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Meso-substituted cationic 3-and 4-n-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 1-16页

作者： Aram G.Gyulkhandanyan marina H.Paronyan Anna G.Gyulkhandanyan Karapet R.Ghazaryan marina V.Parkhats Boris M.Dzhagarov Maria V.Korchenova Ekaterina n.Lazareva Elena S.Tuchina Grigor V.Gyulkhandanyan Valery V.Tuchin H.Buniatyan Institute of Biochemistry national Academy of Sciences of Armenia 5/1 Paruir Sevak Street Yerevan 0014Armenia InSERM U1204 Universite d'Evry vald'Essonne-Universite Paris-Saclay 1 Ruedu Pere JarlanBatiment Maupertuis91025Evry-CourcouronnesFrance B.I.Stepanov Institute of Physics National Academy of Sciences of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus Science Medical Center Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia Laboratory of Laser Molecular Imaging and Machine Learning(LMIML)national Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic *** the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate *** of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in *** aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive *** was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant *** *** complexes of porphyrins are more phototoxic than metal-free porphyrin *** e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen *** was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet *** results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.

关键词： Antibacterial photodynamic therapy cationic porphyrins/metalloporphyrins phototoxicity Zn-metalloporphyrins singlet oxygen quantum yield Gram negative and Gram positive bacteria S.aureus MRSA E.coli Salmonella typhimurium.

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Epitranscriptomics of cancer

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World Journal of Clinical Oncology 2018年第3期9卷 42-55页

作者： marina Tusup Thomas Kundig Steve Pascolo Department of Dermatology University Hospital of Zürich Faculty of Medicine University of Zurich

The functional impact of modifications of cellular RnAs,including m RnAs,mi RnAs and lnc RnAs,is a field of intense *** role of such modifications in cancer has started to be *** and sometimes opposite effects of RnA modifications have been *** RnA modifications promote,while ot-hers decrease the growth and invasiveness of *** present manuscript reviews the current knowledge on the potential impacts of n6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s *** also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RnA modifications may be a new method to treat cancer.

关键词： RnA modifications n6-methyladenosine 5-methylcytidine 2’O-methylation or methylcytidine Pseudouridine Inosine

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Utility of routine blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones

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World Journal of Gastrointestinal Surgery 2017年第6期9卷 149-152页

作者： Offir Ben-Ishay marina Zeltser Yoram Kluger Surgical Oncology Pancreatic and Hepatobiliary Surgery ServiceDepartment of General SurgeryDivision of SurgeryRambam Health Care CampusHaifa 35254Israel

AIM To evaluate the value of blood testing after elective laparoscopic cholecystectomy and its association with procedure related *** Charts of all patients undergoing elective laparoscopic cholecystectomy from January 2013 through December2014 were reviewed retrospectively for demographics,indication for surgery,operative course and *** our institution the decision to perform postoperative blood analysis is left for the discretion of the surgeon,therefore we had the possibility to compare the results of those who had blood analyses results to those who did *** was performed to identify variables associated with the decision to perform postoperative blood *** a univariate and multivariate analyses was performed comparing the two *** subgroup analysis was performed to identify factors associated with procedure related *** Five hundred and thirty-two elective laparoscopic cholecystectomies for symptomatic gallstones were performed during the study ***-four percent of the patients(n=340)had blood tests taken post *** that had laboratory tests taken were older(P=0.006,OR=1.01),had longer surgery(Pns placed(Pnd stayed longer in the hospital(Pnalysis of the patients who experienced complications revealed longer stay in the hospital(Pndex(BMI)(P=0.04,OR=1.08),increased rates of drain placement(P=0.006,OR=3.1)and higher conversion rates(P=0.01,OR=14.6).Postoperative blood tests withdrawals were not associated with complications(P=0.44).On Multivariate analysis BMI and drain placement were independently associated with *** The current study indicate that routine postoperative blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones does not predict complications and may have an added benefit in diagnosis and management of cases w

关键词： Cholecystectomy Blood tests Laparoscopy Complications Post-operative Gallstones symptomatic

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Bacterial and archaeal communities in saline soils from a Los negritos geothermal area in Mexico

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Pedosphere 2023年第2期33卷 312-320页

作者： Joseph GUEVARA-LUnA Mario HERnÁnDEZ-GUZMÁn nina MOnTOYA-CIRIACO Luc DEnDOOVEn marina Olivia FRAnCO-HERnÁnDEZ Paulina ESTRADA-DE LOS SAnTOS María Soledad VÁSQUEZ-MURRIETA Escuela nacional de Ciencias Biológicas Instituto Politécnico NacionalCiudad de México 11340(Mexico) Laboratory of Soil Ecology CinvestavMexico City 07360(Mexico) Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de Tlaxcala.Carretera Federal Tlaxcala-Puebla km.1.5Tlaxcala 90070(Mexico) Unidad Profesional Interdisciplinaria de Biotecnología Instituto Politécnico NacionalCiudad de México 07340(Mexico)

In recent years,there has been a growing need to understand how salinity affects microbial communities in agricultural *** and bacterial community diversities and structures were investigated by high-throughput sequencing analysis of their 16S rRnA in two arable soils with low electrical conductivity(EC)(2.3 and 2.6 dS m^(-1))and a saline soil(EC=17.6 dS m^(-1)).The dominant bacterial phyla in the soils were Proteobacteria(relative abundance(RA)=46.2%),followed by Acidobacteria(RA=13.1%)and Actinobacteria(RA=10.0%),whereas Serratia(RA=6.0%)and Bacillus(RA=4.0%)were the dominant bacterial *** nitrososphaera(53.5%)was the dominant archaeal phylotype in the arable soils,whereas nitrosopumilus(RA=0.4%)dominated in the saline *** archaeal and bacterial community structures were different between the soils and significantly correlated with soil sand,arsenic,barium,and antimony contents,but not with soil salinity.

关键词： agricultural soil compositional approach microbial community mud volcano soil salinity soluble anion

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Mesoporous fibrous silicon nitride by catalytic nitridation of silicon

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Progress in natural Science:Materials International 2019年第2期29卷 190-197页

作者： Tatevik Minasyan Le Liu marina Aghayan Miguel A.Rodriguez Sofiya Aydinyan Irina Hussainova Tallinn University of Technology Functional Advanced Composite Technology Industries 3. Instituto de Cerámica y Vidrio ICV-CSIC ITMO University Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign

The catalytic effect of metal oxide/alumina whiskers（CeO;, Mn;O;, niO, Co;O;, Fe;O;, Cr;O;/AW） was evaluated on their ability to drive the nitridation of silicon and to generate mesoporous fibrous silicon *** powder with different particles size along with the catalyst was nitridized at 1300 °C for 5 h in nitrogen and nitrogen diluted with 10 vol% ammonia atmospheres. nitridation degree of silicon up to 99% was recorded using 1.5 wt% CeO;and Fe;O;catalysts in nitrogen-ammonia atmosphere. The catalyzed samples contain submicronic silicon nitride fibres with a diameter of 400–500 nm and a length of up to few micrometers. The compressive strength of 46 ± 1 MPa was measured for silicon samples catalyzed with nickel oxide/alumina whiskers and nitridized in n;/10 vol%nH;atmosphere. Porous silicon nitride networks were produced with 45–52% porosity, pore sizes in the range of 370–1200 nm and median pore in the range of 495–1655 nm.

关键词： Mesoporous substrate Silicon nitride nanofibers Wet-combustion Catalytic nitridation

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novel method for the preparation of Cs-containing FAU（Y） catalysts for aniline methylation

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 70-76页

作者： Olga A. Ponomareva Polina A. Shaposhnik marina Vo Belova Boris A. Kolozhvari Irina I. Ivanova Department of Chemistry Lomonosov Moscow State University Moscow 119991 Russia A.V. Topchiev Institute of Petrochemical Synthesis Moscow Russia

Cs-containing FAU（Y）-type zeolite catalysts were prepared by conventional and novel ion exchange procedures followed by incipient wetness impregnation with CsOH. The novel ion exchange procedure involved hydrothermal treatment of naY zeolite in aqueous solution of CsCl at 140-200 ℃ for 6-24 h. The samples were characterized by low-temperature nitrogen adsorption, X-ray fluorescence analysis, X-ray powder diffraction, scanning electron microscopy, 23na, 27Al and 133Cs magic angle spinning nuclear magnetic resonance, CO2 and nH3-Temperature programmed desorption. The results show that hydrothermal treatment at 200 ℃ allows to obtain higher degrees of ion-exchange （up to 83%） with respect to conventional method giving maximum 66%- 69%. Catalytic properties of Cs-containing FAU（Y） were studied in aniline methylation. The yield of nomethylani- line is shown to correlate with catalyst＇s basicity. The best catalyst performance was achieved over the catalyst with the highest ion-exchange degree impregnated with CsOH. The selectivity to n-methylaniline over this catalyst reached 96.4%.

关键词： FAU(Y) zeolite ion exchange with cesium aniline alkylation n-methylaniline

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Spontaneous liver rupture as first sign of polyarteritis nodosa

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World Journal of Hepatology 2016年第32期8卷 1414-1418页

作者： Irene Gómez-Luque Felipe Alconchel Rubén Ciria M Dolores Ayllón Antonio Luque marina Sánchez Pedro López-Cillero Javier Briceno General Surgery Reina Sofía University Hospital Department of Surgery Faculty of Medicine and NursingUniversity of Córdoba Unit of Hepatobiliary Surgery and Liver Transplant Reina Sofía University Hospital Department of Pathology Reina Sofía University Hospital

Polyarteritis nodosa(PAn) is one of the systemic vasculitis that affects the media wall of arteries of small and medium diameter. Diagnosis proves difficult due to the unspecific symptoms that dominate the clinical profile. Liver involvement is very diverse, ranging from the development of cirrhotic liver disease to acute abdomen presentation that requires surgery because of liver rupture. The management of these patients requires an expert multidisciplinary team. There are several cases in the literature that describe a sudden liver rupture as the first manifestation of a PAn. In this paper we present the case of a 75 years old patient without any previous disease, who is subjected to major hepatic resection for spontaneous liver rupture.

关键词： Polyarteritis nodosa Spontaneous liver rupture Liver surgery Vasculitis Rheumatology

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Glacial biodiversity of the southernmost glaciers of the European Alps(Clapier and Peirabroc,Italy)

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Journal of Mountain Science 2022年第8期19卷 2139-2159页

作者： Barbara VALLE Mauro GOBBI Marta TOGnETTI marina Serena BORGATTI Chiara COMPOSTELLA Paolo PAnTInI Marco CACCIAnIGA Universitàdegli Studi di Milano Department of BiosciencesVia Celoria 2620133 MilanoItaly MUSE-Science Museum of Trento Research and Museum Collections OfficeClimate and Ecology UnitCorso del Lavoro e della Scienza338122 TrentoItaly Universitàdegli Studi di Milano Dipartimento di Scienze della Terra"A.Desio"Via Mangiagalli 3420133 MilanoItaly Museo Civico di Scienze naturali"E.Caffi" Piazza della Cittadella1024129 BergamoItaly

We applied a multi-taxa approach integrating the co-occurrence of plants,ground beetles,spiders and springtails with soil parameters(temperatures and chemical characteristics)in order to describe the primary succession along two glacier forelands in the Maritime Alps(Italy),a hotspot of Mediterranean *** compared these successions to those from Central Alps:Maritime glacier forelands markedly differ for their higher values of species richness and species *** to our expectation,Maritime glacier forelands follow a‘replacement change model’,like continental succession of Inner Alps and differently from other peripheral *** propose that the temperatures along these Mediterranean glacier forelands are warmer than those along other Alpine glacier forelands,which promote the faster species ***,we found that early and mid successional stages of the investigated glaciers are richer in cold-adapted and endemic species than the later ones:we confirmed that the‘replacement change’model disadvantages pioneer,cold-adapted *** the overall correspondence among coldadapted and endemic species,the most threatened in this climate phase,our results raise new concerns about the extinction risk of these *** also describe supraglacial habitat of Maritime glaciers demonstrating that supraglacial debris represents an environment decoupled from the regional climate and may have an important role as refugium for coldadapted and hygrophilous plant and animal species,whose survival can be threatened by climate change and by a rapid ecological succession in the adjacent forelands.

关键词： Arthropod communities Cold-adapted species Glacier forelands Plant communities Primary succession

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Fibroblasts upregulate expression of adhesion molecules and promote lymphocyte retention in 3D fibroin/gelatin scaffolds

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Bioactive Materials 2021年第10期6卷 3449-3460页

作者： Maxim A.nosenko Anastasia M.Moysenovich Anastasia Y.Arkhipova Kamar-Sulu n.Atretkhany Sergei A.nedospasov marina S.Drutskaya Mikhail M.Moisenovich Center for Precision Genome Editing and Genetic Technologies for Biomedicine Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow119991Russia Biological Faculty Lomonosov Moscow State UniversityMoscow119991Russia Biological Faculty Shenzhen MSU-BIT UniversityShenzhen518172China Sirius University of Science and Technology Federal Territory SiriusKrasnodarsky Krai354340Russia

Bioengineered scaffolds are crucial components in artificial tissue *** general,these scaffolds provide inert three-dimensional(3D)surfaces supporting cell ***,some scaffolds can affect the phenotype of cultured cells,especially,adherent stromal cells,such as *** we report on unique properties of 3D fibroin/gelatin materials,which may rapidly induce expression of adhesion molecules,such as ICAM-1 and VCAM-1,in cultured primary murine embryonic fibroblasts(MEFs).In contrast,two-dimensional(2D)fibroin/gelatin films did not show significant effects on gene expression profiles in fibroblasts as compared to 3D culture ***,TnF expression was induced in MEFs cultured in 3D fibroin/gelatin scaffolds,while genetic or pharmacological TnF ablation resulted in diminished ICAM-1 and VCAM-1 expression by these *** selective MAPK inhibitors,we uncovered critical contribution of JnK to 3D-induced upregulation of these adhesion ***,we observed ICAM-1/VCAM-1-dependent adhesion of lymphocytes to fibroblasts cultured in 3D fibroin/gelatin scaffolds,but not on 2D fibroin/gelatin films,suggesting functional reprogramming in stromal cells,when exposed to 3D ***,we observed significant infiltration of lymphocytes into 3D fibroin/gelatin,but not into collagen scaffolds in vivo upon subcapsular kidney implantation in *** our data highlight the important features of fibroin/gelatin scaffolds,when they are produced as 3D sponges rather than 2D films,which should be considered when using these materials for tissue engineering.

关键词： Bioengineering Cell adhesion Artificial lymphoid tissue Mouse embryonic fibroblasts Stromal cells TnF ICAM-1 VCAM-1 JnK Fibroin/gelatin 3D 2D

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Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 295-318页

作者： Ramón Cantero-Cid Karla marina Montalbán-Hernández Jenny Guevara Alejandro Pascual-Iglesias Elisa Pulido JoséCarlos Casalvilla Cristóbal Marcano Cristina Barragán Serrano Jaime Valentín Gloria Cristina Bonel-Pérez JoséAvendaño-Ortiz Verónica Terrón Roberto Lozano-Rodríguez Alejandro Martín-Quirós Elvira Marín Eva Pena Laura Guerra-Pastrián Eduardo López-Collazo Luis Augusto Aguirre Tumor Immunology Laboratory The Innate Immune Response GroupHospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Digestive Surgery Service La Paz University HospitalMadrid 28046Spain Emergency Department and Emergent Pathology Research Group Hospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Pathologic Anatomy Service Hospital La PazMadrid 28046Spain

BACKGROUnD Colorectal cancer(CRC)accounts for 9.4%of overall cancer deaths,ranking second after lung *** the large number of factors tested to predict their outcome,most patients with similar variables show big differences in ***,right-sided CRC(RCRC)and left-sided CRC(LCRC)patients exhibit large differences in outcome after surgical intervention as assessed by preoperative blood leukocyte *** hypothesised that stronger indexes than circulating(blood)leukocyte ratios to predict RCRC and LCRC patient outcomes will result from combining both circulating and infiltrated(tumour/peritumour fixed tissues)concentrations of *** To seek variables involving leukocyte balances in peripheral blood and tumour tissues and to predict the outcome of CRC *** Sixty-five patients diagnosed with colon adenocarcinoma by the Digestive Surgery Service of the La Paz University Hospital(Madrid,Spain)were enrolled in this study:43 with RCRC and 22 with *** were followed-up from January 2017 to March 2021 to record overall survival(OS)and recurrence-free survival(RFS)after surgical *** concentrations in peripheral blood were determined by routine laboratory ***-fixed samples of tumour and peritumoural tissues were assessed for leukocyte concentrations by immunohistochemical detection of CD4,CD8,and CD14 marker *** of leukocyte concentration in blood and tissues were calculated and evaluated for their predictor values for OS and RFS with Spearman correlations and Cox univariate and multivariate proportional hazards regression,followed by the calculation of the receiver-operating characteristic and area under the curve(AUC)and the determination of Youden’s optimal cutoff values for those variables that significantly correlated with either RCRC or LCRC patient *** patients from the cohort were randomly assigned to modelling and validation sets,and clinician-friendly nomogra

关键词： Left colorectal cancer Leukocyte ratios Prognostic variables Recurrence-free survival Right colorectal cancer Overall survival

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