Epitranscriptomics of cancer

作     者：Marina Tusup Thomas Kundig Steve Pascolo 

作者机构：Department of DermatologyUniversity Hospital of Zürich Faculty of Medicine University of Zurich 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2018年第9卷第3期

页      面：42-55页

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Supported by University of Zurich:"URPP:Translational Cancer research" the"MERIT"project supported by the FP7 European Union’s Research Innovation Funding program 

主　　题：RNA modifications N6-methyladenosine 5-methylcytidine 2’O-methylation or methylcytidine Pseudouridine Inosine 

摘      要：The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense *** role of such modifications in cancer has started to be *** and sometimes opposite effects of RNA modifications have been *** RNA modifications promote,while ot-hers decrease the growth and invasiveness of *** present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s *** also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer.