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Early efficacy of individual regimens containing bedaquiline in patients with drug resistant tuberculosis

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Asian Pacific Journal of Tropical Medicine 2023年第4期16卷 169-175页

作者： oki Nugraha Putra Yulistiani Yulistiani Soedarsono Soedarsono Susi Subay Doctoral Program of Pharmacy Faculty of PharmacyAirlangga UniversitySurabayaIndonesia Program Study of Pharmacy Faculty of MedicineHang Tuah UniversitySurabayaIndonesia Faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Faculty of Medicine Hang Tuah UniversitySurabayaIndonesia Department of Pulmonology and Respiratory Medicine Dr.Soetomo HospitalSurabayaIndonesia

Objective:To evaluate early efficacy of sputum conversion within 6 months of individual regimens containing bedaquiline in patients with drug resistant ***:We conducted a retrospective study among patients with drug resistant tuberculosis who were receiving individual regimens containing *** primary outcome was sputum conversion of both smear and culture within 6 months of *** used medical records of drug resistant tuberculosis patients from January 2020 to December *** study was conducted at *** Hospital,Indonesia from August to October ***:In this study,44 eligible drug resistant tuberculosis patients were initiated on regimens containing *** were 52.3%males and the median age was 45.5 *** rates of previous treatment(70.5%)and lung cavity(36.4%)were *** most common companion drugs included clofazimine,cycloserine,levofloxacin,and *** smear and culture conversion was seen in 79.4%and 82.1%at the 2nd month,*** than 97%patients had smear and culture conversion at the end of 6 ***:Among drug resistant tuberculosis patients,individual regimens containing bedaquiline were associated with high rates of smear and culture conversion at the end of 6 *** efficacy of regimens containing bedaquiline can be used to predict cure rate at the end of treatment.

关键词： Bedaquiline Individual regimen Drug resistant tuberculosis Efficacy

CO_(2)utilization in syngas conversion to dimethyl ether and aromatics:Roles and challenges of zeolites-based catalysts

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Journal of Energy Chemistry 2023年第4期79卷 418-449页

作者： Ali A.Al-Qadri Galal A.Nasser Haruna Adamu oki Muraza Tawfik A.Saleh Department of Chemical Engineering King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Interdisciplinary Research Center for Hydrogen and Energy Storage(IRC-HES) King Fahd University of Petroleum&MineralsDhahran 31261Saudi Arabia Department of Environmental Management Technology and Department of ChemistryAbubakar Tafawa Balewa UniversityBauchiNigeria Department of Chemistry King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Several studies have proven a strong correlation between global warming and CO_(2)***,38 billion tons of CO_(2)are approximately emitted into the *** CO_(2)via chemical conversion to clean fuels and value-added aromatics can substantially contribute to controlling the *** the thermodynamic and environmental limitations of hydrogenation of CO_(2)alone to value-added aromatics and fuels,CO_(2)utilization has currently emerged as a promising and practical approach for the production of fuels and aromatics with simultaneous utilization of both CO and CO_(2)*** such,the approach is economically ***_(2)could be converted directly to fuels by the hydrogenation process or as a part of a syngas *** ether(DME)is a clean fuel with a higher energy density,which could be used as a substituent for several fuels such as *** the same vein,value-added aromatics such as benzene,toluene,and xylene(BTX)can be produced from a similar ***,we report a review that collects the most recent studies for the conversion of CO_(2)to DME and aromatics via zeolite-based bifunctional *** highlighted the main routes for producing DME and aromatics,as well as thoroughly discussed the conducted studies on CO_(2)hydrogenation and CO_(2)-rich syngas utilized as feedstock for conversion to DME and *** CO_(2)hydrogenation mostly occurs through the methanol-mediated reaction route but is most often limited by low selectivity and catalyst deactivation,particularly in the utilization of CO_(2)alone for the reduction *** review takes an overview of the progress made so far and concluded by identifying the roles and challenges of zeolite-based catalysts for CO_(2)utilization and conversion to DME and ***,despite the incredible growth the field received in the last couple of years,however,many research challenges and opportunities associated with this process are still abou

关键词： Clean fuel DME Aromatics Bifunctional catalyst CO_(2)mitigation

Expulsion of geopressured hydrothermal system along active faults and its relation to the occurrence of earthquakes in the Shinanogawa seismic belt, Japan

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Science China Earth Sciences 2005年第2期48卷 273-281页

作者： Yasue oki Osamu Sato Research Institute for Hazards in Snowy Areas Niigata University Niigata 950-2181JapanResearch Institute for Hazards in Snowy Areas Niigata UniversityNiigata 950-2181Japan

The 1995 Northern Niigata Earthquake (M 6.0) occurred at a shallow depth in the Niigata seismic gap. The anomaly areas in temperature, electrical conductivity and Cl- concentration of groundwater trend northeast as linear distribution in the epicentral area and are approximately coincident with the area of the seismic intensity 6 (JMA scale). The distributions of seismic intensity 6 and groundwater anomalies convincingly imaged the presence of a buried active fault beneath the epicentral area. The occurrence of this earthquake and the anomalies of groundwater were related to the expulsion of geopressured hydrothermal system (GHS). All epicenters of the destructive earthquakes along the Shinanogawa seismic belt are actually located in the buried active fault zones characterized by the areas of temperature and geochemical anomalies of groundwater. These earthquakes might have been triggered by the activity of GHS. The expulsion of GHS along an active fault in combination with the thermal softening of fault zone attributed to high rock temperature may reduce fracture strength of the rock, and trigger earthquake occurrence. The dimension of the anomaly area of groundwater temperature at the epicentral area reflected the scale of the earthquake fault. The linear anomaly areas of groundwater resulting from the expulsion of GHS and having no historical destructive earthquake are of the predicated areas of future destructive earthquakes. Monitoring of groundwater conditions in these areas may provide useful information regarding the future occurrence of earthquakes.

关键词： Shinanogawa seismic belt, 1995 Northern Niigata Earthquake, geopressured hydrothermal system (GHS),buried active fault, expulsion of GHS.

A transverse local feedback linearization approach to human head movement control

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Control Theory and Technology 2017年第4期15卷 288-300页

作者： oki, Takafumi Ghosh, Bijoy K. Department of Mathematics and Statistics Texas Tech University Lubbock U.S.A.

In the mid-nineteenth century, Donders had proposed that for every human head rotating away from the primary pointing direction, the rotational vectors in the direction of the corresponding axes of rotation, is restricted to lie on a surface. Donders＇ intuition was that under such a restriction, the head orientation would be a function of its pointing direction. In this paper, we revisit Donders＇ Law and show that indeed the proposed intuition is true for a restricted class of head-orientations satisfying a class of quadratic Donders＇ surfaces, if the head points to a suitable neighborhood of the frontal pointing direction. Moreover, on a suitably chosen subspace of the 3D rotation group SO（3）, we describe a head movement dynamical system with input control signals that are the three external torques on the head provided by muscles. Three output signals are also suitably chosen as follows. Two of the output signals are coordinates of the frontal pointing direction. The third signal measures deviation of the state vector from the Donders＇ surface. We claim that the square system is locally feedback linearizable on the subspace chosen, and the linear dynamics is decomposed into parts, transverse and tangential to the Donders＇ surface. We demonstrate our approach by synthesizing a tracking and path-following controller. Additionally, for different choices of the Donders＇ surface parameters, head gaits are visualized by simulating different movement patterns of the head-top vector, as the head-pointing vector rotates around a circle.

关键词： Head movement Donders' surface transverse feedback linearization Fick-Gimbal

Mobilization and Acquisition of Sparingly Soluble P-Sources by Brassica Cultivars under P-Starved Environment I. Differential Growth Response,P-Efficiency Characteristics and P-Remobilization

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Journal of Integrative Plant Biology 2009年第11期51卷 1008-1023页

作者： Muhammad Shahbaz Akhtar Yoko oki Tadashi Adachi Department of Environmental Management Engineering Faculty of Environmental Science and TechnologyThe Graduate School of Environmental ScienceOkayama University

Phosphorus （P） starvation is highly notorious for limiting plant growth around the globe. To combat P-starvation, plants constantly sense the changes in their environment, and elicit an elegant myriad of plastic responses and rescue strategies to enhance P-solublization and acquisition from bound soil P-forms. Relative growth responses, P-solublization and P- acquisition ability of 14 diverse Brassica cultivars grown with sparingly soluble P-sources （Rock-P （RP） and Ca3（PO4）2 （TCP）） were evaluated in a solution culture experiment. Cultivars showed considerable genetic diversity in terms of biomass accumulation, concentration and contents of P and Ca in shoots and roots, P-stress factor （PSF） and P use efficiency. Cultivars showed variable P-stress tolerance, and cultivars depicting low PSF and high P-efficiency values were better adaptable to P-starvation. In experiment 2, after initial feeding on optimum nutrition for 12 d after transplanting （DAT）, class-I （low P-tolerant （Oscar and Con-II）） and class-II （low P-sensitive （Gold Rush and RL-18）） cultivars were exposed to P-free environment for 25 d. All of the cultivars remobilized P from above ground parts to their roots during growth in P-free environment, the magnitude of which was variable in tested cultivars. P-concentrations （[P]s） at 37 DAT were higher in developing compared with developed leaves. Translocation of absorbed P from metabolically inactive to active sites in P- stressed plants may have helped class-I cultivars to establish a better rooting system, which provided a basis for enhanced P-utilization efficiency （PUE） and tolerance against P-stress. By supplying TCP and RP spatially separated from other nutrients in split root study, class-I cultivars were still able to mobilize RP and TCP more efficiently compared with class-II cultivars. To compare the growth behavior under P-stress, cultivars were grown in pots for 41 d after sowing, using a soil low in P （NaHCO3-extractable P = 3.97 mg/kg, Mehlich

关键词： Brassica Ca3(PO4)2 P-remobilization P-stress P-use efficiency P-stress factor rock phosphate.

Intraspecific Variations of Phosphorus Absorption and Remobilization, P Forms, and Their Internal Buffering in Brassica Cultivars Exposed to a P-Stressed Environment

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Journal of Integrative Plant Biology 2008年第6期50卷 703-716页

作者： M. Shahbaz Akhtar Yoko oki Tadashi Adachi Department of Environmental Management Engineering Faculty of Environmental Science and Technology Graduate School of Environmental Science Okayama University CADGK and Institute of Soil and Environmental Sciences University of Agriculture Faisalabad Pakistan

Translocation of absorbed phosphorus （P） from metabolically inactive sites to active sites in plants growing under P deprivation may increase its P utilization efficiency （PUE）. Acclimation to phosphate （Pi） starvation may be caused by a differential storage pool of vacuolar P, its release, and the intensity of re-translocation of absorbed P as P starvation inducible environmental cues （PSlEC） from ambient environment. Biomass assay and three P forms, namely inorganic （Pi）, organic （Po）, and acid-soluble total （Ptas） were estimated in Brassica cultivars exposed to 10 d P deprivation in the culture media. Considering that -aPi/at denotes the rate of Pi release, Pi release velocity （RSPi） was determined as the tangent to the equations obtained for Pi f（t） at the mean point in the period of greatest Pi decrease, whereas the inverse of the RSPi was an estimate of the internal Pi buffering capacity （IBCPi）. Inter cultivar variations in size of the non-metabolic Pi pool, RSPi, re-translocation of Pi from less to more active metabolic sites, and preferential Pi source and sink compartments were evaluated under P starvation. The cultivar ＇Brown Raya＇ showed the highest Pi storage ability under adequate external P supply, and a more intensive release than ＇Rain Bow＇ and ＇Dunkled＇ under P stress. Cultivar ＇B.S.A＇ was inferior to ＇Con-l＇ in its ability to store and use Pi. Roots and upper leaves were the main sink of Pi stored in the lower and middle leaves of all cultivars and showed lower IBCPi and larger RSPi values than lower and middle leaves. In another trial, six cultivars were exposed to P-free nutrition for 29 d after initial feeding on optimum nutrition for 15 d. With variable magnitude, all of the cultivars re-translocatad P from the above ground parts to their roots under P starvation, and [P] at 44 d after transplanting was higher in developing leaves compared with developed leaves. Under P deprivation, translocation of absorbed P from metabolically inactive to ac

关键词： Brassica internal Pi buffering capacity P absorption and remobilization Pi homeostasis Pi release velocity vacuolar P

Microwave-assisted solvothermal synthesis of ZSM-22 zeolite with controllable crystal lengths

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Particuology 2016年第1期14卷 138-141页

作者： Anas K. Jamil oki Muraza Adnan M. Al-Amer Chemical Engineering Department and Center of ExceUence in Nanotechnology King Fahd University of Petroleum and Minerals PO Box 5040Dhahran 32161 East Province Saudi Arabia

ZSM-22 （TON） zeolite crystal morphology was successfully controlled using a microwave-assisted solvothermal fabrication method. Different co-solvents, including ethanol, 2-propanol, glycerol, and ethylene glycol, were also applied in the synthesis mixture. The effects of various parameters such as the aging time, the type and amount of co-solvent on the ZSM-22 crystal aspect ratio were investigated. When employing this microwave irradiation synthesis, a long aging time was crucial to obtain smaller and more uniform crystal sizes. The addition of co-solvent resulted in elongated ZSM-22 crystals, regard- less of the actual co-solvent used, although ZSM-22 zeolite crystallinity was sensitive to the co-solvent type. In general, the use of a co-solvent stimulated the appearance of ZSM-5 zeolite as an impurity and the amount of this impurity was proportional to the concentration of co-solvent in the synthesis mixture.

关键词： Crystal morphology Nucleation Solvent Hydrothermal crystal growth Crystal structure

Dynamic load balancing with learning model for Sudoku solving system

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Digital Communications and Networks 2020年第1期6卷 108-114页

作者： Nattapong Kitsuwan Praphan Pavarangkoon Hendro Mulyo Widiyanto Eiji oki Department of Computer and Network Engineering The University of Electro-Communications1-5-1ChofugaokaChofu-shiTokyo182-8585Japan

This paper proposes a dynamic load balancing with learning model for a Sudoku problem solving system that has multiple workers and multiple *** objective is to minimise the total processing time of problem *** load balancing with learning model distributes each Sudoku problem to an appropriate pair of worker and solver when it is received by the *** information of the estimated solution time for a specific number of given input values,the estimated finishing time of each worker,and the idle status of each worker is used to determine the worker-solver *** addition,the proposed system can estimate the waiting period for each *** results show that the system has shorter processing time than conventional alternatives.

关键词： Dynamic load balancing Learning model Sudoku

A Straight-bladed Vertical Axis Wind Turbine with a Directed Guide Vane Row-Effect of Guide Vane Geometry on the Performance-

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Journal of Thermal Science 2009年第1期18卷 54-57页

作者： Manabu TAKAO Hideki KUMA Takao MAEDA Yasunari KAMADA Michiaki oki Atsushi MINODA Department of Mechanical Engineering Matsue National College of Technology Department of Mechanical Engineering Mie University

The objective of this study is to show the effect of guide vane geometry on the performance. In order to overcomethe disadvantages of vertical axis wind turbine, a straight-bladed vertical axis wind turbine (S-VAWT) witha directed guide vane row has been proposed and tested by the authors. According to previous studies, it wasclarified that the performance of the turbine can be improved by means of the directed guide vane row. However,the guide vane geometry of S-VAWT has not been optimized so far. In order to clarify the effect of guide vanegeometry, the effects of setting angle and gap between rotor blade and guide vane on power coefficient and startingcharacteristic were investigated in the experiments. The experimental study of the proposed wind turbinewas carried out by a wind tunnel. The wind tunnel with a diameter of 1.8m is open jet type. The wind velocityis 8 m/s in the experiments. The rotor has three straight blades with a profide of NACA0018 and a chord lengthof 100 mm, a diameter of 0.6 m and a blade height of 0.7 m. The guide vane row consists of 3 arc plates.

关键词：换热计算涡轮叶片湍流模型函数计算