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Knowledge, attitudes and practices with regard to the presence, transmission, impact, and control of cystic echinococcosis in Sidi Kacem Province, Morocco

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Infectious Diseases of Poverty 2015年第1期4卷 399-410页

作者： Ikhlass El Berbri marie J.Ducrotoy anne-Françoise Petavy Ouaffa Fassifihri Alexra PShaw Mohammed Bouslikhane Franck Boue Susan C.Welburn Allal Dakkak Department of Pathology and Veterinary Public Health Institut Agronomique et Vétérinaire Hassan IIBP:6202RabatMorocco Department of Parasitology and Medical Mycology Lyon 1 University8 Avenue Rochefeller69373 Lyon Cedex 08France Division of Infection and Pathway Medicine School of Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburgh EH164SBUnited Kingdom Avia-GIS Risschotlei 33B-2980 ZoerselBelgium ANSES Laboratoire de la rage et de la faune sauvage de NancyLaboratoire national de référence pour Echinococcus spp54220 Malzéville cedexFrance

Background:This study is a component of a large research project on five major neglected zoonotic diseases(NZDs)including cystic echinococcosis and was undertaken in the Province of Sidi Kacem over a period of four years(April 2009-March 2013).Methods:Questionnaires were administered at community level in a total of 27 communes and visits were made to all of the 10 abattoirs situated in the Province,to collect qualitative data on determinants of transmission for disease in humans and *** specifically,community knowledge,attitudes and practices related to cystic echinococcosis were assessed,as well as the extent to which local customs and behaviours may promote *** infrastructure and practices,and their role in perpetuating disease transmission were also critically ***:The results show that only 50%of people have heard of the disease,and of those,only 21%are aware of the dog’s role in disease ***-seven per cent of respondents stated that dogs are fed ruminant organs deemed unfit for human *** dogs have access to the family home,including the kitchen,in 39%of *** extent of this close proximity between humans and animals is even more pertinent when one considers that dogs are omnipresent in the community,with an average of 1.8 dogs owned per *** unrestricted access of dogs to abattoirs is a huge issue,which further promotes disease ***:This study would suggest that the high prevalence of cystic echinococcosis in humans and animals in Morocco is largely due to three factors:1)abundance of dogs 2)engagement in risky behaviour of the local population and 3)poor abattoir infrastructure and *** has serious implications in terms of the socio-economic impact of the disease,especially for rural poor communities.

关键词： Attitudes Cystic echinococcosis Knowledge Morocco Transmission factors Practices

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软膜紫外光固化纳米压印中Amonil光刻胶的刻蚀参数优化(英文)

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纳米技术与精密工程 2012年第1期10卷 52-58页

作者：陈静石剑刘正堂 DECANINI Dominique HAGHIRI-GOSNET anne-marie 西北工业大学凝固国家重点实验室西安710072 法国国家科研中心光子与纳米结构实验室马库锡91460 法国巴黎高等师范学院巴黎75005

报道了反应离子刻蚀转移图形过程中对Amonil光刻胶的刻蚀参数优化的结果.利用软膜紫外光固化纳米压印技术,首先制备了线宽/间距均为200 nm的纳米光栅结构.然后采用反应离子刻蚀的方法去除残留的Amonil光刻胶.研究了不同的气体组成、射... 详细信息

报道了反应离子刻蚀转移图形过程中对Amonil光刻胶的刻蚀参数优化的结果.利用软膜紫外光固化纳米压印技术,首先制备了线宽/间距均为200 nm的纳米光栅结构.然后采用反应离子刻蚀的方法去除残留的Amonil光刻胶.研究了不同的气体组成、射频功率、压强和气体流量对刻蚀形貌、表面粗糙度以及刻蚀速度的影响.在优化的工艺条件下,获得了理想的具有垂直侧壁形貌和较小表面粗糙度的纳米光栅阵列.结果表明,选择优化的刻蚀工艺参数,既能有效地改善图形转移的性能,同时也能提高所制备结构的光学应用特性.

关键词：软膜紫外光固化纳米压印反应离子刻蚀刻蚀形貌表面粗糙度

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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

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Science China Materials 2018年第11期61卷 1367-1386页

作者： Serge Mignani Joao Rodrigues Helena Tomas anne-marie Caminade Regis Laurent Xiangyang Shi Jean-Pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging

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#ChronicPain:Automated Building of a Chronic Pain Cohort from Twitter Using Machine Learning

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Health Data Science 2023年第1期3卷 67-76页

作者： Abeed Sarker Sahithi Lakamana Yuting Guo Yao Ge Abimbola Leslie Omolola Okunromade Elena Gonzalez-Polledo Jeanmarie Perrone anne marie McKenzie-Brown Department of Biomedical Informatics School of MedicineEmory UniversityAtlantaGAUSA. Department of Radiology Robert Larner College of MedicineUniversity of VermontBurlingtonVTUSA. Department of Health Policy and Community Health Jiann-Ping Hsu College of Public HealthGeorgia Southern UniversityStatesboroGAUSA. Department of Anthropology Goldsmiths University of LondonLondonUK. Department of Emergency Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA. Department of Anesthesiology School of MedicineEmory UniversityAtlantaGAUSA.

Importance:Drug-likeness of a compound is an overall assessment of its potential to succeed in clinical trials,and is essential for economizing research expenditures by filtering compounds with unfavorable properties and poor development *** this end,a robust drug-likeness prediction method is *** approaches,including discriminative rules,statistical models,and machine learning models,have been developed to predict drug-likeness based on physiochemical properties and structural ***,recent advancements in novel deep learning techniques have significantly advanced drug-likeness prediction,especially in classification ***:In this review,we addressed the evolving landscape of drug-likeness prediction,with emphasis on methods employing novel deep learning techniques,and highlighted the current challenges in drug-likeness prediction,specifically regarding the aspects of generalization and ***,we explored potential remedies and outlined promising avenues for future ***:Despite the hurdles of generalization and interpretability,novel deep learning techniques have great potential in drug-likeness prediction and are worthy of further research efforts.

关键词： spite prediction landscape

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Comparisons of corrosion behaviour for X65 and low Cr steels in high pressure CO2-saturated brine

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Journal of Materials Science & Technology 2020年第6期41卷 21-32页

作者： Yong Hua Sikiru Mohammed Richard Barker anne Neville Institute of Functional Surfaces School of Mechanical Engineering University of Leeds Leeds LS2 9JT United Kingdom

Appropriate materials for injection pipelines and tubing for carbon dioxide geologic storage is fundamental to ensure asset integrity and save *** paper evaluates the corrosion behaviour of X65,1Cr,3Cr and 5Cr,which have the potential to be injection pipeline/tubing *** influence of steel Cr content on the general and localised corrosion behaviour was investigated at time periods from 6 to 192 h at 60℃and 100 *** evolution,morphology and chemistry of corrosion products on the surface of each material were evaluated using a combination of scanning electron microscopy,energy dispersive X-ray spectroscopy and X-ray diffraction and related to their overall corrosion *** indicate that prior to the formation of protective films on the steel surfaces,the resistance of the materials to corrosion increase with increasing Cr content(Corrosion resistance:X651Cr>3Cr>5Cr).In terms of the corrosion products on X65,both inner amorphous and outer crystalline corrosion layers consist of *** the Cr-containing steels,the outer layer also comprises FeCO3,but the inner layer is enriched with Cr,and is predominantly amorphous Cr(OH)*** extent of localised corrosion(determined using surface profilometry)is noticeably less for X65 compared to the Cr-containing *** paper raises questions about the benefits that low Cr steels offer towards extending component design life compared to carbon steel under the test conditions considered here.

关键词： Carbon dioxide Corrosion X65 Low-Cr steels Iron carbonate Chromium hydroxide

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华南、巽他和掸邦地块之间边界断裂的上新世—第四纪大规模构造反转

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地质学报 2022年第8期96卷 2833-2852页

作者： marie-Luce CHEVALIER Paul TAPPONNIER Phan Trong TRINH anne BRIAIS 李海兵徐锐南方海洋科学与工程广东省实验室(广州) 广东广州511458 中国地质科学院地质研究所自然资源部深地动力学重点实验室北京100037 国家自然灾害防治研究院中国应急管理部北京100085 江苏东海大陆深孔地壳活动国家野外科学观测研究站江苏连云港222300 越南科学技术研究院地质科学研究所越南河内100000 法国国家科学研究中心欧洲海洋研究所法国普鲁赞29280 四川省地震局四川成都610041 中国地震局地球物理研究所北京100081

印度-亚洲碰撞后,大陆板块沿着大型的左行走滑断裂挤出。规模最大的哀牢山-红河剪切带(ASRR)将印支地块(巽他地块)与华南地块分隔开来。长约1000 km的红河活动断裂(RRF)沿哀牢山的北侧延伸,目前呈现出右行走滑兼正断的活动性质。本文在... 详细信息

印度-亚洲碰撞后,大陆板块沿着大型的左行走滑断裂挤出。规模最大的哀牢山-红河剪切带(ASRR)将印支地块(巽他地块)与华南地块分隔开来。长约1000 km的红河活动断裂(RRF)沿哀牢山的北侧延伸,目前呈现出右行走滑兼正断的活动性质。本文在讨论了红河断裂系及其周缘的第三纪和现今变形特征(滑移性质反转、渐新世/第四纪位错、全新世滑动速率、GPS测量、地震机制等)基础之上,重点论述了其在上新世—第四纪从云南东南部到越南西北部、北部湾西部、再到更南的沙巴地区的断裂分布和运动学特征。新的数据证实,跨过三联点和越南西北部的奠边府断层之后,华南地块与巽他地块之间的现今大部分右行走滑主要沿着Da River断裂向Day Nui Con Voi(或称大象山)东南方向延伸。Da River断裂与RRF大致平行,是2020年M_(w) 5.0莫州地震的发震断层。进一步研究表明,Da River断裂很可能沿着渐新世—中新世莺歌海/宋红盆地西缘和越南东南海岸(归仁剪切带)向南延伸得更远,至少延伸到“Ile des Cendres”火山群,并可能继续延伸到沙巴-文莱逆冲带的西端,靠近婆罗洲北部的近海活动边缘。最后,我们讨论了在菲律宾群岛、台湾岛和巽他群岛之间南海大部分地区大规模构造反转的运动学效应。

关键词：南海红河断裂—Da River断裂历史地震年轻火山作用走滑构造反转块体构造

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Chemical Investigation of the NO_x Detection Mechanisms by Semiconductor Metal Oxide Nanoparticles

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稀有金属材料与工程 2006年第A03期35卷 40-42页

作者： marie-Isabelle Baraton Lhadi Merhari SPCTS-UMR CNRS 6638 Faculty of SciencesF-87060 LimogesFrance CERAMEC R&D F-87000 LimogesFrance

This work reports an FTIR study of the NO_x adsorption/desorption cycles on tin oxide nanosized particles under the operating conditions of real sensors (150℃,in presence of O_2).The chemical reactions are monitored in situ and correlated with the variations of the SnO_2 electrical *** the basis of the FTIR spectra,two contributing mechanisms for the NO_x detection are *** first one presents the formation of bridged nitrate groups bound to the SnO_2 surface via oxygen vacancies acting as electron donor *** second mechanism also involves surface oxygen vacancies in the coordination of NO_x,but this time the formation of NO_x anionic species is *** mechanisms lead to the decrease of the electrical conductivity under NO_x ***,the bridged nitrate groups are not reversible under gas desorption and thus irreversibly contaminate the surface after the first NO_x *** the contrary,the nitrosyl anionic species are reversible and,from the second NO_x adsorption/desorption cycle,ensure the reproducibility of the sensor response.

关键词： NO_x detection surface reactions FTIR spectroscopy Tin oxide SnO2 nanoparticles chemical sensors

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Nascent mRNA damage:depot and disposal

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3546-3547页

作者： Mark Helm marie-Luise Winz Institute of Pharmaceutical and Biomedical Science(IPBS) Johannes Gutenberg University MainzStaudingerweg 555128 MainzGermany

In a recent study published in Cell,Zhou et al.1 have characterized a highly unusual behavior of specialized stress granules(SG),driven by metabolism of UV-damaged *** cytoplasmic SGs are characterized by an unusual content of intronic sequences and the double-stranded RNA(dsRNA)specific helicase DHX9,both of which are usually found in the nucleus.

关键词： metabolism damage al.

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Heme oxygenase-1 system and gastrointestinal tumors

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World Journal of Gastroenterology 2010年第21期16卷 2633-2637页

作者： marie CM Lin Hsiangfu Kung The Brain Tumor Center and Neurosurgery Division Prince of Wales HospitalThe Chinese University of Hong Kong Li Ka Shing Institute of Medical Sciences the Chinese University of Hong Kong

Heme oxygenase-1(HO-1) system catabolizes heme into three products:carbon monoxide,biliverdin/bilirubin and free *** is involved in many physiological and pathophysiological processes.A great deal of data has demonstrated the roles of HO-1 in the formation,growth and metastasis of *** interest in this system by investigators involved in gastrointestinal tumors is fairly recent,and few papers on HO-1 have touched upon this *** review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to *** implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed.

关键词： Heme oxygenase-1 Gastrointestinal tumors

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Hospital inpatient complications and severity of illness

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Open Journal of Nursing 2013年第8期3卷 5-12页

作者： Ronald Lagoe anne marie Czyz Joseph Bick Shelly Littau Hospital Executive Council Syracuse USA St. Joseph’s Hospital Health Center Syracuse USA

This study evaluated the severity of illness of patients experiencing inpatient hospital complications in two hospitals in the metropolitan area of Syracuse, New York. It involved identification of inpatient complications by All Patients Refined (APR) severity of illness for pneumonia, clostridium difficile colitis, and urinary tract infection. Severity of illness was identified for each patient at the time of admission. The study showed that patients at the two highest levels of severity of illness, Major and Extreme, accounted for 76-93 percent of those with the three complications evaluated. These patients comprised less than 40 percent of the inpatient populations of the hospitals. At the same time, the study showed that only 0-23 percent of patients at Minor or Moderate severity of illness experienced inpatient complications. These low severity of illness categories accounted for 60 percent or more of inpatients in the Syracuse hospitals. Results of the study suggested that efforts to reduce hospital inpatient complications could focus on those patients with high severity of illness. They also suggested that these efforts could largely avoid patients with low severity of illness and, as a result, save clinical and quality assurance resources in hospitals.

关键词： Hospitalization Hospital Complications Quality of Care

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