Microbiota of the gastrointestinal tract: Friend or foe?

作     者：Marina A Senchukova 

作者机构：Department of OncologyOrenburg State Medical UniversityOrenburg 460000Russia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第1期

页      面：19-42页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Gut microbiota Bacterial metabolites Intestinal barrier Dysbiosis Fecal microbiota transplantation Probiotics 

摘      要：The gut microbiota is currently considered an external organ of the human body that provides important mechanisms of metabolic regulation and *** gut microbiota encodes over 3 million genes,which is approximately 150 times more than the total number of genes present in the human *** in the qualitative and quantitative composition of the microbiome lead to disruption in the synthesis of key bacterial metabolites,changes in intestinal barrier function,and inflammation and can cause the development of a wide variety of diseases,such as diabetes,obesity,gastrointestinal disorders,cardiovascular issues,neurological disorders and oncological *** this review,I consider issues related to the role of the microbiome in the regulation of intestinal barrier function,its influence on physiological and pathological processes occurring in the body,and potential new therapeutic strategies aimed at restoring the gut ***,it is important to understand that the gut microbiota and human body should be considered as a single biological system,where change of one element will inevitably affect its other ***,the study of the impact of the intestinal microbiota on health should be considered only taking into account numerous factors,the role of which has not yet been fully elucidated.