The role of singlet oxygen and hydroxyl radical in the photobleaching of meso-substituted cationic pyridyl porphyrins in the presence of folic acid

作     者：Lusine Mkrtchyan Torgom Seferyan Marina Parkhats Sergei Lepeshkevich Boris Dzhagarov Gagik Shmavonyan Elena Tuchina Valery Tuchin Grigor Gyulkhandanyan 

作者机构：Laboratory of BioengineeringInstitute of Biochemistry After H.Buniatyan of the NAS of Armenia 5/1 Paruyr Sevak StreetYerevan 0014Armenia Laboratory of Biomedical ResearchInstitute of Biochemistry after H.Buniatyan of the NAS of Armenia 5/1 Paruyr Sevak StreetYerevan 0014Armenia B.I.Stepanov Institute of Physics NAS of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus National Polytechnic University of Armenia 105 Teryan StreetYerevan 0009Armenia Science Medical CentreSaratov State University 83 Astrakhanskaya StreetSaratov 410012Russia 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2024年第17卷第5期

页      面：67-80页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the RA MESCS Science Committee and Belarusian Republican Foundation for Fundamental Research in the frames of the joint research project SC No.21SC-BRFFR-1F007 and BRFFR Grant No.21ARM-014 accordingly as well as from the Ministry of Science and Higher Education of Russian Federation within the framework of a state assignment(project No.FSRR-2023-0007) 

主　　题：Photodynamic therapy cancer quenchers histidine mannitol 

摘      要：Using a photosensitizer(PS),light,and oxygen,photodynamic therapy creates cytotoxic reactive oxygen species,such as singlet oxygen(1O2),that kill cancer *** cancer cell lines have up to 300 times more folic acid receptors than healthy ***,folic acid is often used to improve selectivity of *** poses a disadvantage for *** this paper,we have studied the photoinduced changes of meso-substituted cationic pyridyl porphyrins in the presence of folic acid using uorescence and absorption *** this work,it was demonstrated that L-histidine,which is a 1O2 quencher,and D-mannitol,which is a hydroxyl radical quencher,can reduce photobleaching of cationic porphyrins and their interaction products with *** implies both singlet oxygen and hydroxyl radicals are involved in ***,our study revealed certain important features of the photobleaching of cationic porphyrins in the presence of folic acid.