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使用气象预测和观察资料评估预测结果在确定热浪和估计热浪对死亡率影响的能力

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环境与职业医学 2015年第1期32卷 89-89页

作者： Kai Zhang Yeh-Hsin Chen Joel D.schwartz Richard B. Rood marie s.o'neill

[背景]热浪与健康预警系统的激活是基于对健康具有危害性的高温天气的预报。[目的]根据在密歇根州底特律市预测和观察到的气象数据,评估高温与死亡率之间的关联;并比较预报结果在预测热浪中的准确性。[方法]从天气观测和6个不同的预报... 详细信息

[背景]热浪与健康预警系统的激活是基于对健康具有危害性的高温天气的预报。[目的]根据在密歇根州底特律市预测和观察到的气象数据,评估高温与死亡率之间的关联;并比较预报结果在预测热浪中的准确性。[方法]从天气观测和6个不同的预报结果中得出表观温度（AT）和热浪天数（热浪的定义为：日平均AT≥温暖季节平均温度的第95百分位、并持续≥2 d）,并对这些数据进行比较。使用泊松回归分析,调整或不调整臭氧和/或PM1（0颗粒物的空气动力学直径≤10μm）,来估计并比较每天全因死亡率与观测所得以及预测所得的AT和热浪天数之间的关联。[结果]1 d前的局部观测结果,即经修正的数字预测,与所有其他的预测相比较,误报的数量约占一半。平均而言,在控制了热浪因素后,与AT=8.5℃的日子相比,观察到AT=25.3℃的日子与3.5%较高的死亡率相关联（95%CI：-1.6%~8.8%）。与非热浪日相比,观察到的热浪日均与6.2%较高的死亡率相关联（95%CI：-0.4%~13.2%）。相对于根据观测指标所得的关联,预测的准确性存在变化,但死亡率与预测高温之间的关联通常倾向于高估高温的影响,而与预测热浪的关联则倾向于低估热浪的影响。[结论]上述研究结果表明,结合局部地区的信息可以提高热浪和健康预警系统预测的准确性。

关键词：全因死亡率系统预测资料评估高温天气观测指标能力气象健康预警

TNFα和IL-6体外对颗粒物的反应：随颗粒物大小、季节、多环芳烃和土壤含量的变化

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环境与职业医学 2016年第12期33卷 1202-1208页

作者： Natalia Manzano-León Jesús serrano-Lomelin Brisa N.sánchez Raúl Quintana-Belmares Elizabeth Vega Inés Vázquez-López Leonora Rojas-Bracho Maria Tania López-Villegas Felipe Vadillo-ortega Andrea De Vizcaya-Ruiz Irma Rosas Perez marie s.o’neill Alvaro R.osornio-Vargas 季麟(翻译) 金泰廙(审校) Departamento de Investigacion Basica Instituto Nacional de CancerologiaMexicoDFMexico school of Public Health University of AlbertaEdmontonAlbertaCanada Department of Environmental Health sciences Department of Epidemiology School of Public HealthUniversity of MichiganAnn ArborMichiganUSA Direccion de Investigacion y Posgrado Instituto Mexicano del PetroleoMexicoDFMexico Gerencia de Ciencias Ambientales Instituto Nacional de Investigaciones NuclearesLa MarquesaOcoyoacacEstado de MexieoMexico Instituto Nacional de Ecologta y Cambio Climatico MexicoDFMexico National Autonomous University of Mexico(UNAM)at the National Institute of Genomic Medicine MexicoDFMexico Departamento de Toxicologla CinvestavMexicoDFMexico Centro de Ciencias de la Atmosfera UNAMMexicoDFMexico Department of Paediatrics University of AlbertaEdmontonAlbertaCanada 不详

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地... 详细信息

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地区为采集地点,每周采集样本,在多雨温暖季节和干燥寒冷季节累积采集90份PM_(10)和PM_(2.5)样本。对其中检测到的元素、多环芳烃(PAHs)和内毒素进行主成分分析(PCA)。在人单核细胞(THP-1)中检测PM诱导肿瘤坏死因子α(TNFα)和白介素6(IL-6)分泌的可能性,并用组分评分建立促炎症反应的模型。[结果]PM的成分随其大小和季节而变化。PCA确定了PM中两种随季节变化的主要组分。燃烧相关的成分(如钒、苯并(a)芘、苯并(a)蒽)组成组分1(C_1),土壤相关的成分(如内毒素、硅、铝)组成组分2(C_2)。多雨温暖季节采集的PM中C_2含量较高,而干燥寒冷季节采集的PM(尤其是PM_(2.5))中C_1含量较高。细胞因子生成水平与PM_(10)和C_2(多雨温暖季节)正相关,但与PM_(2.5)和C_1(干燥寒冷季节)负相关。C_2含量较高的PM暴露水平越高,TNFα分泌越多;样本含有≥0.1%的C_1相关PAHs时,无论样本中C_2含量高低,暴露于该样本后TNFα对PM的反应性分泌都会降低。IL-6检测结果提示PM成分和颗粒大小之间存在复杂的交互作用。[结论]TNFα分泌具有季节性并与PM大小相关,PM中的土壤含量及PAH含量的变化是其根本原因。这些结果提示,流行病学研究中一些健康结局与PM之间关联的季节性差异能用PM组分的混合物来解释。

关键词：多环芳烃主成分分析内毒素检测采集样流行病学研究细胞因子城市地区肿瘤坏死因子α 变异系数苯并

Investigation of Particle Breakdown in the Production of Composite Magnesium Chloride and Zeolite Based Thermochemical Energy s.orage Materials

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Energy Engineering 2023年第10期120卷 2193-2209页

作者： Louis F.marie Karina sałek Tadhg s.o’Donovan HeriotWatt University Institute of MechanicalProcess and Energy EngineeringEdinburghUK

Composite thermochemical energy s.orage(TCEs)represents an exciting field of thermal energy s.orage which could address the issue of seasonal variance in renewable energy ***,there are open questions about their performance and the root cause of some observed *** researchers have observed the breakdown of particles in their production phase,and in their *** study seeks to investigate the underlying cause of this *** and EDX analysis have been conducted on MgCl2 impregnated 13X zeolite composites.of differing diameters,as well as LiX *** was done in order to study the level of impregnation of salt into the zeolite matrix,as well as the effect this impregnation process has.on the morphology of the *** was conducted using ImageJ software to study the effect of the impregnation process.on the diameter of the *** has been found that a by weight impregnation concentration of magnesium chloride of 11.90%for the LiX zeolite,and 7.59%and 5.26%for the large diameter 13X zeolite and the small diameter 13X zeolite respectively has been *** has been found that the impregnation process significantly affects themorphology of 13X zeolite particles,causing large fissures to form,and eventually resulting in the previously found breakdown of these *** has been verified that a primary factor influencing the breakdown of the 13X zeolite particles is the efflorescence and sub-fluorescence phenomena,which leads to a build-up of crystals in the zeolite *** has also been found that prolonged impregnation times and the use of high concentration salt solutions in the soaking process can induce significant crystal growth which also leads to the breakdown of these *** demonstrate that LiX zeolite is the optimum host matrix choice in these *** results will allow for the design of more resilient composite TCEs particles.

关键词： Composites thermochemical energy s.orage salt-in-porous-matrix zeolites seasonal s.orage

Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon

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World Journal of Gastroenterology 2016年第12期22卷 3335-3340页

作者： Anne-marie o'Donnell David Coyle Prem Puri National Children's Research Centre Our Lady's Children's Hospital Crumlin

AIM: To investigate whether the express.on of platelet-derived growth factor receptor-α-positive (PDGFRα+)-cells is altered in Hirschsprung’s disease (HD).METHoDs: HD tissue specimens (n = 10) were collected at the... 详细信息

AIM: To investigate whether the express.on of platelet-derived growth factor receptor-α-positive (PDGFRαsup>+sup>)-cells is altered in Hirschsprung’s disease (HD).METHoDs: HD tissue specimens (n = 10) were collected at the time of pull-through surgery, while colonic control samples were obtained at the time of colos.omy closure in patients with imperforate anus (n = 10). Immunolabelling of PDGFRαsup>+sup>-cells was visualized using confocal micros.opy to assess the distribution of these cells, while Western blot analysis was undertaken to quantify PDGFRα protein ***: Confocal micros.opy revealed PDGFRαsup>+sup>-cells within the mucosa, myenteric plexus and s.ooth muscle in normal controls, with a marked reduction in PDGFRαsup>+sup>-cells in the HD specimens. Western blotting revealed high levels.of PDGFRα protein express.on in normal controls, while there was a striking decrease in PDGFRα protein express.on in the HD ***: These findings suggest that the altered distribution of PDGFRαsup>+sup>-cells in both the aganglionic and ganglionic HD bowel may contribute to the motility dysfunction in HD.

关键词： Platelet-derived growth factor receptor alpha Hirschsprung’ s disease Gastrointestinal motility Aganglionosis Myenteric plexus

Decreased express.on of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease

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World Journal of Gastroenterology 2015年第18期21卷 5635-5640页

作者： Anne marie o’Donnell David Coyle Prem Puri National Children’s Research Centre our Lady’s Children’s Hospital Cnmlin Dublin 12 Ireland

AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the express.on of HCN channels in Hirschsprung's ***:We investigated HCN1,HCN2,HCN3 and HCN4 protein express.on in pull-through specimens from patients with Hirschsprung’s disease(HsCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens.obtained at the time of sigmoid colos.omy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohis.ochemistry was performed to assess protein distribution,which was then visualized using confocal ***:No HCN1 channel express.on was.observed in any of the tissues *** HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HsCR and ***3 channel express.on was found to be markedly decreased in the aganglionic colon vs ganglionic colon and ***2-4 channels were seen to be expressed within neurons.of the myenteric and submucosal plexus.of the ganglionic bowel and normal controls,and also co-localised to interstitial cells.of Cajal in all tissues ***:We demonstrate HCN channel express.on in human colon for the first *** HCN3express.on in aganglionic bowel suggests its potential role in HsCR pathophys.ology.

关键词： Hyperpolarisation-activated nucleotide-gated Interstitial cells of Cajal Hirschsprung’s Pacemaker Ih current

Automatic target tracking on multi-resolution terrain

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Journal of Zhejiang University-science A(Applied Physics & Engineering) 2006年第7期7卷 1275-1281页

作者： WAN Ming ZHANG Wei MURRAY marie o. KAUFMAN Ariet The Boeing Company P.O. Box 3707 MC 7L-40 Seattle W.4 98124-2207 USA Department of Computer setence and Center for Visual Computing State University of New York at Stony BrookStony Brook NY 11794-4400 USA

We propose a high-performance path planning algorithm for automatic target tracking in the applications.of real-time simulation and visualization of large-scale terrain datasets, with a large number of moving objects （such as vehicles） tracking multiple moving targets. By using a modified Dijkstra＇s algorithm, an optimal path between each vehicle-target pair over a weighted grid-presented terrain is computed and updated to eliminate the problem of local minima and losing of tracking. Then, a dynamic path re-planning strategy using multi-resolution representation of a dynamic updating region is proposed to achieve high-performance by trading-off precis.on for efficiency, while guaranteeing accuracy. Primary experimental results s.owed that our algorithm successfully achieved l0 to 96 frames per second interactive path-replanning rates during a terrain simulation scenario with 10 to 100 vehicles and multiple moving targets.

关键词： Target tracking Path planning Dijkstra's algorithm Voxel-based modeling Multi-resolution terrain Real-timevisualization and simulation

Application of high silica zeolite ZsM-5 in a hybrid treatment process based on sequential adsorption and ozonation for VoCs elimination

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Journal of Environmental sciences 2016年第3期28卷 59-68页

作者： Hicham Zaitan marie Hélène Manero Héctor Valdés Laboratoire de Chirmie de la Matiere Condensee(LCMC) Faculte des Sciences et TechniquesUniversite Sidi Mohamed Ben AbdellahB.P.2202FesMaroc Universite de Toulouse INPTUPSLaboratoire de Genie Chimique4Allee Emile MonsoF-31030 ToulouseFrance CNRs Laboratoire de Genie ChimiqueF-31030 ToulouseFrance Laboratorio de Tecnologias Limpias(F.Ingenieria) Universidad Catolica de la Santisima ConcepcionAlonso de Ribera 2850ConcepcionChile

In this study,a hydrophobic synthetic zeolite,namely ZsM-5 is chosen as an adsorbent/catalyst for toluene *** results s.owed that toluene adsorption onto ZsM-5 was favourable,following a Langmuir adsorption isotherm ***-5 zeolite was regenerated using gas.ous.ozone at low *** toluene was.oxidised,releasing mainly Co_2 and H_*** of oxidation by-products such as acetic acid and acetaldehyde were formed and remained adsorbed after the oxidativate regeneration with *** four successive cycles.of adsorption/ozonation,the adsorption efficiency was not affected（92%-99%）.These results s.owed that volatile organic compound（VoC）removal by adsorption onto ZsM-5 zeolite followed by ozone regeneration could be used as a promising hybrid process for the control of VoC emiss.ons in terms.of efficiency.

关键词： Adsorption ozone Toluene VoCs Zeolite

Carcinogenesis.on the background of liver fibrosis: Implications for the management of hepatocellular cancer

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World Journal of Gastroenterology 2018年第39期24卷 4436-4447页

作者： Joanne marie o'Rourke Vandana Mridhu sagar Tahir shah shishir shetty Centre for Liver Research Institute of Biomedical ResearchBirmingham B15 2TTUnited Kingdom NIHR Birmingham Biomedical Research Centre University of Birmingham and University Hospitals Birmingham NHS Foundation Trust

Hepatocellular carcinoma(HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes.of chronic liver disease promote the development of trans.ormed or premalignant hepatocytes and predis.oses to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppress.on is supported by res.onses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progress.on may be delayed and long term durable res.onses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures.of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management.

关键词： Hepatocellular cancer Carcinogenesis Inflammation Fibrosis Immunotherapy

Factors as.ociated with subsequent surgery after septic arthritis.of the knee in children

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World Journal of Clinical Pediatrics 2023年第2期12卷 38-44页

作者： Jennifer marie o’Donnell Ernest Ekunseitan Ishaan swarup orthopaedic surgery University of California San FranciscoSan FranciscoCA 94143United States Medical school University of California San FranciscoSan FranciscoCA 94143United States Pediatric orthopaedic surgery UCSF Benioff Children’s HospitalOaklandCA 94609United States

BACKGRoUND septic arthritis.of the knee in children is a challenging *** debridement is an established treatment,but there is a paucity of literature on long-term *** To determine the rates and factors as.ociated with return to surgery(RTs)and readmiss.on after index surgical debridement for septic arthritis.of the knee in *** This is a retrospective cohort study that utilizes data from the Healthcare Cost and Utilization Project(HCUP).We included patients between ages 0 to 18 years that underwent surgical debridement for septic arthritis.of the knee between 2005 and *** data included age,gender,race,hospital type and insurance *** data including index admiss.on length of stay(Los)and Charlson Comorbidity Index(CCI)were available from the HCUP *** statistics were used to summarize the data and univariate and multivariate analyses were *** Nine-hundred thirty-two cases.of pediatric septic knee were *** cohort was 62.3%male,with mean age of 9.0(±6.1)*** 46%of patients were white and approximately half had Medicaid ***-six patients(3.6%)required RTs at a minimum of 2 year after index surgery,and 172 patients(18.5%)were readmitted at any *** mean readmiss.on Los was 11.6(±11.3)*** CCI was as.ociated with RTs(P=0.041).There were no significant as.ociations in age,gender,race,insurance type,or type of hospital to which patients *** analysis s.owed that both increased CCI(P=0.008)and s.orter Los(P=0.019)were predictive of *** septic arthritis.of the knee is an important condition in *** CCI was as.ociated with RTs at a minimum of 2 years after index *** as.ociation was found with age,gender,race,insurance type,or hospital *** Los and CCI were as.ociated with RTs in multivariate ***,risk of subsequent surgery and readmiss.on after pediatric septic knee arthritis is lo

关键词： septic arthritis knee orthopaedic surgery Infection osteomyelitis Debridement