris TAVINO stan D.WULLSCHLEGER Susan L.HEINZ Environmental Sciences Division Climate Change Science InstituteOak Ridge National LaboratoryOak RidgeTN 37831-6290USA Integrated Operations Support Division Oak Ridge National LaboratoryOak RidgeTN 37831-6290USA Laboratory Modernization Division Oak Ridge National LaboratoryOak RidgeTN 37831-6290USA

Increased concerns about climate change have led to a significant expansion of monitoring, observational, and experimental sites in remote areas of the world. Meanwhile, advances in technology and availability of low-power equipment have allowed increasingly sophisticated measurements with a wide variety of instruments. However, the deployment and use of these technologies in remote locations is often restricted not only by harsh environmental conditions, but also by the availability of electrical power and communication options. In some cases, research stations and military installations can provide power for scientific equipment, data acquisition, storage, and transmission. Clustering of research sites near existing infrastructure has had the unintended consequence of limiting a spatial understanding of large geographic regions. Fortunately, the modern market offers many power and communication solutions, but most of them are oriented toward large industrial applications. Use of those solutions to power a research site is limited because of their cost and need for significant modification for the specific research purposes. Each study has its own unique power requirements and needs for proper instrumentation. A power and communication solution for a vast majority of implementations with or without modification would be of considerable benefit. This article describes design of a universal, scalable hybrid energy module for the Next-Generation Ecosystem Experiments Arctic project(https://***/). Two modules were built, and the authors describe their implementation and findings over a 2-year period at a remote field site on the Seward Peninsula in western Alaska, USA.

关键词： solar energy wind energy communications power sources alternative energy NGEE Arctic

维普期刊数据库

Investigating the consequences of asymmetric endoplasmic reticulum inheritance in Saccharomyces cerevisiae under stress using a combination of single cell measurements and mathematical modelling

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2018年第1期3卷 64-75页

作者： Felix R.H.Jonas Kate E.Royle Rochelle Aw Guy-Bart V.stan Karen M.Polizzi Department of Bioengineering Imperial College LondonLondonSW72AZUnited Kingdom Imperial College Centre for Synthetic Biology LondonSW72AZUnited Kingdom Department of Life Sciences Imperial College LondonLondonSW72AZUnited Kingdom

Adaptation allows organisms to maintain a constant internal environment,which is optimised for *** unfolded protein response(UPR)is an example of a feedback loop that maintains endoplasmic reticulum(ER)homeostasis,and is characteristic of how adaptation is often mediated by transcriptional *** more recent discovery of asymmetric division in maintaining ER homeostasis,however,is an example of how alternative non-transcriptional pathways can exist,but are overlooked by gold standard transcriptomic or proteomic population-based *** this study,we have used a combination of fluorescent reporters,flow cytometry and mathematical modelling to explore the relative roles of asymmetric cell division and the UPR in maintaining ER *** low ER stress,asymmetric division leaves daughter cells with an ER deficiency,necessitating activation of the UPR and prolonged cell cycle during which they can recover ER functionality before *** analysis of and simulation results from our mathematical model reinforce the experimental observations that low ER stress primarily impacts the growth rate of the daughter *** results demonstrate the interplay between homeostatic pathways and the importance of exploring sub-population dynamics to understand population adaptation to quantitatively different stresses.

关键词： Adaptation Asymmetric cell division Endoplasmic reticulum stress Unfolded protein response Saccharomyces cerevisiae

Henkel Technologies and Products for China Aerospace

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料工程 2006年第5期34卷 32-36页

作者： Michael Cichon Helen Wei Li Alex Wong stan Lehmann Raymond Wong Henkel Corporation Bay Point California 94565 U.S.A.

Epoxy structural adhesives and composites have been in use for many years for the construction of aerospace vehicles. Henkel provides many epoxy products. Many other resin systems have been evaluated and several, such as imide, phenolic and cyanate ester, have also achieved significant use. Henkel’s newly developed “Epsilon” chemistry demonstrates unique features that benefit application in aerospace structure that use adhesives and composites.

关键词： adhesive composite epsilon matrix resin structure

维普期刊数据库

三角洲的塑容与修复所有故事都远没到结束的时候

在线全文

学校读者我要写书评

暂无评论

环球人文地理 2024年第21期 38-47页

作者： Phebe Calin stan marius Burcea Designpics Nora Nataliia ondrejprosicky Francescodemarco GrebnerFotografie VOLODYMYR KUCHERENKO 摄图·新视界

多瑙河将三角洲切割成无数漂浮的小岛，它们雕塑着三角洲的面容，收容数以万计的生物。然而，在人们试图将这些土地变成农田后，三角洲似乎发出了“抗议”。开发与保护，到底哪一项决策才是正确的？

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Riemann映射非定理

数学译林 1993年第3期12卷 169-175页

作者：胡作玄 stan.,NK

Pricing Models in Marketing Research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intelligent Information Management 2011年第5期3卷 167-174页

作者： stan Lipovetsky Shon Magnan Andrea Zanetti-Polzi 不详

Pricing a product is one of the most important decisions an organization can make. Marketing research has developed several different approaches to price optimization. They include direct methods such as estimation of willingness to pay, indirect methods such as Gabor-Granger and van Westendorp techniques, and product/price mix methods such as various discrete choice models. All of them are widely used in practical marketing research for evaluation of optimal prices for different products and product innovations. This work describes and compares several main of these approaches.

关键词： Market Research Price Revenue Gabor-Granger Technique Van Westendorp Price Sensitivity Discrete Choice Modeling