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食物蛋白诱导性小肠结肠炎综合征诊断和治疗国际共识指南

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中华临床免疫和变态反应杂志 2018年第1期12卷 109-123页

作者： Anna Nowak-We.grzyn MirnaChehade marion e.groetch Jonathan M.Spergel Robert A.Wood Katrina Allen Dan Atkins Sami Bahna Ashis V.Barad Cecilia Berin Terri Brown Whitehorn A.Wesley Burks Jean-Christoph Caubet Antonella Cianferoni Marisa Conte Carla Davis Alessandro Fiocchi Kate Grimshaw RNutr Ruchi Gupta Brittany Hofmeister J.B.Hwang Yitzhak Katz George N.Konstantinou Stephanie A.Leonard Jennifer Lightdale Sean McGhee Sami Mehr Stefano MiceliSopo Giovanno Monti Antonella Muraro Stacey Katherine Noel Ichiro Nomura Sally Noone Hugh A.Sampson Fallon Schultz Scott H.Sicherer Cecilia C.Thompson Paul J.Turner Carina Venter A.Amity Westcott-Chavez Matthew Greenhawt 李丽莎钱家鸣杨红不详中国医学科学院北京协和医学院北京协和医院变态(过敏)反应科中国医学科学院北京协和医学院北京协和医院消化内科

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIeS）是一种非Ige,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIeS 的知晓率却较低；而且有关FPIeS 病理生... 详细信息

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIeS）是一种非Ige,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIeS 的知晓率却较低；而且有关FPIeS 病理生理学,诊断和治疗的高质量研究数据缺乏；其临床预后尚不明确。这篇国际共识由美国变态反应、哮喘和免疫学会（AAAAI）食物不良反应委员会和国际FPIeS 协会宣传组召集组织国际工作组总结撰写。这是第一部基于临床证据的FPIeS 国际指南,有助于提高FPIeS 的临床诊治水平。当然未来还需要更多有关FPIeS 患病率,病理生理学,诊断标志物和未来治疗方法的研究,以便为FPIeS 患者提供更好的医疗服务。这些指南内容将会在获得更多证据后定期更新。

关键词：食物蛋白诱导性小肠结肠炎综合征指南非Ige 介导的食物过敏

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach Tobias Claff Alexandra Hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa e.Müller Michael Gütschow Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(M^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active M^(pro) by active-site titration.The covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant complex.Four fluorogenic substrates of M^(pro),including a prototypical,internally quenched Dabcyl-eDANS peptide,were compared in terms of solubility under typical assay conditions.By exploiting the new titrant,key kinetic parameters for the M^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 Main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DeSY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA european XFeL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FeL)aimed at producing warm dense matter via soft x-ray isochoric heating.In the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution model.We find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped electrons.The morphology of the complex crater structure indicates the presence of several ion groups with varying temperatures.We find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FeL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

Production of antihypertensive and antidiabetic peptide fractions from quinoa(Chenopodium quinoa Willd.)by electrodialysis with ultrafi ltration membranes

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Food Science and Human Wellness 2022年第6期11卷 1650-1659页

作者： Adrián González-Muñoz marion Valle Rotimi e.Aluko Laurent Bazinet Javier enrione Biopolymer Research and engineering Lab(BiopReL) School of Nutrition and DieteticsFaculty of MedicineUniversidad de los AndesMonseñorÁlvaro del Portillo 12455Chile Centre for Biomedical Research and Innovation(CIIB) Universidad de los AndesChileMonseñorÁlvaro del Portillo 12455Chile Institute of Nutrition and Functional Foods(INAF) UniversitéLavalQuébec QC G1V 0A6Canada Department of Anatomy and Physiology Faculty of MedicineLaval Hospital Research CenterUniversitéLavalQuébec QC G1V 4G5Canada Department of Food and Human Nutritional Sciences University of ManitobaWinnipeg MB R3T 2N2Canada Department of Food Sciences Laboratoire de Transformation Alimentaire et ProcédésÉlectro Membranaire(LTAPEMLaboratory of Food Processing and Electro-Membrane Processes)UniversitéLavalQuébec QC G1V 0A6Canada

Processing bioactive peptides from natural sources using electrodialysis with ultrafiltration membranes(eDUF)have gained attention since it can fractionate in terms of their charge and molecular weight.Quinoa is a pseudo-cereal highlighted by its high protein content,amino acid profile and adapting growing conditions.The present work aimed at the production of quinoa peptides through fractionation using eDUF and to test the fractions according to antihypertensive and antidiabetic activity.experimental data showed the production of peptides ranging between 0.4 and 1.5 k Da.Cationic(CQPF)(3.01%),anionic(AQPF)(1.18%)and the electrically neutral fraction quinoa protein hydrolysate(QPH)-eDUF(~95%)were obtained.In-vitro studies showed the highest glucose uptake modulation in L6 cell skeletal myoblasts in presence of QPH-eDUF and AQPF(17%and 11%)indicating potential antidiabetic activity.The antihypertensive effect studied in-vivo in spontaneously hypertensive rats(SHR),showed a decrease in systolic blood pressure in presence of the fractionated peptides,being 100 mg/kg a dose comparable to Captopril(positive control).These results contribute to the current knowledge of bioactive peptides from quinoa by reporting the relevance of eDUF as tool to produce selected peptide fractions.Nevertheless,further characterization is needed towards peptide sequencing,their respective role in the metabolism and scaling-up production using eDUF.

关键词： Quinoa electrodialysis with ultrafiltration membranes Bioactive peptides Antihypertensive Antidiabetic

Amorphous Ge-Sb-Se-Te chalcogenide films fabrication for potential environmental sensing and nonlinear photonics

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Journal of Materiomics 2022年第5期8卷 1009-1019页

作者： Tomas Halenkovic marion Baillieul Jan Gutwirth Petr Nemec Virginie Nazabal Department of Graphic Arts and Photophysics Faculty of Chemical TechnologyUniversity of PardubiceStudentska 57353210PardubiceCzech Republic Univ Rennes CNRSISCR(Institut des Sciences Chimiques de Rennes)e UMR 6226F-35000RennesFrance

Quaternary Ge-Sb-Se-Te chalcogenide thin films were fabricated by rf magnetron sputtering from Ge_(19)Sb_(17)Se_(64-x)Te_(x)(x=5,10,15,20)sputtering targets in order to select appropriate compositions for infrared sensor and optical nonlinear applications.An influence of chemical composition and deposition parameters on the optical properties,structure and wettability was thus studied.The amorphous thin films seem to be constituted by selenide entities that can include tellurium atoms in variable proportion such as[GeSe_(4-x)Te_(x)]and[SbSe_(3-x)Te_(x)](x=0,1,2)and Ge(Sb)-Ge(Sb)bonds according to Raman spectroscopy.Contact angle measurements of the thin films showed values of 68e71for water and their surface energies in the range of~36e39 mJ$m-2 seem suitable for surface functionalization required for photonic sensor development.Furthermore,the maximum nonlinearity at the telecom wavelength with respect to the highest figure of merit value was found for the thin film with composition Ge_(19)Sb_(17)Se56Te8 having nonlinear refractive index of 28×10^(-18) m2·W^(-1).Due to their low optical bandgap energies,they may find their full interest for nonlinear optics in the mid-infrared range.Wide IR transparency in combination with high(non)linear refractive indices make these materials attractive in the field of midIR sensing and optical nonlinear devices.

关键词： Chalcogenide Thin films Glass Amorphous Optical properties NLO Contact angles Sputtering Raman

Clinical spectrum of ocular manifestations in COVID-19:a case series

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Infectious Medicine 2023年第2期2卷 148-152页

作者： Souheil Zayet Ayoub Mihoubi marion Chatain Nour Sreiri Malek Bouzaien Trimech Vincent Gendrin Fatiha Benjelloun Timothée Klopfenstein Department of Infectious Diseases Nord Franche-Comte Hospital90400 TrevenansFrance Department of Ophthalmology Nord Franche-Comte Hospital90400 TrevenansFrance

In this current case series,all Coronavirus disease 2019 patients had predominant ophthalmological presentation.Only one patient sough care for concomitant respiratory symptoms.We reported herein 2 cases with cranial oculomotor nerve palsy,one patient with confirmed diagnosis of branch retinal vein occlusion,and the last one patient presenting for acute kareto-conjunctivitis with several recurrences,which was unsuccessfully treated with steroids and requiring cliclosporin.These case series highlights the importance of collecting a careful history of ocular presentation,including exposures to possible infected patients with SARS-CoV-2.This this will lead to an early diagnosis and treatment and to make appropriate infection control measures.

关键词： SARS-CoV-2 COVID-19 Diplopia Ophtalmoplegia Neuro-ophtalmology

Physicochemical aspects of allanite flotation

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Journal of Rare earths 2014年第5期32卷 476-486页

作者： Adam Jordens Chris marion Olga Kuzmina Kristian e.Waters Department of Mining and Materials engineering McGill University

This paper investigated the physicochemical properties of allanite, a Re-silicate, by measuring zeta potential in the absence and presence of three different flotation collectors （benzohydroxamic acid, sodium oleate and dodecylamine）. This data was then verified by microflotation experiments and with bubble-particle attachment pictures. The investigated properties of allanite were com- pared to those of quartz, a common gangue mineral in many Re deposits. The results of this work indicated that only dodecylamine was able to achieve a selective separation of allanite and quartz. This was accomplished by lowering the dodecylamine dosage so that only quartz was recovered by microflotation.

关键词： allanite flotation surface chemistry zeta potential bubble-particle attachment rare earths

Tracking traumatic head injuries with the chemical senses

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第1期4卷 46-49页

作者： marion e. Frank Thomas P. Hettinger Oral Health & Diagnostic Sciences School of Dental MedicineUCONN HealthFarmingtonCT 06030USA

Chemosensory disorders, primarily olfactory, have diagnostic significance for preva-lent human illnesses, but the multitude of smells makes measuring function appear daunting. The olfactory system operates under dynamic natural sensing conditions in which many individ-ual odor chemicals are waxing and waning. Yet, in experimentally controlled simulations, mixture-component selective adaptation shows individual or shared prominent characteristic odors are detected but molecular stimulus features are not. As in other biological chemical signaling systems, including taste, odors activate dedicated receptors (OR). Given rapid OR adap-tation with the passage of time, individual odor recognition is momentary. Receptive dendrites of the nearly 400 genetically variable human-OR in the olfactory epithelium critically project axons to the olfactory bulb through perforations in the cribriform plate of the skull. Analytic chemical-quality codes detect single odor-mixture components. However, identities of no more than 3 or 4 most salient odors are perceived due to central mixture-suppression, the mutual inhibition among diverse olfactory-bulb or cortical neurons. The componental codes allow olfaction to readily discern odor quality and valence of a wide range of unrelated chemicals, a few at a time. Head trauma may result in a partial or complete loss of smell and facial trauma a loss of taste-nerve function. Testing smell could plot the course of recovery from chronic traumatic enceph-alopathies that prevail in contact sports. Measuring brain function with olfaction would provide simpler and more direct monitoring of prognosis than biochemical sensors.

关键词： Mixture-component perception Head trauma Contact sports

Investigating the use of an ionic liquid for rare earth mineral flotation

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Journal of Rare earths 2021年第7期39卷 866-874,I0004页

作者： R.Li C.marion e.R.L.espirtu R.Multani Xiaoqi Sun K.e.Waters Department of Mining and Materials engineering McGill University3610 Rue University.MontrealQuebecH3A 0C5Canada Vale Ontario Operations(Base Metals)18 Rink St.Copper CliffOntario POM 1N0Canada Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences155 Yangqiao Road WestFuzhou 350002China

Common collectors for rare earth mineral(ReM) flotation,which include carboxylates and hydroxamates,face problems such as being non-selective and sensitive to impurity ions.A type of ionic liquid(IL),tetraethylammonium mono-(2-ethylhexyl)2-ethylhexyl phosphonate([N_(2222)][eHeHP]),has been investigated previously for rare earth elements(Ree) solvent extraction,and was proven to be selective and effective.In this work,[N_(2222)][eHeHP] was evaluated as a collector in bastnasite(a primary ReM source for Ree production) flotation for the first time.The results were compared with quartz and hematite,two common gangue minerals in ReM deposits.Zeta potential measurements and Fouriertransform infrared spectroscopy(FT-IR) were completed to investigate the surface chemical properties involved in the flotation of these minerals using this collector.The findings were compared with microflotation results.FT-IR and zeta potential measurements suggest adsorption of the collector’s phosphonate group onto bastnäsite and hematite,likely through chemisorption;whereas for quartz,the minimum micro flotation recovery is likely due to no adsorption of IL on its surface.Micro flotation re sults show higher collectability of [N_(2222)] [eHeHP] for hematite than bastnasite,the latter only shows appreciable recovery at pH 5 with elevated dosage of IL(500 g/t).To achieve better separation,a two-stage flotation scheme was designed and evaluated by bench scale flotation on a synthetic mineral mixture.The concentrates and tails were analyzed by magnetic separation,and it is found that bastnasite recovery over 90% with maximum upgrade ratio 1.7 can be achieved with elevated collector dosage.

关键词： Ionic liquid Rare earth Bastnasite Flotation FT-IR Zeta potential