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The role of singlet oxygen and hydroxyl radical in the photobleaching of meso-substituted cationic pyridyl porphyrins in the presence of folic acid

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 67-80页

作者： Lusine Mkrtchyan Torgom Seferyan marina parkhats Sergei Lepeshkevich Boris Dzhagarov Gagik Shmavonyan Elena Tuchina Valery Tuchin Grigor Gyulkhandanyan Laboratory of Bioengineering Institute of Biochemistry After H.Buniatyan of the NAS of Armenia 5/1 Paruyr Sevak StreetYerevan 0014Armenia Laboratory of Biomedical Research Institute of Biochemistry after H.Buniatyan of the NAS of Armenia 5/1 Paruyr Sevak StreetYerevan 0014Armenia B.I.Stepanov Institute of Physics NAS of Belarus 68-2 Nezavisimosti Avenue Minsk 220072Belarus National Polytechnic University of Armenia 105 Teryan Street Yerevan 0009Armenia Science Medical Centre Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia

Using a photosensitizer(PS),light,and oxygen,photodynamic therapy creates cytotoxic reactive oxygen species,such as singlet oxygen(1O2),that kill cancer *** cancer cell lines have up to 300 times more folic acid receptors than healthy ***,folic acid is often used to improve selectivity of *** poses a disadvantage for *** this paper,we have studied the photoinduced changes of meso-substituted cationic pyridyl porphyrins in the presence of folic acid using uorescence and absorption *** this work,it was demonstrated that L-histidine,which is a 1O2 quencher,and D-mannitol,which is a hydroxyl radical quencher,can reduce photobleaching of cationic porphyrins and their interaction products with *** implies both singlet oxygen and hydroxyl radicals are involved in ***,our study revealed certain important features of the photobleaching of cationic porphyrins in the presence of folic acid.

关键词： Photodynamic therapy cancer quenchers histidine mannitol

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Meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 1-16页

作者： Aram G.Gyulkhandanyan marina H.Paronyan Anna G.Gyulkhandanyan Karapet R.Ghazaryan marina V.parkhats Boris M.Dzhagarov Maria V.Korchenova Ekaterina N.Lazareva Elena S.Tuchina Grigor V.Gyulkhandanyan Valery V.Tuchin H.Buniatyan Institute of Biochemistry National Academy of Sciences of Armenia 5/1 Paruir Sevak Street Yerevan 0014Armenia INSERM U1204 Universite d'Evry vald'Essonne-Universite Paris-Saclay 1 Ruedu Pere JarlanBatiment Maupertuis91025Evry-CourcouronnesFrance B.I.Stepanov Institute of Physics National Academy of Sciences of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus Science Medical Center Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia Laboratory of Laser Molecular Imaging and Machine Learning(LMIML)National Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic *** the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate *** of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in *** aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive *** was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant *** *** complexes of porphyrins are more phototoxic than metal-free porphyrin *** e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen *** was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet *** results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.

关键词： Antibacterial photodynamic therapy cationic porphyrins/metalloporphyrins phototoxicity Zn-metalloporphyrins singlet oxygen quantum yield Gram negative and Gram positive bacteria S.aureus MRSA E.coli Salmonella typhimurium.

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