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Current concepts in end-to-side neurorrhaphy

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World Journal of Orthopedics 2011年第11期2卷 102-106页

作者： marios G Lykissas Division of Pediatric Orthopaedic Surgery Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229United States

In peripheral nerve injury,end-to-side neurorrhaphy involves coaptation of the distal stump of a transected nerve to the trunk of an adjacent donor *** has been proposed as an alternative technique when the proximal stump of an injured nerve is unavailable or the nerve gap is too long to be bridged by a nerve *** and clinical data suggests that end-to-side neurorrhaphy can provide satisfactory functional recovery for the recipient nerve,without any deterioration of the donor nerve *** most accepted mechanism of nerve regeneration following end-to-side neurorrhaphy is collateral *** source of the regenerating axons traveling in the epineurium of the donor nerve is thought to be the proximal Ranvier’s nodes at the site of end-to-side neurorrhaphy,however,histologic evidence is still *** neurotomy of the donor nerve may enhance regeneration of motor neurons through end-to-side neurorrhaphy and reinnervation of motor targets.

关键词： End-to-side neurorrhaphy Collateral sprouting Nerve regeneration Peripheral nerve injury

Neuroimaging in Huntington's disease

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World Journal of Radiology 2014年第6期6卷 301-312页

作者： Flavia Niccolini marios Politis Neurodegeneration Imaging Group Department of Clinical Neuroscience King’s College London London SE5 8AF United Kingdom Division of Brain Sciences De-partment of Medicine Hammersmith Hospital Imperial College London London W12 0NN United Kingdom

Huntington's disease(HD) is a progressive and fatal neurodegenerative disorder caused by an expanded tri-nucleotide CAG sequence in huntingtin gene(HTT) on chromosome 4. HD manifests with chorea, cognitive and psychiatric symptoms. Although advances in genetics allow identification of individuals carrying the HD gene, much is still unknown about the mechanisms underly-ing the development of overt clinical symptoms and the transitional period between premanifestation and mani-festation of the disease. HD has no cure and patients rely only in symptomatic treatment. There is an urgent need to identify biomarkers that are able to monitor disease progression and assess the development and efficacy of novel disease modifying drugs. Over the past years, neuroimaging techniques such as magnetic resonance imaging(MRI) and positron emission tomog-raphy(PET) have provided important advances in our understanding of HD. MRI provides information about structural and functional organization of the brain, while PET can detect molecular changes in the brain. MRI and PET are able to detect changes in the brains of HD gene carriers years ahead of the manifestation of the dis-ease and have also proved to be powerful in assessingdisease progression. However, no single technique hasbeen validated as an optimal biomarker. An integrativemultimodal imaging approach, which combines differ-ent MRI and PET techniques, could be recommendedfor monitoring potential neuroprotective and preventivetherapies in HD. In this article we review the currentneuroimaging literature in HD.

关键词： Huntington’s disease Premanifest Huntington’s disease gene carriers Functional magnetic reso-nance imaging Magnetic resonance imaging Positron emission tomography

Neoadjuvant treatment of pancreatic ductal adenocarcinoma:present and future

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 174-196页

作者： Ioannis M.koukourakis Dimitra Desse marios Papadimitriou Manousos konstadoulakis Anna Zygogianni Christos Papadimitriou Oncology Unit Aretaieio University HospitalNational and Kapodistrian University of AthensAthens 11528Greece Radiation Oncology Unit Aretaieio University HospitalNational and Kapodistrian University of AthensAthens 11528Greece Second Department of Surgery Aretaieio University HospitalNational and Kapodistrian University of AthensAthens 11528Greece

Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with a poor *** treatment with acceptable outcomes is yet to be found,with chemo-and radioresistance comprising major impediments towards this *** upfront surgery is the established therapeutic approach for resectable and borderline resectable disease,neoadjuvant treatment has recently monopolized the interest in clinical *** also applies to locally advanced pancreatic adenocarcinomas that could potentially be rendered *** and chemoradiotherapy are the most utilized therapeutic modalities in the neoadjuvant setting,while immunotherapy and targeting agents have been gaining significant *** critical review focuses on the clinical experience gained from retrospective and phase II/III randomized trials,reporting on the outcomes of neoadjuvant chemotherapy and chemoradiotherapy for pancreatic ***,the ongoing trials,including those that involve immunotherapy and targeting agents,are summarized.

关键词： Pancreatic cancer neoadjuvant treatment chemotherapy radiotherapy surgery immunotherapy

Angiogenesis in gastrointestinal stromal tumors:From bench to bedside

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1469-1477页

作者： Stavros P Papadakos Christos Tsagkaris marios Papadakis Andreas S Papazoglou Dimitrios V Moysidis Constantinos G Zografos Stamatios Theocharis First Department of Pathology School of MedicineNational and Kapodistrian University of AthensAthens 10679Greece Faculty of Medicine University of CreteHeraklion 71003Greece University Hospital Witten-Herdecke University of Witten-HerdeckeWuppertal 42283Germany First Department of Cardiology AHEPA University HospitalAristotle University of ThessalonikiThessaloniki 54636Greece First Department of Surgery Athens Medical SchoolNational and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece First Department of Pathology Medical SchoolUniversity of AthensAthens 11527Greece

Gastrointestinal stromal tumors(GISTs)are rare neoplasms with an estimated incidence from 0.78 to 1-1.5 patients per *** most commonly occur in the elderly during the eighth decade of life affecting predominantly the stomach,but also the small intestine,the omentum,mesentery and *** available treatments for GIST are associated with a significant rate of recurrent disease and adverse *** understanding of GIST’s pathophysiology and translation of this knowledge into novel regimens or drug repurposing is essential to counter this *** present review summarizes the existing evidence about the role of angiogenesis in GIST’s development and progression and discusses its clinical underpinnings.

关键词： Gastrointestinal stromal tumor Cancer Oncology Angiogenesis Gastrointestinal oncology Stromal tumors

Seed Germination Traits of Loquat (Eriobotrya japonica Lindl.) as Affected by Various Pre-Sowing Treatments (Cutting of Cotyledons, Removal of Perisperm, Moist Chilling and/or Exogenous Application of Gibberellin)

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 645-656页

作者： Thiresia-Teresa Tzatzani Evangelia Basdeki Evangelia-Vasiliki Ladikou marios-Ioannis NSotiras Georgios Panagiotakis Sryridon Lionakis Ioannis E.Papadakis Laboratory of Subtropical Plants and Tissue Culture Institute of Olive TreeSubtropical Plants and ViticultureHellenic Agricultural Organization-DEMETERChania73134Greece Laboratory of Genetics Department of BiotechnologyAgricultural University of Athens(Member of the European University for Smart Urban Coastal Sustainability-EU-CONEXUS)Athens11855Greece Laboratory of Pomology Department of Crop ScienceAgricultural University of Athens(Member of the European University for Smart Urban Coastal Sustainability-EU-CONEXUS)Athens11855Greece Laboratory of Pomology School of Agricultural SciencesHellenic Mediterranean UniversityHeraklion71410Greece

The purpose of this study was to investigate the effects of various presowing treatments on the germinability(final germination percentage)and germination rate of loquat seeds in order to increase seedling production in nurseries(applied research)as well as provide answers for important physiological issues related to loquat seeds and their seed coat(basic research).Three experiments were carried out with various pre-sowing *** treatments included full or partial removal of seed coat(perisperm),partial cutting of cotyledons as well as moist chilling at 5℃ for 13 days and/or soaking the seeds in water or 250 ppm gibberellic acid(GA_(3))solution for 24 *** to the results,cotyledons excision resulted in delayed germination,regardless of the presence or absence of the seed coat in comparison with the decoated seeds that demonstrated the highest germination rate amongst *** addition,even the partial excision of seed coats affected positively both the germinability and the germination rate,compared to the control-intact ***,control-intact seeds had a higher germination percentage when exposed to moist chilling independently of the application or not of gibberellin;while the combination of gibberellin application and moist chilling improved both the percentage and the rate of germination of decoated *** conclusion,the role of perisperm(seed coat)in the germination procedure of loquat seeds seems to be important,indicating the existence of seed coat-imposed dormancy on loquat ***,the existence of a mild endogenous embryo-dormancy on loquat is also discussed.

关键词： Cotyledon gibberellin seed coat seed testa Eriobotrya japonica plant propagation perisperm sexual propagation seedling dormancy

Impact of bisphosphonate treatment on bone mineral density after kidney transplant

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World Journal of Transplantation 2024年第3期14卷 102-109页

作者： Georgia Andriana Georgopoulou marios Papasotiriou Theodoros Ntrinias Eirini Savvidaki Dimitrios S Goumenos Evangelos Papachristou Department of Nephrology and kidney Transplantation University Hospital of PatrasPatras 26504Greece

BACkGROUND Mineral bone disease is associated with chronic kidney disease and persists after kidney *** treatment contributes to the patho-genesis of this *** treatments have shown positive but inde-finite *** To evaluate the effectiveness and safety of bisphosphonate treatment on post kidney transplantation bone mineral density(BMD).METHODS We included kidney transplant recipients(kTRs)whose BMD was measured after the operation but before the initiation of treatment and their BMD was measured at least one year *** also evaluated the BMD of kTRs using two valid mea-surements after transplantation who received no treatment(control group).RESULTS Out of 254 kTRs,62(39 men)were included in the *** were initiated in 35 kTRs in total(20 men),1.1±2.4 years after operation and for a period of 3.9±2.3 years while 27(19 men)received no *** improved significantly in kTRs who received bisphosphonate treatments(from-2.29±1.07 to-1.66±1.09,PkTRs with established osteoporosis,active treatment had a similar and significant effect on those with osteopenia or normal bone *** In this retrospective study of kTRs receiving bisphosphonate treatment,we showed that active treatment is effective in preventing bone loss irrespective of baseline BMD.

关键词： Mineral and bone disorders Chronic kidney disease kidney transplant recipients Bisphosphonates Bone mineral density

Subtalar dislocation without associated fractures: Case report and review of literature

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World Journal of Orthopedics 2015年第3期6卷 374-379页

作者： Dionisios Giannoulis Dimitrios V Papadopoulos marios G Lykissas Panagiotis koulouvaris Ioannis Gkiatas Alexandros Mavrodontidis Department of Orthopedics University Hospital of Ioannina Department of Orthopedics University Hospital "Attikon"

Isolated subtalar dislocations are unusual injuries due to the inherent instability of the talus. Subtalar dislocations are frequently associated with fractures of the malleoli, the talus, the calcaneus or the fifth metatarsal. Four types of subtalar dislocation have been described according to the direction of the foot in relation to the talus: medial, lateral posterior and anterior. It has been shown that some of these dislocations may spontaneously reduce. A rare case of a 36-year-old male patient who sustained a closed medial subtalar dislocation without any associated fractures of the ankle is reported. The patient suffered a pure closed medial subtalar dislocation that is hardly reported in the literature. Six months after injury the patient did not report any pain, had a satisfactory range of motion, and no signs of residual instability or early posttraumatic osteoarthritis. The traumatic mechanism, the treatment options, and the importance of a stable and prompt closed reduction and early mobilization are discussed.

关键词： Subtalar Dislocation Talus Calcaneus Isolated Medial

Safety and effectiveness of neuromuscular electrical stimulation in cardiac surgery:A systematic review

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World Journal of Cardiology 2024年第1期16卷 27-39页

作者： Christos kourek marios kanellopoulos Vasiliki Raidou Michalis Antonopoulos Eleftherios karatzanos Irini Patsaki Stavros Dimopoulos Medical School of Athens National and Kapodistrian University of AthensAthens 15772Greece Clinical Ergospirometry Exercise and Rehabilitation LaboratoryEvangelismos HospitalAthens 10676Greece Intensive Care Unit Onassis Cardiac Surgery CenterKallithea 17674Greece Department of Physiotherapy University of West AtticaAthens 12243Greece

BACkGROUND Lack of mobilization and prolonged stay in the intensive care unit(ICU)are major factors resulting in the development of ICU-acquired muscle weakness(ICUAW).ICUAW is a type of skeletal muscle dysfunction and a common complication of patients after cardiac surgery,and may be a risk factor for prolonged duration of mechanical ventilation,associated with a higher risk of readmission and higher *** mobilization in the ICU after cardiac surgery has been found to be low with a significant trend to increase over ICU stay and is also associated with a reduced duration of mechanical ventilation and ICU length of *** electrical stimulation(NMES)is an alternative modality of exercise in patients with muscle weakness.A major advantage of NMES is that it can be applied even in sedated patients in the ICU,a fact that might enhance early mobilization in these *** To evaluate safety,feasibility and effectiveness of NMES on functional capacity and muscle strength in patients before and after cardiac *** We performed a search on Pubmed,Physiotherapy Evidence Database(PEDro),Embase and CINAHL databases,selecting papers published between December 2012 and April 2023 and identified published randomized controlled trials(RCTs)that included implementation of NMES in patients before after cardiac *** were assessed for methodological rigor and risk of bias via the *** primary outcomes were safety and functional capacity and the secondary outcomes were muscle strength and *** Ten studies were included in our systematic review,resulting in 703 *** half of them performed NMES and the other half were included in the control group,treated with usual *** studies investigated patients after cardiac surgery and 1 study before cardiac *** capacity was assessed in 8 studies via 6MWT or other indices,and improved only in 1 study before and in 1 after cardiac *** studies

关键词： Neuromuscular electrical stimulation Cardiac surgery coronary artery bypass grafting Heart valve replacement Peak VO2 Safety

Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle

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World Journal of Gastrointestinal Oncology 2022年第5期14卷 959-972页

作者： Christos Liatsos Apostolis Papaefthymiou Nikolaos kyriakos Michail Galanopoulos Michael Doulberis marios Giakoumis Evangelia Petridou Christos Mavrogiannis Theodore Rokkas Jannis kountouras Department of Gastroenterology 401 General Military Hospital of AthensAthens 11525Greece Gastroenterology University Hospital of LarissaLarissa 41336Greece Division of Gastroenterology and Hepatology Medical University DepartmentKantonsspital AarauAarau 1234Switzerland Department of Microbiology “Agia Sofia”Paediatric HospitalGoudiAthens 11527Greece Gastrointestinal and Liver Unit Faculty of NursingKifissia General and Oncology HospitalKaliftakiN.Kifisia 14564Greece Gastroenterological Clinic Henry Dunant HospitalAthens 11525Greece Department of Internal Medicine Second Medical ClinicIppokration HospitalAristotle University of ThessalonikiThessaloniki 41336MacedoniaGreece

Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric *** normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(***)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant *** studies indicate that *** has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the *** comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of ***(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains ***-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis *** *** eradication is suggested to restore gastric microbiota,at least in primary *** is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to *** studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by *** as well as on the relationships between the gastric microbiota and gastric carcinogenesis.

关键词： Helicobacter pylori infection Gastric microbiota Gastric cancer Oncogenesis Dysbiosis Helicobacter pylori eradication