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Hepatocellular carcinoma and hepatitis C virus infection in Latin America: epidemiology, diagnosis and treatment

Hepatoma Research 2020年第5期6卷 1-18页

作者： marina Galicia-Moreno Hugo Christian Monroy-Ramirez marina campos-valdez Jaime Sanchez-Meza Laura Sanchez-Orozco Juan Armendariz-Borunda University of Guadalajara Institute of Molecular Biology in Medicine and Gene TherapyDepartment of Molecular Biology and GenomicsHealth Science University Center(CUCS)Jalisco 44340Mexico Tecnologico de Monterrey Campus GuadalajaraJalisco 45138Mexico

Hepatocellular carcinoma(HCC)is the most common cancer associated with chronic liver disease and *** most common cause of HCC is chronic hepatitis C virus infection and many studies in Europe,Asia and North America have focused on its etiology,epidemiology,diagnostic tools,and therapeutic ***,little is known about these issues in Latin *** aim of this review is to address these aspects of HCC in Latin *** main risk factors associated with developing HCC in this region are:age,concomitant cirrhosis,hepatitis C infection,obesity and hereditary disease such as *** the other hand,screening tests and diagnostic methods of HCC are mostly serum alpha fetoprotein quantification,liver ultrasound,computed tomography,magnetic resonance,and *** diagnostic methods include gut microbiota analysis and the use of nanotechnology and they continue to be ***,according to the Barcelona Clinic Liver Cancer,curative treatments used in HCC patients are mainly liver resection,liver transplantation,and local ablation,each with advantages and *** conclusion,clear strategies are urgently needed to understand the extent of HCC and related problems in this part of the *** review provides greater knowledge of HCC for the proper design of preventive programs by taking into consideration specific characteristics of our ***,this review allows for an understanding of individualizing treatments according to the patient’s needs.

关键词： Liver hepatitis C epidemiology diagnosis treatment hepatocellular carcinoma Latin America

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Food supplementation by an invasive fleshy-fruited shrub sustains body condition of a native frugivorous bird during winter

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Integrative Zoology 2019年第3期14卷 259-269页

作者： Tobias Nicolas ROJAS David Lautaro VERGARA-TABARES Diego Javier valdez marina Flavia PONZIO Susana Inés PELUC Institute of Diversity and Animal Eology(IDEA-CONICET) National University of CórdobaCórdobaArgentina Institute of Health Science Research(INICSA-CONICET) Faculty of Medical SciencesNational University of CórdobaCórdobaArgentina Faculty of Exacts Physics and Nature SciencesNational University of CórdobaCórdobaArgentina Instituto de Ecología Regional(IER-CONICET) National University of TucumánTucumánArgentina.

Birds tend to adjust their behavior and physiology to changes in food availability in their ***al fluctuation of food resources may act as an energetic challenge,augmenting hypothalamus-pituitary-adrenal axis(HPA axis)activity,leading to an increase in corticosterone concentrations and promoting the metabolism of energy *** invasions may alter seasonal food fluctuations by providing a food supply during scarce *** could attenuate the energetic challenge,reducing HPA axis activity and the metabolism of *** a system with seasonal fluctuation in food availability,we tested if fruit supplementation by the invasive fleshy-fruited Pyracantha angustifolia during the season of native fruit scarcity decreases the consumption of energy stores through activity attenuation of the HPA *** measured changes in body condition and circulating corticosterone(CORT)concentration in Turdus chiguanco occurring at sites both invaded and not invaded by *** over 3 time periods that correspond to the periods prior to,during and after highest fruit production of the *** scarcity in the ecosystem appears as an energetic challenge for ***co,given that body mass,fat score and residuals of body mass/tarsus length decreased during winter in a site not invaded by the exotic ***,the presence of the invasive plant seemed to attenuate the metabolism of energetic reserves,as we did not record changes in body condition in birds inhabiting the invaded ***,plasma CORT concentration did not vary between sites or *** evaluation is required to elucidate how enhanced body condition,resulting from the consumption of a fleshy-fruited invasive plant,affects survivorship and reproductive performance in ***.

关键词： biological invasion energetic reserves food fluctuation frugivory plasma corticosterone

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Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?

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Neural Regeneration Research 2022年第9期17卷 1945-1954页

作者： Sofia Fernanda Gonçalves Zorzella-Pezavento Luiza Ayumi Nishiyama Mimura marina Bonifácio Denadai William Danilo Fernandes de Souza Thais Fernanda de campos Fraga-Silva Alexandrina Sartori Department of Chemical and Biological Sciences Institute of BiosciencesSão Paulo State University(UNESP)BotucatuSão PauloBrazil

Multiple sclerosis is an autoimmune treatable but not curable *** are a multiplicity of medications for multiple sclerosis therapy,including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease *** all patients respond well to these therapies,and minor to severe adverse effects have been *** D,called sunshine vitamin,is being studied as a possible light at the end of the *** this review,we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis,the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis ***,based on our and other groups’experimental findings,we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.

关键词： central nervous system cytokines experimental autoimmune encephalomyelitis immunomodulation immunopathogenesis inflammation multiple sclerosis neuroprotection regulatory T cells vitamin D

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Novel Pectin/Chia-Mucilage Membranes:Human Serum Albumin Adsorption,Biocompatibility,and Physical-Chemical Properties

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Journal of Renewable Materials 2023年第6期11卷 2647-2663页

作者： S.E.Burruel-Ibarra R.A.Esquer-Osuna R.G.valdez-Melchor D.A.Cuevas-Acuña L.Quihui-Cota J.Juárez J.C.campos-García E.Valbuena-Gregorio M.A.López-Mata Departamento de Investigación en Polímeros y Materiales Universidad de SonoraHermosilloSonoraMéxico Departamento de Ciencias de la Salud Campus CajemeUniversidad de SonoraCd.ObregónSonoraMéxico Departamento de Nutrición Pública y Salud Coordinación de NutriciónCentro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico Departamento de Física Universidad de SonoraHermosilloSonoraMéxico

This study aimed to characterize the physical-chemical and biological properties of pectin(PC)/chia seed mucilage(CM)***/CM[100/0(control),80/20%,60/40%,and 40/60%w/w]membranes were prepared using the casting *** membranes(PC/CM)were thin,yellow,lightly opaque(≈10%)and capable of blocking light UVB(between 66 at 52%).SEM analysis showed the presence of aggregates in the shape of a sphere(≈13μm)and ovoid(≈25μm).The proportion of 80/20 showed an increase in tensile strength(29%)and elastic modulus(19%)when compared to the *** analysis exhibited intermolecular interactions between PCPC,PC-CM,and CM-CM in the *** thermal analysis(600°C)showed a slight improvement in the percentage of residual mass-loss of 3.31%(80/20)that *** 40/60 membrane showed the lowest percentage of hemolysis(2.94%)but limited human albumin adsorption *** results suggested that the blend PC/CM may be considered as a biomaterial for medical applications.

关键词： Pectin chia mucilage membrane hemolysis albumin biomaterial

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Immune thrombocytopenic purpura induced by intestinal tuberculosis in a liver transplant recipient

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World Journal of Gastroenterology 2014年第25期20卷 8304-8308页

作者： Renata dos Santos Lugao marina Pamponet Motta Matheus Freitas Cardoso de Azevedo Roque Gabriel Rezende de Lima Flávia de Azevedo Abrantes Edson Abdala Flair José Carrilho Daniel Ferraz de campos Mazo Hepatology Branch Clinical DivisionDepartment of GastroenterologyUniversity of S?o Paulo School of Medicine S?o Paulo 05403-000Brazil Liver and Gastrointestinal Transplant Division Department of GastroenterologyUniversity of S?o Paulo School of MedicineS?o Paulo 05403-000 Brazil Department of Infectious and Parasitic Diseases University of S?o Paulo School of Medicine S?o Paulo 05403-000 Brazil

A variety of clinical manifestations are associated directly or indirectly with tuberculosis. Among them, haematological abnormalities can be found in both the pulmonary and extrapulmonary forms of the disease. We report a case of immune thrombocytopenic purpura(ITP) associated with intestinal tuberculosis in a liver transplant recipient. The initial management of thrombocytopenia, with steroids and intravenous immunoglobulin, was not successful, and the lack oftuberculosis symptoms hampered a proper diagnostic evaluation. After the diagnosis of intestinal tuberculosis and the initiation of specific treatment, a progressive increase in the platelet count was observed. The mechanism of ITP associated with tuberculosis has not yet been well elucidated, but this condition should be considered in cases of ITP that are unresponsive to steroids and intravenous immunoglobulin, especially in immunocompromised patients and those from endemic areas.

关键词： Immune thrombocytopenic purpura Tuberculosis Liver transplant Thrombocytopenia Intestinal tuberculosis

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Business Architecture： A Case Study of a Medium Enterprise in Mexico

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通讯和计算机（中英文版） 2014年第1期11卷 22-29页

作者： Alicia valdez Menchaca Sergio Castaneda Alvarado Gloria campos Posada Alma Domfnguez Lugo Alicia Silva Avila Samuel Hernandez Donjuan Research Center Faculty of Engineering Mechanical and Electrical University Autonomous of Coahuila Coahuila Mexico Academic Unit Computer Systems Faculty of Engineering Mechanical and Electrical University Autonomous of CoahuilaCoahuila Mexico

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Allelopathic Effects of Aqueous and Ethanolic Leaves Extracts of Schinus molle L. under Different Kinds of Pruning

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Journal of Agricultural Science and Technology(A) 2017年第3期7卷 169-177页

作者： marina de Lima Nogueira Nádia Alves campos Simone Cristina do Santos Luiz Alberto Beijo Sandro Barbosa Postgraduate Program in Environmental Sciences Federal University of Alfenas (UNIFAL) Alfenas Minas Gerais 3 7130-000 Brazil Department of Biosystems Catholic University of Leuven/Katholieke Universiteit Leuven Leuven 3000 Belgium

Secondary metabolites produced by plants can be used in popular medicine, as well they can interact with plants and other organisms, in which case they are called allelochemicals and influence the neighboring ecosystem. This work aimed to evaluate the allelopathic effects of Schinus molle L. species widely used in reforestation and urban afforestation. Therefore, leaves of S. Molle were collected from different populations located at Alfenas and Nepomuceno in Minas Gerais, Brazil. Cypselae of lettuce （Lactuca sativa L.） were germinated in biochemical oxygen demand （BOD） chamber at 25 ℃ with a photoperiod of 12 h under different extracts concentrations. The experiment was performed in factorial design （2 × 4） with two kinds of extracts （aqueous and ethanol） and four concentrations （2.5, 5, 10 and 20 mg/mL） in randomized blocks. The variables analyzed were germination （%）, germination speed index （GS1）, % of normal seedlings, root length, fresh biomass and dry biomass. Changes in the cell cycle in meristematic cells of the used model were also evaluated. Concentration-dependent effect on all parameters was observed, with the exception of dry biomass exposed to ethanol extract. The root elongation parameter was different between the extracts even in lower concentrations, thus indicating that this is the most sensitive parameter of this species. Toxic effect from S. rnolle extracts was observed in all parameters regardless the kind of pruning management or method of extraction （water or ethanol）.

关键词： Secondary metabolites allelopathic effect Schinus molle L. phytotoxicity cytogenetics.

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Physicochemical and Functional Characterization of <i>Mucuna pruries</i>Depigmented Starch for Potential Industrial Applications

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International Journal of Organic Chemistry 2015年第1期5卷 1-10页

作者： Maira Rubi Segura-campos Sonia marina López-Sánchez Arturo Castellanos-Ruelas David Betancur-Ancona Luis Chel-Guerrero Facultad de Ingeniería Química Universidad Autónoma de Yucatán Mérida México

Starch is a very important biopolymer in the food industry. The velvet bean (M. pruriens) is an excellent potential starch source containing approximately 520 g starch per kg. The objective of this study was to evaluate the physicochemical and functional properties of velvet bean depigmented starch. The starch granules appear oval and spherical shaped. The colour registered L*, a*, b* values of 44.9, 0.324 and 0.341 respectively. The chemical composition registered values of moisture, ash, fat, protein, fibre and NFE of 110.5, 5.8, 5.7, 0.0, 34 and 954.5 g/kg respectively, as well as amylose levels of 215.3 g/kg. Gelatinization onset (To), peak (Tp) and final (Tf) temperatures were of 74.23°C, 80.57°C and 86.39°C. The solubility (3.1% - 16.2%), swelling power (SP) (2.86% - 16.17%) and water absorption capacity (WAC) (2.67 - 15.95 g water/g starch) were directly correlated to temperature (60°C - 90°C). The enthalpy values (4.10 - 13.47 j/g) were directly correlated to the time (1 - 21 days). The retrogradation increased as time increased. The viscosity of M. pruriens depigmented starch decreased slightly during the heating stages and then increased during cooling and the refrigeration and freezing stability registered syneresis ranges from 17.65 to 23.18 mL/50mL and from 16.4 to 22.6 mL/50mL respectively, indicating that the depigmented starch was unstable in heating-cooling processes.

关键词： Depigmented Starch Functional Properties Mucuna pruriens Physicochemical Properties

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Effect of Daily Consumption of <i>Lactobacillus reuteri </i>CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

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Food and Nutrition Sciences 2015年第17期6卷 1583-1590页

作者： Agustina Malpeli Marí a Pí a Taranto Ricardo C. Cravero marina Tavella Victoria Fasano Dimas Vicentin Guillermina Ferrari Graciano Magrini Elvira Hé bert Graciela Font de valdez Ana M. Varea Julio M. Tavella Horacio F. Gonzá lez IDIP—Instituto de Desarrollo e Investigaciones Pediá tricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niñ os de La Plata Ministerio de Salud/Comisi&oacute n de Investigaciones Cientí ficas de la Pro-vincia de Buenos Aires) La Plata Argentina CERELA—Centro de Referencia para Lactobacilos (CONICET) Tucum&aacute n Argentina Sancor CUL Departamento de Investigaci&oacute n Innovaci&oacute n y Desarrollo Sunchales Argentina

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (–7.86 g/dl) and LDL (–7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.

关键词： Lactobacillus reuteri Hypercholesterolemia Cardiovascular Risk Probiotics Functional Foods

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The Influence of Climate Variability on Holoplanktonic Polychaetes Populations of Ocean Sector of the Colombian Pacific Basin

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Open Journal of Ecology 2021年第4期11卷 317-343页

作者： José Manuel Gutiérrez-Salcedo Adibe Cárdenas-Oliva Néstor H. campos Marine Fauna of Colombia Biodiversity and Uses Research Group Universidad Nacional de Colombia Caribbean Headquarters Santa Marta Colombia Museo de Historia Natural marina de Colombia—MHNMC (Makuriwa) Instituto de Investigaciones Marinas y Costeras—INVEMAR Santa Marta Colombia Instituto de Estudios en Ciencias del Mar—CECIMAR. Universidad Nacional de Colombia Caribbean Headquarters Santa Marta Colombia

Studies of holoplanktonic polychaetes in the Tropical Eastern Pacific have focused on their systematics and distribution however, population responses related to climate variability are non-existent. Therefore, the present work described for the first time the influence of the climatic variability 2004-2012 on the holoplanktonic polychaetes populations, as well as their relationship to environmental variables. Species of the Alciopidae, Lopadorrhynchidae and Iospilidae families were identified from 85 samples collected in the Pacific Basin of Colombia, contrasting them with the presence of ENSO, and correlating them with the environmental variables of temperature, salinity and chlorophyll-α concentration. Of the 14 species identified, only Lopadorrhynchus cf. henseni and L. cf. brevis increased their densities under El Niño and correlated positively with temperature. Rhynchonereella cf. petersii correlated negatively with temperature;while R. cf. gracilis and Pelagobia cf. longicirrata were positively correlated with chlorophyll-α concentration and salinity, respectively. Additionally, with the first description of the environmental ranges of the 14 species identified for the Colombian Pacific basin, it was found that the most commons species presented broader environmental ranges. The results from the current research are consistent with previous studies in other regions of the Pacific and latitudes. The responses of the organisms suggest trophic and mobility trends that were not known for tropical holoplanktonic polychaete species.

关键词： Temperature Chlorophyll Oceanic Province Tropical Region El Niño Southern Oscillation—ENOS

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