Metabolomic Fingerprinting of Blood Samples by Direct Infusion Mass Spectrometry:Application in Alzheimer’s Disease Research
作者机构：Department of ChemistryFaculty of Experimental SciencesUniversity of Huelva21007 HuelvaSpain
出 版 物：《Journal of Analysis and Testing》 (分析检测（英文）)
年 卷 期：2017年第1卷第3期
页 面：83-91页
主 题：Metabolomics Direct infusion mass spectrometry Alzheimer’s disease Blood
摘 要：Metabolomics is largely employed in numerous biomedical research fields,such as the study of the underlying pathology of diseases,discovery of diagnostic biomarkers,or drug ***,the main challenge is to obtain comprehensive and unbiased metabolomic profiles due to the huge complexity,heterogeneity,and dynamism of the *** this end,mass spectrometry represents a very interesting analytical platform,since the complexity of metabolome may be overcome through the use of different orthogonal separation techniques,including liquid chromatography,gas chromatography,and capillary ***,direct mass spectrometry analysis has been postulated as a complementary choice to hyphenated *** technique exhibits several advantages such as the ability for high-throughput screening,fast analysis,and wide metabolomic coverage,since there is not exclusion of compounds due to the separation *** present work explores the utility of metabolomics based on direct infusion mass spectrometry for analyzing blood *** most important analytical concerns to be considered are discussed,including sample handling,comprehensive fingerprinting,as well as subsequent identification of metabolites,and global characterization of metabolomic *** conclude,a brief review on the application of these metabolomic platforms in Alzheimer’s disease research is also provided.
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