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Cadaveric liver transplantation for non-acetaminophen fulminant hepatic failure:A 20-year experience

World Journal of Gastroenterology 2007年第9期13卷 1427-1430页

作者： Olivier Detry Arnaud De Roover Carla Coimbra Jean Delwaide marie-France Hans marie Hélène Delbouille Joseé Monard Jean Joris pierre Damas Jacques Belache Michel Meurisse pierre Honoré Department of Liver Surgery and Transplantation University of Liège CHU Sart Tilman B35Liège B4000 Belgium Department of Hepato- gastroenterology University of Liège CHU Sart Tilman B35 Liège B4000 Belgium Department of Anaesthesia and Intensive Care University of Liège CHU Sart Tilman B35Liège B4000Belgium

AIM: To investigate the long-term results of liver transplantation (LT) for non-acetaminophen fulminant hepatic failure (FHF). METHODS: Over a 20-year period, 29 FHF patients underwent cadaveric whole LT. Most frequent causes of FHF were hepatitis B virus and drug-related (not acetaminophen) liver failure. All surviving patients were regularly controlled at the out-patient clinic and none was lost to follow-up. Mean follow-up was 101 mo. RESULTS: One month, one-, five- and ten-year patient survival was 79%, 72%, 68% and 68%, respectively. One month, one-, five- and ten-year graft survival was 69%, 65%, 51% and 38%, respectively. Six patients needed early (< 2 mo) retransplantation, four for primary non-function, one for early acute refractory rejection because of ABO blood group incompatibility, and one for a malignant tumor found in the donor. Two patients with hepatitis B FHF developed cerebral lesions peri-transplantion: One developed irreversible and extensive brain damage leading to death, and one suffered from deep deficits leading to continuous medical care in a specialized institution. CONCLUSION: Long-term outcome of patients transplanted for non-acetaminophen FHF may be excellent. As the quality of life of these patients is also particularly good, LT for FHF is clearly justified, despite lower graft survival compared with LT for other liver diseases.

关键词： Liver transplantation Liver failure Surgery Hepatitis B Liver support

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Impact of ribavirin dose on retreatment of chronic hepatitis C patients

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World Journal of Gastroenterology 2012年第23期18卷 2966-2972页

作者： Christiane Stern Michelle Martinot-Peignoux marie pierre Ripault Nathalie Boyer Corinne Castelnau Dominique Valla Patrick Marcellin Service d'Hépatologie and INSERM U773-CRB3 H pital Beaujon University Paris-Diderot

AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHODS: Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-2a or-2b and RBV. Clinical, biological, virological and histological data were collected. Initial doses and treatment modifications were recorded. The efficacy of retreatment and predictive factors for SVR were analyzed. RESULTS: An SVR was achieved in 42% of patients. SVR was higher in young ( 15.2 mg/kg per day (70% vs 35%, P = 0.04). In logistic regression, predictors of a response were age (P = 0.018), genotype (P = 0.048) and initial RBV dose/body weight (P = 0.022). None of the patients without a complete early virological response achieved an SVR (negative predictive value = 100%). CONCLUSION: Retreatment with PEG-IFN/RBV is effective in genotype 2 or 3 relapsers, especially in young patients. A high dose of RBV seems to be important for the retreatment response.

关键词： Chronic hepatitis C Relapse Retreatment Ribavirin Pegylated interferon

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Casein Kinase 2 Negatively Regulates Abscisic Acid-Activated SnRK2s in the Core Abscisic Acid-Signaling Module

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Molecular Plant 2015年第5期8卷 709-721页

作者： Belmiro Vilela Elena Najar Victoria Lumbreras Jeffrey Leung Montserrat pages Centre for Research in Agricultural Genomics Parc de Recerca UAB Edifici CRAG Campus UAB Bellaterra (Cerdanyola del Vallea) 08193 Barcelona Spain ISV - Institut de Sciences du Vegetal CNRS bat 23 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex France

SnRK2 kinases, PP2C phosphatases and the PYR/PYL/RCAR receptors constitute the core abscisic acid （ABA） signaling module that is thought to contain all of the intrinsic properties to self-regulate the hormone signal output. Here we identify Casein Kinase （CK）2 as a novel negative regulator of SnRK2. CK2 phosphor- ylates a cluster of conserved serines at the ABA box of SnRK2, increasing its binding to PP2C and triggering protein degradation. Consequently, CK2 action has implications on SnRK2 protein levels, as well as kinase activity and its response to abiotic stimuli.

关键词： abiotic stress maize protein phosphorylation

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Cardiac Cell Therapy and Tissue Engineered with Autologous Bone Marrow Mesenchymal Cells Improve Myocardial Perfusion. An Evaluation by Pinhole Gated-SPECT

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生物医学工程学杂志 2005年第S1期22卷 15-16页

作者： Nguyen TRAN pierre-Yves marie Philippe FRANKEN Jean-Fran·ois STOLTZ Jean-pierre VILLEMOT Laboratory of Surgery School Faculty of Medicine-NancyFrance Department of Cell therapy and Tissue Engineering UMR-CNRS7563 Department of Nuclear Medicine-EA344 CHU-NancyFrance Department of Nuclear Medicine AZ-VUB-BrusselsBelgium

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The Global Standard Stratotype-section and Point （GSSP） for the base of the Eocene Series in the Dababiya section （Egypt）

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Episodes 2007年第4期30卷 271-286页

作者： marie-pierre Aubry Khaled Ouda Christian Dupuis William A., Berggren John A. Van Couvering 无 Department of Earth and Planetary Sciences Rutgers University 610 Taylor Road Piscataway New Jersey 08554 USA8 Department of Geology University of Assiut Assiut Egypt Géologie Fondamentale et Appliquée Mons PolytechnicsRue de Houdain 9 B-7000 Mons Belgium The Micropaleontology Project 256 Fifth Avenue New York NY 10001 USA the Members of the Working Group on the Paleocene/Eocene Boundary

The GSSP for the base of the Eocene Series is located at 1.58 m above the base of Section DBH in the Dababiya Quarry, on the east bank of the Nile River, about 35 km south of Luxor, Egypt. It is the base of Bed 1 of the Dababyia Quarry Beds of the El Mahmiya Member of the Esna Formation, interpreted as having recorded the basal inflection of the carbon isotope excursion （CIE）, a prominent （3 to 5%） geochemical signature which is recorded in marine （deep and shallow） and terrestrial settings around the world. The Paleocene/Eocene boundary is thus truly a globally correlatable chronostratigraphic level.

关键词：层型断面始新世第三纪下层埃及

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Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

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World Journal of Gastroenterology 2006年第26期12卷 4185-4190页

作者： Frédéric Di Fiore Stéphane Lecleire Olivier Rigal marie-pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot Jacques-Henri Jacob pierre Michel Digestive Oncology Unit Hepatogastroenterology Department Rouen University HospitalFrance Digestive Oncology unit Francois Baclesse Centre CaenFrance Radiotherapy Department Henri Becquerel Centre RouenFrance

AIM： The aim of the study was to evaluate the predictive factors of survival in patients with locally advanced squamous cell esophageal carcinoma （LASCOC） treated with definitive chemoradiotherapy （CRT） regimen based on the 5FU/CDDP combination. METHODS： All patients with LASCOC treated with a definitive CRT using the 5FU/CDDP combination between 1994 and 2000 were retrospectively included. Clinical complete response （CCR） to CRT was assessed by esophageal endoscopy and C-F-scan 2 mo after CRT completion. Prognostic factors of survival were assessed using univariate and multivariate analysis by the Cox regression model. RESULTS： A total of 116 patients were included in the study. A CCR to CRT was observed in 86/116 （74.1%）. The median survival was 20 mo （range 2-114） and the 5-year survival was 9.4%. Median survival of responder patients to CRT was 25 mo （range 3-114） as compared to 9 mo （range 2-81） in non-responder patients （P 〈 0.001）. In univariate analysis, survival was associated with CCR （P 〈 0.001）, WHO performance status 〈 2 （P = 0.01）, tumour length 〈 6 cm （P = 0.045） and weight loss 〈 10% was in limit of significance （P = 0.053）. In multivariate analysis, survival was dependant to CCR （P 〈 0.0001）, weight loss 〈 10% （P = 0.034） and WHO performance 〈 2 （P = 0.046）. CONCLUSION： Our results suggest that survival in patients with LASCOC b＇eated with definitive CRT was correlated to CCR, weight loss and WHO performance status.

关键词： Definitive chemoradiotherapy Esophageal squamous cell carcinoma Predictive factors

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Physiotherapy,Yoga and Educational Project for Patients Suffering from Pain Due to Hormone Therapy after Breast Cancer:The SKYPE Feasibility Study

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Psycho-Oncologie 2023年第3期17卷 123-131页

作者： Kerstin Faravel marie-Eve Huteau Marta Jarlier Laetitia Meignant pierre Senesse William Jacot Anne Stoebner Département des Soins de support Institut régional du Cancer de MontpellierUniversitéde MontpellierMontpellier Cedex 534298France Unitéde Biométrie Institut régional du Cancer de MontpellierUniversitéde MontpellierMontpellier Cedex 534298France Direction de la recherche clinique et de l’innovation Institut régional du Cancer de MontpellierUniversitéde MontpellierMontpellier Cedex 534298France Département d’Oncologie Médicale Institut régional du Cancer de MontpellierUniversitéde MontpellierMontpellier Cedex 534298France

Approximately 50%of breast cancer patients under hormone therapy experience osteoarticular pain,which increases the risk of treatment discontinuation and *** aim of the study was to assess the feasibility of yoga practice associated with patient education(PE)for at-home practice in breast cancer patients under hormone *** also evaluated osteoarticular pain,flexibility and patients’*** this study,intervention was split into two 6-week periods(P):P1 consisting of a supervised yoga-PE session of 90 minutes/week and 15-minutes of daily at-home yoga,and P2,involving daily autonomous athome yoga *** was evaluated by patient adherence defined as completion of at least 4 out of the 6 supervised yoga-PE sessions and 70%or more of the at-home yoga ***(at inclusion and at the end of each period)consisted in assessment of osteoarticular pain,forward flexibility and patient ***-four women with a median age of 53 years[36–72]were *** was validated with a successful adherence rate reaching 83%,combined with a mean satisfaction score of 10/10[8–10].In addition,58%of patients reported reduced osteoarticular pain,with a 2-point reduction on the numerical rating *** forward flexibility also improved,with a median gain of 8 *** physiotherapy-yoga-PE intervention is a feasible strategy,increasing at-home yoga practice with potential benefit on pain,flexibility,and patient *** of this innovative program is ongoing in a larger randomized multicenter trial.

关键词： Physical therapy Yoga patient education breast cancer pain endocrine therapy SKYPE

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Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons

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World Journal of Gastroenterology 2017年第38期23卷 7037-7046页

作者： Anders Boyd Julie Bottero Fabrice Carrat Joel Gozlan Hayette Rougier pierre-marie Girard Karine Lacombe Institute pierre Louis d’épidémiologie et de SantéPublique(IPLESP UMRS 1136) INSERMSorbonne Universités Service de maladies infectieuses Hopital Saint-AntoineAP-HP Département de santépublique Hopital Saint-AntoineAP-HP Laboratoire de Virologie Hopital Saint-AntoineAP-HP INSERM UMR_S1135 CIMI

AIM To determine whether hepatitis B virus(HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent *** Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol(for all respondents) and intent-to-treat analysis(assuming all non-responders did not vaccinate).RESULTS In total, 1215/4924(24.7%) enrolled subjects with complete HBV serology were identified as nonimmunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HBV vaccination after screening: per-protocol, 11.0%(95%CI: 9.0-13.2); intent-to-treat, 8.2%(95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HBV-endemic countries(P < 0.001), patients with limited healthcare coverage(P = 0.01) and men who have sex with men(P = 0.02). When asked about the reasons for not initiating HBV vaccination, the most frequent response was "will be vaccinated later"(33.4%), followed by "did not want to vaccinate"(29.8%), and "vaccination was not proposed by the physician"(21.5%). Sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%.CONCLUSION HBV-vaccination after HBV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level.

关键词： Health service organization Hepatitis B virus vaccination Public health Testing intervention Vaccine coverage

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Somatic molecular changes and histo-pathological features of colorectal cancer in Tunisia

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World Journal of Gastroenterology 2013年第32期19卷 5286-5294页

作者： Sana Aissi marie pierre Buisine Farid Zerimech Nadia Kourda Amel Moussa Mohamed Manai Nicole Porchet Laboratory of Biochemistry and Molecular Biology Science University of Tunis2092 El Manar TunisTunisia Centre de Recherche Jean-pierre Aubert INSERM U83759000 LilleFrance Laboratory of Biochemistry and Molecular Biology CHRU de Lille59000 LilleFrance Medicine University of H Warembourg University of Lille Nord de France59045 LilleFrance Anatomopathology Department Charles Nicolle Hospital of Tunis1006 TunisTunisia Gastro-Enterology Department Charles Nicolle Hospital of Tunis1006 TunisTunisia

AIM:To determine correlations between family history,clinical features and mutational status of genes involved in the progression of colorectal cancer(CRC).METHODS:Histo-pathological features and molecular changes[KRAS,BRAF and CTNNB1 genes mutations,microsatellite instability(MSI)phenotype,expression of mismatch repair(MMR)and mucin(MUC)5AC proteins,mutation and expression analysis of TP53,MLH1promoter hypermethylation analysis]were examined in a series of 51 unselected Tunisian CRC patients,10 of them had a proven or probable hereditary disease,on the track of new tumoral markers for CRC susceptibility in Tunisian ***:As expected,MSI and MMR expression loss were associated to the presence of familial CRC(75%vs 9%,P<0.001).However,no significant associations have been detected between personal or familial cancer history and KRAS(codons 12 and 13)or TP53(exons 4-9)alterations.A significant inverse relationship has been observed between the presence of MSI and TP53 accumulation(10.0%vs 48.8%,P=0.0335)in CRC tumors,suggesting different molecular pathways to CRC that in turn may reflect different environmental ***,MUC5AC expression was significantly associated to the presence of MSI(46.7%vs 8.3%,P=0.0039),MMR expression loss(46.7%vs8.3%,P=0.0039)and the presence of familial CRC(63%vs 23%,P=0.039).CONCLUSION:These findings suggest that MUC5AC expression analysis may be useful in the screening of Tunisian patients with high risk of CRC.

关键词： DNA mismatch repair KRAS TP53 Mucin 5AC

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The use of wastewater analysis in forensic intelligence:drug consumption comparison between Sydney and different European cities

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Forensic Sciences Research 2019年第2期4卷 141-151页

作者： Anne Bannwarth marie Morelato Lisa Benaglia Frederic Been pierre Esseiva Olivier Delemont Claude Roux Centre for Forensic Science University of Technology SydneyBroadwayNSWAustralia School of Criminal Justice University of LausanneLausanneSwitzerland Department of Pharmaceutical Science Toxicological CentreUniversity of AntwerpAntwerpBelgium

Wastewater analysis offers objective and complementary information to illicit drug agencies by monitoring patterns of illicit drug *** this study,wastewater samples from three different wastewater treatment plants in Sydney,Australia were collected in March *** targeted drugs were analysed and temporal and geographical analyses were performed to obtain a better understanding of the type and amount of illicit drugs consumed in Sydney in comparison with similar studies conducted around Australia and in *** the targeted drugs,methamphetamine was consumed the most,followed by cocaine and 3,4-methylenedioxymethamphetamine(MDMA).Weekly patterns were observed where a peak during the weekend was *** geographical analysis showed differences between the regions *** observation may be related to socio-demographic *** comparison of our study to other data sources from Australia showed a high consumption of methamphetamine in Sydney and Western *** comparison between Sydney and different European cities revealed a difference in consumption,which is in line with traditional market *** information obtained through wastewater analysis provides complementary information regarding illicit drug consumption,the size,and the evolution of the illicit drug ***,ultimately,will assist authorities in making informed decisions.

关键词： Forensic sciences wastewater-based epidemiology illicit drug consumption forensic intelligence

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