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Advanced biomedical hydrogels:molecular architecture and its impact on medical applications

Regenerative Biomaterials 2021年第6期8卷 297-317页

作者： Jonathan T.Peters marissa e.wechsler Nicholas A.Peppas McKetta Department of Chemical engineering The University of Texas at AustinAustin200 E.Dean KeetonAustinTX 78712USA Institute for Biomaterials Drug Deliveryand Regenerative MedicineThe University of Texas at Austin107 W.Dean KeetonAustinTX 78712USA Department of Biomedical engineering and Chemical engineering The University of Texas at San AntonioOne UTSA CircleSan AntonioTX78249USA Department of Biomedical engineering The University of Texas at Austin107 W.Dean KeetonAustinTX 78712USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at Austin107 W.Dean KeetonAustinTX 78712USA Department of Surgery and Perioperative Care and Department of PediatricsDell Medical SchoolThe University of Texas at Austin1601 Trinity St.Bldg.BAustinTX 78712USA

Hydrogels are cross-linked polymeric networks swollen in water,physiological aqueous solutions or biological *** are synthesized by a wide range of polymerization methods that allow for the introduction of linear and branched units with specific molecular *** addition,they can be tuned to exhibit desirable chemical characteristics including hydrophilicity or *** synthesized hydrogels can be anionic,cationic,or amphiphilic and can contain multifunctional crosslinks,junctions or tie *** these characteristics,hydrogels exhibit compatibility with biological systems,and can be synthesized to render systems that swell or collapse in response to external *** versatility and compatibility have led to better understanding of how the hydrogel’s molecular architecture will affect their physicochemical,mechanical and biological *** present a critical summary of the main methods to synthesize hydrogels,which define their architecture,and advanced structural characteristics for macromolecular/biological applications.

关键词： hydrogels networks mesh size hydrogel reactions biological applications biomedical applications

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Macroencapsulation Devices for Cell Therapy

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engineering 2022年第6期8卷 53-70页

作者： Wei Liu Yanfang Wang Jinqiang Wang Olivia LLanier marissa ewechsler Nicholas A.Peppas Zhen Gu Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Biomedical engineering The University of Texas at AustinAustinTX 78712USA Department of Biomedical engineering and Chemical engineering The University of Texas at San AntonioSan AntonioTX 78249USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA Zhejiang Laboratory of Systems and Precision Medicine Zhejiang University Medical CenterHangzhou 311121China MOe Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Macroencapsulation has been widely used in cell therapy due to its capability to provide immune-privileged sites for implanted allogeneic or xenogeneic *** also serves to provide mechanical and physiochemical support for maintaining cell expansion and promoting therapeutic *** devices such as membrane-controlled release systems,hydrogels,micronee-dle(MN)array patches,and three-dimensional(3D)stents have shown promising in-lab and preclinical results in the maintenance of long-term cell survival and the strengthening of treatment *** studies focus on expanding the applications of these devices to new cell-based areas such as chimeric antigen receptor(CAR)-T cell delivery,cardiovascular disease therapy,and the exploration of new materials,construction methods,and working principles to augment treatment efficacy and prolong therapy ***,we survey innovative platforms and approaches,as well as translation outcomes,for advancing the performance and applications of macrodevices for cell-based therapies.A discussion and critique regarding future opportunities and challenges is also provided.

关键词： Drug delivery Cell encapsulation Cell therapy Cell transplantation Biomedical devices

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan eliah G.Overbey Kirill Grigorev Krista A.Ryon marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn e.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher e.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems engineering Colorado State UniversityFort CollinsCO 80523USA element Biosciences San DiegoCA 10055USA Department of environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low earth orbit(LeO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus

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Cellular & Molecular Immunology 2012年第3期9卷 255-266页

作者： Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah e Hammond Molly A Read David L Caudell marissa Nichole Rylander Christopher M Reilly Virginia Tech-Wake Forest School of Biomedical engineering and Science Virginia Polytechnic Institute and State University Blacksburg VA USA Department of Biomedical Sciences and Pathobiology Virginia-Maryland Regional College of Veterinary Medicine Blacksburg VA USA edward Via College of Osteopathic Medicine Blacksburg VA USA Department of Mechanical engineering Virginia Polytechinc Institue and State University Blacksburg VA USA

elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLe） patients and MRLIMp-FasIprIFasJpr（MRLIIpr） autoimmune mice. We investigated if inhibition of HSP90 would reduce disease in MRL/ Ipr mice. In vitro, pretreatment of mesangial cells with HSP90 inhibitor Geldanamycin prior to immune-stimulation showed reduced expression of IL-6, IL-12 and NO. In vivo, we found HSP90 expression was elevated in MRL/Ipr kidneys when compared to C57BL/6 mice and MRIJIpr mice treated with HSP90 inhibitor 17-DMAG. MRIJIpr mice treated with 17-DMAG showed decreased proteinuria and reduced serum anti-dsDNA antibody production. Glomerulonephritis and glomerular IgG and C3 were not significantly affected by administration of 17-DMAG in MRIJIpr. 17-DMAG increased CD8＋ T cells, reduced double-negative T cells, decreased the CD4/CD8 ratio and reduced follicular B cells. These studies suggest that HSP90 may play a role in regulating T-cell differentiation and activation and that HSP90 inhibition may reduce inflammation in lupus.

关键词： Geldanamycin heat shock protein 90 MRUIpr systemic lupus erythematosus 17-DMAG

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How I Work

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国际经济合作 2006年第7期 1-1页

作者： marissa Mayer VP Search Products and User experience Google

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Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 1604-1617页

作者： Katie J.Hogan Hayriye Oztatlı marissa R.Perez Sophia Si Reyhan Umurhan elysa Jui Ziwen Wang emily Y.Jiang Sa R.Han Mani Diba K.Jane Grande-Allen Bora Garipcan Antonios G.Mikos Department of Bioengineering Rice UniversityMS-1426500 Main StreetHoustonTX 77030USA Baylor College of Medicine Medical Scientist Training Program HoustonTX 77030USA Institute of Biomedical engineering Bo�gazic¸i University_Istanbul34684Turkey

Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engineering scaffolds with complex geometries and *** methacryloylated gelatin nanoparticles(GNP-MAs)3DP inks have been developed,which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and ***,novel DBM nanoparticles(DBM-NPs,∼400 nm)were fabricated and characterized prior to incorporation in 3DP *** objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks,assess the impact of ultraviolet(UV)crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal *** addition of methacryloylated DBM-NPs(DBM-NP-MAs)to composite colloidal inks(100:0,95:5 and 75:25 GNP-MA:DBM-NP-MA)did not significantly impact the rheological properties associated with printability,such as viscosity and shear recovery or *** crosslinking with a UV dosage of 3 J/cm2 directly impacted the rate of 3DP scaffold swelling for all GNP-MA:DBM-NP-MA ratios with an∼40%greater increase in scaffold area and pore area in uncrosslinked versus photocrosslinked scaffolds over 21 days in phosphate-buffered saline(PBS).Likewise,degradation(hydrolytic and enzymatic)over 21 days for all DBM-NP-MA content groups was significantly decreased,∼45%less in PBS and collagenase-containing PBS,in UV-crosslinked versus uncrosslinked *** incorporation of DBM-NP-MAs into scaffolds decreased mass loss compared to GNP-MA-only scaffolds during collagenase *** in vitro osteogenic study with bone marrow-derived mesenchymal stem cells demonstrated osteoconductive properties of 3DP scaffolds for the DBM-NP-MA contents examine

关键词： demineralized bone matrix colloidal hydrogels 3D printing bone tissue engineering

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Selenium Concentrations in Southeastern Missouri Soils and Its Impact on Livestock Nutrition

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Agricultural Sciences 2022年第12期13卷 1363-1378页

作者： Michael Aide Indi Braden Shakirah Nakasagga Kevin Sargent Samantha Siemers Miriam Snider marissa Wilson Department of Agriculture Southeast Missouri State University Cape Girardeau USA

Selenium is a trace element in animal nutrition provided through forage. Vegetation should accumulate adequate levels to meet this livestock requirement. This study assessed southeastern Missouri soils for their selenium concentrations. Multiple sites across southeastern Missouri were sampled, from which a total of twenty-six soils were collected. Parent materials ranged from coarse to fine-textured alluvium and terrace deposits, colluvium, loess, limestone residuum and rhyolite residuum from poor to well-drained soils. The mean whole soil selenium contents ranged from less than 0.1 mg Se kg-1 for the Kaintuck pedons to 1.0, 2.2, and 2.4 mg Se kg-1 for the Irondale, Killarney, and Frenchmill pedons. For individual soils, Menfro pedons were deep, well-drained soils developed in loess. Paired Menfro pedons having similar soil morphology and having A-e-Be-Bt-C horizon sequences were selected and the greatest selenium concentrations were in the argillic horizons. Soils having fine textures (clayey) had moderate selenium concentrations, whereas soils having coarse textures (sandy) revealed minimal selenium concentrations. A wide soil selenium concentration variation was shown;however, no toxic selenium levels were measured. Therefore, soil selenium toxicity is not a regional issue. Noting that soil selenium concentrations in medium to fine-textured soils are appropriate for providing selenium to livestock, the need to artificially soil incorporate selenium or add selenium into the livestock ration remains critical for coarse-textured soils.

关键词： Selenite Selenide Animal Nutrition Soil Forages Animal Health Selenomethionine

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Diagnostic accuracy of thoracic imaging modalities for the detection of COVID-19

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World Journal of Radiology 2022年第2期14卷 47-49页

作者： Haben Dawit marissa Absi Nayaar Islam Sanam ebrahimzadeh Matthew D F McInnes Clinical epidemiology Program Ottawa Hospital Research InstituteOttawa K1E4M9ONCanada Department of Radiology The Ottawa Hospital Research Institute Clinical Epidemiology ProgramOttawa K1H8L6ONCanada

The ongoing coronavirus disease 2019(COVID-19)pandemic continues to present diagnostic *** use of thoracic radiography has been studied as a method to improve the diagnostic accuracy of ***‘Living’Cochrane Systematic Review on the diagnostic accuracy of imaging tests for COVID-19 is continuously updated as new information becomes available for *** the most recent version,published in March 2021,a meta-analysis was done to determine the pooled sensitivity and specificity of chest X-ray(CXR)and lung ultrasound(LUS)for the diagnosis of *** gave a sensitivity of 80.6%(95%CI:69.1-88.6)and a specificity of 71.5%(95%CI:59.8-80.8).LUS gave a sensitivity rate of 86.4%(95%CI:72.7-93.9)and specificity of 54.6%(95%CI:35.3-72.6).These results differed from the findings reported in the recent article in this journal where they cited the previous versions of the study in which a metaanalysis for CXR and LUS could not be ***,the article states that COVID-19 could not be distinguished,using chest computed tomography(CT),from other respiratory ***,the latest review version identifies chest CT as having a specificity of 80.0%(95%CI:74.9-84.3),which is much higher than the previous version which indicated a specificity of 61.1%(95%CI:42.3-77.1).Therefore,CXR,chest CT and LUS have the potential to be used in conjunction with other methods in the diagnosis of COVID-19.

关键词： COVID-19 Chest x-ray Computed tomography Lung ultrasound Specificity and sensitivity Diagnostic accuracy

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肺癌全基因组测序

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国际病理科学与临床杂志 2013年第4期33卷 277-285页

作者： marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda e. Clarke edwina e. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚何建行 Thoracic Research Laboratory Department of Thoracic Medicine The Prince Charles Hospital UQ Thoracic Research Centre School of Medicine The University of Queensland Pathology Queensland Department of Anatomical PathologyThe Prince Charles Hospital 重庆市璧山县人民医院肿瘤科重庆402760 广州医学院第一附属医院心胸外科广州510120 广州呼吸疾病研究所广州510120

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。... 详细信息

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免"无辜"患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。

关键词：高通量核苷酸测序 DNA序列分析肺肿瘤非小细胞肺癌小细胞肺癌

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