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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Depleted uranium oxide supported nickel catalyst for autothermal CO_(2)methanation in non-adiabatic reactor under induction heating

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Journal of Energy Chemistry 2023年第10期85卷 310-323,I0010页

作者： Lai Truong-Phuoc Jean-mario Nhut loïc Vidal Cuong Duong-Viet Sécou Sall Corinne Petit Christophe Sutter Mehdi Arab Alex Jourdan Cuong Pham-Huu Institute of Chemistry and Processes for Energy Environment and Health(ICPEES)ECPMUMR 7515 CNRS-University of Strasbourg25 rue Becquerel67087 Strasbourg Cedex 02France BlackLeaf SAS 210 rue Geiler de Kaysersberg67400 IllkirchFrance Institute of Materials Science of Mulhouse IS2MUMR 7361Universitéde Haute-AlsaceCNRS15rue Jean Starcky-BP 248868057 MulhouseFrance ORANO Tricastin Direction de La Recherche&DéveloppementSite du TRICASTIN BP 1626701 Pierrelatte CedexFrance

Undoped nickel-based catalysts supported on depleted uranium oxide allow one to carry out CO_(2)methanation process under extremely low reaction temperature under atmospheric pressure and powered by a contactless induction *** adjusting the reaction conditions,the catalyst is able to perform CO_(2)methanation reaction under autothermal process operated inside a non-adiabatic reactor,without any external energy *** autothermal process is possible thanks to the high apparent density of the UO_x which allows one to confine the reaction heat in a small catalyst volume in order to confine the exothermicity of the reaction inside the catalyst and to operate the reaction at equilibrium heat in-heat *** autothermal operation mode allows one to significantly reduce the complexity of the process compared to that operated using adiabatic reactor,where complete insulation is required to prevent heat disequilibrium,in order to reduce as much as possible,the heat exchange with the external *** catalyst displays an extremely high stability as a function of time on stream as no apparent *** is expected that such new catalyst with unprecedented catalytic performance could open new era in the field of heterogeneous catalysis where traditional supports show their limitations to operate catalytic processes under severe reaction conditions.

关键词： CO_(2)methanation Auto-methanation Induction heating Depleted uranium oxide Electrification process Operando DRIFTS

Bulging intervertebral disc:an asymptotic elasticity solution

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Acta Mechanica Sinica 2018年第6期34卷 1167-1173页

作者： Yu-Cheng lo Liu Wang Orthopaedic Department Changhua Christian HospitalChanghuaChina Department of Aerospace Engineering and EngineeringMechanics Center for Mechanics of SolidsStructures andMaterialsUniversity of Texas at AustinAustinTX78712USA

A bulging intervertebral disc (IVD) occurs when pressure on a spinal disc damages the once healthy disc,causing it to compress or change its normal *** medicine,most attention has been paid clinically to diagnosis of and treatment for such problems,which little effect has been made to understand such issues from a mechanics perspective,i.e.,the bulging deformation of the soft IVD induced by excessive compressive *** report herein a simple elasticity solution to understand the bulging disc *** simplicity,the soft IVD is modeled as an incompressible circular composite layer consisting of an inner nucleus and outer annulus,sandwiched between two vertebral segments which are much stiffer than the IVD and can be treated as rigid *** adopting any assumptions regarding prescribed displacements or stresses,we obtained the stress and displacement fields within the composite layer when a certain compressive stain is applied via an asymptotic *** asymptotic approach is very simple and accurate enough for prediction of the bugling profile of the *** also performed finite-element modeling (FEM) to validate our solutions;the predicted stress and displacement fields inside the composite are in good agreement with the FEM results.

关键词： Bulging intervertebral disc (IVD) Elastic composite layer Asymptotic solution Finite element method

Size Effects of the Critical Temperature in Ferroelectric Thin Films

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Communications in Theoretical Physics 2007年第7期48卷 183-188页

作者： V.C.lo Institute of Physics and Center for Condensed Matter Physics Chinese Academy of SciencesBeijing 100080China

The size effects of the critical behaviors for the systems of interacting spins are discussed extensively *** this paper,the finite-size dependence of the critical temperature and susceptibility of the ferroelectric thinfilm are investigated numerically based on the four-state Potts model with the nearest-neighbor interactions between thedipole *** four orientations of the domains exist in the ferroelectric film and the movement of the domainwalls determines the polarization switching process besides the boundary conditions of the *** critical exponentsare obtained and our investigations show that the boundary conditions play the important roles for the ferroelectricproperties of the thin films and the critical behavior of the thin films strongly depends on the feature of the surface.

关键词： ferroelectric thin film critical temperature size effects

Contributions of biofilm and suspended sludge to nitrogen transformation and nitrous oxide emission in hybrid sequencing batch system

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Journal of Environmental Sciences 2010年第7期22卷 953-960页

作者： Ingwei Wayne lo Kwang Victor lo Don S Mavinic Dean Shiskowski William Ramey Department of Civil Engineering University of British Columbia Associated Engineering Ltd. Department of Microbiology & Immunology University of British Columbia

Hybrid system combines the nature of suspended growth and attached growth has been widely applied to wastewater treatment. In this research, the contributions to N transformation and N2O emission by biofilm and suspended sludge in the hybrid sequencing- batch reactor for a simultaneous nitrification, denitrification and phosphorus removal process were investigated. For the hybrid system, nitrification occurred mostly in the suspended sludge, while the biofilm played the major role in denitrification. The interaction of the biofilm and the suspended sludge in the same reactor resulted in a better overall nitrogen removal performance with simultaneous nitrification and denitrification. However, N2O emission was the main end product of nitrogen removal for the hybrid system; while it was N2 for the biofilm. The relative low N2O emissions from the pure biofilm and the pure suspended sludge corresponded to the relatively high nitrate at the end of the aeration period compared with the hybrid system.

关键词： N2O emission biofilm suspended sludge hybrid system

TagCombine： Recommending Tags to Contents in Software Information Sites

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Journal of Computer Science & Technology 2015年第5期30卷 1017-1035页

作者：王新宇夏鑫 David lo 1.College of Computer Science and Technology Zhejiang University Hangzhou 310027 China 2.School of Information Systems Singapore Management University Singapore Singapore

Nowadays, software engineers use a variety of online media to search and become informed of new and interesting technologies, and to learn from and help one another. We refer to these kinds of online media which help software engineers improve their performance in software development, maintenance, and test processes as software information sites. In this paper, we propose TagCombine, an automatic tag recommendation method which analyzes objects in software information sites. TagCombine has three different components： 1） multi-label ranking component which considers tag recommendation as a multi-label learning problem; 2） similarity-based ranking component which recommends tags from similar objects; 3） tag-term based ranking component which considers the relationship between different terms and tags, and recommends tags after analyzing the terms in the objects. We evaluate TagCombine on four software information sites, Ask Different, Ask Ubuntu, Feecode, and Stack Overflow. On averaging across the four projects, TagCombine achieves recall@5 and recallS10 to 0.619 8 and 0.762 5 respectively, which improves TagRec proposed by Al-Kofahi et al. by 14.56% and 10.55% respectively, and the tag recommendation method proposed by Zangerle et al. by 12.08% and 8.16% respectively.

关键词： software information site online media tag recommendation

Red-leafed species for urban“greening”in the age of global climate change

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Journal of Forestry Research 2021年第1期32卷 151-159页

作者： Ermes lo Piccolo Marco Landi Department of Agriculture Food and EnvironmentUniversity of PisaVia del Borghetto 8056124 PisaItaly CIRSEC Centre for Climatic Change ImpactUniversity of PisaVia del Borghetto 8056124 PisaItaly

Urban trees provide vital ecosystem services such as mitigating heat island,improving air quality by removing various air pollutants,capturing rainwater,and acting as topsoil carbon *** aesthetic value of urban trees is also another feature that has to be considered in the context of urban *** criteria for the selection of urban trees have to respond to new challenges imposed to the cities in a near *** climate change factors increase the harshness of our cities,and thereby the plant resilience to abiotic stresses has also to be seriously considered for planning the urban ***-leafed species,characterized by the permanent presence of foliar anthocyanins,show a greater tolerance to diff erent environmental cues than green-leafed species commonly used in our *** addition,red tree species own a great aesthetic value which has been underestimated in the context of urban areas,especially in the harsh Mediterranean *** this study,we emphasize the“privilege of being red”from diff erent point of view,in order to drive the attention to the possibility to increase the use of red-leafed species for urban“greening”.Some possible negative aspects related to their use are rebutted and the direction of future researches are proposed.

关键词： Abiotic stress Anthocyanin Ecosystem service Photoprotection Urban forestry

A new definition of soil to promote soil awareness,sustainability,security and governance

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International Soil and Water Conservation Research 2022年第1期10卷 99-108页

作者： Carmelo Dazzi Giuseppe lo Papa Department of Agricultural Food and Forest SciencesUniversity of PalermoItaly

In these last decades,the awareness that soil is a very important resource for humans has noticeably *** actions and initiatives to promote soil governance,aiming at sustainable soil manage-ment and soil security have been undertaken by several national and international institutions and in many *** of the changes of soil perception over the centuries allows highlighting a perfect harmony between the evolution of soil awareness and the level of knowledge and technology achieved by humans during their history and *** these many achievements,soils continue to be scarcely considered in politics and *** suggest some thoughts and reflections that could lead to an up-to-date and effective definition of soil that directly focuses the public attention on its economic *** our opinion,soil economic value could be the only aspect that truly attracts the attention of politicians and administrators,which could increase soil awareness and encourage soil sustainability,security and Sustainable Development Goals and finally promote soil governance.

关键词： Definition of soil Soil perception Soil governance Soil awareness Ecosystem services Soil security

Could JC virus provoke metastasis in colon cancer?

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World Journal of Gastroenterology 2014年第42期20卷 15745-15749页

作者： Emanuele Sinagra Dario Raimondo Elena Gallo mario Stella mario Cottone Ambrogio Orlando Francesca Rossi Emanuele Orlando Marco Messina Giovanni Tomasello Attilio Ignazio lo Monte Ennio La Rocca Aroldo Gabriele Rizzo Gastroenterology and Endoscopy Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto course in Surgical Biotechnology and Regenerative Medicine University of Palermo Euro-Mediterranean Institute of Science and Technology (IEMEST) Unit of Pathology Ospedali Riuniti Villa Sofia - Cervello University of Palermo DIBIMIS Unit of Internal Medicine Ospedali Riuniti Villa Sofia - Cervello University of Palermo Oncology Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto Department of Surgical and Oncological Disciplines School of Medicine University of Palermo Unità Operativa di Medicina interna e trapiantologia Ospedale San Raffaele

AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic ***: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 ***: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors.

关键词： John Cunningham virus Colon cancer Me-tastasis