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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux marie-aude coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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Percutaneous pelvic osteotomy in cerebral palsy patients: Surgical technique and indications

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World Journal of Orthopedics 2013年第4期4卷 279-286页

作者： Federico Canavese marie Rousset Antoine Samba Geraldo de coulon Pediatric Surgery Department University Hospital Estaing Pediatric Orthopedic Surgery Department Geneva University Hospitals

AIM: To describe the surgical technique of and indications for percutaneous pelvic osteotomy in patients with severe cerebral ***: Twenty-one non-ambulatory children and adolescents(22 hips) were consecutively treated with percutaneous pelvic osteotomy, which was used in conjunction with varus, derotational, shortening femoral osteotomy and soft tissue release, to correct progressive hip subluxation and acetabular dysplasia. The age, gender, Gross Motor Function Classification System level, side(s) of operated hip, total time of follow-up, immediate post-operative immobilization, complications, and the need for revision surgery were recorded for all patients. RESULTS: Seventeen patients(81%) were classified as GMFCS level Ⅳ, and 4(19%) patients were classified as GMFCS level Ⅴ. At the time of surgery, the mean age was10.3 years(range: 4-15 years). The mean Reimers' migration percentage improved from 63%(range: 3%-100%) pre-operatively to 6.5%(range: 0%-70%) at the final follow-up(p < 0.05). The mean acetabular angle(AA) improved from 34.1°(range: 19°-50°) pre-operatively to 14.1°(range: 5°-27°)(P < 0.05). Surgical correction of MP and AA was comparable in hips with open(n = 14) or closed(n = 8) triradiate cartilage(P < 0.05). All operated hips were pain-free at the time of the final follow-up visit, although one patient had pain for 6 mo after surgery. We did not observe any cases of bone graft dislodgement or avascular necrosis of the femoral ***: Pelvic osteotomy through a less invasive surgical approach appears to be a valid alternative with similar outcomes to those of standard techniques. This method allows for less muscle stripping and blood loss and a shorter operating time.

关键词： Percutaneous pelvic osteotomy Cerebral palsy Hip Acetabular dysplasia Children Non-ambulatory

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Overcoming the limitations of 3D sensors with wide field of view metasurface-enhanced scanning lidar

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Advanced Photonics 2023年第4期5卷 51-65页

作者： Emil Marinov Renato Juliano Martins Mohamed Aziz Ben Youssef Christina Kyrou Pierre-marie coulon Patrice Genevet Universite Cote d’Azur CNRSCRHEAValbonneFrance

Lidar, a technology at the heart of autonomous driving and robotic mobility, performs 3D imaging ofa complex scene by measuring the time of flight of returning light pulses. Many technological challenges,including enhancement of the observation field of view (FoV), acceleration of the imaging frame rate,improvement of the ambiguity range, reduction of fabrication cost, and component size, must besimultaneously addressed so that lidar technology reaches the performance needed to strongly impact theglobal market. We propose an innovative solution to address the problem of wide FoV and extendedunambiguous range using an acousto-optic modulator that rapidly scans a large-area metasurface *** further exploit a multiplexing illumination technique traditionally deployed in the context of telecommu-nication theory to extend the ambiguity range and to drastically improve the signal-to-noise ratio of themeasured signal. Compacting our metasurface-scanning lidar system to chip-scale dimension would opennew and exciting perspectives, eventually relevant to the autonomous vehicles and robotic industries.

关键词： light detection and ranging metasurfaces beam steering code division multiple access

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Displacement Talbot lithography for nanoengineering of III-nitride materials

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Microsystems & Nanoengineering 2019年第1期5卷 38-49页

作者： Pierre-marie coulon Benjamin Damilano Blandine Alloing Pierre Chausse Sebastian Walde Johannes Enslin Robert Armstrong Stephane Vezian Sylvia Hagedorn Tim Wernicke Jean Massies Jesus Zuniga‐Perez Markus Weyers Michael Kneissl Philip A.Shields Department of Electrical&Electronic Engineering University of BathBath BA27AYUK Universite Cote d’Azur CNRSCRHEArue B.Gregory06560 ValbonneFrance Ferdinand-Braun-Institut Leibniz-Institut fur HochstfrequenztechnikGustav-Kirchhoff-Str.412489 BerlinGermany Technische Universität Berlin Institute of Solid State Physics10623 BerlinGermany

Nano-engineering III-nitride semiconductors offers a route to further control the optoelectronic properties,enabling novel functionalities and *** a variety of lithography techniques are currently employed to nanoengineer these materials,the scalability and cost of the fabrication process can be an obstacle for large-scale *** this paper,we report on the use of a fast,robust and flexible emerging patterning technique called Displacement Talbot lithography(DTL),to successfully nano-engineer III-nitride ***,along with its novel and unique combination with a lateral planar displacement(D^(2)TL),allow the fabrication of a variety of periodic nanopatterns with a broad range of filling factors such as nanoholes,nanodots,nanorings and nanolines;all these features being achievable from one single *** illustrate the enormous possibilities opened by DTL/D2TL,dielectric and metal masks with a number of nanopatterns have been generated,allowing for the selective area growth of InGaN/GaN core-shell nanorods,the top-down plasma etching of III-nitride nanostructures,the top-down sublimation of GaN nanostructures,the hybrid top-down/bottom-up growth of AlN nanorods and GaN nanotubes,and the fabrication of nanopatterned sapphire substrates for AlN *** with their planar counterparts,these 3D nanostructures enable the reduction or filtering of structural defects and/or the enhancement of the light extraction,therefore improving the efficiency of the final *** results,achieved on a wafer scale via DTL and upscalable to larger surfaces,have the potential to unlock the manufacturing of nano-engineered III-nitride materials.

关键词： Talbot planar nitride

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Immobilization of Lactobacillus plantarum NCIMB 8826 ameliorates Citrobacter rodentium induced lesions and enhances the gut inflammatory response in C57BL/6 weanling mice

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Food Production, Processing and Nutrition 2022年第1期4卷 447-458页

作者： Emmanuel Kyereh Diana coulon Ingeborg Langohr Anne Raggio Michael Keenan Subramaniam Sathivel School of Nutrition and Food Sciences Louisiana State University Agriculture Center220 H.D.Wilson LaboratoriesLSU Agricultural CenterBaton RougeLA 70803USA Bioassay Core Laboratory Agricultural CenterLouisiana State UniversityBaton RougeLAUSA Department of Pathobiological Sciences Louisiana State UniversityBaton RougeLAUSA Department of Biological and Agriculture Engineering Louisiana State UniversityBaton RougeLAUSA

Infectious diarrhea is a major cause of infant mortality in most developing countries. In this research, we evaluated the potential of immobilized Lactobacillus plantarum NCIMB 8826 on weanimix infant cereal and its effectiveness in reducing the severity of Citrobacter rodentium-induced diarrhea in weanling mice. Thirty-six C57BL/6 weanling mice were placed into four groups (n = 9 each;negative, positive, prevention and cure). Mice received either L. plantarum (109 CFU/g) immobilized on weanimix infant cereal 3 days before C. rodentium (109 CFU/ ml) infection (Prevention) or 3 days after C. rodentium infection (Cure). A positive control group was infected with C. rodentium only, while a nega-tive control group received neither L. plantarum nor C. rodentium. Positive control mice showed colonic mucosal and submucosal inflammation, erosion, and mucosal epithelia hyperplasia with the C. rodentium infection. Mice in the prevention and cure groups had less severe histologic alterations in the colon. Some beneficial effect of L. plantarum was observed in cecal short-chain fatty acid concentrations, which stimulates water and electrolytes absorption to reduce diarrhea. Our findings demonstrated that L. plantarum NCIMB 8826 could be immobilized on weanimix infant cereal to help reduce diarrhea during weaning.

关键词： Probiotics Citrobacter rodentium Lactobacillus plantarum Inflammation Weanimix

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Nanovolcano microelectrode arrays: toward long- term on-demand registration of transmembrane action potentials by controlled electroporation

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Microsystems & Nanoengineering 2020年第1期6卷 578-589页

作者： Benoit X.E.Desbiolles Etienne de coulon Nicolas Maino Arnaud Bertsch Stephan Rohr Philippe Renaud Laboratory of Microsystems LMIS4 Ecole Polytechnique Federale de LausanneLausanneSwitzerland Department of Physiology Laboratory of Cellular Optics IIUniversity of BernBernSwitzerland

Volcano-shaped microelectrodes(nanovolcanoes)functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular *** nanovolcanoes exhibit recording characteristics similar to those of state-of-the-art micro-nanoelectrode arrays that use electroporation as an insertion *** this study,we investigated whether the use of electroporation improves the performance of nanovolcano arrays in terms of action potential amplitudes,recording durations,and *** with neonatal rat cardiomyocyte monolayers grown on nanovolcano arrays demonstrated that electroporation pulses with characteristics derived from analytical models increased the efficiency of nanovolcano recordings,as they enabled multiple on-demand registration of intracellular action potentials with amplitudes as high as 62 mV and parallel recordings in up to~76%of the available *** performance of nanovolcanoes showed no dependence on the presence of functionalized nanopatterns,indicating that the tip geometry itself is instrumental for establishing a tight seal at the cell–electrode interface,which ultimately determines the quality of ***,the use of electroporation permitted the recording of attenuated cardiomyocyte action potentials during consecutive days at identical sites,indicating that nanovolcano recordings are nondestructive and permit long-term on-demand recordings from excitable cardiac *** from demonstrating that less complex manufacturing processes can be used for next-generation nanovolcano arrays,the finding that the devices are suitable for performing on-demand recordings of electrical activity from multiple sites of excitable cardiac tissues over extended periods of time opens the possibility of using the devices not only in basic research but also in the context of comprehensive drug testing.

关键词： arrays recording action

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Water balance prediction in stormwater infiltration basins using 2-D modeling:An application to evaluate the clogging process

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International Journal of Sediment Research 2018年第4期33卷 371-384页

作者： Patrice Cannavo Anas coulon Sylvain Charpentier Béatrice Béchet Laure Vidal-Beaudet Agrocampus Ouest Institute for Research on Urban Sciences and Techniques (IRSTV) Research Unit Environmental Physics and Horticulture Research(EPHor) Bretagne Loire University French Institute of Science and Technology for Transport Development and Networks (IFSTTAR) IRSTV Geotechnical engineeringEnvironment Natural hazards and Earth sciences Department (GERS) Water and Environment Laboratory (LEE)

Sustainable urban drainage systems are built along roads and in urban areas to collect urban runoff and avoid flooding, and to filter water pollutants. Sediment collected by runoff is deposited in the stormwater basin and progressively reduces water infiltration efficiency, leading to the clogging of the basin. To help stormwater basin managers and stakeholders better understand and predict clogging rates in order to elaborate maintenance plans and schedules, water transport prediction models are necessary. However,because of the heterogeneous sediment hydrodynamic properties inside the stormwater basin, a twodimensional(2-D) water flow model is required to predict water levels and possible overflow as accurately as possible. Saturated hydraulic conductivity(Ks) and sediment water retention curves were measured in the overall sediment layer of the stormwater basin, in addition to sediment layer thickness and organic matter content(11 sampling points). Sediment depth was used to predict organic matter(OM) content, and the OM was used to predict Ks. Water height in the basin was modeled with the HYDRUS-2 D model by taking into account the sediment hydrodynamic properties distribution. The HYDRUS-2 D model gave a satisfactory representation of the measured data. Scenarios of the hydraulic properties of stormwater basin sediment were tested over time, and hydraulic resistance, R, was calculated to assess the stormwater basin performance. Presently, after 20 years of functioning, the stormwater basin still ensures efficient water infiltration, but the first outflow(Hydraulic resistance,R > 24 h)) is expected to appear in the next 5 years, and clogging(R > 47 h) in the next 13 years. This 2-D water balance model makes it possible to integrate the hydrodynamic heterogeneity of a stormwater basin. It gives interesting perspectives to better predict 2-D/3-D contaminant transport.

关键词： 2-D water transport Hydraulic conductivity Sediment water retention Stormwater basin efficiency

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Solid state anaerobic digestion of water poor feedstock for methane yield:an overview of process characteristics and challenges

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Waste Disposal and Sustainable Energy 2021年第3期3卷 227-245页

作者： Kunwar Paritosh Vinod Kumar Nidhi Pareek Dinabandhu Sahoo Yadira Bajon Fernandez Frederic coulon Tanja Radu Nupur Kesharwani Vivekanand Vivekanand Centre for Energy and Environment Malaviya National Institute of TechnologyJaipurRajasthan 302017India School of Water Energy and EnvironmentCranfield UniversityCranfield MK430 ALUK Department of Microbiology School of Life SciencesCentral University of Rajasthan BandarsindriKishangarhAjmerRajasthan 305801India Department of Botany University of DelhiDelhi 110007India School of Architecture Building and Civil EngineeringLoughborough UniversityLoughborough LE113TUUK Department of Civil Engineering National Institute of TechnologyRaipurChhattisgarh 492010India

Solid state anaerobic digestion(SSAD)of water poor feedstock may be a promising technology for energy *** having high solid concentration like lignocellulosic biomass,crop residues,forestry waste and organic fraction of municipal waste may be the appropriate feedstock for its biochemical conversion into energy carries like biomethane through *** to liquid state anaerobic digestion(LSAD),SSAD can handle higher organic loading rates(OLR),requires less water and smaller reactor volume and may have lower energy demand for heating or stirring and higher volumetric methane *** these,pathogen inactivation may also be achieved in SSAD of biodegradable *** 60%of recently built AD systems have adopted SSAD ***,the process stability of an SSAD system may have several constraints like limited mass transfer,process inhibitors and selection of digester type and should be addressed prior to the implementation of SSAD *** this article,a comprehensive overview of the key aspects influencing the performance of SSAD is discussed along with the need for mathematical modelling *** to this,reactor configuration for SSAD and digestate management requirement and practice for solid-state condition are reviewed for a better insight of SSAD technology.

关键词： Solid state anaerobic digestion Clean energy Mathematical modelling Digestate management Biogas Biomass

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大型汽轮机叶轮钢材的断裂力学试验和金属试验

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华东电力 1979年第S2期 42-55页

作者： A.coulon 电力部核电局阿尔斯通一大西洋公司

引言由于核电站的大容量汽轮机低压转子的尺寸较大(轮毂直径为3米,长12米,重量接近160吨),因此,其低压转子不能做成整体结构,即不能由一个单独的锻件制成。由阿尔斯通——大西洋公司所发展的工艺是:将预先加工好的嵌装叶片用的叶轮红套... 详细信息

引言由于核电站的大容量汽轮机低压转子的尺寸较大(轮毂直径为3米,长12米,重量接近160吨),因此,其低压转子不能做成整体结构,即不能由一个单独的锻件制成。由阿尔斯通——大西洋公司所发展的工艺是:将预先加工好的嵌装叶片用的叶轮红套在已经加工好的主轴上。这些叶轮——其数量一般与叶片级数(或“动叶级”)相同——是一

关键词：钢锭汽轮机叶轮钢材脆化冲击韧性冲击韧度断裂力学裂纹力学

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Redevelopment of urban brownfield sites in China:Motivation,history,policies and improved management

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Eco-Environment & Health 2022年第2期1卷 63-72页

作者： Yiming Sun Hong Li Shuo Lei Kirk TSemple Frederic coulon Qing Hu Jingyang Gao Guanlin Guo Qingbao Gu Kevin C.Jones State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences100012BeijingPR China Lancaster Environment Centre(LEC) Lancaster UniversityLancasterLA14YQUK Centre for Ecology and Hydrology Library AvenueBailriggLancaster LA14APUK State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental Sciences100012BeijingPR China School of Water Energy and EnvironmentCranfield UniversityMK430ALUK Southern University of Science and Technology 518055ShenzhenGuangdongPR China Beijing Huanding Environmental Big Data Institute 100083BeijingPR China Technical Centre for Soil Agricultural and Rural Ecology and EnvironmentMinistry of Ecology and Environment100012BeijingPR China

Rapid urbanisation in China has resulted in an increased demand for land in towns and *** upgrade and modernise,China has also moved many major industries from urban centres to less populated *** the high economic value of urban land,the transformation and utilisation of brownfield areas have become important economically and *** Chinese government has recognised the need for strong frameworks to safeguard soil and groundwater quality,with brownfield sites a key category for *** scientific,regulatory and decision-making frameworks are needed and being adopted to ensure practical,careful and wise use of central and localised government resources,to manage the reuse and regeneration of these brownfield *** paper reviews the context,policies and management procedures of developing brownfield sites in countries with a history of brownfield management and discusses China’s current situation and priorities for brownfield governance and *** include(1)clarification of brownfield site soil contamination risk control standards and risk assessment procedures,(2)the responsibilities of different national and local agencies,(3)the establishment of a national expert committee to advise on best practices,policy and process,(4)the use of registered brownfield databases at national,provincial,municipal and county levels,and(5)the set up of soil pollution prevention fund at the provincial level.

关键词： Brownfield Urban soils Management China USA UK

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