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Myelinosome organelles in pathological retinas: ubiquitous presence and dual role in ocular proteostasis maintenance

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Neural Regeneration Research 2023年第5期18卷 1009-1016页

作者： marina G.Yefimova Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of SciencesSt-PetersburgRussia Laboratoire STIM CNRS ERL 7003 Universitéde PoitiersPoitiersFrance

The timely and efficient elimination of aberrant proteins and damaged organelles, formed in response to various genetic and environmental stressors, is a vital need for all cells of the body. Recent lines of evidence point out several non-classical strategies employed by ocular tissues to cope with aberrant constituents generated in the retina and in the retinal pigmented epithelium cells exposed to various stressors. Along with conventional strategies relying upon the intracellular degradation of aberrant constituents through ubiquitin-proteasome and/or lysosome-dependent autophagy proteolysis, two non-conventional mechanisms also contribute to proteostasis maintenance in ocular tissues. An exosome-mediated clearing and a myelinosome-driven secretion mechanism do not require intracellular degradation but provide the export of aberrant constituents and “waste proteins” outside of the cells. The current review is centered on the non-degradative myelinosome-driven secretion mechanism, which operates in the retina of transgenic Huntington’s disease R6/1 model mice. Myelinosome-driven secretion is supported by rare organelles myelinosomes that are detected not only in degenerative Huntington’s disease R6/1 retina but also in various pathological states of the retina and of the retinal pigmented epithelium. The intra-retinal traffic and inter-cellular exchange of myelinosomes was discussed in the context of a dual role of the myelinosome-driven secretion mechanism for proteostasis maintenance in different ocular compartments. Special focus was made on the interplay between degradative and non-degradative strategies in ocular pathophysiology, to delineate potential therapeutic approaches to counteract several vision diseases.

关键词： autophagy Huntington’s disease Müller cells myelinosome-driven secretion myelinosomes ocular pathophysiology proteostasis retina retinal pigmented epithelium ubiquitin-proteasome system

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The birth hour of mammals:insights from intra-specific variation in wild blue monkeys

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Current Zoology 2022年第5期68卷 499-506页

作者： marina Cords Emma Gometz Department of Ecology Evolution and Environmental BiologyColumbia UniversityNew YorkNY 10027USA New York Consortium in Evolutionary Primatology 695 Park AvenueNew YorkNY 10065USA

While most mammals show birth hour peaks at times of the 24-h cycle when they are less active,there are exceptions to this general *** exceptions have been little explored,but may clarify evolutionary reasons for the diel timing of *** investigated intraspecific variation in birth hour in wild blue monkeys Cercopithecus mitis stuhlmanni,a diurnal primate,to identify factors that differentiated daytime versus nighttime *** and life history data from 14 groups over 14 years revealed that 4%of 484 births occurred during the *** of daytime birth varied with mother’s age,peaking at 15.7 *** whose annual timing deviated most from the population’s peak birth months were 5 times more likely to occur during daytime than those that deviated *** was no evidence that mother’s rank or infant sex influenced birth hour,and mixed evidence that daytime births were more probable in larger *** did not differ significantly for infants born during the day versus ***-aged mothers may be able to handle the consequences of an unusual birth hour more successfully than mothers with less experience or those weakened by *** birth may be more advantageous in the off-season because nights are colder at that time of *** findings are consistent with hypotheses relating birth hour to the risk of losing social protection in group-living animals,but are not consistent with those emphasizing risk of conspecific *** of within-species variation can help in evaluating evolutionary hypotheses for non-random birth hour.

关键词： birth timing Cercopithecus mitis circadian pattern diel cycle guenon parturition

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Spectroscopy of compounds from the family of rare-earth orthoborates

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Journal of Rare Earths 2009年第4期27卷 607-611页

作者： marina N.Popova Institute of Spectroscopy Russian Academy of Sciences 5 Fizicheskaya Str. Troitsk Moscow Region 142190 Russia

This paper is devoted to the rare-earth borates described by the general formula RM3（BO3）4, M = Al, Fe, and Cr, that have non-centrosymmetric trigonal slructure of the natural mineral huntite. It give a brief review of a spectroscopic research on YbAI3（BO3）4 （YbAB）, on a large group of magnetic iron borates, and on NdCra（BO3）4.

关键词： YbAl3(BO3)4 rare-earth iron and chromium borates magnetic ordering Fourier-transform optical spectroscopy

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Issues of origin,morphology and clinical significance of tumor microvessels in gastric cancer

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World Journal of Gastroenterology 2021年第48期27卷 8262-8282页

作者： marina A Senchukova Department of Oncology Orenburg State Medical UniversityOrenburg 460021Russia

Gastric cancer(GC)remains a serious oncological problem,ranking third in the structure of mortality from malignant *** treatment outcomes for this pathology largely depends on understanding the pathogenesis and biological characteristics of GC,including the identification and characterization of diagnostic,prognostic,predictive,and therapeutic *** is known that the main cause of death from malignant neoplasms and GC,in particular,is tumor *** that angiogenesis is a critical process for tumor growth and metastasis,it is now considered an important marker of disease prognosis and sensitivity to anticancer *** the presented review,modern concepts of the mechanisms of tumor vessel formation and the peculiarities of their morphology are considered;data on numerous factors influencing the formation of tumor microvessels and their role in GC progression are summarized;and various approaches to the classification of tumor vessels,as well as the methods for assessing angiogenesis activity in a tumor,are ***,results from studies on the prognostic and predictive significance of tumor microvessels in GC are also discussed,and a new classification of tumor microvessels in GC,based on their morphology and clinical significance,is proposed for consideration.

关键词： Gastric cancer Angiogenesis Tumor microvessels Vascular endothelial growth factor Hypoxia Prognosis

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Microbiota of the gastrointestinal tract: Friend or foe?

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World Journal of Gastroenterology 2023年第1期29卷 19-42页

作者： marina A Senchukova Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia

The gut microbiota is currently considered an external organ of the human body that provides important mechanisms of metabolic regulation and *** gut microbiota encodes over 3 million genes,which is approximately 150 times more than the total number of genes present in the human *** in the qualitative and quantitative composition of the microbiome lead to disruption in the synthesis of key bacterial metabolites,changes in intestinal barrier function,and inflammation and can cause the development of a wide variety of diseases,such as diabetes,obesity,gastrointestinal disorders,cardiovascular issues,neurological disorders and oncological *** this review,I consider issues related to the role of the microbiome in the regulation of intestinal barrier function,its influence on physiological and pathological processes occurring in the body,and potential new therapeutic strategies aimed at restoring the gut ***,it is important to understand that the gut microbiota and human body should be considered as a single biological system,where change of one element will inevitably affect its other ***,the study of the impact of the intestinal microbiota on health should be considered only taking into account numerous factors,the role of which has not yet been fully elucidated.

关键词： Gut microbiota Bacterial metabolites Intestinal barrier Dysbiosis Fecal microbiota transplantation Probiotics

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CMT1A current gene therapy approaches and promising biomarkers

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Neural Regeneration Research 2023年第7期18卷 1434-1440页

作者： marina Stavrou Kleopas AKleopa Neuroscience Department The Cyprus Institute of Neurology and GeneticsNicosiaCyprus Center for Neuromuscular Disorders The Cyprus Institute of Neurology and GeneticsNicosiaCyprus

Charcot-Marie-Tooth neuropathies(CMT)constitute a group of common but highly heterogeneous,non-syndromic genetic disorders affecting predominantly the peripheral nervous *** type 1A(CMT1A)is the most frequent type and accounts for almost~50%of all diagnosed CMT ***1A results from the duplication of the peripheral myelin protein 22(PMP22)*** of PMP22 protein overloads the protein folding apparatus in Schwann cells and activates the unfolded protein *** leads to Schwann cell apoptosis,dys-and de-myelination and secondary axonal degeneration,ultimately causing neurological *** the last decades,several different gene therapies have been developed to treat *** all of them remain at the pre-clinical stage using CMT1A animal models overexpressing *** therapeutic goal is to achieve gene silencing,directly or indirectly,thereby reversing the CMT1A genetic mechanism allowing the recovery of myelination and prevention of axonal *** promising treatments are rapidly emerging,treatment-responsive and clinically relevant biomarkers are becoming *** biomarkers and sensitive clinical evaluation tools will facilitate the design and successful completion of future clinical trials for CMT1A.

关键词： axonal degeneration biomarkers Charcot-Marie-Tooth disease gene therapy inherited neuropathy mouse models

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Genetic heterogeneity of colorectal cancer and the microbiome

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 443-463页

作者： marina A Senchukova Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia

In 2020,the International Agency for Research on Cancer and the World Health Organization's GLOBOCAN database ranked colorectal cancer(CRC)as the third most common cancer in the *** cases of CRC(>95%)are sporadic and develop from colorectal polyps that can progress to intramucosal carcinoma and *** evidence is accumulating that the gut microbiota can play a key role in the initiation and progression of CRC,as well as in the treatment of CRC,acting as an important metabolic and immunological *** that may determine the microbiota role in CRC carcinogenesis include inflammation,changes in intestinal stem cell function,impact of bacterial metabolites on gut mucosa,accumulation of genetic mutations and other *** this review,I discuss the major mechanisms of the development of sporadic CRC,provide detailed characteristics of the bacteria that are most often associated with CRC,and analyze the role of the microbiome and microbial metabolites in inflammation initiation,activation of proliferative activity in intestinal epithelial and stem cells,and the development of genetic and epigenetic changes in CRC.I consider longterm studies in this direction to be very important,as they open up new opportunities for the treatment and prevention of CRC.

关键词： Gut microbiota Bacterial metabolites Colorectal cancer Colorectal polyp Stem cells Epigenetic changes

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Fungi Associated with Sand and Plants from Marine Coastlines: Potential Relevance for Human Health

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Advances in Microbiology（微生物学） 2024年第6期 303页

作者： marina Carrasco-Acosta Pilar Garcia-Jimenez

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A path for diagnosis and therapy of colon cancer: a continuous quality improvement

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Chinese Journal of Cancer Research 2014年第6期26卷 717-723页

作者： Jacopo Giuliani marina Marzola Department of Medical Oncology Mater Salutis Hospital Clinical Oncology Unit St. Anna University-Hospital

Objective： Prognosis of colorectal cancer strongly depends on stage at diagnosis, which can be cured in most cases at an early stage. The results were supported by different screening programmes. Few data concerning analysis of different phases of Colorectal Cancer Program were reported in literature. The aim of this study is to analyze ＂step by step＂, from a longitudinal type, the Colorectal Cancer Program, active at our Institution, verifying compliance with standards of ***： We compared two different populations during the same period： patients referring to our Clinical Oncology Unit coming from Regional Colorectal Cancer Screening Program and the other population that was not in any Colorectal Cancer ***： Considering patients from the Regional Colorectal Cancer Screening Program（19 patients, corresponding to 24.0% of the general case study）, 3（15.8%） were deceased and 16（84.2%） were alive without evidence of the disease（NED）. Concerning patients that are not coming from Regional Colorectal Cancer Screening Program（61 patients, corresponding to 76.0% of the general case study）, 9（14.8%） were deceased, 43（70.5%） were NED, 8（13.1%） were alive with metastases and 1（1.6%） was lost during follow-up（PFU）. Conclusions： On the basis of this experience, we concluded for high-quality care for both populations. Any critical point should be carefully analyzed in order to implement quality of care.

关键词： Colorectal cancer screening colorectal cancer program quality of care

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Global-in-time Uniform Convergence for Linear Hyperbolic-Parabolic Singular Perturbations

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1161-1170页

作者： marina GHISI Massimo GOBBINO Universitàdegli Studi di Pisa Dipartimento di Matematicavia M.Buonarroti 256127 PISAItaly Universitàdegli Studi di Pisa Dipartimento di Matematica Applicata "Ulisse Dini"via Bonanno 25/B56126 PISAItaly

We consider the Cauchy problem εu^″ε ＋ δu′ε ＋ Auε = 0, uε（0） = uo, u′ε（0） = ul, where ε 〉 0, δ 〉 0, H is a Hilbert space, and A is a self-adjoint linear non-negative operator on H with dense domain D（A）. We study the convergence of （uε） to the solution of the limit problem ,δu＇＋ Au = 0, u（0） = u0. For initial data （u0, u1） ∈ D（A1/2）× H, we prove global-in-time convergence with respect to strong topologies. Moreover, we estimate the convergence rate in the case where （u0, u1）∈ D（A3/2） ∈ D（A1/2）, and we show that this regularity requirement is sharp for our estimates. We give also an upper bound for ｜u′ε（t）｜ which does not depend on ε.

关键词： Parabolic equations Damped hyperbolic equations Singular perturbations

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