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Proper progression of neurogenesis relies on a defined pattern of SUMO-modified proteins

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Neural Regeneration Research 2022年第8期17卷 1731-1732页

作者： mario García-domínguez Andalusian Centre for Molecular Biology and Regenerative Medicine-CABIMER CSIC-Universidad de Sevilla-Universidad Pablo de Olavide SevilleSpain

Neurogenesis is a complex process involving the orchestration of many transcription factors and other *** regulation of their activities is crucial for proper progression of neurogenesis.A few decades ago,covalent attachment of Small Ubiquitin-like MOdifier(SUMO)to other proteins was revealed as a major regulator of protein activities,constituting an essential posttranslational modification system in *** then,hundreds of proteins have been shown to be targets of SUMO,which is implicated in controlling many relevant processes in eukaryotic *** include the development and function of the nervous system,with SUMO tightly linked to synapsis and to neurodegenerative diseases(Yau et al.,2020).The SUMO protease SENP7 has been involved in neurogenesis(Juárez-Vicente et al.,2016),while sumoylation of BRAF35,a subunit of the LSD1 histone demethylase complex,assures the undifferentiated state of neural progenitors(Ceballos-Chávez et al.,2012).In addition,increased sumoylation in mouse brain-derived neural stem cells results in enhanced neuronal differentiation(Bernstock et al.,2019).

关键词： pattern diseases

Impact of radiative cooling on the energy performance of courtyards in Mediterranean climate

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Building Simulation 2024年第9期17卷 1491-1513页

作者： Carlos-Antonio domínguez-Torres Antonio domínguez-Delgado Escuela Técnica Superior de Arquitectura Universidad de SevillaAv.de Reina Mercedes241012 SevillaSpain Department of Applied Mathematics 1 Escuela Técnica Superior de ArquitecturaUniversidad de SevillaAv.de Reina Mercedes241012 SevillaSpain

Radiative cooling has proven to be a useful tool to address the problems of lack of comfort and excessive energy consumption in situations of high temperatures,overheating and heat ***,incorporating courtyards in warm climate zones has been found to be highly beneficial in addressing similar ***,there is interest in analyzing the combined effects of both:radiative cooling and *** paper presents an analysis of the impact of the application of radiative cooling on a courtyard using a comprehensive simulation approach that includes a CFD model for the thermodynamic airflow in the adjacent roofs and inside the courtyard,equations for the transient heat conduction through roofs,walls and courtyard slabs,and a hybrid raytracing-radiosity model for the evaluation of the solar radiation reaching the building surfaces and its reflections,both of specular and diffuse origin,and for the calculation of the thermal radiation exchange,especially with the *** results show that in the hot season,the courtyard with radiative cooling always provides lower temperatures than the initial courtyard does,with a temperature range of 18.33℃to 33.78℃,compared to a range of 19.32℃to 38.00℃in the initial courtyard,and producing a greater difference with outdoor temperatures that can reach 12℃versus 8℃for the reference *** addition,it was found that the courtyard with radiative cooling is able to significantly reduce the observed nighttime overheating by providing lower temperatures than the outdoor temperatures in the 50%of the nights *** was also found that the thermal loads to achieve indoor thermal comfort in the spaces adjacent to the courtyard were reduced by 63.46%to 69.85%.

关键词： radiative cooling passive cooling CFD three-dimensional modeling energy saving thermal comfort

The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： Martha Pérez-domínguez Evangelina ávila-Mu?oz Eduardo domínguez-Rivas Angélica Zepeda Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes IL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

Behavior of ductile steel X-braced RC frames in seismic zones

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 845-869页

作者： Eber Alberto Godínez-domínguez Arturo Tena-Colunga Facultad de Ingeniería Universidad Autónoma de Chiapas Tuxtla Gutiérrez 29050 Mexico Departamento de Materiales Universidad Autónoma Metropolitana México City 02200 Mexico

A satisfactory ductile performance of moment-resisting reinforced concrete concentric braced frame structures (RC-MRCBFs) is not warranted by only following the provisions proposed in Mexico’s Federal District Code (MFDC-04). The nonlinear behavior of low to medium rise ductile RC-MRCBFs using steel X-bracing susceptible to buckling is evaluated in this study. The height of the studied structures ranges from 4 to 20 stories and they were located for design in the lakebed zone of Mexico City. The design of RC-MRCBFs was carried out considering variable contribution of the two main lines of defense of the dual system (RC columns and steel braces). In order to observe the principal elements responsible for dissipating the earthquake input energy, yielding mappings for diff erent load-steps were obtained using both nonlinear static and dynamic analyses. Some design parameters currently proposed in MFDC-04 as global ductility capacities, overstrength reduction factors and story drifts corresponding to diff erent limit states were assessed as a function of both the considered shear strength and slenderness ratios for the studied RC-MRCBFs using pushover analyses. Additionally, envelopes of response maxima of dynamic parameters were obtained from the story and global hysteresis curves. Finally, a brief discussion regarding residual drifts, residual drift ratios, mappings of residual deformations in steel braces and residual rotations in RC beams and columns is presented. From the analysis of the obtained results, it is concluded that when a suitable design criterion is considered, good structural behavior of RC-MRCBFs with steel-X bracing can be obtained. It is also observed that the shear strength balance has an impact in the height-wise distribution of residual drifts, and an important “shake-down” eff ect is obtained for all cases. There is a need to improve design parameters currently proposed in MFDC to promote an adequate seismic performance of RC-MRCBFs.

关键词： RC braced-frames seismic design nonlinear dynamic analyses steel-X bracing overstrength collapse mechanism story drifts residual drifts

Steroid-responsive pancreatitides

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World Journal of Clinical Cases 2020年第16期8卷 3411-3430页

作者： mario Pelaez-Luna Andrea Soriano-Rios Ana C Lira-Treviño Luis Uscanga-domínguez Department of Gastroenterology National Institute of Medical Sciences and Nutrition"Salvador Zubiran"Mexico City 14000Mexico

Autoimmune pancreatitis has received considerable attention,especially due to the marked effect of corticosteroid therapy on its clinical ***,especially regarding type 1 autoimmune pancreatitis,has significantly increased over the last decades,and despite significant differences in pathophysiology and outcomes,both type 1 and 2 autoimmune pancreatitis are still considered different types of the same *** have proposed a different nomenclature reflecting these *** the term steroid-responsive pancreatitides may be interpreted as synonymous to type 1 and 2 autoimmune pancreatitis,these are not the only pancreatic conditions that show a response to steroid *** pancreatitis caused by vasculitis and connective tissue diseases and acute pancreatitis secondary to checkpoint inhibitors or programmed cell death receptor antibody-mediated blockage cancer therapy may also benefit from steroid *** review presents current concepts on these disorders,aiming to increase awareness,analyze similarities and differences,and propose a new nomenclature that reflects their specific particularities,clustering them under the term"steroid-responsive pancreatitides".

关键词： Autoimmune pancreatitis Lymphoplasmacytic sclerosing pancreatitis Idiopathic duct centric chronic pancreatitis Vasculitis Immune checkpoint inhibitors Corticosteroids

Building geometry data from online maps for accurate thermal simulations of districts

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Building Simulation 2023年第9期16卷 1659-1674页

作者： Laura Romero Rodríguez JoséSánchez Ramos ServandoÁlvarez domínguez Grupo Termotecnia.Departamento de Máquinas y Motores Térmicos University of CádizPuerto RealCádizSpain Grupo Termotecnia.Departamento de Ingenieria Energética University of SevilleSevilleSpain

Current approaches for simulating the energy performance of buildings on a large scale are limited by numerous assumptions and simplifications,which can lead to inaccurate *** new tools and procedures are emerging to improve accuracy,there remains a need for more user-friendly *** study proposes a new tool based on online maps to create the geometry of districts in a simple *** tool also enables an automatic evaluation of all buildings through dynamic hourly simulations,using a building simulation software and allowing to consider different weather *** illustrate the procedure,a district at risk of energy poverty in Seville(Spain)is modeled,where hourly temperature data for a whole year are available to demonstrate the need for building *** tool is used to evaluate the energy demands of the district under several retrofitting alternatives,and free-floating simulations are also performed to evaluate the improvement of thermal comfort without air-conditioning *** aim is not to discuss the actual values for this particular case,but rather to identify the correct direction for large-scale studies,so as to make them more easily ***,it may be concluded that the results provided by comprehensive tools,such as the one proposed in this study,enable easy yet accurate evaluations of buildings on a large scale with significant time savings,as well as the identification of locations where retrofitting interventions would have the greatest impact.

关键词： buildings districts energy demand efficiency GIS urban scale

The immune hunger games:the effects of fasting on monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1098-1100页

作者： Jorge domínguez-Andrés Holger Reinecke Yahya Sohrabi Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Nijmegen Medical Centre6500HBNijmegenthe Netherlands Department of Cardiology I-Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzech Republic Department of Medical Genetics Third Faculty of MedicineCharles UniversityPragueCzech Republic

Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic ***,how these practices affect immune function is not well *** a recent study published in Immunity,Janssen et *** into the complex relationship among fasting,refeeding,and the immune *** fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].

关键词： becoming fasting she

Metabolomic Fingerprinting of Blood Samples by Direct Infusion Mass Spectrometry:Application in Alzheimer’s Disease Research

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Journal of Analysis and Testing 2017年第3期1卷 83-91页

作者： Rau´l Gonza´lez-domı´nguez Department of Chemistry Faculty of Experimental SciencesUniversity of Huelva21007 HuelvaSpain

Metabolomics is largely employed in numerous biomedical research fields,such as the study of the underlying pathology of diseases,discovery of diagnostic biomarkers,or drug ***,the main challenge is to obtain comprehensive and unbiased metabolomic profiles due to the huge complexity,heterogeneity,and dynamism of the *** this end,mass spectrometry represents a very interesting analytical platform,since the complexity of metabolome may be overcome through the use of different orthogonal separation techniques,including liquid chromatography,gas chromatography,and capillary ***,direct mass spectrometry analysis has been postulated as a complementary choice to hyphenated *** technique exhibits several advantages such as the ability for high-throughput screening,fast analysis,and wide metabolomic coverage,since there is not exclusion of compounds due to the separation *** present work explores the utility of metabolomics based on direct infusion mass spectrometry for analyzing blood *** most important analytical concerns to be considered are discussed,including sample handling,comprehensive fingerprinting,as well as subsequent identification of metabolites,and global characterization of metabolomic *** conclude,a brief review on the application of these metabolomic platforms in Alzheimer’s disease research is also provided.

关键词： Metabolomics Direct infusion mass spectrometry Alzheimer’s disease Blood

Spatiotemporal variation in the adult sex ratio,male aggregation,and movement of two tropical cloud forest dung beetles

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Current Zoology 2022年第6期68卷 635-644页

作者： Julliana BARRETTO Martha L.BAENA Israel Huesca domınguez Federico ESCOBAR Red de Ecoetologıa Instituto de EcologıaXalapaC.P.91073Mexico Instituto de Investigaciones Biologicas Universidad Veracruzana.Av.Luis Castelazo Ayala s/n Col.IndustrialAnimasXalapaC.P.91190Mexico

While theory suggests that at conception the sex ratio should be balanced(1:1),this can be variable across space and time in wild ***,studies of the environmental factors that regulate adult sex ratio(ASR)in species with different life history traits are *** capture–recapture over a year,we analyzed the influence of habitat type(forest and nonforest)and season(rainy and dry)on variation in ASR,male aggregation and the trajectory movement of 2 dung beetle species with different life history traits:Deltochilum mexicanum(a hornless roller species)and Dichotomius satanas(a tunneler species with horns on its head and thorax).We found opposite *** *** population tends to be female-biased,but the population of *** tends to be predominantly male,and observed values were not related to habitat type or ***,the 95%confidence intervals estimated were highly variable between seasons depending on *** examining the monthly variation in ASR for both habitats,we found that it depends on the *** addition,male aggregation differed between species depending on habitat type and season,and species movement patterns were closely related to their habitat *** on our results,we argue that comparative population studies of species with different life history traits are necessary to understand the variation in demographic parameters as well as its ecological and evolutionary implications in the face of spatial and climatic environmental variation.

关键词： habitat preference mark-recapture mean crowding seasonality Scarabaeinae sex proportion