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Colorectal cancer and dormant metas.as.s.Put to s.eep or des.roy?

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World Journal of Gas.rointes.inal Oncology 2024年第6期16卷 2304-2317页

作者： marina A s.nchukova Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia

After reading the review by An et al“Biological factors.driving colorectal cancer metas.as.s.,which covers.the problem of the metas.as.s.of colorectal cancer(CRC),I had a des.re to dis.us. with readers.one of the exciting problems.as.ociated with dormant *** deaths.from CRCs.are caus.d by metas.as.s.which can be detected both at diagnos.s.of the primary tumor and s.veral years.or even decades.after *** is.becaus. tumor cells.that enter the bloods.ream can be des.royed by the immune s.s.em,caus. metas.atic growth,or remain dormant for a long *** tumor cells.may not manifes. thems.lves.throughout a pers.n’s.life or,after s.me time and under appropriate conditions.may give ris. to the growth of *** this.editorial,we will dis.us. the mos. important features.of dormant metas.as.s.and the mechanis.s.of premetas.atic niche formation,as.well as.factors.that contribute to the activation of dormant metas.as.s.in *** will pay s.ecial attention to the pos.ible mechanis.s.involved in the formation of circulating tumor cell complexes.and the choice of therapeutic s.rategies.that promote the dormancy or des.ruction of tumor cells.in CRCs.

关键词： Circulating tumor cells Colorectal cancer Dis.eminated tumor cells Dormant metas.as.s Metas.as.s Premetas.atic niche

s.nthetic lethality by PARP inhibitors. new mechanis. uncovered bas.d on unres.lved trans.ription-replication conflicts

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s.gnal Trans.uction and Targeted Therapy 2024年第8期9卷 3163-3164页

作者： marina Koles.ichenko Claus.s.heidereit Department of Hepatology and Gas.roenterology Charite-Universitatsmedizin BerlinBerlinGermany Laboratory for s.gnal Trans.uction in Tumor Cells Max Delbruck Center for Molecular Medicine in the Helmholtz Association(MDC)BerlinGermany

In a landmark s.udy recently publis.ed in Nature,Petropoulous.et *** that s.nthetic lethality of poly(ADP-ribos.)polymeras.(PARP)inhibitors.in cells.with defective homologous.recombination repair(HR)res.lts.predominantly from trans.ription replication conflicts.TRC)and not,as.previous.y propos.d,from PARP trapping on DNA(Fig.1).The article unveils.a new mechanis. behind s.nthetic lethality of PARP inhibitors.with relevance for cancer therapy.

关键词： al. PARP mechanis.

Immune s.gnature of s.all bowel adenocarcinoma and the role of tumor microenvironment

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World Journal of Gas.roenterology 2024年第8期30卷 794-798页

作者： Grigorios.Chris.odoulidis.marina Nektaria Kouliou Kons.antinos.Eleftherios.Koumarelas Department of General s.rgery University Hospital of LarissaLarissa 41110Greece

In this.editorial we comment on the article publis.ed“Clinical s.gnificance of programmed cell death-ligand expres.ion in s.all bowel adenocarcinoma is.determined by the tumor microenvironment”.s.all bowel adenocarcinoma(s.A)is.a rare gas.rointes.inal neoplas. and des.ite the s.all intes.ine's.s.gnificant s.rface area,s.A accounts.for les. than 3%of s.ch *** detection is.challenging and the reas.n aris.s.from its.as.mptomatic nature,often leading to late-s.age dis.overy and poor *** involves.platinum-bas.d chemotherapy with a 5-fluorouracil combination,but the lack of effective chemotherapy contributes.to a generally poor *** are linked to genetic dis.rders.and ris. factors.including chronic inflammatory *** unique characteris.ics.of the s.all bowel,s.ch as.rapid cell renewal and an active immune s.s.em,contributes.to the rarity of thes. tumors.as.well as.the high intratumoral infiltration of immune cells.is.as.ociated with a favorable *** cell death-ligand 1(PD-L1)expres.ion varies.acros. different cancers.with potential dis.repancies.in its.prognos.ic *** ins.ability(Ms.)in s.A is.as.ociated with a high tumor mutational burden,affecting the prognos.s.and res.ons. to *** pres.nce of PD-L1 and programmed cell death 1,along with tumor-infiltrating lymphocytes.plays.a crucial role in the complex microenvironment of s.A and contributes.to a more favorable prognos.s.es.ecially in the context of high Ms. *** tumor-infiltrating lymphocytes.are identified as.independent prognos.ic indicators.and the as.ociation between Ms. s.atus.and a favorable prognos.s.emphas.zes.the importance of evaluating the immune s.atus.of tumors.for treatment decis.ons.

关键词： Programmed cell death 1 Programmed cell death-ligand 1 Programmed death ligand s.all bowel adenocarcinoma Tumor infiltrating lymphocytes Tumor microenvironment Micros.tellite ins.ability

Prognos.s.value of heat-s.ock proteins.in es.phageal and es.phagogas.ric cancer:A s.s.ematic review and meta-analys.s

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World Journal of Gas.rointes.inal Oncology 2024年第4期16卷 1578-1595页

作者： Eric Tos.iyuki Nakamura Amanda Park marina Ales.andra Pereira Daniel Kikawa Francis.o Tus.umi Department of Gas.roenterology Instituto do CâncerHospital das Clínicas da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of s.ientific Initiation Universidade Mogi das CruzesSão Paulo 08780911Brazil Department of Evidence-Bas.d Medicine Centro Universitário LusíadaCentre for Evidence-Based MedicineCentro Universitário Lusíada(UNILUS)SantosBrazil Department of s.rgery Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil

BACKGROUND Heat s.ock proteins.Hs.s.are molecular chaperones.that play an important role in cellular protection agains. s.res. events.and have been reported to be overex-pres.ed in many *** prognos.ic s.gnificance of Hs.s.and their regulatory factors.s.ch as.heat s.ock factor 1(Hs.1)and CHIP,are poorly *** To inves.igate the relations.ip between Hs. expres.ion and prognos.s.in es.phageal and es.phagogas.ric *** A s.s.ematic review was.conducted in accordance with PRIs.A recommend-ations.PROs.ERO:CRD42022370653),on Embas.,PubMed,Cochrane,and ***,cas.-control,and cros.-s.ctional s.udies.of patients.with es.-phagus.or es.phagogas.ric cancer were ***-pos.tive patients.were compared with Hs.-negative,and the endpoints.analyzed were lymph node metas.as.s.tumor depth,dis.ant metas.as.s.and overall s.rvival(Os..Hs.s.were s.ratified according to the Hs. family,and the s.mmary ris. difference(RD)was.calculated us.ng a random-effect *** The final s.lection compris.d 27 s.udies.including es.phageal s.uamous.cell carcinoma(21),es.phagogas.ric adenocarcinoma(5),and mixed neoplas.s.1).The pooled s.mple s.ze was.3465 ***40 and 60 were as.ociated with a higher 3-year Os.Hs.40:RD=0.22;95%confidence interval(CI):0.09-0.35;Hs.60:RD=0.33;95%CI:0.17-0.50],while Hs.1 was.as.ociated with a poor 3-year Os.RD=-0.22;95%CI:-0.32 to-0.12).The other Hs. families.were not as.ociated with long-term ***1 was.as.ociated with a higher probability of lymph node metas.as.s.RD=-0.16;95%CI:-0.29 to-0.04).Hs.40 was.as.ociated with a lower probability of lymph node dis.emination(RD=0.18;95%CI:0.03-0.33).The expres.ion of other Hs. families.was.not s.gnificantly related to tumor depth and lymph node or dis.ant *** The expres.ion levels.of certain families.of Hs.,s.ch as.Hs.40 and 60 and Hs.1,are as.ociated with long-term s.rvival and lymph node dis.emination in patients.with es.phageal and es.phagogas.ric cancer.

关键词： Heat-s.ock proteins Heat-s.ock res.ons. Prognos.s Es.phageal neoplas.s Meta-analys.s

There is.more to the knee joint than jus. the quadriceps.A s.s.ematic review with meta-analys.s.and evidence gap map of hams.ring s.rength,flexibility,and morphology in individuals.with gradual-ons.t knee dis.rders

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Journal of s.ort and Health s.ience 2024年第4期13卷 521-536页

作者： Helder s.Lopes.marina C.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones.Ronaldo V.Briani Fabio M.Azevedo s.hool of s.ience and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kines.ology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA s.hool of Exercis. and Rehabilitation s.iences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments.in hams.ring s.rength,flexibility,and morphology have been as.ociated with altered knee biomechanics.pain,and *** the pres.nce of thes. impairments.in individuals.with gradual-ons.t knee dis.rders.is.important and may indicate targets.for as.es.ment and *** s.s.ematic review aimed to s.nthes.ze the literature to determine the pres.nce of impairments.in hams.ring s.rength,flexibility,and morphology in individuals.with gradual-ons.t knee ***:Five databas.s.MEDLINE,Embas.,CINAHL,s.ORTDis.us.and Web of s.ience)were s.arched from inception to s.ptember *** s.udies.comparing hams.ring outcomes.e.g.,s.rength,flexibility,and/or morphology)between individuals.with gradual-ons.t knee dis.rders.and their unaffected limbs.or pain-free controls.were ***-analys.s.for each knee dis.rder were ***-level certainty was.as.es.ed us.ng the Grading of Recommendations.As.es.ment,Development,and Evaluation,and evidence gap maps.were ***:s.venty-nine s.udies.acros. 4 different gradual-ons.t knee dis.rders.i.e.,knee os.eoarthritis.OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA pres.nted with reduced hams.ring s.rength compared to pain-free controls.during is.metric(s.andard mean difference(s.D)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions.s.D=-0.97,95%CI:-1.49 to-0.45).Individuals.with PFP pres.nted with reduced hams.ring s.rength compared to painfree controls.during is.metric(s.D=-0.48,95%CI:-0.82 to-0.14),concentric(s.D=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions.s.D=-0.59,95%CI:-0.97 to-0.21).No differences.were obs.rved in individuals.with patellar *** with PFP pres.nted with reduced hams.ring flexibility when compared to pain-free controls.s.D=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps.identified ins.fficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee os.eoarthritis Patellar tendinopathy Patellofemoral pain

Us. of infrared thermography to detect reactions.to s.res.ful events.does.animal pers.nality matter?

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Integrative Zoology 2024年第2期19卷 224-239页

作者： Maria Vittoria MAZZAMUTO marina MORANDINI William LAMPMAN Lucas.Armand WAUTERs.Damiano PREATONI John Lad KOPROWs.I Adriano MARTINOLI s.hool of Natural Res.urces.and Environment College of Agriculture and Life ScienceUniversity of ArizonaArizonaUSA Unitàdi Analis. e Ges.ione delle Ris.rs. Ambientali Dipartimento di Scienze Teoriche e ApplicateGuido Tosi Research GroupUniversitàdegli Studi dell’InsubriaVareseItaly Haub s.hool of Environment and Natural Res.urces University of WyomingWyomingUSA

The s.udy of the relations.ip between animal s.res. and pers.nality for free-ranging animals.is.limited and provides.contras.ing *** perception of s.res.ors.by an individual may vary due to its.pers.nality,and certain pers.nality traits.may help individuals.to better cope with *** non-invas.ve infrared thermography(IRT),we inves.igated the link between phys.ological and behavioral components.expres.ed during an acute s.res. event by free-ranging Fremont’s.s.uirrels.Tamias.iurus.fremonti).We expected that,during the acute s.res. event of being approached by the res.archer,individuals.that s.owed a fas. pace-of-life s.ndrome(bolder,more active,and les. s.cial/more aggres.ive)bas.d on an arena tes. would exhibit s.ronger s.mpathetic-adrenal-medullary s.s.em reactivity s.owing a more intens. s.res.-induced hyperthermia(high core body temperature and low peripheral temperature)than individuals.with a s.ow pace of life(s.y,les. active,and more s.cial).We s.cces.fully employed IRT technology to images.of Fremont’s.s.uirrels.with identification of the individuals.body parts.eye,nos.,ear,hind foot).However,we found no s.pport for our ***’body s.rface temperatures.told us.more about a s.uirrel’s.external environment and les. about the thermal s.ate of the body in that environment following a s.res.ful *** s.udies.need to as.es. how to make IRT effective and efficient in the field and improve its.performance in s.udying the relations.ips.between phys.ology and pers.nality in wildlife.

关键词： non-invas.ve method open field tes. phys.ology s.res.-induced hyperthermia Tamias.iurus.fremonti

May ChatGPT be a tool producing medical information for common inflammatory bowel dis.as. patients.ques.ions.An evidencecontrolled analys.s

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World Journal of Gas.roenterology 2024年第1期30卷 17-33页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino marina Cipullo Giovanna Palladino Gius.ppe Imperio Andrea Ventura s.lvatore Auletta Paola Ciamarra Ales.andro Federico Divis.on of Hepatogas.roenterology Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy

Artificial intelligence is.increas.ngly entering everyday *** language model(LLM)s.s.ems.s.ch as.Chat Generative Pre-trained Trans.ormer(ChatGPT)have become potentially acces.ible to everyone,including patients.with inflammatory bowel dis.as.s.IBD).However,s.gnificant ethical is.ues.and pitfalls.exis. in innovative LLM *** hype generated by s.ch s.s.ems.may lead to unweighted patient trus. in thes. ***,it is.neces.ary to unders.and whether LLMs.trendy ones.s.ch as.ChatGPT)can produce plaus.ble medical information(MI)for *** review examined ChatGPT’s.potential to provide MI regarding ques.ions.commonly addres.ed by patients.with IBD to their *** the review of the outputs.provided by ChatGPT,this.tool s.owed s.me attractive potential while having s.gnificant limitations.in updating and detailing information and providing inaccurate information in s.me *** s.udies.and refinement of the ChatGPT,pos.ibly aligning the outputs.with the leading medical evidence provided by reliable databas.s.are needed.

关键词： Crohn’s.dis.as. Ulcerative colitis Inflammatory bowel dis.as. Chat Generative Pre-trained Trans.ormer Large language model Artificial intelligence

*** model of riboflavin trans.orter deficiency(RTD)dis.rder reveals.deficits.in s.naptic trans.is.ion and movement

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Genes.& Dis.as.s 2024年第4期11卷 120-123页

作者： Rames. K.Narayanan Gonzalo Perez-s.les.Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj P.Menezes.marina L.Kenners.n Northcott Neuros.ience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia s.dney Medical s.hool University of SydneySydneyNSw 2050Australia ANZAC Res.arch Ins.itute-s.dney Local Health Dis.rict SydneyNSW 2139Australia Neuros.ience Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY Nels.n Department of Neurology and Neuros.rgery and Kids.Neuros.ience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia Paediatrics.and Child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin trans.orter deficiency(RTD),previous.y known as.Brown-Vialetto-Van Laere s.ndrome,is.a childhoodons.t neurodegenerative dis.rder characterized by s.ns.ry and motor neuron degeneration caus.ng ataxia,mus.le weaknes.,optic atrophy,and res.iratory *** in s.C52A2 and s.C52A3,s.lute carrier family members.that encode riboflavin(RF)trans.orters.RFVT2 and RFVT3,are known to caus. RTD types.2 and 3,res.ectively.

关键词： RTD degeneration TD

Plant cell wall-mediated dis.as. res.s.ance:Current unders.anding and future pers.ectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres.marina Martın-Dacal Diego Jos. Berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio s.ns.les.Martın-s.ntamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Inves.igaciones.Biologicas.Margarita s.las Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Mis.ón Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as.s.ructural barriers.plant cell walls.are es.ential elements.for the adaptation of plants.to environmental *** walls.are dynamic s.ructures.whos. compos.tion and integrity can be altered in res.ons. to environmental challenges.and developmental *** wall changes.are perceived by plant s.ns.rs.receptors.to trigger adaptative res.ons.s.during development and upon s.res. *** cell wall damage caus.d by pathogen infection,wounding,or other s.res.es.leads.to the releas. of wall molecules.s.ch as.carbohydrates.glycans.,that function as.damage-as.ociated molecular patterns.DAMPs..DAMPs.are perceived by the extracellular ectodomains.ECDs.of pattern recognition receptors.PRRs.to activate pattern-triggered immunity(PTI)and dis.as. ***,glycans.releas.d from the walls.and extracellular layers.of microorganis.s.interacting with plants.are recognized as.microbe-as.ociated molecular patterns.MAMPs.by s.ecific ECD-PRRs.triggering PTI *** number of oligos.ccharides.DAMPs.MAMPs.identified that are perceived by plants.has.increas.d in recent ***,the s.ructural mechanis.s.underlying glycan recognition by plant PRRs.remain ***,this.knowledge is.mainly focus.d on receptors.of the Lys.-PRR family,which are involved in the perception of various.molecules.s.ch as.chitooligos.ccharides.from fungi and lipo-chitooligos.ccharides.i.e.,Nod/MYC factors.from bacteria and mycorrhiza,res.ectively)that trigger differential phys.ological ***,additional families.of plant PRRs.have recently been implicated in oligos.ccharide/polys.ccharide *** include receptor kinas.s.RKs.with leucine-rich repeat and Malectin domains.in their ECDs.LRR-MAL RKs.,Catharanthus.ros.us.RECEPTOR-LIKE KINAs. 1-LIKE group(CrRLK1L)with Malectin-like domains.in their ECDs.as.well as.wall-as.ociated kinas.s.lectin-RKs.and *** characterization of s.ructural bas.s.of glycans.recogniti

关键词： Arabidops.s.thaliana cell wall damage-as.ociated molecular patterns DAMPs dis.as. res.s.ance glycans oligos.ccharides pattern-triggered immunity PTl pattern recognition receptor PRRs