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Applying Earth Observation Technologies to Economic Consequence Modeling:A Case Study of COVID‑19 in Los Angeles County,California

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International Journal of Disaster Risk Science 2024年第1期15卷 18-31页

作者： Fynnwin Prager marina T.Mendoza Charles K.Huyck Adam Rose Paul Amyx Gregory Yetman Kristy F.Tiampo California State University Dominguez HillsCarsonCA 90747USA ImageCat Inc.Long BeachCA 90802USA University of Southern California Los AngelesCA 90015USA CIESIN–Center for International Earth Science Information Network Columbia UniversityPalisadesNY 10964USA Cooperative Institute for Research in Environmental Sciences(CIRES) University of Colorado BoulderBoulderCO 80309USA

Earth observation(EO) technologies,such as very high-resolution optical satellite data available from Maxar,can enhance economic consequence modeling of disasters by capturing the fine-grained and real-time behavioral responses of businesses and the *** investigated this unique approach to economic consequence modeling to determine whether crowd-sourced interpretations of EO data can be used to illuminate key economic behavioral responses that could be used for computable general equilibrium modeling of supply chain repercussions and resilience *** applied our methodology to the COVID-19 pandemic experience in Los Angeles County,California as a case *** also proposed a dynamic adjustment approach to account for the changing character of EO through longer-term disasters in the economic modeling *** found that despite limitations,EO data can increase sectoral and temporal resolution,which leads to significant differences from other data sources in terms of direct and total impact *** findings from this analytical approach have important implications for economic consequence modeling of disasters,as well as providing useful information to policymakers and emergency managers,whose goal is to reduce disaster costs and to improve economic resilience.

关键词： Computable general equilibrium models COVID-19 Disaster economic impacts Earth observation Economic consequence analysis Los Angeles County

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What If the Protection against Oxidation of Chromia-Forming Alloys Was Not Always Due to the Chromia Layer?

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American Journal of Analytical Chemistry 2024年第9期15卷 286-302页

作者： Boris Contri Stéphane Valette marina Soustre Pierre Lefort IRCER European Ceramics Centre UMR CNRS 7315 University of Limoges 12 rue Atlantis Limoges Cedex France

Chromia-forming alloys have good resistance to oxidizing agents such as O2, CO2, … It is accepted that the protection of these alloys is always due to the chromia layer formed at the surface of the alloys, which acts as a barrier between the oxidizing gases and the alloy substrates, forming a diffusion zone that limits the overall reaction rate and leads to parabolic kinetics. But this was not verified in the study devoted to Inconel®625 the oxidation in CO2 that was followed by TGA, with characterizations by XRD, EDS and FIB microscopy. Contrary to what was expected and accepted in similar studies on other chromia-forming alloys, it was shown that the diffusion step that governs the overall reaction rate is not located inside the chromia layer but inside the alloy, precisely inside a zone just beneath the interface alloy/chromia, this zone being depleted in chromium. The chromia layer, therefore, plays no kinetic role and does not directly protect the underlying alloy. This result was demonstrated using a simple test that consisted in removing the chromia layer from the surface of samples partially oxidized and then to continue the thermal treatment: insofar as the kinetics continued without any change in rate, this proved that this surface layer of oxide did not protect the substrate. Based on previous work on many chromia-forming alloys, the possibility of a similar reaction mechanism is discussed. If the chromia layer is not the source of protection for a number of chromia-forming alloys, as is suspected, this might have major consequences in terms of industrial applications.

关键词： Chromia-Forming Alloys Chromia Layer Oxidation Protection Inconel®625 Kinetics

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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra marina Alessandra Pereira Leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes marina C.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones Ronaldo V.Briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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Neurobiology of Supporting Syntactic Chains of Self-Grooming in Rodents and Its Biochecmical Characteristics

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Journal of Biosciences and Medicines 2024年第4期12卷 330-352页

作者： Giorgi Andronikashvili Tea Gurashvili Khatuna Dondoladze marina Nikolaishvili Malkhaz Makashvili Beritashvili Center for Experimental Biomedicine Laboratory of Neurology Tbilisi Georgia Department of Neuro Physiology Grigor Robakidze University Tbilisi Georgia Department of Physiology Ilia State University Tbilisi Georgia

Grooming is an innate behavior that serves multiple purposes and has a dual nature, reflecting both comfort and stress. Auto-grooming, in particular, is highly sensitive to stressors and can be influenced by natural and synthetic anxiolytics. Researchers believe that rodent grooming can be a valuable tool in translational neurobiological studies, specifically focusing on aberrant grooming, such as the syntactic chain of grooming, which can serve as an experimental model for certain human psycho-nervous disorders.

关键词： Grooming Microstructure Translational Medicine Clinical Medicine Stress

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Analysis of the COVID-19, Outbreak in Brazil Using Topological Weighted Centroid: An Intelligent Geographic Information System Approach

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Journal of Data Analysis and Information Processing 2024年第2期12卷 248-266页

作者： Masoud Asadi-Zeydabadi marina Mizukoshi Massimo Buscema Giulia Massini Weldon Lodwick Department of Physics University of Colorado Denver Colorado USA Institute of Mathematics and Statistics Federal University of Goi&#225s Goiania Goi&#225s Brazil Semeion Research Center Rome Italy Department of Mathematical and Statistical Sciences University of Colorado Denver Colorado USA

This study used Topological Weighted Centroid (TWC) to analyze the Coronavirus outbreak in Brazil. This analysis only uses latitude and longitude in formation of the capitals with the confirmed cases on May 24, 2020 to illustrate the usefulness of TWC though any date could have been used. There are three types of TWC analyses, each type having five associated algorithms that produce fifteen maps, TWC-Original, TWC-Frequency and TWC-Windowing. We focus on TWC-Original to illustrate our approach. The TWC method without using the transportation information predicts the network for COVID-19 outbreak that matches very well with the main radial transportation routes network in Brazil.

关键词： COVID-19 Topological Weighted Centroid (TWC) Algorithms TWC-Original TWC-Frequency and TWC-Windowing

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From cortex to cord: motor circuit plasticity after spinal cord injury

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Neural Regeneration Research 2019年第12期14卷 2054-2062页

作者： Andrew R. Brown marina martinez Département de Neurosciences Facultéde MédecineUniversitéde MontréalQuébecCanada H?pital du Sacré-Coeur de Montréal(CIUSS-NIM) MontréalQuébecCanada Groupe de Recherche sur le Système Nerveux Central Universitéde MontréalMontréalQuébecCanada

Spinal cord injury is associated with chronic sensorimotor deficits due to the interruption of ascending and descending tracts between the brain and spinal cord. Functional recovery after anatomically complete spinal cord injury is limited due to the lack of long-distance axonal regeneration of severed fibers in the adult central nervous system. Most spinal cord injuries in humans, however, are anatomically incomplete. Although restorative treatment options for spinal cord injury remain currently limited, research from experimental models of spinal cord injury have revealed a tremendous capability for both spontaneous and treatment-induced plasticity of the corticospinal system that supports functional recovery. We review recent advances in the understanding of corticospinal circuit plasticity after spinal cord injury and concentrate mainly on the hindlimb motor cortex, its corticospinal projections, and the role of spinal mechanisms that support locomotor recovery. First, we discuss plasticity that occurs at the level of motor cortex and the reorganization of cortical movement representations. Next, we explore downstream plasticity in corticospinal projections. We then review the role of spinal mechanisms in locomotor recovery. We conclude with a perspective on harnessing neuroplasticity with therapeutic interventions to promote functional recovery.

关键词： spinal cord injury motor cortex motor map corticospinal tract neuroplasticity functionalrecovery animal models forelimb hindlimb locomotion

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Unveiling the Threat: Case Reports of Extra-Pulmonary Tuberculosis among Sanctuary Chimpanzees

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Advances in Infectious Diseases 2024年第1期14卷 105-132页

作者： Emeline Chanove Yedra Feltrer Antoine Collomb-Clerc Angela Ceballos-Caro marina Spinu Department of Infectious Diseases University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Romania International Primate Health and Welfare Group (IPHWG) Madrid Spain NeuroX Institute and Brain Mind Institute School of Life Sciences Swiss Federal Institute of Technology (EPFL) Lausanne Switzerland Malaria and Emerging Parasitic Diseases Laboratory National Centre for Microbiology Instituto de Salud Carlos III Madrid Spain

Primate sanctuaries across Africa play a pivotal role in the rescue and rehabilitation of confiscated and rescued wild primates, many of whom have had extensive contact with humans prior to their arrival and throughout the rehabilitation process, heightening the risk of disease transmission. While tuberculosis is not naturally occurring in free-living chimpanzees, it has been extensively observed in captive primates that have been in close proximity to humans or other captive primates infected with Mycobacterium tuberculosis. This case report delves into an outbreak of extra-pulmonary tuberculosis among juvenile chimpanzees within a sanctuary, detailing the associated diagnostic challenges and treatment approaches. The five cases had close contact with a caregiver infected with tuberculosis, subsequently transmitting the infection to other in-contact chimpanzees. Prolonged treatment, employing the human protocol of quadri-therapy (rifampicin, isoniazid, pyrazinamide, and ethambutol), followed by bi-therapy (rifampicin and isoniazid), resulted in complete resolution for all five cases. These cases underscore the critical importance of maintaining high levels of biosecurity, implementing effective quarantine measures, and adhering to strict hygiene practices when working with non-human primates.

关键词： Extrapulmonary Tuberculosis Tuberculosis Chimpanzees Zoonotic Risk Biosecurity Diagnosis Challenges

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Study of Some Biodemographic Parameters of Caryedon serratus Olivier (Coleoptera: Chrysomelidae) Insect Pest of Tamarind (Tamarindus indica Lin.) Fruit, in Burkina Faso

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Advances in Entomology 2024年第2期12卷 67-77页

作者： Kilo Francine marina Ki Koï Wenceslas Kam Emmanuel Kabore Antoine Sanon Zakaria Ilboudo Laboratoire d’Entomologie Fondamentale et Appliqué e (LEFA) UFR/SVT Universit&eacute Joseph KI-ZERBO Ouagadougou Burkina Faso Institut Supé rieur du D&eacuteveloppement Durable Universit&eacute de Fada N’gourma Fada N’gourma Burkina Faso

The lack of food security leads us to turn to the riches of the forest, namely non-timber forest products (NTFP) and timber forest products (TFP). In Burkina, these products are a source of income for families, improving their living conditions. Tamarindus indica L. that is a NFTP, is widely used in both rural and urban areas. Unfortunately, tamarind is subject to attack by Caryedon serratus. Its biological activity begins on the fruit before the harvest. The aim of our study is to evaluate some biodemographic parameters of the insect pest C. serratus Olivier. First100 healthy T. indica pods were placed in contact with ten pairs of C. serratus for 24 hours. 25 pods, each carrying a maximum of two eggs, were divided into five batches of 5 pods. Then a pair of C. serratus aged less than 24 h was placed in contact with 4 healthy pods for 24 h. Every day, the pair was removed and transferred to another box containing 4 new healthy pods. A total of 20 replicates were performed. The results showed that C. serratus has an average lifespan of 14 days. However, the female (16 days) lived longer and laid an average of 34 eggs during her lifetime. The egg-laying period lasted 14 days, the number of eggs increased until reaching a maximum peak on the 4th day. C. serratus has an embryonic development time of 3 days and an emergence rate of 66.63%. However, the weight of males and females differed significantly (p = 0.0108). We found an intrinsic rate of natural increase of 0.12 and a population doubling time was 5.68 days. These results have enabled us to gain a better understanding of its development cycle and its capacity for regeneration. This allows us to implement control strategies for better stock protection.

关键词： Biodemographic Parameters Stock Caryedon serratus Tamarindus indica

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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： Gian Luca Rampioni Vinciguerra marina Capece Luca Reggiani Bonetti Giovanni Nigita Federica Calore Sydney Rentsch Paolo Magistri Roberto Ballarin Fabrizio Di Benedetto Rosario Distefano Roberto Cirombella Andrea Vecchione Barbara Belletti Gustavo Baldassarre Francesca Lovat Carlo M.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of Diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy Division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient *** report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC ***,we discovered that miR-15a repressed IGF1R expression via Fra-2 *** miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient *** a genetic mouse model,Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent ***,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGF1R Fra miR

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